World Health Organisation: Global Tuberculosis Report 2013. 2013, Available at: http://www.who.int/tb/publications/global_report/en/,
Google Scholar
Colditz GA, Brewer TF, Berkey CS, Burdick E, Fineberg HV, Mosteller F: Efficacy of BCG vaccine in the prevention of tuberculosis. JAMA. 1994, 271: 698-702. 10.1001/jama.1994.03510330076038.
Article
CAS
PubMed
Google Scholar
Ottenhoff THM, Kaufmann SHE: Vaccines against tuberculosis: where are we and where do we need to go?. PLoS Pathog. 2012, 8: e1002607-10.1371/journal.ppat.1002607.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, Lockhart S, Shea JE, McClain JB, Hussey GD, Hanekom WA, Mahomed H, McShane H: Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet. 2013, 6736: 1-8.
Google Scholar
Hawkridge T, Scriba TJ, Gelderbloem S, Smit E, Tameris M, Moyo S, Lang T, Veldsman A, Hatherill M, Van Der Merwe L, Fletcher HA, Mahomed H, Hill AVS, Hanekom WA, Hussey GD, McShane H: Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. J Infect Dis. 2008, 198: 544-552. 10.1086/590185.
Article
PubMed
PubMed Central
Google Scholar
Sander CR, Pathan AA, Beveridge NER, Poulton I, Minassian A, Alder N, Van Wijgerden J, Hill AVS, Gleeson FV, Davies RJO, Pasvol G, McShane H: Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals. Am J Respir Crit Care Med. 2009, 179: 724-733. 10.1164/rccm.200809-1486OC.
Article
CAS
PubMed
PubMed Central
Google Scholar
Minassian AM, Rowland R, Beveridge NER, Poulton ID, Satti I, Harris S, Poyntz H, Hamill M, Griffiths K, Sander CR, Ambrozak DR, Price DA, Hill BJ, Casazza JP, Douek DC, Koup RA, Roederer M, Winston A, Ross J, Sherrard J, Rooney G, Williams N, Lawrie AM, Fletcher HA, Pathan AA, McShane H: A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults. BMJ Open. 2011, 1: e000223-
Article
PubMed
PubMed Central
Google Scholar
Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Mauff K, Hughes EJ, Moyo S, Brittain N, Lawrie A, Mulenga H, de Kock M, Gelderbloem S, Veldsman A, Hatherill M, Geldenhuys H, Hill AVS, Hussey GD, Mahomed H, Hanekom WA, McShane H: Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants. J Infect Dis. 2011, 203: 1832-1843. 10.1093/infdis/jir195.
Article
CAS
PubMed
Google Scholar
Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Isaacs F, Keyser A, Moyo S, Brittain N, Lawrie A, Gelderbloem S, Veldsman A, Hatherill M, Hawkridge A, Hill AVS, Hussey GD, Mahomed H, McShane H, Hanekom WA: Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells. Eur J Immunol. 2010, 40: 279-290.
Article
CAS
PubMed
PubMed Central
Google Scholar
Griffiths KL, Pathan AA, Minassian AM, Sander CR, Beveridge NER, Hill AVS, Fletcher HA, McShane H: Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. PLoS One. 2011, 6: e23463-10.1371/journal.pone.0023463.
Article
CAS
PubMed
PubMed Central
Google Scholar
De Cassan SC, Pathan AA, Sander CR, Minassian A, Rowland R, Hill AVS, McShane H, Fletcher HA: Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A. Clin Vaccine Immunol. 2010, 17: 1066-1073. 10.1128/CVI.00047-10.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dye C, Fine PE: A major event for new tuberculosis vaccines. Lancet. 2013, 6736: 3-5.
Google Scholar
Querec TD, Akondy RS, Lee EK, Cao W, Nakaya HI, Teuwen D, Pirani A, Gernert K, Deng J, Marzolf B, Kennedy K, Wu H, Bennouna S, Oluoch H, Miller J, Vencio RZ, Mulligan M, Aderem A, Ahmed R, Pulendran B: Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat Immunol. 2009, 10: 116-125.
Article
CAS
PubMed
Google Scholar
Gaucher D, Therrien R, Kettaf N, Angermann BR, Boucher G, Filali-Mouhim A, Moser JM, Mehta RS, Drake DR, Castro E, Akondy R, Rinfret A, Yassine-Diab B, Said EA, Chouikh Y, Cameron MJ, Clum R, Kelvin D, Somogyi R, Greller LD, Balderas RS, Wilkinson P, Pantaleo G, Tartaglia J, Haddad EK, Sékaly R-P: Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J Exp Med. 2008, 205: 3119-3131. 10.1084/jem.20082292.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li G-M, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R, Pulendran B: Systems biology of vaccination for seasonal influenza in humans. Nat Immunol. 2011, 12: 786-795. 10.1038/ni.2067.
Article
CAS
PubMed
PubMed Central
Google Scholar
Furman D, Jojic V, Kidd B, Shen-Orr S, Price J, Jarrell J, Tse T, Huang H, Lund P, Maecker HT, Utz PJ, Dekker CL, Koller D, Davis MM: Apoptosis and other immune biomarkers predict influenza vaccine responsiveness. Mol Syst Biol. 2013, 9: 659-
Article
PubMed
PubMed Central
Google Scholar
Ravindran R, Khan N, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D, Pulendran B: Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science. 2013, 2 (December): 1-8.
Google Scholar
Pulendran B, Oh JZ, Nakaya HI, Ravindran R, Kazmin DA: Immunity to viruses: learning from successful human vaccines. Immunol Rev. 2013, 255: 243-255. 10.1111/imr.12099.
Article
PubMed
PubMed Central
Google Scholar
Goronzy JJ, Weyand CM: Understanding immunosenescence to improve responses to vaccines. Nat Immunol. 2013, 14: 428-436. 10.1038/ni.2588.
Article
CAS
PubMed
PubMed Central
Google Scholar
Antrobus RD, Lillie PJ, Berthoud TK, Spencer AJ, McLaren JE, Ladell K, Lambe T, Milicic A, Price DA, Hill AVS, Gilbert SC: A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP + M1 in Adults Aged over 50 Years. PLoS One. 2012, 7: e48322-10.1371/journal.pone.0048322.
Article
CAS
PubMed
PubMed Central
Google Scholar
McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G: The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine. 2012, 30: 2060-2067. 10.1016/j.vaccine.2012.01.015.
Article
PubMed
PubMed Central
Google Scholar
Bodewes R, Fraaij PLA, Osterhaus ADME, Rimmelzwaan GF: Pediatric influenza vaccination: understanding the T-cell response. Expert Rev Vaccines. 2012, 11: 963-971. 10.1586/erv.12.69.
Article
CAS
PubMed
Google Scholar
Meyer J, Harris SA, Satti I, Poulton ID, Poyntz HC, Tanner R, Rowland R, Griffiths KL, Fletcher HA, McShane H: Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery. Vaccine. 2013, 31: 1026-1033. 10.1016/j.vaccine.2012.12.042.
Article
CAS
PubMed
Google Scholar
Kauffmann A, Huber W: Microarray data quality control improves the detection of differentially expressed genes. Genomics. 2010, 95: 138-142. 10.1016/j.ygeno.2010.01.003.
Article
CAS
PubMed
Google Scholar
Smyth GK: Limma: linear models for microarray data. Bioinforma Comput Biol Solut using R Bioconductor. Edited by: Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W. 2005, New York: Springer, 397-420.
Chapter
Google Scholar
Shi W, Oshlack A, Smyth GK: Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips. Nucleic Acids Res. 2010, 38: e204-10.1093/nar/gkq871.
Article
PubMed
PubMed Central
Google Scholar
Ritchie ME, Diyagama D, Neilson J, van Laar R, Dobrovic A, Holloway A, Smyth GK: Empirical array quality weights in the analysis of microarray data. BMC Bioinformatics. 2006, 7: 261-10.1186/1471-2105-7-261.
Article
PubMed
PubMed Central
Google Scholar
Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A. 2001, 98: 5116-5121. 10.1073/pnas.091062498.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang S: A comprehensive evaluation of SAM, the SAM R-package and a simple modification to improve its performance. BMC Bioinformatics. 2007, 8: 230-10.1186/1471-2105-8-230.
Article
PubMed
PubMed Central
Google Scholar
Shen-Orr SS, Tibshirani R, Khatri P, Bodian DL, Staedtler F, Perry NM, Hastie T, Sarwal MM, Davis MM, Butte AJ: Cell type-specific gene expression differences in complex tissues. Nat Methods. 2010, 7: 287-289. 10.1038/nmeth.1439.
Article
CAS
PubMed
PubMed Central
Google Scholar
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005, 102: 15545-15550. 10.1073/pnas.0506580102.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mootha VK, Lindgren CM, Eriksson K-F, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003, 34: 267-273. 10.1038/ng1180.
Article
CAS
PubMed
Google Scholar
Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C, Schmidt DS, Johnson SE, Milton A, Rajam G, Kasturi S, Carlone GM, Quinn C, Chaussabel D, Palucka AK, Mulligan MJ, Ahmed R, Stephens DS, Nakaya HI, Pulendran B: Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nat Immunol. 2013, 15: 1-12.
Article
Google Scholar
Quintin J, Saeed S, Martens JHA, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg B-J, Wijmenga C, Joosten LAB, Xavier RJ, van der Meer JWM, Stunnenberg HG, Netea MG: Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe. 2012, 12: 223-232. 10.1016/j.chom.2012.06.006.
Article
CAS
PubMed
Google Scholar
Zang S, Guo R, Zhang L, Lu Y: Integration of statistical inference methods and a novel control measure to improve sensitivity and specificity of data analysis in expression profiling studies. J Biomed Inform. 2007, 40: 552-560. 10.1016/j.jbi.2007.01.002.
Article
CAS
PubMed
Google Scholar
McShane H, Pathan AA, Sander CR, Keating SM, Gilbert SC, Huygen K, Fletcher HA, Hill AV: Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nat Med. 2004, 10: 1240-1244. 10.1038/nm1128.
Article
CAS
PubMed
Google Scholar
Naranbhai V, Hill AVS, Abdool Karim SS, Naidoo K, Abdool Karim Q, Warimwe GM, McShane H, Fletcher H: Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy. J Infect Dis. 2013, 209: 1-10.
Google Scholar
Warimwe GM, Murungi LM, Kamuyu G, Nyangweso GM, Wambua J, Naranbhai V, Fletcher HA, Hill AVS, Bejon P, Osier FHA, Marsh K: The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children. PLoS One. 2013, 8: e57320-10.1371/journal.pone.0057320.
Article
CAS
PubMed
PubMed Central
Google Scholar
Merekoulias G, Alexopoulos EC, Belezos T, Panagiotopoulou E: Lymphocyte to monocyte ratio as a screening tool for influenza. Plos Curr. 2010, 2: RRN1154-
Article
PubMed
PubMed Central
Google Scholar
Warimwe GM, Fletcher HA, Olotu A, Agnandji ST, Hill AVS, Marsh K, Bejon P: Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data. BMC Med. 2013, 11: 184-10.1186/1741-7015-11-184.
Article
PubMed
PubMed Central
Google Scholar
Berthoud TK, Fletcher H, Porter D, Thompson F, Hill AVS, Todryk SM: Comparing human T cell and NK cell responses in viral-based malaria vaccine trials. Vaccine. 2009, 28: 21-27. 10.1016/j.vaccine.2009.09.132.
Article
PubMed
Google Scholar
Matsumiya M, Stylianou E, Griffiths K, Lang Z, Meyer J, Harris SA, Rowland R, Minassian AM, Pathan AA, Fletcher H, Mcshane H: Roles for treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A. PLoS One. 2013, 8: 1-14.
Article
Google Scholar
Holmgaard RB, Zamarin D, Munn DH, Wolchok JD, Allison JP: Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J Exp Med. 2013, 210: 1389-1402. 10.1084/jem.20130066.
Article
CAS
PubMed
PubMed Central
Google Scholar