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  1. Atazanavir/ritonavir and darunavir/ritonavir are common protease inhibitor-based regimens for treating patients with HIV. Studies comparing these drugs in clinical practice are lacking.

    Authors: Tony Antoniou, Leah Szadkowski, Sharon Walmsley, Curtis Cooper, Ann N. Burchell, Ahmed M. Bayoumi, Julio S. G. Montaner, Mona Loutfy, Marina B. Klein, Nima Machouf, Christos Tsoukas, Alexander Wong, Robert S. Hogg and Janet Raboud
    Citation: BMC Infectious Diseases 2017 17:266
    Content type: Research article Published on:

  2. We conducted a systematic review and network meta-analysis (NMA) to examine the efficacy and completion rates of treatments for latent tuberculosis infection (LTBI). While a previous review found newer, short-...

    Authors: Christopher Pease, Brian Hutton, Fatemeh Yazdi, Dianna Wolfe, Candyce Hamel, Pauline Quach, Becky Skidmore, David Moher and Gonzalo G. Alvarez
    Citation: BMC Infectious Diseases 2017 17:265
    Content type: Research article Published on:

  3. Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI) among young women, can result in serious sequelae. Although the course of infection is often ...

    Authors: B. M. Hoenderboom, A. A. M. van Oeffelen, B. H. B. van Benthem, J. E. A. M. van Bergen, N. H. T. M. Dukers-Muijrers, H. M. Götz, C. J. P. A. Hoebe, A. A. Hogewoning, F. R. M. van der Klis, D. van Baarle, J. A. Land, M. A. B. van der Sande, M. G. van Veen, F. de Vries, S. A. Morré and I. V. F. van den Broek
    Citation: BMC Infectious Diseases 2017 17:264
    Content type: Study protocol Published on:

  4. Alcohol abuse is an important public health problem, frequently unrecognized among people living with HIV/AIDS (PLWHA), and requires investigation and intervention. It is usually associated with lower adherenc...

    Authors: Cláudio Moss da Silva, Raúl Andrés Mendoza-Sassi, Luisa Dias da Mota, Maíba Mikhael Nader and Ana Maria Barral de Martinez
    Citation: BMC Infectious Diseases 2017 17:263
    Content type: Research article Published on:

  5. Whether the non-inferior efficacy and safety results of switching virologically suppressed HIV-1-infected patients from nevirapine immediate-release (NVP-IR) to NVP extended-release (NVP-XR) demonstrated in th...

    Authors: Chun-Yuan Lee, Hui-Min Chang, Calvin M Kunin, Susan Shin-Jung Lee, Yao-Shen Chen and Hung-Chin Tsai
    Citation: BMC Infectious Diseases 2017 17:261
    Content type: Research article Published on:

  6. Hepatitis C infection is a major public health concern in low- and middle-income countries where an estimated 71.1 million individuals are living with chronic infection. The World Health Organization (WHO) has...

    Authors: Alessandra Berto, Jeremy Day, Nguyen Van Vinh Chau, Guy E. Thwaites, Ngoc Nghiem My, Stephen Baker and Thomas C. Darton
    Citation: BMC Infectious Diseases 2017 17:260
    Content type: Research article Published on:

  7. To reduce the burden of severe influenza, most industrialized countries target specific risk-groups with influenza vaccines, e.g. the elderly or individuals with comorbidities. Since children are the main spre...

    Authors: Felix Weidemann, Cornelius Remschmidt, Silke Buda, Udo Buchholz, Bernhard Ultsch and Ole Wichmann
    Citation: BMC Infectious Diseases 2017 17:258
    Content type: Research article Published on:

  8. Low-dose primaquine is a key candidate for use in malaria transmission reduction and elimination campaigns such as mass drug administration (MDA). Uncertainty about the therapeutic dose range (TDR) required fo...

    Authors: Daniel Joseph Hayes, Clifford George Banda, Alexandra Chipasula-Teleka and Dianne Janette Terlouw
    Citation: BMC Infectious Diseases 2017 17:254
    Content type: Research article Published on:

  9. While the macrophage polarization is well characterized in helminth infections, the natural heterogeneity of monocytes with multiple cell phenotypes might influence the outcome of neglected diseases, such hook...

    Authors: Lívia Silva Araújo Passos, Pedro Henrique Gazzinelli-Guimarães, Tiago Antônio de Oliveira Mendes, Ana Clara Gazzinelli Guimarães, Denise da Silveira Lemos, Natasha Delaqua Ricci, Ricardo Gonçalves, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara and Lilian Lacerda Bueno
    Citation: BMC Infectious Diseases 2017 17:253
    Content type: Research article Published on:

  10. While Candida pneumonia is life-threatening, biomarker measurements to early detect suspected Candida pneumonia are lacking. This study compared the diagnostic values of measuring levels of (1, 3)-β-D-glucan in e...

    Authors: Kang-Cheng Su, Kun-Ta Chou, Yi-Han Hsiao, Ching-Min Tseng, Vincent Yi-Fong Su, Yu-Chin Lee, Diahn-Warng Perng and Yu Ru Kou
    Citation: BMC Infectious Diseases 2017 17:252
    Content type: Research article Published on:

  11. Death under care is a major challenge for tuberculosis (TB) treatment programs. We derived and validated a simple score to predict mortality during tuberculosis treatment in high endemicity areas.

    Authors: Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Virginie Poka-Mayap, Hadja Koté Fatime-Abaicho, Patrick Thierry Enono-Edende and André Pascal Kengne
    Citation: BMC Infectious Diseases 2017 17:251
    Content type: Research article Published on:

  12. Rubella is an acute infectious disease caused by Rubella virus (RUBV). RUBV remains an important pathogen worldwide, causing approximately 100 000 cases of congenital rubella syndrome (CRS) every year; and the...

    Authors: Josue Zanga, Makola Kennedy Mbanzulu, Arnold-Freddy Kabasele, Nlandu Roger Ngatu and Dimosi Roger Wumba
    Citation: BMC Infectious Diseases 2017 17:250
    Content type: Research article Published on:

  13. Human papillomavirus (HPV) is one of the most common sexually transmitted pathogens. This observational study was conducted to estimate the trend of hospitalization for genital warts (GWs) in the Veneto region...

    Authors: Silvia Cocchio, Tatjana Baldovin, Chiara Bertoncello, Alessandra Buja, Patrizia Furlan, Mario Saia and Vincenzo Baldo
    Citation: BMC Infectious Diseases 2017 17:249
    Content type: Research article Published on:

  14. Beta-hemolytic streptococci carrier rates in children living in low-income countries are high ranging from 10 to 50%. Although most of these children are asymptomatic, they are a reservoir and pose a risk of t...

    Authors: Irene Nayiga, Emmy Okello, Peter Lwabi and Grace Ndeezi
    Citation: BMC Infectious Diseases 2017 17:248
    Content type: Research article Published on:

  15. Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries. A new Tdap vaccine was manufactured in ...

    Authors: Hyo Jin Kwon, Seung Beom Han, Bo Ram Kim, Kyu Ri Kang, Dong Ho Huh, Gi Sub Choi, Dong Ho Ahn and Jin Han Kang
    Citation: BMC Infectious Diseases 2017 17:247
    Content type: Research article Published on:

  16. Combination antiretroviral therapy (cART) has reduced mortality from AIDS-related illnesses and chronic comorbidities have become prevalent among HIV-infected patients. We examined the association between hepa...

    Authors: Carmine Rossi, Janet Raboud, Sharon Walmsley, Curtis Cooper, Tony Antoniou, Ann N. Burchell, Mark Hull, Jason Chia, Robert S. Hogg, Erica E.M. Moodie and Marina B. Klein
    Citation: BMC Infectious Diseases 2017 17:246
    Content type: Research article Published on:

  17. Respiratory morbidity in Australian Indigenous children is higher than their non-Indigenous counterparts, irrespective of urban or remote residence. There are limited studies addressing acute respiratory illne...

    Authors: Kerry-Ann F. O’Grady, Kerry K. Hall, Theo P. Sloots, Jennie Anderson and Anne B. Chang
    Citation: BMC Infectious Diseases 2017 17:245
    Content type: Research article Published on:

  18. Schistosomiasis, one of the neglected tropical diseases, is endemic in more than 70 countries. However, the clinical diagnosis of patients with a low degree of infection is an unsolved...

    Authors: Kongzhen Gu, Yuesheng Li, Patrick Driguez, Qingren Zeng, Xinlin Yu, Hui Sun, Liting Cai, Yongkang He, Wenyang Wang and Donald P. McManus
    Citation: BMC Infectious Diseases 2017 17:244
    Content type: Research article Published on:

  19. Outbreaks of measles re-emerged in Guangxi province during 2013–2014, where measles again became a major public health concern. A better understanding of the patterns of measles cases would help in identifying...

    Authors: Xianyan Tang, Alan Geater, Edward McNeil, Qiuyun Deng, Aihu Dong and Ge Zhong
    Citation: BMC Infectious Diseases 2017 17:243
    Content type: Research article Published on:

  20. Pertussis (whooping cough) is well known to be underreported, particularly among adults, who can act as an infectious reservoir, potentially putting susceptible newborns at risk of serious illness. The purpose...

    Authors: Péter Torzsa, Raghavendra Devadiga and Monica Tafalla
    Citation: BMC Infectious Diseases 2017 17:242
    Content type: Research article Published on:

  21. Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. Therefore the population h...

    Authors: Eva van Doorn, Olga Pleguezuelos, Heng Liu, Ana Fernandez, Robin Bannister, Gregory Stoloff, Fredrik Oftung, Stephen Norley, Anke Huckriede, Henderik W. Frijlink and Eelko Hak
    Citation: BMC Infectious Diseases 2017 17:241
    Content type: Study protocol Published on:

  22. Acute focal bacterial nephritis (AFBN) is a rare disease currently described only in case reports and small case series. In this study we summarize the clinical features of AFBN as has been documented in the l...

    Authors: Nadine Sieger, Iason Kyriazis, Alexander Schaudinn, Panagiotis Kallidonis, Jochen Neuhaus, Evangelos N. Liatsikos, Roman Ganzer and Jens-Uwe Stolzenburg
    Citation: BMC Infectious Diseases 2017 17:240
    Content type: Research article Published on:

  23. Two lineages of Zika virus (ZIKV) have been classified according to the phylogenetic analysis: African and Asian lineages. It is unclear whether differences exist between the two strains in host cell permissiv...

    Authors: Wangheng Hou, Najealicka Armstrong, Lilian Akello Obwolo, Michael Thomas, Xiaowu Pang, Kevin S. Jones and Qiyi Tang
    Citation: BMC Infectious Diseases 2017 17:239
    Content type: Research article Published on:

  24. Seasonal influenza epidemics place considerable strain on health services. Robust systems of surveillance are therefore required to ensure preparedness. Sentinel surveillance does not accurately capture the co...

    Authors: Maria Peppa, W. John Edmunds and Sebastian Funk
    Citation: BMC Infectious Diseases 2017 17:238
    Content type: Research article Published on:

  25. Children with cardiac defects need many hospitalizations and repetitive antibiotic therapies, with an increasing risk of colonization with multidrug-resistant bacteria (MDRB) such as extended-spectrum β-lactam...

    Authors: Amine Cheikh, Bouchra Belefquih, Younes Chajai, Younes Cheikhaoui, Amine El Hassani and Amina Benouda
    Citation: BMC Infectious Diseases 2017 17:237
    Content type: Research article Published on:

  26. Tuberculosis and HIV co-infection is one of the main drivers of poor outcome for both diseases in Zambia. HIV infection has been found to predict TB infection/disease and TB has been reported as a major cause ...

    Authors: Pascalina Chanda-Kapata, Nathan Kapata, Eveline Klinkenberg, Martin P. Grobusch and Frank Cobelens
    Citation: BMC Infectious Diseases 2017 17:236
    Content type: Research article Published on:

  27. In chronic hepatitis C, the fibrosis progression rates are extremely variable and can be influenced by factors associated with the host, virus and environment. Among the associated metabolic factors, hepatic s...

    Authors: Mariana Cavalheiro Magri, Thamiris Vaz Gago Prata, Caroline Manchiero, Bianca Peixoto Dantas, Celso Carmo Mazza and Fátima Mitiko Tengan
    Citation: BMC Infectious Diseases 2017 17:235
    Content type: Research article Published on:

  28. Increased incidence of cardiovascular diseases (CVD) in both HIV infection and type 2 diabetes (T2D) compared to the general population has been described. Little is known about the combined effect of HIV infe...

    Authors: Malene Hove-Skovsgaard, Julie Christine Gaardbo, Lilian Kolte, Kamilla Winding, Ingebjørg Seljeflot, Asbjørn Svardal, Rolf Kristian Berge, Jan Gerstoft, Henrik Ullum, Marius Trøseid and Susanne Dam Nielsen
    Citation: BMC Infectious Diseases 2017 17:234
    Content type: Research article Published on:

  29. Culturing has long been the gold standard for detecting aetiologic agents in bacterial infections. In some cases, however, culturing fails to detect the infection. To further investigate culture-negative sampl...

    Authors: Camilla Stavnsbjerg, Niels Frimodt-Møller, Claus Moser and Thomas Bjarnsholt
    Citation: BMC Infectious Diseases 2017 17:233
    Content type: Research article Published on:

  30. Vaccination against seasonal influenza strains is recommended for “high risk” patient groups such as infants, elderly and those with respiratory or circulatory diseases. However, efficacy of the trivalent infl...

    Authors: M. D Heath, N. J. Swan, A. C. Marriott, N. J. Silman, B. Hallis, C. Prevosto, K. E. Gooch and M. A. Skinner
    Citation: BMC Infectious Diseases 2017 17:232
    Content type: Research article Published on:

  31. We describe drug-induced liver injury (DILI) secondary to antituberculous treatment (ATT) in a large tuberculosis (TB) centre in London; we identify the proportion who had risk factors for DILI and the timing ...

    Authors: Aula Abbara, Sarah Chitty, Jennifer K. Roe, Rohma Ghani, Simon M. Collin, Andrew Ritchie, Onn Min Kon, John Dzvova, Harriet Davidson, Thomas E. Edwards, Charlotte Hateley, Matthew Routledge, Jim Buckley, Robert N. Davidson and Laurence John
    Citation: BMC Infectious Diseases 2017 17:231
    Content type: Research article Published on:

  33. Identification of carbapenemase-producing Enterobacteriaceae (CPE) in faecal specimens is challenging. This fact is particularly critical because low-level carbapenem-resistant organisms such as IMP-producing CPE...

    Authors: Norihisa Yamamoto, Ryuji Kawahara, Yukihiro Akeda, Rathina Kumar Shanmugakani, Hisao Yoshida, Hideharu Hagiya, Naohiro Hara, Isao Nishi, Satomi Yukawa, Rumiko Asada, Yumi Sasaki, Kazuhiro Maeda, Noriko Sakamoto, Shigeyuki Hamada and Kazunori Tomono
    Citation: BMC Infectious Diseases 2017 17:229
    Content type: Research article Published on:

  34. Levels of non-neutralising antibodies (AB) to the C5 domain of HIV Env gp120 are inversely related to progression of HIV infection. In this phase I/II clinical study we investigated safety of Vacc-C5, a peptid...

    Authors: Kristin Brekke, Maja Sommerfelt, Mats Ökvist, Anne Margarita Dyrhol-Riise and Dag Kvale
    Citation: BMC Infectious Diseases 2017 17:228
    Content type: Research article Published on:

  35. Periprosthetic joint infections are mainly caused by Gram-positive cocci. Leuconostoc mesenteroides is a rare microorganism mainly causing bloodstream infections. At times, it might be confused with another type ...

    Authors: Rafael Franco-Cendejas, Claudia A. Colín-Castro, Melissa Hernández-Durán, Luis E. López-Jácome, Silvestre Ortega-Peña, Guillermo Cerón-González, Samuel Vanegas-Rodríguez, Jaime A. Mondragón-Eguiluz and Eduardo Acosta-Rodríguez
    Citation: BMC Infectious Diseases 2017 17:227
    Content type: Case report Published on:

  36. There is limited data on the genotype distribution of human papillomavirus (HPV) in the Taihu River Basin, home to 1.29 million people on the coast of eastern China. This study evaluated the prevalence and gen...

    Authors: Jing-fen Lu, Guo-rong Shen, Qiong Li, Xu Chen, Chun-fang Ma and Tong-hua Zhu
    Citation: BMC Infectious Diseases 2017 17:226
    Content type: Research article Published on:

  37. Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determi...

    Authors: Anu Ramachandran, Yukari Manabe, Radha Rajasingham and Maunank Shah
    Citation: BMC Infectious Diseases 2017 17:225
    Content type: Research article Published on:

  38. The outcome of CMV/HIV co-infection in infants treated early with combined antiretroviral therapy (cART) in resource-limited settings has not been described.

    Authors: Anfumbom K. W. Kfutwah, Paul Alain T. Ngoupo, Casimir Ledoux Sofeu, Francis Ateba Ndongo, Georgette Guemkam, Suzie Tetang Ndiang, Félicité Owona, Ida Calixte Penda, Patrice Tchendjou, Christine Rouzioux, Josiane Warszawski, Albert Faye and Mathurin Cyrille Tejiokem
    Citation: BMC Infectious Diseases 2017 17:224
    Content type: Research article Published on:

  39. Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel. A robust, rapid and cost effective diagnostic test ...

    Authors: Sandeep Verma, Ruchi Singh, Vanila Sharma, Ram Avtar Bumb, Narendra Singh Negi, V Ramesh and Poonam Salotra
    Citation: BMC Infectious Diseases 2017 17:223
    Content type: Research article Published on:

  40. This multi-country prospective study of infants aged <1 year aims to assess the frequency of influenza virus and respiratory syncytial virus (RSV) infections associated with hospitalizations, to describe clini...

    Authors: Mark G. Thompson, Danielle R. Hunt, Ali K. Arbaji, Artan Simaku, Veronica L. Tallo, Holly M. Biggs, Carolyn Kulb, Aubree Gordon, Ilham Abu Khader, Silvia Bino, Marilla G. Lucero, Eduardo Azziz-Baumgartner, Pat Shifflett, Felix Sanchez, Basima I. Marar, Ilirjana Bakalli…
    Citation: BMC Infectious Diseases 2017 17:222
    Content type: Study protocol Published on:

  41. Chagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by heart failure and sudden death. Identifying which factors are involved in evolution and treatment response is actually challengi...

    Authors: Héctor Rodríguez-Angulo, Juan Marques, Ivan Mendoza, Marco Villegas, Alfredo Mijares, Núria Gironès and Manuel Fresno
    Citation: BMC Infectious Diseases 2017 17:221
    Content type: Research article Published on:

  42. Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact...

    Authors: Lucy Pembrey, Dagmar Waiblinger, Paul Griffiths, Mauli Patel, Rafaq Azad and John Wright
    Citation: BMC Infectious Diseases 2017 17:220
    Content type: Research article Published on:

  43. Efforts to control the global burden of tuberculosis (TB) have been jeopardized by the rapid evolution of multi-drug resistant Mycobacterium tuberculosis (MTB), which is resistant to at least isoniazid and rifamp...

    Authors: Setegn Eshetie, Mucheye Gizachew, Mulat Dagnew, Gemechu Kumera, Haile Woldie, Fekadu Ambaw, Belay Tessema and Feleke Moges
    Citation: BMC Infectious Diseases 2017 17:219
    Content type: Research article Published on:

  44. In Vietnam, dengue fever (DF) is still a leading cause of hospitalization. The main objective of this study was to evaluate the seasonality and association with climate factors (temperature and precipitation) ...

    Authors: Hu Suk Lee, Hung Nguyen-Viet, Vu Sinh Nam, Mihye Lee, Sungho Won, Phuc Pham Duc and Delia Grace
    Citation: BMC Infectious Diseases 2017 17:218
    Content type: Research article Published on:

  45. Herpes simplex virus (HSV) is a common human pathogen that causes a variety of diseases, including oral-labial, genital lesions and life-threatening encephalitis. The antiviral nucleoside analogues such as acy...

    Authors: Jue Hou, Zili Zhang, Qiang Huang, Jun Yan, Xiaohu Zhang, Xiaoliang Yu, Guihua Tan, Chunfu Zheng, Feng Xu and Sudan He
    Citation: BMC Infectious Diseases 2017 17:217
    Content type: Research article Published on:

  46. Imported cases of infections due to Dengue (DENV) and Chikungunya (CHIKV) viruses and, more recently, Zika virus (ZIKV) are commonly reported among travelers returning from endemic regions. In areas where pote...

    Authors: Claudia Fortuna, Maria Elena Remoli, Caterina Rizzo, Eleonora Benedetti, Cristiano Fiorentini, Antonino Bella, Claudio Argentini, Francesca Farchi, Concetta Castilletti, Maria Rosaria Capobianchi, Lorenzo Zammarchi, Alessandro Bartoloni, Nadia Zanchetta, Maria Rita Gismondo, Luca Ceccherini Nelli, Giustina Vitale…
    Citation: BMC Infectious Diseases 2017 17:216
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:335

  47. Little is known about the applicability of dual treatments based on integrase inhibitors. We explored the combination of lamivudine + dolutegravir as an option when switching from standard cART in virologicall...

    Authors: Franco Maggiolo, Roberto Gulminetti, Layla Pagnucco, Margherita Digaetano, Simone Benatti, Daniela Valenti, Annapaola Callegaro, Diego Ripamonti and Cristina Mussini
    Citation: BMC Infectious Diseases 2017 17:215
    Content type: Research article Published on:

  48. The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of...

    Authors: ShalloDaba Hamusse, Meaza Demissie, Dejene Teshome, Mohammed Suaudi Hassen and Bernt Lindtjørn
    Citation: BMC Infectious Diseases 2017 17:214
    Content type: Research article Published on:

  49. Although sickle cell disease (SCD) children are highly susceptible to bacterial infections (BIs), there is a dreadful lack of data related to the burden and spectrum of BIs in sub-Saharan Africa (SSA), the hig...

    Authors: Anastasie Nicole Alima Yanda, Jobert Richie N. Nansseu, Hubert Désiré Mbassi Awa, Sandra A. Tatah, Judith Seungue, Charlotte Eposse and Paul Olivier N. Koki
    Citation: BMC Infectious Diseases 2017 17:211
    Content type: Research article Published on:

  50. Mannose-binding lectin (MBL) is an important protein in the lectin pathway of the immune system. This study explores the association between MBL polymorphism and the susceptibility to tuberculosis (TB). The as...

    Authors: Yan-Ling Guo, Yang Liu, Wu-Juan Ban, Qi Sun and Guang-Li Shi
    Citation: BMC Infectious Diseases 2017 17:210
    Content type: Research article Published on:

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