Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255–73.
CAS
PubMed
Google Scholar
Modlin RL, Melancon-Kaplan J, Young SM, Pirmez C, Kino H, Convit J, et al. Learning from lesions: patterns of tissue inflammation in leprosy. Proc Natl Acad Sci U S A. 1988;85:1213–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Smith WC, Aerts A. Role of contact tracing and prevention strategies in the interruption of leprosy transmission. Lepr Rev. 2014;85:2–17.
PubMed
Google Scholar
Global leprosy. update on the 2012 situation. Wkly Epidemiol Rec. 2013;88:365–79.
Google Scholar
Massone C, Clapasson A, Nunzi E. Borderline lepromatous leprosy in an Italian man. Am J Trop Med Hyg. 2013;88:211.
Article
PubMed
PubMed Central
Google Scholar
Geluk A, van Meijgaarden KE, Wilson L, Bobosha K, van der Ploeg-van Schip JJ, van den Eeden SJ, et al. Longitudinal immune responses and gene expression profiles in type 1 leprosy reactions. J Clin Immunol. 2014;34:245–55.
Article
CAS
PubMed
Google Scholar
Nolen L, Haberling D, Scollard D, Truman R, Rodriguez-Lainz A, Blum L, et al. Incidence of Hansen’s Disease - United States, 1994–2011. MMWR Morb Mortal Wkly Rep. 2014;63:969–72.
PubMed
Google Scholar
Geluk A. Biomarkers for leprosy: would you prefer T (cells)? Lepr Rev. 2013;84:3–12.
PubMed
Google Scholar
Ottenhoff TH. New pathways of protective and pathological host defense to mycobacteria. Trends Microbiol. 2012;20:419–28.
Article
CAS
PubMed
Google Scholar
Montoya D, Modlin RL. Learning from leprosy: insight into the human innate immune response. Adv Immunol. 2010;105:1–24.
Article
CAS
PubMed
Google Scholar
Gupta UD, Katoch K, Singh HB, Natrajan M, Katoch VM. Persister studies in leprosy patients after multi-drug treatment. Int J Lepr Other Mycobact Dis. 2005;73:100–4.
CAS
PubMed
Google Scholar
Britton WJ, Lockwood DN. Leprosy. Lancet. 2004;363:1209–19.
Article
PubMed
Google Scholar
Lockwood DN, Suneetha L, Sagili KD, Chaduvula MV, Mohammed I, Van BW, et al. Cytokine and Protein Markers of Leprosy Reactions in Skin and Nerves: Baseline Results for the North Indian INFIR Cohort. PLoS Negl Trop Dis. 2011;5:e1327.
Article
CAS
PubMed
PubMed Central
Google Scholar
Polycarpou A, Walker SL, Lockwood DN. New findings in the pathogenesis of leprosy and implications for the management of leprosy. Curr Opin Infect Dis. 2013;26:413–9.
CAS
PubMed
Google Scholar
Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science. 1991;254:277–9.
Article
CAS
PubMed
Google Scholar
Yamamura M, Wang XH, Ohmen JD, Uyemura K, Rea TH, Bloom BR, et al. Cytokine patterns of immunologically mediated tissue damage. J Immunol. 1992;149:1470–5.
CAS
PubMed
Google Scholar
Raffe SF, Thapa M, Khadge S, Tamang K, Hagge D, Lockwood DN. Diagnosis and treatment of leprosy reactions in integrated services - the patients’ perspective in Nepal. PLoS Negl Trop Dis. 2013;7:e2089.
Article
PubMed
PubMed Central
Google Scholar
Lockwood DN, Saunderson P. Nerve damage in Leprosy: a continuing challenge for scientists, clinicians and service providers. Int Health. 2012;4:77–85.
Article
PubMed
Google Scholar
Ranque B, Nguyen VT, Vu HT, Nguyen TH, Nguyen NB, Pham XK, et al. Age is an important risk factor for onset and sequelae of reversal reactions in Vietnamese patients with leprosy. Clin Infect Dis. 2007;44:33–40.
Article
PubMed
Google Scholar
Roche PW, Le MJ, Butlin CR. Risk factors for type 1 reactions in leprosy. Int J Lepr Other Mycobact Dis. 1997;65:450–5.
CAS
PubMed
Google Scholar
Walker SL, Nicholls PG, Butlin CR, Nery JA, Roy HK, Rangel E, et al. Development and validation of a severity scale for leprosy type 1 reactions. PLoS Negl Trop Dis. 2008;2:e351.
Article
PubMed
PubMed Central
Google Scholar
Walker SL, Lockwood DN. Leprosy type 1 (reversal) reactions and their management. Lepr Rev. 2008;79:372–86.
PubMed
Google Scholar
Geluk A, Bobosha K, van der Ploeg-van Schip JJ, Spencer JS, Banu S, Martins SB, et al. New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy. J Immunol. 2012;188:4782–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Geluk A, van der Ploeg-van Schip JJ, Teles RO, Franken KL, Prins C, Drijfhout JW, et al. Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection. Clin Vaccine Immunol. 2008;15:522–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Spencer JS, Duthie MS, Geluk A, Balagon MF, Kim HJ, Wheat WH, et al. Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy. Mem Inst Oswaldo Cruz. 2012;107 Suppl 1:79–89.
Article
CAS
PubMed
Google Scholar
Ruhwald M, Dominguez J, Latorre I, Losi M, Richeldi L, Pasticci MB, et al. A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis. Tuberculosis (Edinb). 2011;91:260–7.
Article
Google Scholar
Bobosha K, Tang ST, van der Ploeg-van Schip JJ, Bekele Y, Martins MV, Lund O, et al. Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal. Mem Inst Oswaldo Cruz. 2012;107 Suppl 1:112–23.
Article
CAS
PubMed
Google Scholar
Bobosha K, Tjon Kon Fat EM, van den Eeden SJ, Bekele Y, Van Der Ploeg-Van Schip JJ, de Dood CJ, et al. Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae. PLoS Negl Trop Dis. 2014;8:e2845.
Article
PubMed
PubMed Central
Google Scholar
Scollard DM, Chaduvula MV, Martinez A, Fowlkes N, Nath I, Stryjewska BM, et al. Increased CXC ligand 10 levels and gene expression in type 1 leprosy reactions. Clin Vaccine Immunol. 2011;18:947–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Berrington WR, Kunwar CB, Neupane K, van den Eeden SJ, Vary Jr JC, Peterson GJ, et al. Differential Dermal Expression of CCL17 and CCL18 in Tuberculoid and Lepromatous Leprosy. PLoS Negl Trop Dis. 2014;8:e3263.
Article
PubMed
PubMed Central
Google Scholar
Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, et al. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science. 2013;339:1448–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bobosha K, van der Ploeg-van Schip JJ, Esquenazi DA, Guimaraes MM, Martins MV, Bekele Y, et al. Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls. J Trop Med. 2012;2012:132049.
Article
PubMed
PubMed Central
Google Scholar
Martins MV, Guimaraes MM, Spencer JS, Hacker MA, Costa LS, Carvalho FM, et al. Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy. PLoS Negl Trop Dis. 2012;6:e1616.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bell LC, Breen R, Miller RF, Noursadeghi M, Lipman M. Paradoxical reactions and immune reconstitution inflammatory syndrome in tuberculosis. Int J Infect Dis. 2015;32:39–45.
Article
CAS
PubMed
Google Scholar
Sarfo FS, Phillips RO, Ampadu E, Sarpong F, Adentwe E, Wansbrough-Jones M. Dynamics of the cytokine response to Mycobacterium ulcerans during antibiotic treatment for M. ulcerans disease (Buruli ulcer) in humans. Clin Vaccine Immunol. 2009;16:61–5.
Article
CAS
PubMed
Google Scholar
Grant AV, Alter A, Huong NT, Orlova M, Van TN, Ba NN, et al. Crohn’s disease susceptibility genes are associated with leprosy in the Vietnamese population. J Infect Dis. 2012;206:1763–7.
Article
CAS
PubMed
Google Scholar
Friedman DJ, Kunzli BM, Rahim YI, Sevigny J, Berberat PO, Enjyoji K, et al. From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A. 2009;106:16788–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sieling PA, Abrams JS, Yamamura M, Salgame P, Bloom BR, Rea TH, et al. Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J Immunol. 1993;150:5501–10.
CAS
PubMed
Google Scholar
Adams LB, Pena MT, Sharma R, Hagge DA, Schurr E, Truman RW. Insights from animal models on the immunogenetics of leprosy: a review. Mem Inst Oswaldo Cruz. 2012;107 Suppl 1:197–208.
Article
CAS
PubMed
Google Scholar
Adams LB, Scollard DM, Ray NA, Cooper AM, Frank AA, Orme IM, et al. The study of Mycobacterium leprae infection in interferon-gamma gene--disrupted mice as a model to explore the immunopathologic spectrum of leprosy. J Infect Dis. 2002;185 Suppl 1:S1–8.
Article
CAS
PubMed
Google Scholar
Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, et al. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 2009;6:343–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Misch EA, Macdonald M, Ranjit C, Sapkota BR, Wells RD, Siddiqui MR, et al. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis. 2008;2:e231.
Article
PubMed
PubMed Central
Google Scholar
Aggarwal S, Ali S, Chopra R, Srivastava A, Kalaiarasan P, Malhotra D, et al. Genetic variations and interactions in anti-inflammatory cytokine pathway genes in the outcome of leprosy: a study conducted on a MassARRAY platform. J Infect Dis. 2011;204:1264–73.
Article
CAS
PubMed
Google Scholar
Moraes MO, Pacheco AG, Schonkeren JJ, Vanderborght PR, Nery JA, Santos AR, et al. Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy. Genes Immun. 2004;5:592–5.
Article
CAS
PubMed
Google Scholar
Sreenivasan P, Misra RS, Wilfred D, Nath I. Lepromatous leprosy patients show T helper 1-like cytokine profile with differential expression of interleukin-10 during type 1 and 2 reactions. Immunology. 1998;95:529–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Manandhar R, Shrestha N, Butlin CR, Roche PW. High levels of inflammatory cytokines are associated with poor clinical response to steroid treatment and recurrent episodes of type 1 reactions in leprosy. Clin Exp Immunol. 2002;128:333–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hagge DA, Scollard DM, Ray NA, Marks VT, Deming AT, Spencer JS, et al. IL-10 and NOS2 Modulate Antigen-Specific Reactivity and Nerve Infiltration by T Cells in Experimental Leprosy. PLoS Negl Trop Dis. 2014;8:e3149.
Article
PubMed
PubMed Central
Google Scholar
Ferrara G, Bleck B, Richeldi L, Reibman J, Fabbri LM, Rom WN, et al. Mycobacterium tuberculosis induces CCL18 expression in human macrophages. Scand J Immunol. 2008;68:668–74.
Article
CAS
PubMed
Google Scholar
Schraufstatter IU, Zhao M, Khaldoyanidi SK, Discipio RG. The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum. Immunology. 2012;135:287–98.
Article
CAS
PubMed
PubMed Central
Google Scholar
Verreck FA, De BT, Langenberg DM, Van Der ZL, Ottenhoff TH. Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation. J Leukoc Biol. 2006;79:285–93.
Article
CAS
PubMed
Google Scholar
Levis WR, Martiniuk F. Psoriasis and leprosy are teaching us T-cell plasticity. J Drugs Dermatol. 2013;12:1082.
PubMed
Google Scholar
Corstjens PL, de Dood CJ, van der Ploeg-van Schip JJ, Wiesmeijer KC, Riuttamaki T, van Meijgaarden KE, et al. Lateral flow assay for simultaneous detection of cellular- and humoral immune responses. Clin Biochem. 2011;44:1241–6.
Article
CAS
PubMed
PubMed Central
Google Scholar