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Table 1 Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI

From: Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption

T-cell compartment

Proliferative Stimulus/Phenotypic Markers Expression*

Correlation with CD4 count change from baseline to nadir during TI**

CD4

anti-CD3

-0.07 (p = 0.87)

 

SEB

0.43 (p = 0.30)

 

CMV

-0.59 (p = 0.045)***

 

Gag p55 peptide pool

-0.40 (p = 0.17)

 

%CD57+

-0.69 (p = 0.0095)***

 

CD57+ MFI

-0.03 (p = 0.93)

 

%CD28

-0.38 (p = 0.19)

 

CD28+ MFI

-0.18 (p = 0.55)

CD8

anti-CD3

-0.09 (p = 0.81)

 

SEB

0.14 (p = 0.75)

 

CMV

-0.48 (p = 0.12)

 

Gag p55 peptide pool

-0.01 (p = 0.96)

 

%CD57+

0.01 (p = 0.97)

 

CD57+ MFI

0.29 (p = 0.34)

 

%CD28

0.33 (p = 0.27)

 

CD28+ MFI

-0.10 (p = 0.73)

Baseline CD4+ count

 

-0.61 (p = 0.030)***

Baseline viral load

 

-0.35 (p = 0.24)

  1. *CMV = cytomegalovirus lysate; SEB = streptococcus enterotoxin B; MFI = mean fluorescence intensity.
  2. **Spearman nonparametric correlation test (p-value).
  3. ***p < 0.05