- Research article
- Open Access
Cost-effectiveness of option B+ in prevention of mother-to-child transmission of HIV in Yunnan Province, China
BMC Infectious Diseases volume 19, Article number: 517 (2019)
Although Option B+ may be more costly than Options B, it may provide additional health benefits that are currently unclear in Yunnan province. We created deterministic models to estimate the cost-effectiveness of Option B+.
Data were used in two deterministic models simulating a cohort of 2000 HIV+ pregnant women. A decision tree model simulated the number of averted infants infections and QALY acquired for infants in the PMTCT period for Options B and B+. The minimum cost was calculated. A Markov decision model simulated the number of maternal life year gained and serodiscordant partner infections averted in the ten years after PMTCT for Option B or B+. ICER per life year gained was calculated. Deterministic sensitivity analyses were conducted.
If fully implemented, Option B and Option B+ averted 1016.85 infections and acquired 588,01.02 QALYs.The cost of Option B was US$1,229,338.47, the cost of Option B+ was 1,176,128.63. However, when Options B and B+ were compared over ten years, Option B+ not only improved mothers’ten-year survival from 69.7 to 89.2%, saving more than 3890 life-years, but also averted 3068 HIV infections between serodiscordant partners. Option B+ yielded a favourable ICER of $32.99per QALY acquired in infants and $5149per life year gained in mothers. A 1% MTCT rate, a 90% coverage rate and a 20-year horizon could decrease the ICER per QALY acquired in children and LY gained in mothers.
Option B+ is a cost-effective treatment for comprehensive HIV prevention for infants and serodiscordant partners and life-long treatment for mothers in Yunnan province, China. Option B+ could be implemented in Yunnan province, especially as the goals of elimination mother-to-child transmission of HIV and “90–90-90” achieved, Option B+ would be more attractive.
The recommendations of the World Health Organization (WHO) on the prevention of mother-to-child transmission (PMTCT) of HIV infection have evolved significantly over time. Up to 2011, the WHO recommended that all pregnant women with HIV infection and CD4 count below 350 cells/mm3 initiate antiretroviral therapy(ART) at gestation week 14 and continue until one week post-partum. This strategy became known as PMTCT Option A [1, 2]. In the same year, the guidelines also commanded the other strategy, Option B, which extended ART for mothers out through the end of breastfeeding [1, 2]. Then, in light of new, compelling evidence that early ART improved treatment outcomes and sustained viral suppression reduced odds of onward sexual transmission [3,4,5,6,7], the WHO introduced a new strategy in 2013, Option B+,which utilized a new ART. PMTCT Option B+ is providing life-long ART to all pregnant women who once tested HIV positive regardless of CD4 counts or clinical stage . In theory, Option B+ was expected to not only achieve the Global Plan Target of new pediatric HIV infections elimination in 2015, but also achieve the universal access to HIV treatment for mothers to keep mother alive .
Option B+ has already been adopted by a range of low- and middle-income countries, including Malawi, Zambia,Tanzania, South Africa and Kenya [1, 6, 8, 9]. Early studies indicate the incremental cost of switching from Option B to Option B+ in PMTCT programs ranged from US$92,813 to US$605,739 per 1000 women  and the Incremental cost-effectiveness ratio (ICER) was US$1370 per year of life saved compared with Option B  and ranged from US$6000 to US$23,000 per infection averted compared with Option A . Although the most analyses have identified the likely cost-effective of Option B+, a recent review of published cost-effectiveness analyses of Option B+ for prevention of mother-to-child transmission of HIV in developing countries demonstrated whether Option B+ was dominant, cost-effective or non cost-effective depended on the differences of the decision model structure and input parameter values. So decision makers still need additional analyses of model to inform the local funding decision .
PMTCT programs became a key public health priority in China in 2002  and Option B+ began to implement in PMTCT programs in 2015 . China’s Yunnan Province, currently has the highest prevalence of HIV infection nationwide. PMTCT programs have been operating since 2003. It’s reported that HIV prevalence in antenatal care (ANC) in Yunnan province is estimated at 0.3%, which translates to approximately 2000 new HIV-exposed infants born to pregnant women with HIV each year. Because HIV counseling and testing has been included in ANC nationwide in China since 2011 , and because there is nearly 100% uptake of ANC in Yunnan, pregnant women who have HIV infections are relatively easily identified. Next step, the effective ART is critical. Presently, Option B + is also offered to HIV-infected pregnant women in Yunnan, which means the more expensive second-line ART and life-long ART. Option B+ may be more costly than Option A and Option B while it may provide more health benefits, but it keeps unclear currently in Yunnan province. Therefore, we aimed to project the clinical outcomes and cost-effectiveness of the Option B+ from short-term and long-term respectively in Yunnan Province so as to help inform the funding evidence for the decision making of the optimal ART regimen for PMTCT and HIV/AIDS prevention and therapy.
The methodology we applied in the study was in accordance with the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement guidelines .
Based on the data from the information system of preventing mother-to-child transmission of HIV, Syphilis and Hepatitis B in Yunnan maternal and infant health care hospital, a hypothesis cohort of HIV-infected women was estimated with the number of 2000 (720,435 pregnant women were tested and HIV prevalence rate in pregnant women was about 0.3%). The mean age of pregnant women with HIV at first ANC visit was 25 years. Mean CD4 count was 445 (36% of women with CD4 count≤350 cell/μl). Among them 1120 chose to delivery (the termination rate was about 44%).
The cost-effectiveness of option B+ in short-term
We defined the short-term of the study as the period of prevention mother-to-child transmission of HIV (from the first ANC to the period of infants with 18 months old).We examined two strategies in our analyses: (1) WHO Option B(comparator), (2) WHO Option B+. These two strategies are compared in Table 1.
All the analyses was from the health care system perspective. Clinical outcomes included number of pediatric infections averted and quality adjusted life-years (QALY) acquired for infants. Economic outcomes included ANC costs, cost of ART, delivery cost and cost of infant formula feeding, cost of infant prophylaxis and early infant diagnosis. Incremental cost-effectiveness ratio (ICER) per pediatric infection averted and per QALY acquired, in US dollars (US$) in 2016, were calculated. We calculated QALY by weighting with health utilities of 0.74. All costs and health outcomes were discounted at 3% per year. We used WHO guidance as criteria to interpret cost-effectiveness . The net number of QALY acquired by a single averted paediatric HIV infection was a function of the difference between the expected number of QALY of a child without HIV infection and the excepted number of QALY of a child with HIV infection. We adopted the health utilities of 0.74 for the HIV sample  and of 1 for the general sample to weight the life years gained and the determined QALY acquired. An intervention was considered cost-effective compared with the next least-expensive alternative if its ICER was less than 3 times the 2016 Yunnan Province per capita gross domestic product (GDP, US$ 4222) , or US$ 13,000 per life-year or QALY acquired.
Based on the applicability of simple decision tree, which are most useful to model events or health status without occurring repeatedly and the likelihood of events occurring in the model keeps unchanged over time . Decision tree model was used to do the analyses. We modeled ANC coverage at100%, HIV testing and counselling coverage within ANC at 100% and adherence to PMTCT regimens for women and infants all at 100% according to the reality of Yunnan province . To demonstrate the features of every strategy, all women in the base-case analyses were assumed to be identified as HIV-infected at their first ANC visit.
Among parameters related to the analyses, the rate of mother-to-child transmission of HIV for Option B and Option B+ were from the surveillance data of Yunnan province, 3.86 and 3.86% respectively. All the cost in the PMTCT period recommended by the surveillance data of Yunnan Maternal and Infant Health Care Hospital. The cost of rapid HIV testing was US$4.06 per test and all pregnant women were assumed to undergo at least one HIV test during the first antenatal visit for Option B and Option B+. Option B to determine the eligibility for ART at a cost of US$ 13.06 per test and 4 times in the PMTCT period. Costs of ARVs for Option B included 6 months during pregnancy and 42 days after delivery. The cost of drugs per woman receiving B and B+ in the PMTCT programs was US$253.79 per woman (consisting of US$235.65 for maternal ART, US$18.14 for infant ARVs prophylaxis). The cost of ART per year was derived from a cost of ART study including Yunnan province in China .
In the sensitivity analysis, efficacy of Option B/Option B+ in reducing transmission rates were varied using ranges reported in the literature. We also took into account the lifetime ART cost for infants with HIV.
All the parameters related to disease progression, ART regimens, and cost in base case analysis and sensitivity analysis were showed in Table 2 and Additional file 1. The simple decision tree used for modeling infant outcomes is shown in Fig. 1.
The cost-effectiveness of option B+ in long-term
We defined the long-term as the 10 years starting from the date of PMTCT services concluded for the 2000 pregnant women. Based on the applicability of Markov modeling, which was mostly used for more complex events occurring over time . A Markov decision model was used to simulate a cohort of 2000 pregnant women living with HIV. After entering the model and receiving one of the ART regimens (Option B—ART eligibility based on CD4 count, or Option B + —lifelong ART regardless of CD4 count), subsequent “movement” through three health states was defined by CD4 cell count levels and a death state (as the absorbing state, see Fig. 2). We estimated one month as a “cycle”, a total 120 “cycles” were calculated in 10 years. Under the different ART regimens, the pregnant women living with HIV have different CD4+ transforming stages, meanwhile, the women living with HIV at different CD4+ levels have different transmission probability to their serodiscordant partners. The Markov decision model simulated the mother life-years saved andQALY acquired (life years were weighted by the health utility classified by CD4+ count level reported by a published study ), serodiscordant infections averted(calculated by the sex acts per month with regular partner reported by a publish study in Yunnan province ), and costs of treatment for mothers for 10 years after finishing PMTCT services. Incremental cost-effectiveness ratio (ICER) per life year gained and per QALY acquired were calculated in US dollars (US$) in 2016. All costs and health outcomes were discounted at 3% per year. We also used WHO guidance as criteria to interpret cost-effectiveness . The detail progression of the modeling listed in Additional file 1.
In sensitivity analysis, time horizons (5 years, 20 years), and ART coverage rates (45, 90%) were specially investigated. All input parameters used in the Markov decision tree model and plausible ranges used for the sensitivity analysis are described in Table 3. The final Markov decision model is shown in Fig. 3 and all variable assignments are described in Table 4.
We used TreeAge Pro2016 to perform all statistical analyses.
Cost-effectiveness analyses: infant health outcomes in the short-term
Table 5 shows the cost, outcomes, and cost-effectiveness of the two different strategies modelled via the decision tree model to prevent new infant infections. If fully implemented, Option B and Option B+ averted 1016.85 infections and acquired 588,01.02 QALYs.The cost of Option B was US$1,229,338.47, the cost of Option B+ was 1,176,128.63. Option B+ made a minimize cost when compared with Option B.
Sensitivity analysis for infant health outcomes
Table 6 shows the results of our sensitivity analyses. For infant outcomes, Option B+ dominated as the most-effective strategy for the prevention of new pediatric infections and for the QALY acquisition for infants when compared with Option B.
Cost-effectiveness analyses: maternal and serodiscordant partner outcomes in the long-term
Compared to Option B, Option B+ had an ICER per life-year gained and QALY acquired for mothers was US$ 5183.96 and US$ 5355.42 respectively. However, when we included the benefit of serodiscordant partners over 10 years, 410 infections were averted with Option B at a cost per infection averted of US$ 8098.99, and 3068 infections were averted with Option B+ at a cost per infection averted of US$ 7655.70.
As shown in Table 7, the total discounted cost of ART for Option B (ART based on CD4 count eligibility) was US$ 3.32 million and for Option B+ (lifelong ART regardless of CD4 count) was US$ 23.49 million. The cost per life-year saved and QALY acquired was US$ 324.13 and US$ 348.23, respectively, for Option B and US$ 1660.69 and US$ 1764.76, respectively, for Option B+. As also shown in Fig. 4 about the results of Markov cohort analysis, Option B resulted in a 10-year survival rate of 69.7%, 10,254 life-years saved, and 9544 QALY acquired, while Option B+ resulted in a 10-year survival rate of 89.2%, 14,144 life-years saved, and 13,310 QALYs acquired.
Sensitivity analysis for maternal and serodiscordant health outcomes
Table 8 shows the partial results of sensitivity analysis on input parameters affecting maternal and serodiscordant transmission outcomes. For maternal outcomes, Option B remained the most cost effective option with changes in discount rate, coverage rate of ART and time horizon. For serodiscordant transmission outcomes, Option B+ remained the most cost effective option with changes in discount rate, coverage rate of ART and time horizon. One-way sensitivity analysis shows the robust of model to the changes of parameters.
As showed in Figs. 5, 6, 7, the model was most sensitive to the coverage rate of ART for Option B+. With the coverage rate of ART increasing to 90%, the ICER per life-year gained and ICER per QALY acquired compared to Option B were US$ 5149.40 and US$ 5319.36 respectively. Otherwise for Option B+, In 20-years horizon, the ICER per life-year gained and QALY acquired compared to Option B were US$3568.22 and US$3715.56 respectively.
In the short-term(PMTCT period), our study found that when the ART regimen transferred from Option B to Option B+,comparing with Option B, Option B+ had an less cost when getting the same effect,which demonstrated Option B+ is dominant. We consider that Option B+ responses a dominant strategy in preventing new infections among infants.
In the long-term (10 years starting from the date of PMTCT services concluded), our study found that although the total discounted cost, cost per life-year saved and cost per QALY gained for mothers of Option B+ (lifelong ART regardless of CD4)were more than Option B (ART eligibility based on CD4 count) in 10 years, Option B+ resulted in a survival rate of 89.2%, a better survival outcomes than Option B, with a survival rate of 69.7%. For their partners at 10 years, Option B+ resulted in a cost of US$ 7655.70 per infection averted, which was lower than Option B. If we considered the benefits of the maternal survival and serodiscordant infections, Option B+ could show a higher cost-effective. Otherwise the ICER per life-year gained and QALY acquired was US$5183.96 and US$5355.42 respectively, when compared to Option B for mothers. Using the WHO standards for determining the cost-effectiveness of a strategy , the ICER per life-year saved and QALY acquired of Option B+ was less than the 3 × Yunnan’s per capita GDP(US$13,000) threshold, we found that Option B+ responses a cost-effective strategy in keeping mother alive and preventing new serodiscordant infections among their partners.
The sensitivity analyses verified the robustness of our cost-effective measures after changing a variety of parameters. In the short-term, by the increasing of efficacy of Option B/Option B+ in reducing transmission rates, the cost per infant infection averted and the cost per QALY acquired of Option B + decreased slightly, especially as the goal of elimination of mother-to-child transmission of HIV achieved, Option B+ would be more attractive.In view of the lifetime ART(69.5 years) for the infected children, when the lifetime ATR cost was include into the total cost, Option B+ could dominate the most-effective option to prevent new infant infections in Yunnan Province. In the long-term, sensitivity analyses showed the cost-effective of life-year gained, QALY acquired and serodiscordant infection averted were most sensitive to the coverage of ART. Expanding the coverage of ART to those eligible women appears to be more cost-effective, particularly when the coverage rate of ART researches to 90%, the ICER per life-year gained and per QALY acquired compared with Option B decreased, with US$ 5149.40 and US$ 5319.36 respectively. Especially with the year increasing to 20 years, to implement Option B+ will demonstrate the priorities, all the ICER per life year gained and per QALY acquired have declined less than 1 × GDP, with US$ 3568.22 and US$ 3715.56 respectively. From a comprehensive and long-term perspective, Option B+ would be the optimal strategy in Yunnan province when the goals of “90–90-90” (90% of all people living with HIV will know their HIV status, 90% of all people with diagnosed HIV will receive sustained antiretroviral therapy and 90% of all people receiving antiretroviral therapy will have viral suppression.)and “95–95-95” (95% of all people living with HIV will know their HIV status, 95% of all people with diagnosed HIV will receive sustained antiretroviral therapy and 95% of all people receiving antiretroviral therapy will have viral suppression.) achieved.
In comparison with previous cost-effectiveness studies in low- and middle- income countries, less differences were observed. All the previous studies demonstrated the cost effective of Option B+. A previous modeling study of mother-to-child transmission of HIV in Ghana , suggested that Option B+ is a cost-effective use of limited resource. In Uganda, lifelong ART was associated with highly cost-effective for prevention mother-to-child transmission of HIV and acquiring additional public health benefit . In Malawi, when averted infants infections and maternal survival outcomes were considered together, Option B+ represented a more cost-effective policy option . In Nigeria, lifelong ART could provide the greatest incremental benefit to prevent HIV transmission among HIV serodiscordant couples . Our study comprehensively included the benefits of infants, mothers and serodiscordant partners together, overcoming the deficiency of the previous cost-effective analyses of Option B+ to omit the important benefits . In China, there is few study to model the cost-effectiveness evaluation of Option B+. Option B+ is recently endorsed by WHO to scale up the PMTCT programs in countries with high-burden . Our study is the first study to develop the cost-effectiveness models informed by the field data of Yunnnan, China and addressed the potential cost saving associated with Option B+ from short-term and long-term. We hope our study could assist the province to complete a policy switching from previous strategies to Option B+ and supply scientific evidences for the applicability of Option B+ in Yunnan province. Future research efforts in the cost-effective analyses of Option B+ should be directed at providing more evidences in different areas in China and also across different cultures. We believe our study could supply a useful framework to other similar studies.
Our study had some important limitations. Firstly, most the parameters included in the models are based on the Yunnan context. For example, Yunnan province is with the highest HIV prevalence level in China, different HIV prevalence level could address different cost-effective results of Option B+. So applying the results elsewhere should be with more cautions. Secondly, our study adopted a perspective of health care system, because the direct cost is the major component of total cost of implementation of Option B+. A further study should be conducted by using the perspective of societal prevention so that Option B+ could be more preferable as more evidences indicated the possible influence to the family and society. Thirdly, our study didn’t consider the other factors associated with decision making regarding the resource allocation. These factors may include society and culture factors.
In conclusion, we have presented an economic analysis that provides evidence that HIV PMTCT Option B+ is a cost-effective strategy for comprehensive HIV prevention for infants and serodiscordant partners and life-long treatment for mothers in Yunnan Province, China. Option B+ could be implemented in Yunnan province, especially as the goals of eMTCT(MTCT< 2%) and “90–90-90”(coverage rate of ART> 90%) achieved, Option B+ would be more attractive.
Gross domestic product
Incremental cost-effectiveness ratio
Prevention of mother-to-child transmission
World Health Organization
Ishikawa N, Shimbo T, Miyano S, et al. Health outcomes and cost impact of the new WHO 2013 guidelines on prevention of mother-to-child transmission of HIV in Zambia. PLoS One. 2014;9:e90991.
Fasawe O, Avila C, Shaffer N, et al. Cost-effectiveness analysis of option B+ for HIV prevention and treatment of mothers and children in Malawi. PLoS One. 2013;8:e57778.
Ciaranello A, Perez F, Engelsmann B, et al. Cost-effectiveness of World Health Organization 2010 guidelines for preventing of mother-to-child HIV transmission in Zimbabwe. Clin Infect Dis. 2013;56:430–46.
Mkners A, Philips A, Kreif N, et al. Health-related quality-of-life of people with HIV in the era of combination antiretroviral treatment: a cross-sectional comparison with the general population. Lancet HIV. 2014;1:32–40.
Tsague L, Abrams E. Commentary: antiretroviral treatment for regnant and breastfeeding women- the shifting paradigm. AIDS. 2014;28:S119–21.
Gopalappa C, Stover J, Shaffer N, et al. The cost and benefits of option B+ for the prevention of mother-to-child transmission of HIV. AIDS. 2014;28:S5–S14.
Delva W, Eaton J, Meng F, et al. HIV treatment as prevention: optimising the impact of expended HIV treatment programmes. PLoS Med. 2012;9:1–12.
Ngarina M, Tarimo E, Naburi H, et al. Women’s preference regarding infant or maternal antiretroviral prophylaxis for prevention of mother-to-child transmission of HIV during breastfeeding and their views on option B+ in Dar Es Salaam, Tanzania. PLoS One. 2014;9:e85310.
Shaffer N, Abrams E, Becquet R. Option B+ for prevention of mother-to-child transmission of HIV in resource-constrained settings: great promise but some early caution. AIDS. 2014;28:599–601.
Brien L, Shaffer N, Sangrujee N, et al. The incremental cost of switching from option B to option B+ for the prevention of mother-to-child transmission of HIV. Bull World Health Organ. 2014;92:162–70.
Karnon J, Orji N. Option B+ for the prevention of mother-to-child transmission of HIV infection in developing countries: a review of published cost-effectiveness analyses. Health Policy Plan. 2016;31:1133–41.
Yan L. The process of prevention of mother-to-child transmission of AIDS. J Kunming Med Univ. 2012;11:1–3.
Department of maternal and child health service. National Health and family planning Commission of the People’s republic of China, National Center for women and Children’s health, China CDC.Decipherment of the proposal of prevention mother-to-child transmission of HIV, syphilis and hepatitis B(2015 version). China J Women Children Health. 2015;6:1–2.
Department of maternal and child health service, National Health and Family Planning Commission of the People’s Republic of China.The proposal of prevention mother-to-child transmission of HIV, syphilis and hepatitis B(2011 version). http://www.moh.gov.cn/fys/s7900/201102/a0c03b2192a1483384b4f798d9ba603d.shtml.2011-02-28/2016-12-28.
Husereau D, Drummond M, Petrou S, et al. Consolidated Health Economic Evaluation Reporting Standards(CHEERS) statement.Value in Health, 2013;16:e1-e5.
Yunnan Bureau of Statistics. Economic Development Report of Yunnan Province in 2015. http://www.stats.yn.gov.cn/TJJMH_Model/newsview.aspx?id=4003423.2016-01-17/2016-11-28.
Halpern M, Luce B, Brown R, et al. Health and economic outcomes modeling practices: a suggested framework[J]. Value in Health. 1998;1:131-147.
People.cn. Yunnan: the prevention mother to child transmission rate of Yunnan province ranks at the advanced level. http://yn.people.com.cn/n2/2017/1129/c378439-30977974.html. 2017-11-29/2019-01-28.
Zhiwei G. The direct medical costs analysis of natioanl free antiretroviral treatment for HIV/AIDS patients. Beijing: Chinese academy of medical sciences & Peking union medical college. 2008.
Semrau K, Aldrovandi G. MTCT HIV-1transmission update: transmission routes and mechanisms. Encyclopedia of AIDS. 2014:1–7.
Anglaret X, Minga A, Gabillard D, et al. AIDS and non-AIDS morbidity and mortality across the spectrum of CD4 cell counts in HIV-infected adults before starting antiretroviral therapy in cote d'Ivoire. Clinical Infectious Disease. 2012;54:714–23.
Mitchell K, Lépine A, Terris-Prestholt F, et al. Modelling the impact and cost-effectiveness of combination prevention amongst HIV serodiscordant couples in Nigeria. AIDS. 2015;29:20135–2044.
Qi Jinlei. An epidemiological study of HIV sexual transmission in married spouses in Yunnan Province.Kunming: Kunming Medical University, 2012.
Hargrove J, Humphrey J. Mortality among HIV-positive postpartum women with high CD4 cell counts in Zimbabwe[J]. AIDS. 2010;24:F11–4.
Kate M. Mitchell, Aurélia Lépine, Fern Terris-Prestholt, et al. Modelling the impact and cost-effectiveness of combination prevention among HIV serodiscordant couples in Nigeria. AIDS 2015;29:20135–2044.
VanDeusen A, Paintsil E, Agyarko-Poku T, et al. Cost effectiveness of option B plus for prevention of mother-to-child transmission of HIV in resource-limited countries:evidence from Kumasi,Ghana. BMC Infect Dis. 2015;15:130–40.
Kuznik A, Lamorde M, Hermans S, et al. Evaluation the cost-effectiveness of combination antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Uganda[J]. Bull World Health Organ. 2012;90:595–603.
The authors would like to thank Dr. Jennifer M. McGoogan for comments on the manuscript and English language editing. We also thank Dr. Wu Zunyou from the National Center for AIDS/STD Control and Prevention, of the Chinese Centers for Disease Control and Preventionfor his help with study design and manuscript development. Finally, we thank all those involved in HIV PMTCT programs in Yunnan Province.
This work was supported by National “12nd five-year” Major Science and Technology Program (grant number: 2013ZX10004906) and Doctoral Innovation and Science Foundation of Kunming Medical University (grant number:2017B001). The funding organization had no role in the development of study design, collection, analyses, and interpretation of data, the writing of the report, or the final decision to submit the manuscript for publication.
Availability of data and materials
The full database is available from the corresponding author on reasonable request.
Ethics approval and consent to participate
Because our study used the clustered data to do the analyses and didn’t refer to the individual information, the local ethics committee (Ethics Research Committee of Kunming Medical University) ruled that no ethical approval was allowed in this particular case. We used the previously clustered data in the study and no participants were involved to do the investigation. Ethics Research Committee of Kunming Medical University ruled no participatory consent was included. All the data used in the study have got the agreement of Yunnan AIDS Bureau.
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Additional file 1:
Appendix The process of decision model construction the model input parameters and process of decision tree and Markov decision tree model. (DOC 29 kb)
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
About this article
Cite this article
Wang, X., Guo, G., Zheng, J. et al. Cost-effectiveness of option B+ in prevention of mother-to-child transmission of HIV in Yunnan Province, China. BMC Infect Dis 19, 517 (2019). https://doi.org/10.1186/s12879-019-3976-5
- Option B +
- HIV prevention
- Cost-effectiveness analyses
- Decision making