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  1. Interferon-alpha monotherapy is effective in less than one-third patients with chronic hepatitis C. The dose-effect, tolerability and durability of interferon-alpha treatment and its long-term effect on the pr...

    Authors: Ming-Lung Yu, Chia-Yen Dai, Shinn-Cherng Chen, Li-Po Lee, Ming-Yen Hsieh, Zu-Yau Lin, Ming-Yuh Hsieh, Liang-Yen Wang, Jung-Fa Tsai, Wen-Yu Chang and Wan-Long Chuang

    Citation: BMC Infectious Diseases 2005 5:27

    Content type: Research article

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  2. It has been postulated that genetic predisposition may influence the susceptibility to SARS-coronavirus infection and disease outcomes. A recent study has suggested that the deletion allele (D allele) of the angi...

    Authors: KC Allen Chan, Nelson LS Tang, David SC Hui, Grace TY Chung, Alan KL Wu, Stephen SC Chim, Rossa WK Chiu, Nelson Lee, KW Choi, YM Sung, Paul KS Chan, YK Tong, ST Lai, WC Yu, Owen Tsang and YM Dennis Lo

    Citation: BMC Infectious Diseases 2005 5:26

    Content type: Research article

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  3. Inhalation anthrax is characterized by a systemic spread of the challenge agent, Bacillus anthracis. It causes severe damage, including multiple hemorrhagic lesions, to host tissues and organs. It is widely belie...

    Authors: Serguei G Popov, Taissia G Popova, Svetlana Hopkins, Raymond S Weinstein, Rebecca MacAfee, Karl J Fryxell, Vikas Chandhoke, Charles Bailey and Ken Alibek

    Citation: BMC Infectious Diseases 2005 5:25

    Content type: Research article

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  4. The increasing problem of infections due to multidrug-resistant Gram-negative bacteria has led to re-use of polymyxins in several countries. However, there are already clinical isolates of Gram-negative bacter...

    Authors: Matthew E Falagas, Ioannis A Bliziotis, Sofia K Kasiakou, George Samonis, Panayiota Athanassopoulou and Argyris Michalopoulos

    Citation: BMC Infectious Diseases 2005 5:24

    Content type: Research article

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  5. Hydroxyurea (HU) is an immunomodulatory agent that has been documented to enhance the antiretroviral activity of nucleoside reverse transcriptase inhibitors, such as abacavir (ABC) and didanosine (ddI), and wo...

    Authors: Susan Swindells, Calvin J Cohen, Daniel S Berger, Karen T Tashima, Qiming Liao, Bonnie F Pobiner, Jerry W Snidow, Gary E Pakes and Jaime E Hernandez

    Citation: BMC Infectious Diseases 2005 5:23

    Content type: Research article

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  6. Invasive fungal infections, such as candidemia, caused by Candida species have been increasing. Candidemia is not only associated with a high mortality (30% to 40%) but also extends the length of hospital stay an...

    Authors: Ming-Fang Cheng, Yun-Liang Yang, Tzy-Jyun Yao, Chin-Yu Lin, Jih-Shin Liu, Ran-Bin Tang, Kwok-Woon Yu, Yu-Hua Fan, Kai-Sheng Hsieh, Monto Ho and Hsiu-Jung Lo

    Citation: BMC Infectious Diseases 2005 5:22

    Content type: Research article

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  7. An association between Henoch-Schonlein purpura (HSP) and seropositivity for Bartonella henselae (BH) has been described. The objective of this study was to see if such an association exists in northern Alberta.

    Authors: Joan L Robinson, Donald W Spady, Errol Prasad, Dorothy McColl and Harvey Artsob

    Citation: BMC Infectious Diseases 2005 5:21

    Content type: Research article

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  8. Seasonal RSV infections occur every year and affect particularly children under six months of age. Passive immunoprophylaxis with monoclonal antibody Palivizumab is recommended in the period with high risk of ...

    Authors: Elena Terletskaia-Ladwig, Gisela Enders, Gunnar Schalasta and Martin Enders

    Citation: BMC Infectious Diseases 2005 5:20

    Content type: Research article

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  9. Tuberculosis poses a great challenge, especially in children. The response of BCG Test may be different in previously vaccinated children and needs to be considered before interpreting positivity for TB. This ...

    Authors: Mohit Singla, Vaibhav Sahai, Sukhbir Sodhi and Rakesh Pal Gupta

    Citation: BMC Infectious Diseases 2005 5:19

    Content type: Research article

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  10. Leishmaniases are among the most proteiform parasitic infections in humans ranging from unapparent to cutaneous, mucocutaneous or visceral diseases. The various clinical issues depend on complex and still poor...

    Authors: Yves JF Garin, Pascale Meneceur, Francine Pratlong, Jean-Pierre Dedet, Francis Derouin and Frédéric Lorenzo

    Citation: BMC Infectious Diseases 2005 5:18

    Content type: Research article

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  11. Trying to confront with the widespread burden of infectious diseases, the society worldwide invests considerably on research. We evaluated the contribution of different world regions in research production in ...

    Authors: Ioannis A Bliziotis, Konstantinos Paraschakis, Paschalis I Vergidis, Antonia I Karavasiou and Matthew E Falagas

    Citation: BMC Infectious Diseases 2005 5:16

    Content type: Research article

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  12. The human immunodeficiency virus type 1 (HIV-1) proviral DNA persists in infected cells, even after prolonged successful HAART. In the present study, a relative quantification assay of HIV-1 proviral DNA by Li...

    Authors: Benoît Kabamba-Mukadi, Philippe Henrivaux, Jean Ruelle, Nicole Delferrière, Monique Bodéus and Patrick Goubau

    Citation: BMC Infectious Diseases 2005 5:15

    Content type: Technical advance

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  13. Scrapie and BSE belong to a group of fatal, transmissible, neurodegenerative diseases called TSE. In order to minimize the risk of natural scrapie and presumed natural BSE in sheep, breeding programmes towards...

    Authors: Mario Van Poucke, Jo Vandesompele, Marc Mattheeuws, Alex Van Zeveren and Luc J Peelman

    Citation: BMC Infectious Diseases 2005 5:13

    Content type: Technical advance

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  14. Bacterial vaginosis (BV) – a syndrome characterised by a shift in vaginal flora – appears to be particularly common in sub-Saharan Africa, but little is known of the pattern of vaginal flora associated with BV...

    Authors: Edward Demba, Linda Morison, Maarten Schim van der Loeff, Akum A Awasana, Euphemia Gooding, Robin Bailey, Philippe Mayaud and Beryl West

    Citation: BMC Infectious Diseases 2005 5:12

    Content type: Research article

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  15. Rabies is the most important viral zoonosis from a global perspective. Worldwide efforts to combat the disease by oral vaccination of reservoirs have managed to eradicate wildlife rabies in large areas of cent...

    Authors: Dirk Eisinger, Hans-Hermann Thulke, Thomas Selhorst and Thomas Müller

    Citation: BMC Infectious Diseases 2005 5:10

    Content type: Research article

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  16. Others and we have previously described the potent in vivo and in vitro activity of the broad-spectrum antiviral agent PAP (Pokeweed antiviral protein) against a wide range of viruses. The purpose of the present ...

    Authors: Fatih M Uckun, Larisa Rustamova, Alexei O Vassilev, Heather E Tibbles and Alexander S Petkevich

    Citation: BMC Infectious Diseases 2005 5:9

    Content type: Research article

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  17. In Malaysia, Shigella spp. was reported to be the third commonest bacterial agent responsible for childhood diarrhoea. Currently, isolation of the bacterium and confirmation of the disease by microbiological and ...

    Authors: Kwai Lin Thong, Susan Ling Ling Hoe, SD Puthucheary and Rohani Md Yasin

    Citation: BMC Infectious Diseases 2005 5:8

    Content type: Research article

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  18. This report describes a large international chocolate-associated Salmonella outbreak originating from Germany.

    Authors: Dirk Werber, Johannes Dreesman, Fabian Feil, Ulrich van Treeck, Gerhard Fell, Steen Ethelberg, Anja M Hauri, Peter Roggentin, Rita Prager, Ian ST Fisher, Susanne C Behnke, Edda Bartelt, Ekkehard Weise, Andrea Ellis, Anja Siitonen, Yvonne Andersson…

    Citation: BMC Infectious Diseases 2005 5:7

    Content type: Research article

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  19. Four human coronaviruses are currently known to infect the respiratory tract: human coronaviruses OC43 (HCoV-OC43) and 229E (HCoV-229E), SARS associated coronavirus (SARS-CoV) and the recently identified human...

    Authors: Elien Moës, Leen Vijgen, Els Keyaerts, Kalina Zlateva, Sandra Li, Piet Maes, Krzysztof Pyrc, Ben Berkhout, Lia van der Hoek and Marc Van Ranst

    Citation: BMC Infectious Diseases 2005 5:6

    Content type: Research article

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  20. Many studies associated nosocomial infections with increased hospital costs due to extra days in hospital, staff time, extra investigations and drug treatment. The cost of antibiotic treatment for these infect...

    Authors: Dilara Inan, Rabin Saba, Filiz Gunseren, Gozde Ongut, Ozge Turhan, Ata Nevzat Yalcin and Latife Mamikoglu

    Citation: BMC Infectious Diseases 2005 5:5

    Content type: Research article

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  21. In the field of clinical mycobacteriology, Mycobacterium tuberculosis (MTB) can be a difficult organism to manipulate due to the restrictive environment of a containment level 3 (CL3) laboratory. Tests for rapid ...

    Authors: Kym S Blackwood, Tamara V Burdz, Christine Y Turenne, Meenu K Sharma, Amin M Kabani and Joyce N Wolfe

    Citation: BMC Infectious Diseases 2005 5:4

    Content type: Research article

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  22. Enterococcal meningitis is an uncommon disease usually caused by Enterococcus faecalis and Enterococcus faecium and is associated with a high mortality rate. Enterococcus casseliflavus has been implicated in a wi...

    Authors: Chiara Iaria, Giovanna Stassi, Gaetano Bruno Costa, Rita Di Leo, Antonio Toscano and Antonio Cascio

    Citation: BMC Infectious Diseases 2005 5:3

    Content type: Case report

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  23. Hyperlipidemia secondary to protease inhibitors (PI) may abate by switching to anti-HIV medications without lipid effects.

    Authors: Philip H Keiser, Michael G Sension, Edwin DeJesus, Allan Rodriguez, Jeffrey F Olliffe, Vanessa C Williams, John H Wakeford, Jerry W Snidow, Anne D Shachoy-Clark, Julie W Fleming, Gary E Pakes and Jaime E Hernandez

    Citation: BMC Infectious Diseases 2005 5:2

    Content type: Research article

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  24. The intravenous use of polymyxins has been considered to be associated with considerable nephrotoxicity and neurotoxicity. For this reason, the systemic administration of polymyxins had been abandoned for abou...

    Authors: Matthew E Falagas, Michael Rizos, Ioannis A Bliziotis, Kostas Rellos, Sofia K Kasiakou and Argyris Michalopoulos

    Citation: BMC Infectious Diseases 2005 5:1

    Content type: Research article

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  25. MDR Mycobacterium tuberculosis is the major cause of treatment failure in tuberculosis patients, especially in immunosuppressed. We described a young polymyositis patient on immunosuppressive therapy who was star...

    Authors: Chiranjoy Mukhopadhyay, Ankita Garg and Archana Ayyagari

    Citation: BMC Infectious Diseases 2004 4:63

    Content type: Case report

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  26. Micrococcus species may cause intracranial abscesses, meningitis, pneumonia, and septic arthritis in immunosuppressed or immunocompetent hosts. In addition, strains identified as Micrococcus spp. have been repor...

    Authors: Fevzi Altuntas, Orhan Yildiz, Bülent Eser, Kürsat Gündogan, Bulent Sumerkan and Mustafa Çetin

    Citation: BMC Infectious Diseases 2004 4:62

    Content type: Case report

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  27. Wasting and micronutrient malnutrition have not been well characterized in adults with pulmonary tuberculosis. We hypothesized that micronutrient malnutrition is associated with wasting and higher plasma human...

    Authors: Monique van Lettow, Anthony D Harries, Johnny J Kumwenda, Ed E Zijlstra, Tamara D Clark, Taha E Taha and Richard D Semba

    Citation: BMC Infectious Diseases 2004 4:61

    Content type: Research article

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  28. Since the mid-1980's there has been a worldwide resurgence of severe disease from group A streptococcus (GAS), with clonal clusters implicated in Europe and the United States. However GAS associated sepsis and...

    Authors: Marilyn Hassell, Peter Fagan, Phillip Carson and Bart J Currie

    Citation: BMC Infectious Diseases 2004 4:60

    Content type: Research article

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  29. Tertiary care hospitals are a potential source for development and spread of bacterial resistance being in the loop to receive outpatients and referrals from community nursing homes and hospitals. The liberal ...

    Authors: Lexley M Pinto Pereira, Marjorie Phillips, Hema Ramlal, Karen Teemul and P Prabhakar

    Citation: BMC Infectious Diseases 2004 4:59

    Content type: Research article

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  30. Management of patients with bleeding oesophageal varices comprises of mainly diagnostic endoscopy, sclerotherapy and band ligation. One of the major problems to do any of the above is the active bleeding which...

    Authors: Shyama Chatterjee and Eric Van Marck

    Citation: BMC Infectious Diseases 2004 4:58

    Content type: Study protocol

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  31. Pneumocystis jiroveci pneumonia (PCP) is an important opportunistic infection among immunosuppressed patients, especially in those infected with human immunodeficiency virus (HIV). The clinical presentation of...

    Authors: Alan KL Wu, Vincent CC Cheng, Bone SF Tang, Ivan FN Hung, Rodney A Lee, David S Hui and Kwok Y Yuen

    Citation: BMC Infectious Diseases 2004 4:57

    Content type: Case report

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  32. TT virus is prevalent worldwide, but its prevalence and genotype distribution in Central and East-Europe has not been determined. The high prevalence of TTV in multiply-transfused patients points to the import...

    Authors: Martina Saláková, Vratislav Němeček, Jaroslav König and Ruth Tachezy

    Citation: BMC Infectious Diseases 2004 4:56

    Content type: Research article

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  33. Molecular detection of herpesviruses DNA is considered as the reference standard assay for diagnosis of central nervous system infections. In this study nested PCR and real time PCR techniques for detection of...

    Authors: Lorenzo Drago, Alessandra Lombardi, Elena De Vecchi, Giuseppe Giuliani, Rosaria Bartolone and Maria Rita Gismondo

    Citation: BMC Infectious Diseases 2004 4:55

    Content type: Technical advance

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  34. Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrPSc. In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrPC) ...

    Authors: Lotus Yung, Yong Huang, Pierre Lessard, Giuseppe Legname, Emil T Lin, Michael Baldwin, Stanley B Prusiner, Chongsuk Ryou and B Joseph Guglielmo

    Citation: BMC Infectious Diseases 2004 4:53

    Content type: Research article

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  35. Literature on the spectrum of opportunistic disease in human immunodeficiency virus (HIV)-infected patients from developing countries is sparse. The objective of this study was to document the spectrum and det...

    Authors: SK Sharma, Tamilarasu Kadhiravan, Amit Banga, Tarun Goyal, Indrish Bhatia and PK Saha

    Citation: BMC Infectious Diseases 2004 4:52

    Content type: Research article

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  36. Old, stationary cultures of Mycobacterium tuberculosis contain a majority of bacteria that can grow in broth cultures but cannot grow on solid medium plates. These may be in a non-replicating, dormant growth phas...

    Authors: Jasvir Dhillon, Douglas B Lowrie and Denis A Mitchison

    Citation: BMC Infectious Diseases 2004 4:51

    Content type: Research article

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  37. The process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency dec...

    Authors: Johan Van Weyenbergh, Gisélia Santana, Argemiro D'Oliveira Jr, Anibal F Santos Jr, Carlos H Costa, Edgar M Carvalho, Aldina Barral and Manoel Barral-Netto

    Citation: BMC Infectious Diseases 2004 4:50

    Content type: Research article

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  38. Past estimates have put the prevalence of schistosomiasis between 40% and 50% in the Malawi population overall based on studies undertaken ten years or more ago. More recent surveys in known high risk areas fi...

    Authors: Cameron Bowie, Bernadette Purcell, Bina Shaba, Peter Makaula and Maria Perez

    Citation: BMC Infectious Diseases 2004 4:49

    Content type: Research article

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  39. An increase in the number of attendees due to acute gastroenteritis and fever was noted at one hospital emergency room in Taiwan over a seven-day period from July to August, 2001. Molecular and epidemiological...

    Authors: Po-Liang Lu, In-Jane Hwang, Ya-Lina Tung, Shang-Jyh Hwang, Chun-Lu Lin and LK Siu

    Citation: BMC Infectious Diseases 2004 4:48

    Content type: Research article

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  40. Diagnosis of HIV infection is recently occurring with increasing frequency in middle-aged and in older individuals. As HAART became available, a minimal beneficial effect on immunological outcome in older in r...

    Authors: Mario Tumbarello, Ricardo Rabagliati, Katleen de Gaetano Donati, Silvia Bertagnolio, Eva Montuori, Enrica Tamburrini, Evelina Tacconelli and Roberto Cauda

    Citation: BMC Infectious Diseases 2004 4:46

    Content type: Research article

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  41. Between November 2 and 10, 2002 several patients with psoriasis and personnel staying in the health centre in Gran Canaria, Spain fell ill with diarrhoea, vomiting or both. Patient original came from Norway, S...

    Authors: Hanne M Eriksen, Philippe J Guerin, Karin Nygård, Marika Hjertqvist, Birgitta de Jong, Angela MC Rose, Markku Kuusi, Ulrike Durr, AG Rojas, Cato Mør and Preben Aavitsland

    Citation: BMC Infectious Diseases 2004 4:45

    Content type: Research article

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  42. Tuberculosis (TB) is increasing in the world and drug-resistant (DR) disease beckons new treatments.

    Authors: Roberto Suárez-Méndez, Idrian García-García, Norma Fernández-Olivera, Magalys Valdés-Quintana, María T Milanés-Virelles, Dalia Carbonell, Delfina Machado-Molina, Carmen M Valenzuela-Silva and Pedro A López-Saura

    Citation: BMC Infectious Diseases 2004 4:44

    Content type: Research article

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  43. Methicillin resistant Staphylococcus aureus (MRSA) is the leading pathogenic cause of nosocomial infections, especially in bacteraemia and sepsis. The essential therapy for MRSA infection is glycopeptides. Therap...

    Authors: Emine Alp, Suveyda Gozukucuk, Ozlem Canoz, Beyhan Kirmaci and Mehmet Doganay

    Citation: BMC Infectious Diseases 2004 4:43

    Content type: Research article

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  44. For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission. In the absence of vac...

    Authors: A Robert Neurath, Nathan Strick, Yun-Yao Li and Asim K Debnath

    Citation: BMC Infectious Diseases 2004 4:41

    Content type: Research article

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