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  1. The role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C p...

    Authors: Ching-Chih Hu, Chih-Lang Lin, Liang-Che Chang, Cheng-Hung Chien, Li-Wei Chen, Ching-Jung Liu and Rong-Nan Chien
    Citation: BMC Infectious Diseases 2015 15:156
    Content type: Research article Published on:

  2. Daily throughout 2011, about 900 new HIV infections occurred in children and 630 children died as a result of AIDS-related complications worldwide. Late diagnosis, mortality trends, causes of and risk factors ...

    Authors: Sandra Fagundes Moreira-Silva, Eliana Zandonade and Angélica Espinosa Miranda
    Citation: BMC Infectious Diseases 2015 15:155
    Content type: Research article Published on:

  3. We evaluated the short-term spontaneous fluctuations of HBV DNA and HBsAg levels in Senegalese patients with chronic infection with hepatitis B virus and normal ALT and determined factors related to these fluc...

    Authors: Sarah Maylin, Jean-Marie Sire, Papa Saliou Mbaye, François Simon, Anna Sarr, Marie-Louise Evra, Fatou Fall, Jean Daveiga, Aboubakry Diallo, Jean-Marc Debonne, Loic Chartier and Muriel Vray
    Citation: BMC Infectious Diseases 2015 15:154
    Content type: Research article Published on:

  4. Tetrandrine is a natural chemical product purified from fourstamen stephania root which recently has been shown to act similarly as synthesized drug efflux pump inhibitor verapamil. The aim of the study is to exa...

    Authors: Zhe Zhang, Jie Yan, Kaijin Xu, Zhongkang Ji and Lanjuan Li
    Citation: BMC Infectious Diseases 2015 15:153
    Content type: Research article Published on:

  5. Healthcare-associated infections (HAIs) are a frequent complication associated with hospitalization of infants in neonatal intensive care units (NICUs). The aim of this study was to evaluate and describe the r...

    Authors: Valeria Crivaro, Lidija Bogdanović, Maria Bagattini, Vita Dora Iula, Mariarosaria Catania, Francesco Raimondi, Maria Triassi and Raffaele Zarrilli
    Citation: BMC Infectious Diseases 2015 15:152
    Content type: Research article Published on:

  6. Mannose-binding lectin (MBL) and MBL-associated serine proteases 2 (MASP-2) are important proteins in the lectin pathway of the immune system. Polymorphism of MBL and MASP-2 genes may affect the serum concentrati...

    Authors: Mengshi Chen, Ying Liang, Wufei Li, Mian Wang, Li Hu, Benjamin Kwaku Abuaku, Xin Huang, Hongzhuan Tan and Shi Wu Wen
    Citation: BMC Infectious Diseases 2015 15:151
    Content type: Research article Published on:

  7. Respiratory syncytial virus (RSV) infection is a common cause of pediatric hospitalization. microRNA, key regulators of the immune system, have not previously been investigated in respiratory specimens during ...

    Authors: Christopher S Inchley, Tonje Sonerud, Hans O Fjærli and Britt Nakstad
    Citation: BMC Infectious Diseases 2015 15:150
    Content type: Research article Published on:

  8. Universal hepatitis B virus (HBV) vaccination of newborn babies was introduced in Italy in 1991 and was extended to 12-years-old children for the first 12 years of application so as to cover in a dozen years t...

    Authors: Nicola Coppola, Anna Rita Corvino, Stefania De Pascalis, Giuseppe Signoriello, Eliana Di Fiore, Albert Nienhaus, Evangelista Sagnelli and Monica Lamberti
    Citation: BMC Infectious Diseases 2015 15:149
    Content type: Research article Published on:

  9. Several studies suggested that vaccines could have non-specific effects on mortality depending on the type of vaccine. Non-specific effects seem to be different in boys and girls. In this study we want to inve...

    Authors: Tessa M Schurink-van’t Klooster, Mirjam J Knol, Hester E de Melker and Marianne AB van der Sande
    Citation: BMC Infectious Diseases 2015 15:148
    Content type: Research article Published on:

  10. Schistosoma mansoni infection represents a major cause of morbidity and mortality in many areas of the developing world. Effective vaccines against schistosomiasis are not available and disease management relies ...

    Authors: Shereen F Mossallam, Eglal I Amer, Radwa E Ewaisha, Amal M Khalil, Hamida M Aboushleib and Mohammed Bahey-El-Din
    Citation: BMC Infectious Diseases 2015 15:147
    Content type: Research article Published on:

  11. Hand, foot, and mouth disease (HFMD) is the most common communicable disease in China. Shandong Province is one of the most seriously affected areas. The distribution of HFMD had spatial heterogeneity and seas...

    Authors: Yunxia Liu, Xianjun Wang, Chunkun Pang, Zhongshang Yuan, Hongkai Li and Fuzhong Xue
    Citation: BMC Infectious Diseases 2015 15:146
    Content type: Research article Published on:

  12. Pulmonary exacerbations (PEx) are critical events in cystic fibrosis (CF), responsible for reduced quality of life and permanent loss of lung function. Approximately 1/4 of PEx are associated with failure to r...

    Authors: John C Lam, Ranjani Somayaji, Michael G Surette, Harvey R Rabin and Michael D Parkins
    Citation: BMC Infectious Diseases 2015 15:145
    Content type: Research article Published on:

  13. Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting. Modelling mass ...

    Authors: Jaline Gerardin, Philip Eckhoff and Edward A Wenger
    Citation: BMC Infectious Diseases 2015 15:144
    Content type: Research article Published on:

  14. After the 2009 influenza A(H1N1)pdm09 pandemic, China established its first severe acute respiratory infections (SARI) sentinel surveillance system.

    Authors: Zhibin Peng, Luzhao Feng, Greene M Carolyn, Kaili Wang, Guozhong Zhu, Yequn Zhang, Jumei Hu, Yiwei Huang, Huiqiong Pan, Nongjian Guo, Chunyan Xing, Yanhui Chu, Zhaolong Cao, Deshan Yu, Linling Liu, Zeling Chen…
    Citation: BMC Infectious Diseases 2015 15:143
    Content type: Research article Published on:

  15. An outbreak of dengue virus (DENV) occurred in Yunnan province. More than 2,000 individuals were infected from August to November 2013. In this study, we aimed to characterize the origin and prevalence of DENV...

    Authors: Binghui Wang, Yaping Li, Yue Feng, Hongning Zhou, Yaobo Liang, Jiejie Dai, Weihong Qin, Yunzhang Hu, Yajuan Wang, Li Zhang, Zulqarnain Baloch, Henglin Yang and Xueshan Xia
    Citation: BMC Infectious Diseases 2015 15:142
    Content type: Research article Published on:

  16. The recent emergence of Clostridium difficile infections has included this condition among top nosocomial infections, due to its incidence, complications and important fatality, as well as to significant economic...

    Authors: Ruxandra Laza, Ruxandra Jurac, Alexandru Crişan, Voichiţa Lăzureanu, Monica Licker, Emilian Damian Popovici and Luminiţa Mirela Bădiţoiu
    Citation: BMC Infectious Diseases 2015 15:141
    Content type: Research article Published on:

  17. Fungal skull base osteomyelitis (SBO) is a severe complication of otitis externa or sinonasal infection, and is mainly caused by Aspergillus species. Here we investigate innate and adaptive immune responses in pa...

    Authors: Corine E Delsing, Katharina L Becker, Anna Simon, Bart Jan Kullberg, Chantal P Bleeker-Rovers, Frank L van de Veerdonk and Mihai G Netea
    Citation: BMC Infectious Diseases 2015 15:140
    Content type: Research article Published on:

  18. In limited resource settings, sputum smear conversion at the end of the intensive phase of tuberculosis treatment is an indicator not only of patients’ response to treatment, but also of anti-tuberculosis prog...

    Authors: Fabrice Nembot Djouma, Michel Noubom, Jérôme Ateudjieu and Hubert Donfack
    Citation: BMC Infectious Diseases 2015 15:139
    Content type: Research article Published on:

  19. Increased levels of markers of systemic inflammation have been associated with serious non-AIDS events even in patients on fully suppressive antiretroviral therapy. We explored residual viremia and systemic in...

    Authors: Alejandro Arenas-Pinto, Ana Milinkovic, Dimitra Peppa, Anna McKendry, Mala Maini and Richard Gilson
    Citation: BMC Infectious Diseases 2015 15:138
    Content type: Research article Published on:

  20. Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to...

    Authors: Cornelius Remschmidt, Thorsten Rieck, Birte Bödeker and Ole Wichmann
    Citation: BMC Infectious Diseases 2015 15:137
    Content type: Research article Published on:

  21. Some studies have suggested that helminth infections increase the risk of malaria infection and are associated with increased number of malaria attacks and anaemia. Thus interventions to control helminth infec...

    Authors: Safari M Kinung’hi, Pascal Magnussen, Coleman Kishamawe, Jim Todd and Birgitte J Vennervald
    Citation: BMC Infectious Diseases 2015 15:136
    Content type: Research article Published on:

  22. Infectious disease surveillance has recently seen many changes including rapid growth of informal surveillance, acting both as competitor and a facilitator to traditional surveillance, as well as the implement...

    Authors: Chi Y Bahk, David A Scales, Sumiko R Mekaru, John S Brownstein and Clark C Freifeld
    Citation: BMC Infectious Diseases 2015 15:135
    Content type: Research article Published on:

  23. Recently we developed and validated generic quality indicators that define ‘appropriate antibiotic use’ in hospitalized adults treated for a (suspected) bacterial infection. Previous studies have shown that wi...

    Authors: Frederike V van Daalen, Jan M Prins, Brent C Opmeer, Marja A Boermeester, Caroline E Visser, Reinier M van Hest, Marlies E J L Hulscher and Suzanne E Geerlings
    Citation: BMC Infectious Diseases 2015 15:134
    Content type: Study protocol Published on:

  24. Insulin resistance is a strong predictor of the development of type 2 diabetes mellitus. Chronic helminth infections might protect against insulin resistance via a caloric restriction state and indirectly via ...

    Authors: Dicky L Tahapary, Karin de Ruiter, Ivonne Martin, Lisette van Lieshout, Bruno Guigas, Pradana Soewondo, Yenny Djuardi, Aprilianto E Wiria, Oleg A Mayboroda, Jeanine J Houwing-Duistermaat, Hengki Tasman, Erliyani Sartono, Maria Yazdanbakhsh, Johannes W A Smit and Taniawati Supali
    Citation: BMC Infectious Diseases 2015 15:133
    Content type: Study protocol Published on:

  25. In Nigeria, reports of the outcomes of prevention of mother to child transmission of HIV (PMTCT) interventions had been limited to the MTCT rates of HIV, with no information on HIV-free survival (HFS) in the H...

    Authors: Emmanuel A Anígilájé, Othniel J Dabit, Ayodotun Olutola, Bem Ageda and Sunday A Aderibigbe
    Citation: BMC Infectious Diseases 2015 15:132
    Content type: Research article Published on:

  26. We have recovered one blaNDM-1-harboring bacterial strain, designated as XM1570, from a sputum sample obtained from a fatal case of pneumonia in China.

    Authors: Peng Li, Chaojie Yang, Jing Xie, Nan Liu, Houzhao Wang, Ling Zhang, Xu Wang, Yong Wang, Shaofu Qiu and Hongbin Song
    Citation: BMC Infectious Diseases 2015 15:131
    Content type: Research article Published on:

  27. Achieving the goal of eliminating mother-to-child HIV transmission (MTCT) necessitates increased access to antiretroviral therapy (ART) for HIV-infected pregnant women. Option B provides ART through pregnancy ...

    Authors: Adam VanDeusen, Elijah Paintsil, Thomas Agyarko-Poku and Elisa F Long
    Citation: BMC Infectious Diseases 2015 15:130
    Content type: Research article Published on:

  28. Antibiotic-associated diarrhea (AAD) is a common adverse effect of antibiotic (AB) treatment. This study aimed to measure the overall prevalence of AAD (including mild to moderate diarrhea) in hospitalized AB ...

    Authors: Monique M Elseviers, Yoleen Van Camp, Sander Nayaert, Khyra Duré, Lieven Annemans, Ann Tanghe and Sebastian Vermeersch
    Citation: BMC Infectious Diseases 2015 15:129
    Content type: Research article Published on:

  29. Antifungal prophylaxis is a promising strategy for reducing invasive fungal infections (IFIs) in allogeneic hematopoietic cell transplant (alloHCT) recipients, but the optimum prophylactic agent is unknown. We...

    Authors: Eric J Bow, David J Vanness, Monica Slavin, Catherine Cordonnier, Oliver A Cornely, David I Marks, Antonio Pagliuca, Carlos Solano, Lael Cragin, Alissa J Shaul, Sonja Sorensen, Richard Chambers, Michal Kantecki, David Weinstein and Haran Schlamm
    Citation: BMC Infectious Diseases 2015 15:128
    Content type: Research article Published on:

  30. Antibiotic resistance is a threat in developing countries (DCs) because of the high burden of bacterial disease and the presence of risk factors for its emergence and spread. This threat is of particular conce...

    Authors: Bich-Tram Huynh, Michael Padget, Benoit Garin, Perlinot Herindrainy, Elsa Kermorvant-Duchemin, Laurence Watier, Didier Guillemot and Elisabeth Delarocque-Astagneau
    Citation: BMC Infectious Diseases 2015 15:127
    Content type: Research article Published on:

  31. The available pharmacokinetic data on anti-tubercular drugs in children raises the concern of suboptimal plasma concentrations attained when doses extrapolated from adult studies are used. Also, there is lack ...

    Authors: Aparna Mukherjee, Thirumurthy Velpandian, Mohit Singla, Kunwar Kanhiya, Sushil K Kabra and Rakesh Lodha
    Citation: BMC Infectious Diseases 2015 15:126
    Content type: Research article Published on:

  32. There is little data regarding the effect of ramping up new screening interventions on their uptake by target populations into routine care services in developing countries. This study aimed to determine patie...

    Authors: Edward Tieru Dassah, Yaw Adu-Sarkodie and Philippe Mayaud
    Citation: BMC Infectious Diseases 2015 15:125
    Content type: Research article Published on:

  33. Acute respiratory infections (ARIs) are common in children and mostly caused by viruses, but the significance of the detection of multiple viruses in ARIs is unclear. This study investigated 14 respiratory vir...

    Authors: Binglin Cui, Dangui Zhang, Hui Pan, Fan Zhang, Jeremy Farrar, Frieda Law, H Rogier van Doorn, Beiyan Wu and William Ba-Thein
    Citation: BMC Infectious Diseases 2015 15:124
    Content type: Research article Published on:

  35. Pseudomonas aeruginosa is an important nosocomial pathogen, commonly causing infections in immunocompromised patients. The aim of this study was to examine the genetic relatedness of metallo-beta-lactamase (MBL) ...

    Authors: Mai Mahmoud Zafer, Mohamed Hamed Al-Agamy, Hadir Ahmed El-Mahallawy, Magdy Aly Amin and Seif El Din Ashour
    Citation: BMC Infectious Diseases 2015 15:122
    Content type: Research article Published on:

  36. Measles cases may cluster in densely populated urban centers in sub-Saharan Africa as susceptible individuals share spatially dependent risk factors and may cluster among human immunodeficiency virus (HIV)-inf...

    Authors: Jessie Pinchoff, James Chipeta, Gibson Chitundu Banda, Samuel Miti, Timothy Shields, Frank Curriero and William John Moss
    Citation: BMC Infectious Diseases 2015 15:121
    Content type: Research article Published on:

  37. Hepatitis B Virus (HBV) disproportionately affects new immigrants from endemic regions such as China. Untreated infections increase health risks for liver diseases including cancer. Yet most of those infected ...

    Authors: Grace X Ma, Guo Yolanda Zhang, Shumenghui Zhai, Xiang Ma, Yin Tan, Steven E Shive and Min Qi Wang
    Citation: BMC Infectious Diseases 2015 15:120
    Content type: Research article Published on:

  38. Successful antiretroviral therapy (ART) has dramatically reduced mortality among HIV-infected children. However, there is growing concern about long-term effects associated to ART. The aim of this study was to...

    Authors: Daniel Blázquez, José Tomás Ramos-Amador, Talía Saínz, María José Mellado, Marta García-Ascaso, María Isabel De José, Pablo Rojo, María Luisa Navarro, María Ángeles Muñoz-Fernández, Jesús Saavedra, Miguel Angel Roa, Santiago Jiménez, José Beceiro, Luis Prieto, Milagros García Hortelano and María Isabel González-Tomé
    Citation: BMC Infectious Diseases 2015 15:119
    Content type: Research article Published on:

  39. Although neonatal infections cause a significant proportion of deaths in the first week of life, little is known about the burden of neonatal disease originating from maternal infection or colonization globall...

    Authors: Grace J Chan, Anne CC Lee, Abdullah H Baqui, Jingwen Tan and Robert E Black
    Citation: BMC Infectious Diseases 2015 15:118
    Content type: Research article Published on:

  40. Tuberculosis (TB) is a global public health concern. It is even more so as its incidence seems to be increasing in South Africa. The aim of this study was to describe and compare the tuberculosis infection con...

    Authors: Ntambwe Malangu and Michah Mngomezulu
    Citation: BMC Infectious Diseases 2015 15:117
    Content type: Research article Published on:

  41. Staphylococcus aureus is one of the most common and lethal causes of bloodstream infection and the incidence is increasing. We carried out a prospective observational study of patients with Staphylococcus aureus ...

    Authors: Julie Paulsen, Arne Mehl, Åsa Askim, Erik Solligård, Bjørn Olav Åsvold and Jan Kristian Damås
    Citation: BMC Infectious Diseases 2015 15:116
    Content type: Research article Published on:

  42. Women in sub-Saharan Africa are vulnerable to acquiring HIV infection and reproductive tract infections. Bacterial vaginosis (BV), a disruption of the vaginal microbiota, has been shown to be strongly associat...

    Authors: Vicky Jespers, Janneke van de Wijgert, Piet Cools, Rita Verhelst, Hans Verstraelen, Sinead Delany-Moretlwe, Mary Mwaura, Gilles F Ndayisaba, Kishor Mandaliya, Joris Menten, Liselotte Hardy and Tania Crucitti
    Citation: BMC Infectious Diseases 2015 15:115
    Content type: Research article Published on:

  43. The use of recombinant viral vectors expressing T. gondii antigens is a safe and efficient approach to induce immune responses against the parasite, as well as a valuable tool for vaccine development. We have pre...

    Authors: Xiu-Zhen Li, Xiao-Hu Wang, Li-Jun Xia, Ya-Biao Weng, Jorge A Hernandez, Li-Qing Tu, Lu-Tao Li, Shou-Jun Li and Zi-Guo Yuan
    Citation: BMC Infectious Diseases 2015 15:114
    Content type: Research article Published on:

  44. Streptococcus pyogenes (group A streptococcus; GAS) is an etiological agent for pharyngitis, pyoderma, and invasive infections in humans. Pharyngitis and pyoderma may lead to serious immune sequelae such as rheum...

    Authors: Mohan G Karmarkar, Gouri P Hule, Ainslie Cameron, Preeti R Mehta, Uday Khopkar, Niwrutti K Hase and Kadaba S Sriprakash
    Citation: BMC Infectious Diseases 2015 15:113
    Content type: Research article Published on:

  45. Ethiopia, a high tuberculosis (TB) burden country, reports one of the highest incidence rates of extra-pulmonary TB dominated by cervical lymphadenitis (TBLN). Infection with Mycobacterium bovis has previously be...

    Authors: Stefan Berg, Esther Schelling, Elena Hailu, Rebuma Firdessa, Balako Gumi, Girume Erenso, Endalamaw Gadisa, Araya Mengistu, Meseret Habtamu, Jemal Hussein, Teklu Kiros, Shiferaw Bekele, Wondale Mekonnen, Yohannes Derese, Jakob Zinsstag, Gobena Ameni…
    Citation: BMC Infectious Diseases 2015 15:112
    Content type: Research article Published on:

  46. Syphilis and HIV infections in pregnancy result in a number of adverse outcomes including neonatal death and vertical transmission. Ethiopia is a country where these infections are highly prevalent. However, d...

    Authors: Mengistu Endris, Tekalign Deressa, Yeshambel Belyhun and Feleke Moges
    Citation: BMC Infectious Diseases 2015 15:111
    Content type: Research article Published on:

  47. Early warning and robust estimation of influenza burden are critical to inform hospital preparedness and operational, treatment, and vaccination policies. Methods to enhance influenza-like illness (ILI) survei...

    Authors: Lydia N Drumright, Simon DW Frost, Alex J Elliot, Mike Catchpole, Richard G Pebody, Mark Atkins, John Harrison, Penny Parker and Alison H Holmes
    Citation: BMC Infectious Diseases 2015 15:110
    Content type: Research article Published on:

  48. Influenza H7N9 has become an endemic pathogen in China where circulating virus is found extensively in wild birds and domestic poultry. Two epidemic waves of Human H7N9 infections have taken place in Eastern a...

    Authors: Amber Farooqui, Alberto J Leon, Linxi Huang, Suwu Wu, Yingmu Cai, Pengzhou Lin, Weihong Chen, Xibin Fang, Tiansheng Zeng, Yisu Liu, Li Zhang, Ting Su, Weibin Chen, Elodie Ghedin, Huachen Zhu, Yi Guan…
    Citation: BMC Infectious Diseases 2015 15:109
    Content type: Research article Published on:

  49. Candida albicans remains as the first cause of nosocomial fungal infections in hospitals worldwide and its susceptibility pattern should be better described in our tertiary care hospitals.

    Authors: Giovanni Rodríguez-Leguizamón, Alessandro Fiori, Katrien Lagrou, María Antonia Gaona, Milciades Ibáñez, Manuel Alfonso Patarroyo, Patrick Van Dijck and Arley Gómez-López
    Citation: BMC Infectious Diseases 2015 15:108
    Content type: Research article Published on:

  50. While enterococci resistant to multiple antimicrobials are spreading in hospitals worldwide, causing urinary tract, wound and bloodstream infections, there is little published data on these infections from Afr...

    Authors: Håvard Aamodt, Stein Christian Mohn, Samuel Maselle, Karim P Manji, Rob Willems, Roland Jureen, Nina Langeland and Bjørn Blomberg
    Citation: BMC Infectious Diseases 2015 15:107
    Content type: Research article Published on:

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