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  1. In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for thes...

    Authors: Paul Kosiyo, Walter Otieno, Jesse Gitaka, Elly O. Munde and Collins Ouma

    Citation: BMC Infectious Diseases 2021 21:329

    Content type: Research article

    Published on:

  2. The epidemiology on the human papillomavirus (HPV) among females in Southern China is not well-established. Baseline data on the prevalence of HPV infection in China prior to mass prophylactic HPV vaccination ...

    Authors: Li-pei Luo, Ping He, Qiao-tu Liu, Yang-hua Jiang, Yang-nan Zhang, Qing-zhao Li, Qiu Li, Sheng-tao Li, Fan Yang, Hua Ling, Xin-gui Dai, Zhong-yu Li and Hong-liang Chen

    Citation: BMC Infectious Diseases 2021 21:328

    Content type: Research article

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  3. Previous studies found that S100A9 may involve in the pathophysiology of community-acquired pneumonia (CAP). However, the role of S100A9 was unclear in the CAP. The goal was to explore the correlations of seru...

    Authors: Hong-Yan Liu, Hui-Xian Xiang, Ying Xiang, Zheng Xu, Chun-Mei Feng, Jun Fei, Lin Fu and Hui Zhao

    Citation: BMC Infectious Diseases 2021 21:327

    Content type: Research article

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  4. Malaria is a major cause of morbidity and mortality in pediatrics in malaria endemic areas. Artemisinin-based combination therapies (ACTs) are the drugs of choice for malaria management particularly across mal...

    Authors: Workineh Shibeshi, Getachew Alemkere, Assefa Mulu and Ephrem Engidawork

    Citation: BMC Infectious Diseases 2021 21:326

    Content type: Research article

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  5. Rapid and simple serological assays for characterizing antibody responses are important in the current COVID-19 pandemic caused by SARS-CoV-2. Multiplex immunoblot (IB) assays termed COVID-19 IB assays were de...

    Authors: Jyotsna Shah, Song Liu, Hari-Hara Potula, Prerna Bhargava, Iris Cruz, Denise Force, Ammar Bazerbashi and Ranjan Ramasamy

    Citation: BMC Infectious Diseases 2021 21:325

    Content type: Research article

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  6. Ebola virus disease (EVD) is a severe, often fatal illness in humans and nonhuman primates caused by the Ebola virus. The recently approved rVSV-EBOV vaccine is not available in many high-risk countries hence ...

    Authors: Frankline Sevidzem Wirsiy, Alphonse Um Boock and Jane-Francis Tatah Kihla Akoachere

    Citation: BMC Infectious Diseases 2021 21:324

    Content type: Research article

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  7. Parainfluenza virus (PIV) is a leading cause of acute respiratory illness (ARI) in children. However, few studies have characterized the clinical features and outcomes associated with PIV infections among youn...

    Authors: Leigh M. Howard, Danielle A. Rankin, Andrew J. Spieker, Wenying Gu, Zaid Haddadin, Varvara Probst, Herdi Rahman, Rendie McHenry, Claudia Guevara Pulido, John V. Williams, Samir Faouri, Asem Shehabi, Najwa Khuri-Bulos and Natasha B. Halasa

    Citation: BMC Infectious Diseases 2021 21:323

    Content type: Research article

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  8. Acute respiratory tract infection (ARI) is a leading cause of hospitalization, morbidity, and mortality worldwide. Respiratory microbes that were simultaneously detected in the respiratory tracts of hospitaliz...

    Authors: Phuong Thai Truong, Shinji Saito, Ikuyo Takayama, Hiroyuki Furuya, Binh Gia Nguyen, Thanh Van Do, Phuong Thu Phan, Cuong Duy Do, Co Xuan Dao, Thach The Pham, Tuan Quoc Dang, Chau Quy Ngo, Ngan Thi Le, Vuong Minh Bui, Dung Trung Le, Van Thi Tuong Vu…

    Citation: BMC Infectious Diseases 2021 21:320

    Content type: Research article

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  9. Hepatitis C virus reinfections in HIV-positive men-who-have-sex-with-men (MSM) challenge the effectiveness of antiviral treatment. To fight this problem, an adapted sexual risk reduction intervention was imple...

    Authors: Patrizia Künzler-Heule, Katharina Fierz, Axel Jeremias Schmidt, Manuela Rasi, Jasmina Bogdanovic, Agnes Kocher, Sandra Engberg, Manuel Battegay, Christiana Nöstlinger, Andreas Lehner, Roger Kouyos, Patrick Schmid, Dominique Laurent Braun, Jan Fehr and Dunja Nicca

    Citation: BMC Infectious Diseases 2021 21:319

    Content type: Research article

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  10. Accurate diagnosis in patients with suspected coronavirus disease 2019 (COVID-19) is essential to guide treatment and limit spread of the virus. The combined nasal and throat swab is used widely, but its diagn...

    Authors: Kuan Ken Lee, Dimitrios Doudesis, Daniella A. Ross, Anda Bularga, Claire L. MacKintosh, Oliver Koch, Ingolfur Johannessen, Kate Templeton, Sara Jenks, Andrew R. Chapman, Anoop S. V. Shah, Atul Anand, Meghan R. Perry and Nicholas L. Mills

    Citation: BMC Infectious Diseases 2021 21:318

    Content type: Research article

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  11. We demonstrated that an early dysregulated cytokine response [high interleukin-10 to tissue necrosis factor (IL-10/TNF) ratio] predicted poor outcomes in patients with Staphylococcus aureus bacteremia (SAB). Howe...

    Authors: Karen Tan, Emi Minejima, Mimi Lou, Wendy J. Mack, Paul Nieberg and Annie Wong-Beringer

    Citation: BMC Infectious Diseases 2021 21:317

    Content type: Research article

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  12. Blood stream infection (BSI) and sepsis are serious clinical conditions and identification of the disease-causing pathogen is important for patient management. The RISE (Rapid Identification of SEpsis) study w...

    Authors: David Nestor, Hanna Andersson, Pernilla Kihlberg, Sara Olson, Ingrid Ziegler, Gunlög Rasmussen, Jan Källman, Sara Cajander, Paula Mölling and Martin Sundqvist

    Citation: BMC Infectious Diseases 2021 21:316

    Content type: Research article

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  13. The primary objective of our study was to examine predictors for readmission in a prospective cohort of sepsis patients admitted to an emergency department (ED) and identified by the new Sepsis-3 criteria.

    Authors: Peer Oscar Overgaard Stenholt, S. M. Osama Bin Abdullah, Rune Husås Sørensen and Finn Erland Nielsen

    Citation: BMC Infectious Diseases 2021 21:315

    Content type: Research article

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  14. Older patients hospitalized with community-acquired pneumonia (CAP) are at high risk for short-term mortality. Activity of daily living (ADL) is associated with clinical outcomes in older patients. We aimed to...

    Authors: Yu Kang, Xiang-Yang Fang, Dong Wang and Xiao-Juan Wang

    Citation: BMC Infectious Diseases 2021 21:314

    Content type: Research article

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  15. Currently, the association of nutritional risk screening score with the development of nonventilator hospital-acquired pneumonia (NV-HAP) is unknown. This study investigated whether nutritional risk screening ...

    Authors: Zhihui Chen, Hongmei Wu, Jiehong Jiang, Kun Xu, Shengchun Gao, Le Chen, Haihong Wang and Xiuyang Li

    Citation: BMC Infectious Diseases 2021 21:313

    Content type: Research article

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  16. Staphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and is associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicate...

    Authors: Carly L. Botheras, Steven J. Bowe, Raquel Cowan and Eugene Athan

    Citation: BMC Infectious Diseases 2021 21:312

    Content type: Research article

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  17. Dengue infection is caused by an arbovirus with a wide range of presentations, varying from asymptomatic disease to unspecific febrile illness and haemorrhagic syndrome with shock, which can evolve to death. I...

    Authors: Marielton dos Passos Cunha, Amaro Nunes Duarte-Neto, Shahab Zaki Pour, Ludhmila Abrahão Hajjar, Fernando Pereira Frassetto, Marisa Dolhnikoff, Paulo Hilario do Nascimento Saldiva and Paolo Marinho de Andrade Zanotto

    Citation: BMC Infectious Diseases 2021 21:311

    Content type: Case report

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  18. Recent seroepidemiological studies have suggested that tularemia could be an endemic bacterial zoonosis in Iran.

    Authors: Saber Esmaeili, Mahdi Rohani, Ahmad Ghasemi, Mohammad Mehdi Gouya, Simin Khayatzadeh, Ahmad Mahmoudi, Hossein Ahangari Cohan, Anders Johansson, Max Maurin and Ehsan Mostafavi

    Citation: BMC Infectious Diseases 2021 21:310

    Content type: Research article

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  19. Population external validity is the extent to which an experimental study results can be generalized from a specific sample to a defined population. In order to apply the results of a study, we should be able ...

    Authors: Vered Daitch, Mical Paul, George L. Daikos, Emanuele Durante-Mangoni, Dafna Yahav, Yehuda Carmeli, Yael Dishon Benattar, Anna Skiada, Roberto Andini, Noa Eliakim-Raz, Amir Nutman, Oren Zusman, Anastasia Antoniadou, Giusi Cavezza, Amos Adler, Yaakov Dickstein…

    Citation: BMC Infectious Diseases 2021 21:309

    Content type: Research article

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  20. Covid-19 is a disease with high morbidity and mortality among elderly residents of long-term care facilities (LTCF). During an outbreak of SARS-CoV-2 infection in the LTCF an effective screening tool is essent...

    Authors: P. Sabaka, A. Koščálová, I. Straka, J. Hodosy, R. Lipták, B. Kmotorková, M. Kachlíková and A. Kušnírová

    Citation: BMC Infectious Diseases 2021 21:308

    Content type: Research article

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  21. Limited clinical studies describe the pharmacodynamics of fosfomycin (FOS), tigecycline (TGC) and colistin methanesulfonate (CMS) in combination against KPC-producing Klebsiella pneumoniae (KPC-Kp). Population ph...

    Authors: Guoan Wang, Wei Yu, Yushan Cui, Qingyi Shi, Chen Huang and Yonghong Xiao

    Citation: BMC Infectious Diseases 2021 21:307

    Content type: Research article

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  22. Acute respiratory infections (ARIs) are among the leading causes of hospitalization in children. Understanding the local dominant viral etiologies is important to inform infection control practices and clinica...

    Authors: Cheng Lei, Lisong Yang, Cheong Tat Lou, Fan Yang, Kin Ian SiTou, Hao Hu, King Io, Kun Tat Cheok, Baoquan Pan and Carolina Oi Lam Ung

    Citation: BMC Infectious Diseases 2021 21:306

    Content type: Research article

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  23. Iranian children were vaccinated with the scheduled two doses of monovalent measles vaccine (mMV) from 1984. In December 2003, a nationwide campaign of measles-rubella (MR) immunization was established to vacc...

    Authors: Hana Saffar, Maryam Khalifeloo, Mohammad-Jafar Saffar, Alireza Abdollahi, Mohammad-Reza Parsaei, Gholam-Reza Ghorbani, Samaneh Salarvand and Mohsen Aarabi

    Citation: BMC Infectious Diseases 2021 21:305

    Content type: Research article

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  24. Coronavirus disease once thought to be a respiratory infection is now recognised as a multi-system disease affecting the respiratory, cardiovascular, gastrointestinal, neurological, immune, and hematopoietic s...

    Authors: Bodunrin Osikomaiya, Olufemi Erinoso, Kikelomo Ololade Wright, Aina Olufemi Odusola, Babafemi Thomas, Oluwatosin Adeyemi, Abimbola Bowale, Olusola Adejumo, Ayodeji Falana, Ismail Abdus-salam, Olusegun Ogboye, Akin Osibogun and Akin Abayomi

    Citation: BMC Infectious Diseases 2021 21:304

    Content type: Research article

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  25. Proper detection of disease-causing organisms is very critical in controlling the course of outbreaks and avoiding large-scale epidemics. Nonetheless, availability of resources to address these gaps have been ...

    Authors: Michael Owusu, Bernard Nkrumah, Godfred Acheampong, Ebenezer Kofi Mensah, Abass Abdul-Karim Komei, Festus Kofi Sroda, Sambian David, Shannon Emery, Lucy Maryogo Robinson, Kwame Asante and David Opare

    Citation: BMC Infectious Diseases 2021 21:303

    Content type: Research article

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  26. To explore population aging and the epidemic trend of pulmonary tuberculosis (PTB) in the elderly, and provide a basis for the prevention and control of pulmonary tuberculosis among the elderly.

    Authors: Shi-jin Li, Yi-fan Li, Wan-mei Song, Qian-yun Zhang, Si-qi Liu, Ting-ting Xu, Qi-qi An, Jin-yue Liu and Huai-chen Li

    Citation: BMC Infectious Diseases 2021 21:302

    Content type: Research article

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  27. Acute kidney injury (AKI) is expected to occur commonly in patients with chronic hepatitis C. In addition, AKI may affect the survival of patients with chronic hepatitis C. However, few studies are available o...

    Authors: Hankyu Jeon, Jae Heon Kim, Sang Soo Lee, Hee Jin Kim, Ra Ri Cha, Hyun Chin Cho, Jae Min Lee, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok-Jae Lee

    Citation: BMC Infectious Diseases 2021 21:301

    Content type: Research article

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  28. Pseudomonas aeruginosa is the leading cause of nosocomial infections, especially in people with a compromised immune system. Targeting virulence factors by neutralizing antibodies is a novel paradigm for the trea...

    Authors: Zahra Shadman, Safar Farajnia, Mohammad Pazhang, Mohammadreza Tohidkia, Leila Rahbarnia, Saeed Najavand and Sayna Toraby

    Citation: BMC Infectious Diseases 2021 21:300

    Content type: Research article

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  30. Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is spreading globally and causes most frequently fever and respiratory symptoms, i.e. Coronavirus disease 2019 (COVID-19), however, distinct neurological ...

    Authors: Jana Werner, Ina Reichen, Michael Huber, Irene A. Abela, Michael Weller and Ilijas Jelcic

    Citation: BMC Infectious Diseases 2021 21:298

    Content type: Case report

    Published on:

  31. Levamisole has shown clinical benefits in the management of COVID-19 via its immunomodulatory effect. However, the exact role of Levamisole effect in clinical status of COVID-19 patients is unknown. We aimed t...

    Authors: Amirreza Roostaei Firozabad, Zohreh Akhoundi Meybodi, Seyed Ruhollah Mousavinasab, Adeleh Sahebnasagh, Mohsen Gholinataj Jelodar, Iman Karimzadeh, Solomon Habtemariam and Fatemeh Saghafi

    Citation: BMC Infectious Diseases 2021 21:297

    Content type: Research article

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  32. Invasive aspergillosis (IA) is a rare complication in solid organ transplant (SOT) recipients. Although IA has significant implications on graft and patient survival, data on diagnosis and management of this i...

    Authors: Dionysios Neofytos, Carolina Garcia-Vidal, Frédéric Lamoth, Christoph Lichtenstern, Alessandro Perrella and Jörg Janne Vehreschild

    Citation: BMC Infectious Diseases 2021 21:296

    Content type: Guidelines

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  33. Escherichia coli (E. coli) is one of the important causative pathogens of neonatal invasive infection. The epidemiological and clinical profile of invasive E. coli infection in Chinese newborns is not well charac...

    Authors: Jidong Lai, Yao Zhu, Lixia Tang and Xinzhu Lin

    Citation: BMC Infectious Diseases 2021 21:295

    Content type: Research article

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  34. HIV endemic populations are displaying higher incidence of metabolic disorders. HIV and the standard treatment are both associated with altered lipid and cholesterol metabolism, however gallstone disease (a ch...

    Authors: Suman Mewa Kinoo, Anil A. Chuturgoon, Bugwan Singh and Savania Nagiah

    Citation: BMC Infectious Diseases 2021 21:294

    Content type: Research article

    Published on:

  35. Respiratory syncytial virus (RSV) infection causes substantial morbidity and mortality in children and adults. Socioeconomic status (SES) is known to influence many health outcomes, but there have been few stu...

    Authors: Jenna E. Holmen, Lindsay Kim, Bryanna Cikesh, Pam Daily Kirley, Shua J. Chai, Nancy M. Bennett, Christina B. Felsen, Patricia Ryan, Maya Monroe, Evan J. Anderson, Kyle P. Openo, Kathryn Como-Sabetti, Erica Bye, H. Keipp Talbot, William Schaffner, Alison Muse…

    Citation: BMC Infectious Diseases 2021 21:293

    Content type: Research article

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  36. The World Health Organization (WHO) End TB strategy aims to reduce mortality due to tuberculosis (TB) to less than 5% by 2035. However, mortality due to multidrug-resistant tuberculosis (MDR-TB) remains partic...

    Authors: Enock Kizito, Joseph Musaazi, Kenneth Mutesasira, Fred Twinomugisha, Helen Namwanje, Timothy Kiyemba, Debora B. Freitas Lopez, Nicholas Sebuliba Nicholas, Abel Nkolo, Estella Birabwa, Seyoum Dejene and Stella Zawedde-Muyanja

    Citation: BMC Infectious Diseases 2021 21:292

    Content type: Research article

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  37. Information on the etiology and age-specific burden of respiratory viral infections among school-aged children remains limited. Though school aged children are often recognized as driving the transmission of i...

    Authors: Jonathan M. Read, Shanta Zimmer, Charles Vukotich Jr, Mary Lou Schweizer, David Galloway, Carrie Lingle, Gaby Yearwood, Patti Calderone, Eva Noble, Talia Quadelacy, Kyra Grantz, Charles Rinaldo, Hongjiang Gao, Jeanette Rainey, Amra Uzicanin and Derek A. T. Cummings

    Citation: BMC Infectious Diseases 2021 21:291

    Content type: Research article

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  38. Leprosy continues to be an important cause of physical disability in endemic countries such as Brazil. Knowledge of determinants of these events may lead to better control measures and targeted interventions t...

    Authors: Mauro Niskier Sanchez, Joilda Silva Nery, Júlia Moreira Pescarini, André Alves Mendes, Maria Yury Ichihara, Camila Silveira Silva Teixeira, Maria Lúcia Fernandes Penna, Liam Smeeth, Laura Cunha Rodrigues, Maurício Lima Barreto, Elizabeth B. Brickley and Gerson Oliveira Penna

    Citation: BMC Infectious Diseases 2021 21:290

    Content type: Research article

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  39. Information about the clinical and microbiological characteristics of IMP-producing Enterobacterales has been limited. Here, we describe an institutional outbreak of IMP-producing Enterobacter cloacae complex (EC...

    Authors: Sohei Harada, Kotaro Aoki, Daisuke Ohkushi, Koh Okamoto, Kazumi Takehana, Tomomi Akatsuchi, Keito Ida, Daigo Shoji, Yoshikazu Ishii, Yohei Doi, Kyoji Moriya and Brian Hayama

    Citation: BMC Infectious Diseases 2021 21:289

    Content type: Research article

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  41. Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that infects immunodeficient children. The aim of the study is to determine the clinical features and peripheral immune state of Talaromyces marne...

    Authors: Qiang Zeng, Yingkang Jin, Genquan Yin, Diyuan Yang, Wenyan Li, Tingting Shi, Gen Lu, Li Huang and Huifeng Fan

    Citation: BMC Infectious Diseases 2021 21:287

    Content type: Research article

    Published on:

  42. Dengue fever prevalence is rising globally and it causes significant morbidity and mortality. Fluid extravasation during the critical phase of dengue haemorrhagic fever (DHF) leads to shock, multi-organ failur...

    Authors: PMW Madanayake, AEU Jayawardena, S L Wijekoon, N Perera and JKP Wanigasuriya

    Citation: BMC Infectious Diseases 2021 21:286

    Content type: Research article

    Published on:

  43. The systemic response to an infection might influence the pharmacokinetics of antibiotics. To evaluate the desired possibility of an earlier (< 24 h) IV-to-oral switch therapy in febrile non-ICU, hospitalized ...

    Authors: Annemieke K. van den Broek, Jan M. Prins, Caroline E. Visser and Reinier M. van Hest

    Citation: BMC Infectious Diseases 2021 21:285

    Content type: Research article

    Published on:

  44. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are novel hypoglycemic agents which reduce reabsorption of glucose at the renal proximal tubule, resulting in significant glycosuria and increased risk of gen...

    Authors: Caroline Bartolo, Victoria Hall, N. Deborah Friedman, Chloe Lanyon, Andrew Fuller, C. Orla Morrissey and Eugene Athan

    Citation: BMC Infectious Diseases 2021 21:284

    Content type: Case report

    Published on:

  45. Pneumonia is one of the complications of COVID-19. Primary care electronic health records (EHR) have shown the utility as a surveillance system. We therefore analyse the trends of pneumonia during two waves of...

    Authors: Ermengol Coma, Leonardo Méndez-Boo, Núria Mora, Carolina Guiriguet, Mència Benítez, Francesc Fina, Mireia Fàbregas, Elisabet Balló, Francisa Ramos, Manuel Medina and Josep M. Argimon

    Citation: BMC Infectious Diseases 2021 21:283

    Content type: Research article

    Published on:

  46. Brazil has a high leprosy burden and poor treatment outcomes (TOs), manifesting in high relapse rates. Pernambuco, an impoverished Brazilian state suffering notable geographical health inequalities, has ‘hyperend...

    Authors: Divya Khanna, Gilles de Wildt, Luiz Antonio Miranda de Souza Duarte Filho, Mitali Bajaj, Jo Freda Lai, Esme Gardiner, Andrea Maia Fernandes de Araújo Fonseca, Antje Lindenmeyer and Patrícia Sammarco Rosa

    Citation: BMC Infectious Diseases 2021 21:282

    Content type: Research article

    Published on:

  47. Tuberculosis is a major global public health concern. Patients with tuberculosis who require critical care have a high mortality and delay in initiating antituberculous therapy is associated with increased mor...

    Authors: Kim de Vasconcellos, Praksha Ramjathan and Dhivendra Singh

    Citation: BMC Infectious Diseases 2021 21:281

    Content type: Research article

    Published on:

  48. Brucellosis is a major public health problem that seriously affects developing countries and could cause significant economic losses to the livestock industry and great harm to human health. Reasonable predict...

    Authors: Mengmeng Zhai, Wenhan Li, Ping Tie, Xuchun Wang, Tao Xie, Hao Ren, Zhuang Zhang, Weimei Song, Dichen Quan, Meichen Li, Limin Chen and Lixia Qiu

    Citation: BMC Infectious Diseases 2021 21:280

    Content type: Research article

    Published on:

  49. The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such as Togo have no data on the high-risk HPV (HR-HPV) inf...

    Authors: Akouélé P. Kuassi-Kpede, Essolakina Dolou, Théodora M. Zohoncon, Ina Marie Angèle Traore, Gnatoulma Katawa, R. Alice Ouedraogo, Esther Mah Traore, Prosper Bado, T. Clarisse Ouedraogo, Florencia Wendkuuni Djigma, Simplice Damintoti Karou and Jacques Simpore

    Citation: BMC Infectious Diseases 2021 21:278

    Content type: Research article

    Published on:

  50. Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant disease associated with neurological complications, including cerebral abscesses (CA). They tend to be unique, supratentorial and lobar....

    Authors: Xavier A. Santander, Anwar Saab, Juan Manuel Revuelta-Barbero and Elena Múñez

    Citation: BMC Infectious Diseases 2021 21:277

    Content type: Case report

    Published on:

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