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Table 3 Differentially expressed genes following Ag85A stimulation post-MVA85A vaccination

From: Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

Vaccinated infants: day 28- day-7

Day 28 samples: vaccinated- placebo

SYMBOL

logFC

Fold change

adj.P.Val

SYMBOL

logFC

Fold change

adj.P.Val

LOC400759

2.04

4.11

0.0047

LOC400759

2.71

6.55

0.012

GBP5

2.16

4.46

0.0079

STAT1

2.69

6.46

0.012

LOC730249

1.93

3.82

0.0079

STAT1

2.31

4.96

0.012

WARS

1.37

2.58

0.0079

CXCL10

3.41

10.64

0.015

ANKRD22

1.67

3.19

0.018

CCL8

4.02

16.21

0.027

GBP4

1.4

2.63

0.018

GBP4

2.19

4.55

0.027

WARS

1.25

2.38

0.018

CXCL9

1.95

3.86

0.027

TAP1

0.79

1.73

0.0234

STAT1

1.78

3.44

0.027

AIM2

1.05

2.07

0.0251

WARS

1.69

3.23

0.027

PSME2

0.72

1.65

0.0251

IFI35

1.49

2.8

0.027

CXCL9

1.63

3.09

0.0259

WARS

1.73

3.31

0.03

GBP1

1.9

3.72

0.0349

GBP1

2.86

7.28

0.031

STAT1

1.15

2.22

0.0354

PARP9

1.56

2.94

0.031

STAT1

1.32

2.49

0.0476

FBXO6

1.84

3.57

0.037

STAT1

0.92

1.89

0.0746

PARP9

1.46

2.75

0.051

GBP1

1.87

3.66

0.0911

PARP14

1.24

2.36

0.051

CD38

0.8

1.74

0.0925

PSME2

1.12

2.17

0.051

CXCL10

2.3

4.92

0.1295

GBP5

2.65

6.3

0.058

LAP3

1.13

2.19

0.1295

EPSTI1

1.51

2.85

0.058

CEACAM1

0.96

1.95

0.1412

GBP1

3.01

8.05

0.062

PARP14

0.71

1.63

0.1412

IFNG

2.17

4.51

0.062

IFNG

1.67

3.19

0.1599

P2RX7

1.77

3.42

0.062

    

SAMD9L

1.37

2.58

0.062

    

PTER

1.18

2.27

0.062

    

UBE2L6

1.14

2.21

0.076

    

IFIT3

2.35

5.09

0.08

    

SNHG5

-1.17

-2.25

0.08

    

LOC730249

2.32

5

0.082

    

PLA2G4C

1.39

2.61

0.082

  1. PBMC stimulated for 12 hours with Ag85A peptide pools, genes identified using the R package limma. Genes in italics have an adjusted p value 0.05 < p < 0.2).