Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998, 338: 853-860. 10.1056/NEJM199803263381301.
Article
PubMed
Google Scholar
Deeks SG, Wrin T, Liegler T, Hoh R, Hayden M, Barbour JD, Hellmann NS, Petropoulos CJ, McCune JM, Hellerstein MK, Grant RM: Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. N Engl J Med. 2001, 344: 472-480. 10.1056/NEJM200102153440702.
Article
CAS
PubMed
Google Scholar
Katlama C, Dominguez S, Gourlain K, Duvivier C, Delaugerre C, Legrand M, Tubiana R, Reynes J, Molina JM, Peytavin G, Calvez V, Costagliola D: Benefit of treatment interruption in HIV-infected patients with multiple therapeutic failures: a randomized controlled trial (ANRS 097). AIDS. 2004, 18: 217-226. 10.1097/00002030-200401230-00011.
Article
CAS
PubMed
Google Scholar
Lawrence J, Mayers DL, Hullsiek KH, Collins G, Abrams DI, Reisler RB, Crane LR, Schmetter BS, Dionne TJ, Saldanha JM, Jones MC, Baxter JD: Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus. N Engl J Med. 2003, 349: 837-846. 10.1056/NEJMoa035103.
Article
PubMed
Google Scholar
El Sadr WM, Lundgren JD, Neaton JD, Gordin F, Abrams D, Arduino RC, Babiker A, Burman W, Clumeck N, Cohen CJ, Cohn D, Cooper D, Darbyshire J, Emery S, Fatkenheuer G, Gazzard B, Grund B, Hoy J, Klingman K, Losso M, Markowitz N, Neuhaus J, Phillips A, Rappoport C: CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med. 2006, 355: 2283-2296. 10.1056/NEJMoa062360.
Article
CAS
PubMed
Google Scholar
Gamberg J, Pardoe I, Bowmer MI, Howley C, Grant M: Lack of CD28 expression on HIV-specific cytotoxic T lymphocytes is associated with disease progression. Immunol Cell Biol. 2004, 82: 38-46. 10.1111/j.1440-1711.2004.01204.x.
Article
CAS
PubMed
Google Scholar
Topp MS, Riddell SR, Akatsuka Y, Jensen MC, Blattman JN, Greenberg PD: Restoration of CD28 expression in CD28-CD8+ memory effector T cells reconstitute antigen-induced IL-2 production. J Exp Med. 2003, 198: 947-955. 10.1084/jem.20021288.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA: Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003, 101: 2711-2720. 10.1182/blood-2002-07-2103.
Article
CAS
PubMed
Google Scholar
Palmer BE, Blyveis N, Fontenot AP, Wilson CC: Functional and phenotypic characterization of CD57+CD4+ T cells and their association with HIV-1-induced T cell dysfunction. J Immunol. 2005, 175: 8415-8423.
Article
CAS
PubMed
Google Scholar
Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW, Van Baarle D, Kostense S, Miedema F, McLaughlin M, Ehler L, Metcalf J, Liu S, Connors M: HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol. 2002, 3: 1061-1068. 10.1038/ni845.
Article
CAS
PubMed
Google Scholar
Younes SA, Yassine-Diab B, Dumont AR, Boulassel MR, Grossman Z, Routy JP, Sekaly RP: HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J Exp Med. 2003, 198: 1909-1922. 10.1084/jem.20031598.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schrier RD, Wiley CA, Spina C, McCutchan JA, Grant I: Pathogenic and protective correlates of T cell proliferation in AIDS. HNRC Group. HIV Neurobehavioral Research Center. J Clin Invest. 1996, 98: 731-740. 10.1172/JCI118845.
Article
CAS
PubMed
PubMed Central
Google Scholar
Garcia F, Plana M, Mestre G, Arnedo M, Gil C, Miro JM, Cruceta A, Pumarola T, Gallart T, Gatell JM: Immunological and virological factors at baseline may predict response to structured therapy interruption in early stage chronic HIV-1 infection. AIDS. 2002, 16: 1761-1765. 10.1097/00002030-200209060-00008.
Article
CAS
PubMed
Google Scholar
Boschi A, Tinelli C, Ortolani P, Moscatelli G, Morigi G, Arlotti M: CD4+ cell-count-guided treatment interruptions in chronic HIV-infected patients with good response to highly active antiretroviral therapy. AIDS. 2004, 18: 2381-2389.
PubMed
Google Scholar
Thiebaut R, Pellegrin I, Chene G, Viallard JF, Fleury H, Moreau JF, Pellegrin JL, Blanco P: Immunological markers after long-term treatment interruption in chronically HIV-1 infected patients with CD4 cell count above 400 x 10(6) cells/l. AIDS. 2005, 19: 53-61.
Article
PubMed
Google Scholar
Ledergerber B, Lundgren JD, Walker AS, Sabin C, Justice A, Reiss P, Mussini C, Wit F, d'Arminio MA, Weber R, Fusco G, Staszewski S, Law M, Hogg R, Lampe F, Gill MJ, Castelli F, Phillips AN: Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes. Lancet. 2004, 364: 51-62. 10.1016/S0140-6736(04)16589-6.
Article
PubMed
Google Scholar
Harari A, Vallelian F, Meylan PR, Pantaleo G: Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol. 2005, 174: 1037-1045.
Article
CAS
PubMed
Google Scholar