Figure 2

Panel A shows FACS contour plots generated by staining PBMC from baseline time points from 2 study subjects. Shown are CD3+ lymphocytes staining positively for CD57 but negatively for CD8, i.e. CD4+CD57+ cells. The number in the box in each plot indicates the percentage of CD4+CD57+ lymphocytes. Patient #2 on the left had a CD4 T-cell change during TI that was below the median while patient #1 on the right had a CD4 T-cell change that was above the median for the group. Panel B shows the correlation between the percentage of CD4+CD57+ cells at baseline and CD4 count loss during TI for all 13 patients tested. Spearman nonparametric correlation tests were used to assess the significance of the association between these parameters; p values <0.05 were considered significant.