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  1. Bacterial meningitis remains an important infection globally, with the greatest burden in children in low-income settings, including Papua New Guinea (PNG). We present serotype, antimicrobial susceptibility an...

    Authors: Andrew R. Greenhill, Suparat Phuanukoonnon, Audrey Michael, Mition Yoannes, Tilda Orami, Helen Smith, Denise Murphy, Christopher Blyth, John Reeder, Peter Siba, William Pomat and Deborah Lehmann
    Citation: BMC Infectious Diseases 2015 15:485
    Content type: Research article Published on:

  2. The adoption of quadrivalent influenza vaccine (QIV) to replace trivalent influenza vaccine (TIV) in immunization programs is growing worldwide, thus helping to address the problem of influenza B lineage misma...

    Authors: Edward W. Thommes, Afisi Ismaila, Ayman Chit, Genevieve Meier and Christopher T. Bauch
    Citation: BMC Infectious Diseases 2015 15:465
    Content type: Research article Published on:

  3. Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome (HFRS) that is caused by the Puumala virus. Periodic outbreaks have been described in endemic areas, with a substantial numbe...

    Authors: Hanno Bunz, Peter Weyrich, Andreas Peter, Dorothea Baumann, Otto Tschritter, Martina Guthoff, Robert Beck, Gerhard Jahn, Ferruh Artunc, Hans-Ulrich Häring, Nils Heyne and Robert Wagner
    Citation: BMC Infectious Diseases 2015 15:464
    Content type: Research article Published on:

  4. Molecular resistance detection (MRD) of resistance to second-line anti-tuberculous drugs provides faster results than phenotypic tests, may shorten treatment and allow earlier separation among patients with an...

    Authors: AH van’t Hoog, I. Bergval, N. Tukvadze, S. Sengstake, R. Aspindzelashvili, RM Anthony and F. Cobelens
    Citation: BMC Infectious Diseases 2015 15:473
    Content type: Research article Published on:

  5. Lyme disease, caused by Borrelia burgdorferi, is the most common tick-borne infection in the United States. Although humans can be infected by at least 16 different strains of B. burgdorferi, the overwhelming maj...

    Authors: Camilo E. Khatchikian, Robert B. Nadelman, John Nowakowski, Ira Schwartz, Michael Z. Levy, Dustin Brisson and Gary P. Wormser
    Citation: BMC Infectious Diseases 2015 15:472
    Content type: Research article Published on:

  6. Recent advances in Hepatitis C therapeutics offer the possibility of cure but will be expensive. The cost of treatment may be partially offset by the avoidance of advanced liver disease. We performed a micro-c...

    Authors: Jennifer Ann Kieran, Suzanne Norris, Aisling O’Leary, Cathal Walsh, Raphael Merriman, D. Houlihan, P. Aiden McCormick, Susan McKiernan, Colm Bergin and Michael Barry
    Citation: BMC Infectious Diseases 2015 15:471
    Content type: Research article Published on:

  7. Abacavir is one of the recommended nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infections among children and adolescents. However, there are concerns that the antiviral efficac...

    Authors: Olatunji O. Adetokunboh, Anel Schoonees, Tolulope A. Balogun and Charles S. Wiysonge
    Citation: BMC Infectious Diseases 2015 15:469
    Content type: Research article Published on:

  8. Candidaemia and other forms of invasive candidiasis (C/IC) in the intensive care unit are challenging conditions that are associated with high rates of mortality. New guidelines from the European Society for C...

    Authors: Georg Auzinger, E. Geoffrey Playford, Christopher N. Graham, Hediyyih N. Knox, David Weinstein, Michal Kantecki, Haran Schlamm and Claudie Charbonneau
    Citation: BMC Infectious Diseases 2015 15:463
    Content type: Research article Published on:

  9. Despite acute respiratory infections being a major cause of death among children in developing countries including India, there is a lack of community-based studies that document its burden and aetiology.

    Authors: Anand Krishnan, Ritvik Amarchand, Vivek Gupta, Kathryn E. Lafond, Rizwan Abdulkader Suliankatchi, Siddhartha Saha, Sanjay Rai, Puneet Misra, Debjani Ram Purakayastha, Abhishek Wahi, Vishnubhatla Sreenivas, Arti Kapil, Fatimah Dawood, Chandrakant S. Pandav, Shobha Broor, Suresh K. Kapoor…
    Citation: BMC Infectious Diseases 2015 15:462
    Content type: Research article Published on:

  10. Multi drug resistant tuberculosis (MDR-TB) is an emerging challenge for TB control programs globally. According to World health organization, 2012 report Ethiopia stands 15th out of the 27 high priority countries...

    Authors: Feleke Mekonnen, Belay Tessema, Feleke Moges, Aschalew Gelaw, Setegn Eshetie and Gemechu Kumera
    Citation: BMC Infectious Diseases 2015 15:461
    Content type: Research article Published on:

  11. A rapid rise in PubMed citations on methicillin-resistant Staphylococcus aureus (MRSA) occurred after 2000, but the relationship of trends in citation to epidemiologic trends for infectious disease is not known.

    Authors: Ethan Morgan and Michael Z. David
    Citation: BMC Infectious Diseases 2015 15:460
    Content type: Research article Published on:

  12. Both cervical cancer and human immunodeficiency virus (HIV) are major public health problems in Sub-Saharan Africa. The objectives of the study were to investigate human papillomavirus (HPV) prevalence accordi...

    Authors: Zizipho Z A Mbulawa, David Coetzee and Anna-Lise Williamson
    Citation: BMC Infectious Diseases 2015 15:459
    Content type: Research article Published on:

  13. The Gram stain has been used as an essential tool for antimicrobial stewardship in our hospital since the 1970s. The objective of this study was to clarify the difference in the targeted therapies selected bas...

    Authors: Tomohiro Taniguchi, Sanefumi Tsuha, Soichi Shiiki and Masashi Narita
    Citation: BMC Infectious Diseases 2015 15:458
    Content type: Research article Published on:

  14. In our study, we investigated whether circulating T follicular helper (Tfh) and the related cytokines are involved in human cystic echinococcosis (CE).

    Authors: Fengbo Zhang, Nannan Pang, Yuejie Zhu, Dexian Zhou, Hui Zhao, Jinwei Hu, Xiumin Ma, Jun Li, Hao Wen, Buka Samten, Haining Fan and Jianbing Ding
    Citation: BMC Infectious Diseases 2015 15:457
    Content type: Research article Published on:

  15. In conjunction with the spread of HIV infection, tuberculosis (TB) remains a major cause of illness and death worldwide. The Ethiopian national report reveals that extra pulmonary tuberculosis is on the rise a...

    Authors: Workneh Korma, Adane Mihret, Jemal Hussien, Richard Anthony, Mekuria Lakew and Abraham Aseffa
    Citation: BMC Infectious Diseases 2015 15:456
    Content type: Research article Published on:

  16. Skin and soft tissue infections (SSTIs) are common in the era of community-associated methicillin resistant Staphylococcus aureus among HIV-infected patients. Recurrent infections are frequent. Risk factors for r...

    Authors: Vagish Hemmige, Moira McNulty, Ethan Silverman and Michael Z. David
    Citation: BMC Infectious Diseases 2015 15:455
    Content type: Research article Published on:

  17. Artemisinin-based combination treatments (ACTs) or intravenous artesunate are used in over 100 countries for uncomplicated or severe falciparum malaria. Although intravenous artesunate may cause delayed haemol...

    Authors: Akintunde Sowunmi, Kazeem Akano, Adejumoke I. Ayede, Godwin Ntadom, Bayo Fatunmbi, Temitope Aderoyeje and Elsie O. Adewoye
    Citation: BMC Infectious Diseases 2015 15:454
    Content type: Research article Published on:

  18. As the average age of the HIV-positive population increases, there is increasing need to monitor patients for the development of comorbidities as well as for drug toxicities.

    Authors: Jennifer Gillis, Ahmed M Bayoumi, Ann N Burchell, Curtis Cooper, Marina B Klein, Mona Loutfy, Nima Machouf, Julio SG Montaner, Chris Tsoukas, Robert S Hogg and Janet Raboud
    Citation: BMC Infectious Diseases 2015 15:453
    Content type: Research article Published on:

  19. While WHO recommendations are to treat people earlier and earlier, it will considerably increase the number of HIV infected people eligible for antiretroviral therapy (ART). In South Africa, a country which ca...

    Authors: Mélanie PLAZY, François DABIS, Kevindra NAIDU, Joanna ORNE-GLIEMANN, Till BARNIGHAUSEN and Rosemary DRAY-SPIRA
    Citation: BMC Infectious Diseases 2015 15:452
    Content type: Research article Published on:

  21. The use of molecular diagnostic techniques for the evaluation of the impact of pneumococcal conjugate vaccines (PCVs) has not been documented. We aimed to evaluate the impact of PCVs on invasive pneumococcal d...

    Authors: Stefano Tempia, Nicole Wolter, Cheryl Cohen, Sibongile Walaza, Claire von Mollendorf, Adam L. Cohen, Jocelyn Moyes, Linda de Gouveia, Susan Nzenze, Florette Treurnicht, Marietjie Venter, Michelle J. Groome, Shabir A. Madhi and Anne von Gottberg
    Citation: BMC Infectious Diseases 2015 15:450
    Content type: Research article Published on:

  22. The most common cause of Gram-negative bacterial neonatal meningitis is E. coli K1. It has a mortality rate of 10–15 %, and neurological sequelae in 30–50 % of cases. Infections can be attributable to nosocomial ...

    Authors: Aldukali Alkeskas, Pauline Ogrodzki, Mohamed Saad, Naqash Masood, Nasreddin R. Rhoma, Karen Moore, Audrey Farbos, Konrad Paszkiewicz and Stephen Forsythe
    Citation: BMC Infectious Diseases 2015 15:449
    Content type: Research article Published on:

  23. Toxoplasma gondii can infect almost all warm-blood animals including human beings. The high incidence and severe damage that can be caused by T. gondii infection clearly indicates the need for the development of ...

    Authors: Shuai Wang, YuJian Wang, XiaoNi Sun, ZhenChao Zhang, TingQi Liu, Javaid Ali Gadahi, Ibrahim Adam Hassan, LiXin Xu, RuoFeng Yan, XiaoKai Song and XiangRui Li
    Citation: BMC Infectious Diseases 2015 15:448
    Content type: Research article Published on:

  24. Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries.

    Authors: Débora Natalia Marcone, Lizette O. Durand, Eduardo Azziz-Baumgartner, Santiago Vidaurreta, Jorge Ekstrom, Guadalupe Carballal and Marcela Echavarria
    Citation: BMC Infectious Diseases 2015 15:447
    Content type: Research article Published on:

  25. Rotavirus is the most common cause of severe gastroenteritis in children under the age of 5 years worldwide. It is well recognised that rotavirus can cause signs and symptoms beyond the gastrointestinal tract,...

    Authors: Konstantinos Karampatsas, Christina Spyridou, Ian R. Morrison, Cheuk Y. W. Tong and Andrew J. Prendergast
    Citation: BMC Infectious Diseases 2015 15:446
    Content type: Case report Published on:

  26. Visceral leishmaniasis (VL), i.e., infection with Leishmania sp. associated with high fever, weight loss, massive splenomegaly and markedly altered laboratory parameters, is generally fatal if untreated. The poss...

    Authors: Oussama Mouri, Mathilde Benhamou, Gaëlle Leroux, Nathalie Chartrel, Alain Devidas, Marc Thellier, Zahir Amoura, Nathalie Costedoat-Chalumeau and Pierre Buffet
    Citation: BMC Infectious Diseases 2015 15:445
    Content type: Case report Published on:

  27. Staphylococcus aureus is one of most common pathogens in humans. Methicillin-resistant S. aureus (MRSA) accounts for 64 % of S. aureus bacteremia isolated in intensive care units (ICUs), and heteroresistant vanco...

    Authors: Han-Chung Hu, Kuo-Chin Kao, Li-Chung Chiu, Chih-Hao Chang, Chen-Yiu Hung, Li-Fu Li, Tsui-Ping Liu, Lee-Chung Lin, Ning-Hung Chen, Chung-Chi Huang, Cheng-Ta Yang and Jang-Jih Lu
    Citation: BMC Infectious Diseases 2015 15:444
    Content type: Research article Published on:

  28. Growing evidence suggests respiratory syncytial virus (RSV) is an important cause of respiratory disease in adults. However, the adult burden remains largely uncharacterized as most RSV studies focus on childr...

    Authors: Douglas M. Fleming, Robert J. Taylor, Roger L. Lustig, Cynthia Schuck-Paim, François Haguinet, David J Webb, John Logie, Gonçalo Matias and Sylvia Taylor
    Citation: BMC Infectious Diseases 2015 15:443
    Content type: Research article Published on:

  30. Nosocomial infections are the most common complication during inpatient hospital care. An increasing proportion of these infections are caused by multidrug-resistant organisms (MDROs). This report describes an...

    Authors: Miriam G. Gerlich, Jens Piegsa, Christian Schäfer, Nils-Olaf Hübner, Florian Wilke, Susanne Reuter, Georg Engel, Ralf Ewert, Franziska Claus, Claudia Hübner, Walter Ried, Steffen Flessa, Axel Kramer and Wolfgang Hoffmann
    Citation: BMC Infectious Diseases 2015 15:441
    Content type: Study protocol Published on:

  31. In Germany, 17 % of the general human population have antibodies to hepatitis E virus (HEV) (recomLine HEV-IgG/IgM immunoassay [Mikrogen GmbH]). Wild boars represent an animal reservoir for HEV genotype 3, whi...

    Authors: A. Schielke, V. Ibrahim, I. Czogiel, M. Faber, C. Schrader, P. Dremsek, R. G. Ulrich and R. Johne
    Citation: BMC Infectious Diseases 2015 15:440
    Content type: Research article Published on:

  32. Pregnant women in malaria endemic areas are at high risk of P. falciparum infection and its complications. This study investigated the prevalence and risk factors for P. falciparum infection and malaria among pre...

    Authors: Judith K. Anchang-Kimbi, Vera Ngenwie Nkweti, Helen Ngum Ntonifor, Tobias O. Apinjoh, Rolland Bantar Tata, Hanesh Fru Chi and Eric Akum Achidi
    Citation: BMC Infectious Diseases 2015 15:439
    Content type: Research article Published on:

  33. With the renewed emphasis to implement isoniazid preventive therapy (IPT) in Sub-Saharan Africa, we investigated the effect of IPT on immunological profiles among household contacts with latent tuberculosis.

    Authors: Irene Andia Biraro, Moses Egesa, Simon Kimuda, Steven G. Smith, Frederic Toulza, Jonathan Levin, Moses Joloba, Achilles Katamba, Stephen Cose, Hazel M. Dockrell and Alison M Elliott
    Citation: BMC Infectious Diseases 2015 15:438
    Content type: Research article Published on:

  34. It has been widely acknowledged that well-planned and executed communication programmes can contribute to achieving malaria prevention and treatment goals. This however requires a good understanding of current...

    Authors: Jane C Umeano-Enemuoh, Benjamim Uzochukwu, Nkoli Ezumah, Lindsay Mangham-Jefferies, Virginia Wiseman and Obinna Onwujekwe
    Citation: BMC Infectious Diseases 2015 15:437
    Content type: Research article Published on:

  35. A birth cohort dedicated to studying infections in early childhood may be assisted by parental recording of symptoms on a daily basis and a collection of biomaterials. We aimed at testing the feasibility of th...

    Authors: Beate Zoch, André Karch, Johannes Dreesman, Masyar Monazahian, Armin Baillot and Rafael T. Mikolajczyk
    Citation: BMC Infectious Diseases 2015 15:436
    Content type: Research article Published on:

  36. The number of catheter related bloodstream infections (CRBSI) could be reduced and the outcome improved if specific standards in the quality of care were maintained. Therefore, the development of quality assur...

    Authors: Anke Bramesfeld, Stephanie Wrede, Klaus Richter, Mareike Steen, Björn Broge, Jürgen Pauletzki and Joachim Szecsenyi
    Citation: BMC Infectious Diseases 2015 15:435
    Content type: Research article Published on:

  37. Intestinal macrophages are key regulators of inflammatory responses to the gut microbiome and play a central role in maintaining tissue homeostasis and epithelial integrity. However, little is known about the ...

    Authors: Edana Cassol, Theresa Rossouw, Susan Malfeld, Phetole Mahasha, Tomas Slavik, Chris Seebregts, Robert Bond, Johannie du Plessis, Carl Janssen, Tania Roskams, Frederik Nevens, Massimo Alfano, Guido Poli and Schalk W. van der Merwe
    Citation: BMC Infectious Diseases 2015 15:430
    Content type: Research article Published on:

  38. Evidence on influenza vaccine effectiveness (VE) is commonly derived from observational studies. However, these studies are prone to confounding by indication and healthy vaccinee bias. We aimed to systematica...

    Authors: Cornelius Remschmidt, Ole Wichmann and Thomas Harder
    Citation: BMC Infectious Diseases 2015 15:429
    Content type: Research article Published on:

  39. In the current Ebola epidemic in Western Africa, many healthcare workers have become infected. Some of these have been medically evacuated to hospitals in Europe and the USA. These clinical experiences provide...

    Authors: Nicola Petrosillo, Emanuele Nicastri, Simone Lanini, Maria Rosaria Capobianchi, Antonino Di Caro, Mario Antonini, Vincenzo Puro, Francesco Nicola Lauria, Nakono Shindo, Nicola Magrini, Gary P. Kobinger and Giuseppe Ippolito
    Citation: BMC Infectious Diseases 2015 15:432
    Content type: Case report Published on:

  40. Hepatitis A is still a neglected health problem in the world. The most affected areas are the ones with disadvantaged socioeconomic conditions. In Brazil, seroprevalence studies showed that 64.7 % of the gener...

    Authors: Saulo A. S. Mantovani, Breno Matos Delfino, Antonio C. Martins, Humberto Oliart-Guzmán, Thasciany M. Pereira, Fernando L. C. C. Branco, Athos Muniz Braña, José A. Filgueira-Júnior, Ana P. Santos, Rayanne A. Arruda, Andréia S. Guimarães, Alanderson A. Ramalho, Cristieli Sergio de Menezes Oliveira, Thiago S. Araújo, Nancy Arróspide, Carlos H. M. L. Estrada…
    Citation: BMC Infectious Diseases 2015 15:428
    Content type: Research article Published on:

  41. Enterococcus spp. are particularly important etiological agents of nosocomial infections. However, the clinical characteristics of and risk factors for enterococcal infections in clinical settings are poorly unde...

    Authors: Toshiki Kajihara, Shigeki Nakamura, Naoki Iwanaga, Kazuhiro Oshima, Takahiro Takazono, Taiga Miyazaki, Koichi Izumikawa, Katsunori Yanagihara, Nobuoki Kohno and Shigeru Kohno
    Citation: BMC Infectious Diseases 2015 15:426
    Content type: Research article Published on:

  42. The objective of this study was to explore the prevalence of microbiological contamination of mobile phones that belong to clinicians in intensive care units (ICUs), pediatric intensive care units (PICUs), and...

    Authors: Mohammed Heyba, Mohammad Ismaiel, Abdulrahman Alotaibi, Mohamed Mahmoud, Hussain Baqer, Ali Safar, Noura Al-Sweih and Abdullah Al-Taiar
    Citation: BMC Infectious Diseases 2015 15:434
    Content type: Research article Published on:

  43. Acinetobacter baumannii strains co-producing carbapenemase and 16S rRNA methylase are highly resistant to carbapenems and aminoglycosides.

    Authors: Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Tran Thi Thanh Nga, Le Thi Anh Thu, Nguyen Truong Son, Norio Ohmagari and Teruo Kirikae
    Citation: BMC Infectious Diseases 2015 15:433
    Content type: Research article Published on:

  44. This study was designed to explore the epidemiological and clinical profiles of respiratory syncytial virus (RSV) infection in neonates from the Suzhou area of China, taking into consideration how climate fact...

    Authors: Lianghua Lu, Yongdong Yan, Bin Yang, Zhihui Xiao, Xing Feng, Yuqing Wang, Wei Ji, Maximillion Mize, Chuangli Hao and Zhengrong Chen
    Citation: BMC Infectious Diseases 2015 15:431
    Content type: Research article Published on:

  45. The primary influenza prevention strategy is focused on annual vaccination according to the categories identified in the various countries as being at greatest risk of complications. Many studies were conducte...

    Authors: Claudia Pileggi, Francesca Lotito, Aida Bianco, Carmelo G. A. Nobile and Maria Pavia
    Citation: BMC Infectious Diseases 2015 15:427
    Content type: Research article Published on:

  46. Salmonella enterica, serovar Typhi (S. Typhi), a causative agent of enteric fever (typhoid fever), predominately affects populations in developing regions with poor access to clean food and water. In addition, tr...

    Authors: Tia Sorrell, Daniel J. Selig, Mark S. Riddle and Chad K. Porter
    Citation: BMC Infectious Diseases 2015 15:424
    Content type: Research article Published on:

  47. Sustaining high uptake of praziquantel is key for long-term control of schistosomiasis. During mass treatment in 2013, we randomized 12 primary schools into two groups; one group received education messages fo...

    Authors: Simon Muhumuza, Annette Olsen, Anne Katahoire and Fred Nuwaha
    Citation: BMC Infectious Diseases 2015 15:423
    Content type: Research article Published on:

  48. Chronic kidney disease, including end-stage renal disease, has been identified as a possible risk factor for primary septicemia and wound infection by Vibrio vulnificus. However, cases of severe septicemia, necro...

    Authors: Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma and Soo Wan Kim
    Citation: BMC Infectious Diseases 2015 15:422
    Content type: Case report Published on:

  49. Traditional cardiovascular disease (CVD) risk factors contribute to increase risk of CVD in people living with HIV (PLWH). Of all world regions, sub-Saharan Africa has the highest prevalence of HIV yet little ...

    Authors: Tecla M. Temu, Nicholas Kirui, Celestine Wanjalla, Alfred M. Ndungu, Jemima H. Kamano, Thomas S. Inui and Gerald S. Bloomfield
    Citation: BMC Infectious Diseases 2015 15:421
    Content type: Research article Published on:

  50. Pneumococcal diseases remain a leading cause of vaccine-preventable death worldwide in children <5 years of age. The seven-valent pneumococcal conjugate vaccine (PCV7) was approved in 2001 in Europe and was in...

    Authors: Myint Tin Tin Htar, Dina Christopoulou and Heinz-Josef Schmitt
    Citation: BMC Infectious Diseases 2015 15:419
    Content type: Debate Published on:

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BMC Infectious Diseases

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