Zhao G, Shen B, Xie Q, Xu LX, Yan RF, Song XK, et al. Detection of Toxoplasma gondii in free-range chickens in China based on circulating antigens and antibodies. Vet Parasitol. 2012;185:72–7.
Article
PubMed
Google Scholar
Zhang M, Yang Z, Wang S, Tao L, Xu L, Yan R, et al. Detection of Toxoplasma gondii in shellfish and fish in parts of China. Vet Parasitol. 2014;200:85–9.
Article
CAS
PubMed
Google Scholar
Alvarado-Esquivel C, Sanchez-Okrucky R, Dubey JP. Serological evidence of Toxoplasma gondii infection in captive marine mammals in Mexico. Vet Parasitol. 2012;184:321–4.
Article
CAS
PubMed
Google Scholar
Vado-Solis IA, Suarez-Solis V, Jimenez-Delgadillo B, Zavala-Velazquez JE, Segura-Correa JC. Toxoplasma gondii presence in women with spontaneous abortion in Yucatan, Mexico. J Parasitol. 2013;99:383–5.
Article
PubMed
Google Scholar
Edwards JF, Dubey JP. Toxoplasma gondii abortion storm in sheep on a Texas farm and isolation of mouse virulent atypical genotype T. gondii from an aborted lamb from a chronically infected ewe. Vet Parasitol. 2013;192:129–36.
Article
PubMed
Google Scholar
Pfaff AW, de-la-Torre A, Rochet E, Brunet J, Sabou M, Sauer A, et al. New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. Int J Parasitol. 2014;44:99–107.
Article
CAS
PubMed
Google Scholar
Atreya AR, Arora S, Gadiraju VT, Martagon-Villamil J, Skiest DJ. Toxoplasma encephalitis in an HIV-infected patient on highly active antiretroviral therapy despite sustained immune response. Int J STD AIDS. 2014;25:383–6.
Article
PubMed
Google Scholar
Kim JH, Kang KI, Kang WC, Sohn HJ, Jean YH, Park BK, et al. Porcine abortion outbreak associated with Toxoplasma gondii in Jeju Island, Korea. J Vet Sci. 2009;10:147–51.
Article
PubMed
PubMed Central
Google Scholar
Rodriguez JB, Szajnman SH. New antibacterials for the treatment of toxoplasmosis; a patent review. Expert Opin Ther Pat. 2012;22:311–33.
Article
CAS
PubMed
Google Scholar
Kur J, Holec-Gasior L, Hiszczynska-Sawicka E. Current status of toxoplasmosis vaccine development. Expert Rev Vaccines. 2009;8:791–808.
Article
CAS
PubMed
Google Scholar
Garrison EM, Arrizabalaga G. Disruption of a mitochondrial MutS DNA repair enzyme homologue confers drug resistance in the parasite Toxoplasma gondii. Mol Microbiol. 2009;72:425–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nagamune K, Moreno SN, Sibley LD. Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis. Antimicrob Agents Chemother. 2007;51:3816–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Buxton D, Innes EA. A commercial vaccine for ovine toxoplasmosis. Parasitology. 1995;110(Suppl):S11–16.
Article
PubMed
Google Scholar
Zhang NZ, Chen J, Wang M, Petersen E, Zhu XQ. Vaccines against Toxoplasma gondii: new developments and perspectives. Expert Rev Vaccines. 2013;12:1287–99.
Article
CAS
PubMed
Google Scholar
Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, Klee SR, et al. Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature. 2000;404:502–6.
Article
CAS
PubMed
Google Scholar
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002;99:16899–903.
Article
PubMed
Google Scholar
Kristensen R, Torp M, Kosiak B, Holst-Jensen A. Phylogeny and toxigenic potential is correlated in Fusarium species as revealed by partial translation elongation factor 1 alpha gene sequences. Mycol Res. 2005;109:173–86.
Article
CAS
PubMed
Google Scholar
Condeelis J. Elongation factor 1 alpha, translation and the cytoskeleton. Trends Biochem Sci. 1995;20:169–70.
Article
CAS
PubMed
Google Scholar
Ridgley EL, Xiong ZH, Kaur KJ, Ruben L. Genomic organization and expression of elongation factor-1 alpha genes in Trypanosoma brucei. Mol Biochem Parasitol. 1996;79:119–23.
Article
CAS
PubMed
Google Scholar
Toueille M, Saint-Jean B, Castroviejo M, Benedetto JP. The elongation factor 1A: a novel regulator in the DNA replication/repair protein network in wheat cells? Plant Physiol Biochem. 2007;45:113–8.
Article
CAS
PubMed
Google Scholar
Lamberti A, Longo O, Marra M, Tagliaferri P, Bismuto E, Fiengo A, et al. C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. Cell Death Differ. 2007;14:952–62.
CAS
PubMed
Google Scholar
Nandan D, Reiner NE. Leishmania donovani engages in regulatory interference by targeting macrophage protein tyrosine phosphatase SHP-1. Clin Immunol. 2005;114:266–77.
Article
CAS
PubMed
Google Scholar
Matsubayashi M, Teramoto-Kimata I, Uni S, Lillehoj HS, Matsuda H, Furuya M, et al. Elongation factor-1alpha is a novel protein associated with host cell invasion and a potential protective antigen of Cryptosporidium parvum. J Biol Chem. 2013;288:34111–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang S, Zhao G, Wang W, Xie Q, Zhang M, Yuan C, et al. Pathogenicity of two Toxoplasma gondii strains in chickens of different ages infected via intraperitoneal injection. Avian Pathol. 2014;43:91–5.
Article
PubMed
Google Scholar
Hassan IA, Wang S, Xu L, Yan R, Song X, Li X. DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice. Parasites Vectors. 2014;7:431.
Article
PubMed
PubMed Central
Google Scholar
Sasai K, Aita M, Lillehoj HS, Miyamoto T, Fukata T, Baba E. Dynamics of lymphocyte subpopulation changes in the cecal tonsils of chickens infected with Salmonella enteritidis. Vet Microbiol. 2000;74:345–51.
Article
CAS
PubMed
Google Scholar
Song H, Yan R, Xu L, Song X, Shah MA, Zhu H, et al. Efficacy of DNA vaccines carrying Eimeria acervulina lactate dehydrogenase antigen gene against coccidiosis. Exp Parasitol. 2010;126:224–31.
Article
CAS
PubMed
Google Scholar
Correa D, Canedo-Solares I, Ortiz-Alegria LB, Caballero-Ortega H, Rico-Torres CP. Congenital and acquired toxoplasmosis: diversity and role of antibodies in different compartments of the host. Parasite Immunol. 2007;29:651–60.
Article
CAS
PubMed
Google Scholar
Kang H, Remington JS, Suzuki Y. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J Immunol. 2000;164:2629–34.
Article
CAS
PubMed
Google Scholar
Xu Y, Zhang NZ, Tan QD, Chen J, Lu J, Xu QM, et al. Evaluation of immuno-efficacy of a novel DNA vaccine encoding Toxoplasma gondii rhoptry protein 38 (TgROP38) against chronic toxoplasmosis in a murine model. BMC Infect Dis. 2014;14:525.
Article
PubMed
PubMed Central
Google Scholar
Qu D, Han J, Du A. Evaluation of protective effect of multiantigenic DNA vaccine encoding MIC3 and ROP18 antigen segments of Toxoplasma gondii in mice. Parasitol Res. 2013;112:2593–9.
Article
PubMed
Google Scholar
Chen J, Li ZY, Huang SY, Petersen E, Song HQ, Zhou DH, et al. Protective efficacy of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice. BMC Infect Dis. 2014;14:487.
Article
PubMed
PubMed Central
Google Scholar
Chen J, Zhou DH, Li ZY, Petersen E, Huang SY, Song HQ, et al. Toxoplasma gondii: protective immunity induced by rhoptry protein 9 (TgROP9) against acute toxoplasmosis. Exp Parasitol. 2014;139:42–8.
Article
CAS
PubMed
Google Scholar
Gomez-Marin JE, Montoya-De-Londono MT, Castano-Osorio JC, Heine FA, Duque AM, Chemla C, et al. Frequency of specific anti-Toxoplasma gondii IgM, IgA and IgE in colombian patients with acute and chronic ocular toxoplasmosis. Mem Inst Oswaldo Cruz. 2000;95:89–94.
Article
CAS
PubMed
Google Scholar
Lynch LF, Lynch MI, Ferreira RS, Vasconcelos MS, Melo N, Ferreira S, et al. Ocular toxoplasmosis: evaluation of lacrimal-specific secretory IgA levels in both patients with active and inactive phases of the disease. Mem Inst Oswaldo Cruz. 2011;106:625–8.
Article
PubMed
Google Scholar
Amin A, Mazloomzadeh S, Haniloo A, Mohammadian F, Fazaeli A. Evaluation of anti-toxoplasma IgG, IgM, and IgA in mothers with spontaneous abortion in Zanjan, Northwest Iran. Korean J Parasitol. 2012;50:371–4.
Article
PubMed
PubMed Central
Google Scholar
Vouldoukis I, Mazier D, Moynet D, Thiolat D, Malvy D, Mossalayi MD. IgE mediates killing of intracellular Toxoplasma gondii by human macrophages through CD23-dependent, interleukin-10 sensitive pathway. PLoS One. 2011;6:e18289.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cong H, Yuan Q, Zhao Q, Zhao L, Yin H, Zhou H, et al. Comparative efficacy of a multi-epitope DNA vaccine via intranasal, peroral, and intramuscular delivery against lethal Toxoplasma gondii infection in mice. Parasites & vectors. 2014;7:145.
Article
Google Scholar
Wang HL, Zhang TE, Yin LT, Pang M, Guan L, Liu HL, et al. Partial Protective Effect of Intranasal Immunization with Recombinant Toxoplasma gondii Rhoptry Protein 17 against Toxoplasmosis in Mice. PLoS One. 2014;9:e108377.
Article
PubMed
PubMed Central
Google Scholar
Schulthess J, Fourreau D, Darche S, Meresse B, Kasper L, Cerf-Bensussan N, et al. Mucosal immunity in Toxoplasma gondii infection. Parasite. 2008;15:389–95.
Article
CAS
PubMed
Google Scholar
Konishi E, Nakao M. Naturally occurring immunoglobulin M antibodies: enhancement of phagocytic and microbicidal activities of human neutrophils against Toxoplasma gondii. Parasitology. 1992;104(Pt 3):427–32.
Article
PubMed
Google Scholar
Kaneko Y, Takashima Y, Xuaun X, Igarashi I, Nagasawa H, Mikami T, et al. Natural IgM antibodies in sera from various animals but not the cat kill Toxoplasma gondii by activating the classical complement pathway. Parasitology. 2004;128:123–9.
Article
CAS
PubMed
Google Scholar
Couper KN, Roberts CW, Brombacher F, Alexander J, Johnson LL. Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion. Infect Immun. 2005;73:8060–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matowicka-Karna J, Kemona H. IgE antibodies in toxoplasmosis. Postepy Hig Med Dosw. 2014;68:597–602.
Article
Google Scholar
Hassan IA, Wang S, Xu L, Yan R, Song X, Li X. Immunoglobulin and cytokine changes induced following immunization with a DNA vaccine encoding Toxoplasma gondii selenium-dependent glutathione reductase protein. Exp Parasitol. 2014;146C:1–10.
Article
Google Scholar
Hassan IA, Wang S, Xu L, Yan R, Song X, XiangRui L. Immunological response and protection of mice immunized with plasmid encoding T. gondii glycolytic enzyme Malate Dehydrogenase. Parasite Immunol. 2014;36:674–83.
Article
CAS
PubMed
Google Scholar
Takacs AC, Swierzy IJ, Luder CG. Interferon-gamma restricts Toxoplasma gondii development in murine skeletal muscle cells via nitric oxide production and immunity-related GTPases. PLoS One. 2012;7:e45440.
Article
CAS
PubMed
PubMed Central
Google Scholar
Suzuki Y, Sa Q, Gehman M, Ochiai E. Interferon-gamma- and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brain. Expert Rev Mol Med. 2011;13:e31.
Article
PubMed
PubMed Central
Google Scholar
Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP. Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infect Immun. 2013;81:4341–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sturge CR, Yarovinsky F. Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection. Infect Immun. 2014;82:3090–7.
Article
PubMed
PubMed Central
Google Scholar
Tan F, Hu X, Luo FJ, Pan CW, Chen XG. Induction of protective Th1 immune responses in mice by vaccination with recombinant Toxoplasma gondii nucleoside triphosphate hydrolase-II. Vaccine. 2011;29:2742–8.
Article
CAS
PubMed
Google Scholar
Gigley JP, Fox BA, Bzik DJ. Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol. 2009;182:1069–78.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yuan ZG, Zhang XX, Lin RQ, Petersen E, He S, Yu M, et al. Protective effect against toxoplasmosis in mice induced by DNA immunization with gene encoding Toxoplasma gondii ROP18. Vaccine. 2011;29:6614–9.
Article
CAS
PubMed
Google Scholar
Song X, Gao H, Qian Y. Th17 Differentiation and Their Pro-inflammation Function. Adv Exp Med Biol. 2014;841:99–151.
Article
PubMed
Google Scholar
Guiton R, Vasseur V, Charron S, Arias MT, Van Langendonck N, Buzoni-Gatel D, et al. Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice. J Infect Dis. 2010;202:427–35.
Article
CAS
PubMed
Google Scholar
Kelly MN, Kolls JK, Happel K, Schwartzman JD, Schwarzenberger P, Combe C, et al. Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun. 2005;73:617–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Travis MA, Sheppard D. TGF-beta activation and function in immunity. Annu Rev Immunol. 2014;32:51–82.
Article
CAS
PubMed
Google Scholar
Cekanaviciute E, Dietrich HK, Axtell RC, Williams AM, Egusquiza R, Wai KM, et al. Astrocytic TGF-beta signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J Immunol. 2014;193:139–49.
Article
CAS
PubMed
PubMed Central
Google Scholar
Langermans JA, Nibbering PH, Van Vuren-Van Der Hulst ME, Van Furth R. Transforming growth factor-beta suppresses interferon-gamma-induced toxoplasmastatic activity in murine macrophages by inhibition of tumour necrosis factor-alpha production. Parasite Immunol. 2001;23:169–75.
Article
CAS
PubMed
Google Scholar
Schluter D, Bertsch D, Frei K, Hubers SB, Wiestler OD, Hof H, et al. Interferon-gamma antagonizes transforming growth factor-beta2-mediated immunosuppression in murine Toxoplasma encephalitis. J Neuroimmunol. 1998;81:38–48.
Article
CAS
PubMed
Google Scholar
Rozenfeld C, Martinez R, Seabra S, Sant'anna C, Goncalves JG, Bozza M, et al. Toxoplasma gondii prevents neuron degeneration by interferon-gamma-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-beta1 production by infected microglia. Am J Pathol. 2005;167:1021–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dupont CD, Christian DA, Selleck EM, Pepper M, Leney-Greene M, Harms Pritchard G, et al. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. PLoS Pathog. 2014;10:e1004047.
Article
PubMed
PubMed Central
Google Scholar
Miceli MC, Parnes JR. The roles of CD4 and CD8 in T cell activation. Semin Immunol. 1991;3:133–41.
CAS
PubMed
Google Scholar
Martini M, Testi MG, Pasetto M, Picchio MC, Innamorati G, Mazzocco M, et al. IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer. Vaccine. 2010;28:3548–57.
Article
CAS
PubMed
Google Scholar
Zhou F. Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation. Int Rev Immunol. 2009;28:239–60.
Article
CAS
PubMed
Google Scholar
Lyons RE, Anthony JP, Ferguson DJ, Byrne N, Alexander J, Roberts F, et al. Immunological studies of chronic ocular toxoplasmosis: up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6. Infect Immun. 2001;69:2589–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao G, Zhou A, Lu G, Meng M, Sun M, Bai Y, et al. Identification and characterization of Toxoplasma gondii aspartic protease 1 as a novel vaccine candidate against toxoplasmosis. Parasites & vectors. 2013;6:175.
Article
CAS
Google Scholar
Chen J, Huang SY, Li ZY, Yuan ZG, Zhou DH, Petersen E, et al. Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice. Vaccine. 2013;31:1734–9.
Article
CAS
PubMed
Google Scholar
Parthasarathy S, Fong MY, Ramaswamy K, Lau YL. Protective immune response in BALB/c mice induced by DNA vaccine of the ROP8 gene of Toxoplasma gondii. AmJTrop Med Hyg. 2013;88:883–7.
Article
CAS
Google Scholar