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Table 4 Comparison of differentially expressed genes in South African infants and UK adults post-MVA85A

From: Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

  Fold change
SYMBOL RSA infants UK adults
CXCL10 3.2 6.5
ANKRD22 2.6 2.0
INDO 2.5 1.3
GBP5 2.5 2.2
ANKRD22 2.5 1.7
IDO1 2.4 1.4
FCGR1C 2.1 1.7
LOC400759 2.0 2.1
FAM26F 1.9 1.8
XRN1 1.7 1.0
PARP9 1.7 1.8
UBE2L6 1.6 1.6
SGK1 -1.6 1.1
CABC1 -1.6 -1.3
CARD17 1.6 1.2
CASP1 1.6 1.7
SGK1 -1.6 1.1
MRPL44 1.5 1.1
ZNF395 -1.5 -1.3
ETV7 1.5 1.0
CASP4 1.5 1.2
PCBP2 -1.5 -1.2
FAIM3 -1.5 -1.3
  1. South African infants: unstimulated whole blood taken 1 day post-vaccination. UK adults: unstimulated PBMC taken 2 days post-vaccination. All genes are differentially expressed between MVA85A and candin vaccinated infants (fdr < 0.05); genes in bold are also significantly different between day 0 and day 2 in UK adults vaccinated with MVA85A.