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  1. Cellulitis is a common infectious disease. Although blood culture is frequently used in the diagnosis and subsequent treatment of cellulitis, it is a contentious diagnostic test. To help clinicians determine w...

    Authors: Chun-Yuan Lee, Calvin M. Kunin, Chung Chang, Susan Shin-Jung Lee, Yao-Shen Chen and Hung-Chin Tsai
    Citation: BMC Infectious Diseases 2016 16:581
  2. Granulysin (GNLY) is produced by human lymphocyte subpopulations and exhibits antimicrobial activity against Mycobacterium tuberculosis. We examined the association between GNLY levels in blood and latent tubercu...

    Authors: Pham Huu Thuong, Do Bang Tam, Shinsaku Sakurada, Nguyen Thi Le Hang, Minako Hijikata, Le Thi Hong, Phan Thi Minh Ngoc, Pham Thu Anh, Vu Cao Cuong, Ikumi Matsushita, Luu Thi Lien and Naoto Keicho
    Citation: BMC Infectious Diseases 2016 16:580
  3. Dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the genus Flavivirus, and infection with a virus within this genus induces antibodies that are cross-reactive to other flaviviruses. Particularl...

    Authors: Yuka Saito, Meng Ling Moi, Nozomi Takeshita, Chang-Kweng Lim, Hajime Shiba, Kuniaki Hosono, Masayuki Saijo, Ichiro Kurane and Tomohiko Takasaki
    Citation: BMC Infectious Diseases 2016 16:578
  4. Nearly every year Influenza affects most countries worldwide and the risk of a new pandemic is always present. Therefore, influenza is a major concern for public health. School-age individuals are often the mo...

    Authors: Constanze Ciavarella, Laura Fumanelli, Stefano Merler, Ciro Cattuto and Marco Ajelli
    Citation: BMC Infectious Diseases 2016 16:576
  5. An outbreak of pneumococcal meningitis among non-infant children and adults occurred in the Brong-Ahafo region of Ghana between December 2015 and April 2016 despite the recent nationwide implementation of a va...

    Authors: Brenda Anna Kwambana-Adams, Franklin Asiedu-Bekoe, Badu Sarkodie, Osei Kuffour Afreh, George Khumalo Kuma, Godfred Owusu-Okyere, Ebenezer Foster-Nyarko, Sally-Ann Ohene, Charles Okot, Archibald Kwame Worwui, Catherine Okoi, Madikay Senghore, Jacob Kweku Otu, Chinelo Ebruke, Richard Bannerman, Kwame Amponsa-Achiano…
    Citation: BMC Infectious Diseases 2016 16:575
  6. Aggregatibacter aphrophilus, a commensal of the oro-pharyngeal flora and member of the HACEK group of organisms, is an uncommonly encountered clinical pathogen. It has already been des...

    Authors: Morgane Choquet, Emilie Pluquet, Sandrine Castelain, Raphaël Guihéneuf and Véronique Decroix
    Citation: BMC Infectious Diseases 2016 16:574
  7. Tuberculous meningitis in adults is well characterized in Vietnam, but there are no data on the disease in children. We present a prospective descriptive study of Vietnamese children with TBM to define the pre...

    Authors: Nguyen Duc Bang, Maxine Caws, Thai Thanh Truc, Tran Ngoc Duong, Nguyen Huy Dung, Dang Thi Minh Ha, Guy E. Thwaites, Doortje Heemskerk, Joel Tarning, Laura Merson, Pham Van Toi, Jeremy J. Farrar, Marcel Wolbers, Thomas Pouplin and Jeremy N. Day
    Citation: BMC Infectious Diseases 2016 16:573
  8. Co-infection with Mycobacterium tuberculosis remains a leading cause of morbidity and mortality among HIV infected individuals especially in developing countries. Early initiation of cART in these patients when C...

    Authors: Simon Mutembo, Jane N. Mutanga, Kebby Musokotwane, Lutangu Alisheke and Christopher C. Whalen
    Citation: BMC Infectious Diseases 2016 16:572
  9. Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) reduce HIV-1 transmission within heterosexual HIV-1 serodiscordant couples. Prioritizing couples at highest HIV-1 transmission risk for ART and ...

    Authors: Elizabeth M. Irungu, Renee Heffron, Nelly Mugo, Kenneth Ngure, Elly Katabira, Nulu Bulya, Elizabeth Bukusi, Josephine Odoyo, Stephen Asiimwe, Edna Tindimwebwa, Connie Celum and Jared M. Baeten
    Citation: BMC Infectious Diseases 2016 16:571
  10. Klebsiella pneumoniae (KP) is a significant paediatric bloodstream pathogen in children. There is little data from Africa. In this study we describe the epidemiology of multi-drug resistant Klebsiella pneumoniae ...

    Authors: Heloise Buys, Rudzani Muloiwa, Colleen Bamford and Brian Eley
    Citation: BMC Infectious Diseases 2016 16:570
  11. Acute reduction in hemoglobin levels is frequently seen during sepsis. Previous studies have focused on the management of anemia in patients with septic shock admitted to intensive care units (ICU’s), includin...

    Authors: Gassan Fuad Muady, Haim Bitterman, Arie Laor, Moshe Vardi, Vitally Urin and Nesrin Ghanem-Zoubi
    Citation: BMC Infectious Diseases 2016 16:569
  12. Outcome of patients with streptococcal prosthetic joint infections (PJIs) is not well known.

    Authors: E. Fiaux, M. Titecat, O. Robineau, J. Lora-Tamayo, Y. El Samad, M. Etienne, N. Frebourg, N. Blondiaux, B. Brunschweiler, F. Dujardin, E. Beltrand, C. Loiez, V. Cattoir, J. P. Canarelli, C. Hulet, M. Valette…
    Citation: BMC Infectious Diseases 2016 16:568
  13. Fever is a common cause of hospital admission in Bangladesh but causative agents, other than malaria, are not routinely investigated. Enteric fever is thought to be common.

    Authors: Rapeephan R. Maude, Aniruddha Ghose, Rasheda Samad, Hanna K. de Jong, Masako Fukushima, Lalith Wijedoru, Mahtab Uddin Hassan, Md Amir Hossain, Md Rezaul Karim, Abdullah Abu Sayeed, Stannie van den Ende, Sujat Pal, A. S. M. Zahed, Wahid Rahman, Rifat Karnain, Rezina Islam…
    Citation: BMC Infectious Diseases 2016 16:567
  14. The rodent borne Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in central and northern Europe. The number of cases has increased and northern Sweden has experienced large outbreaks in...

    Authors: Kristina Bergstedt Oscarsson, Alette Brorstad, Maria Baudin, Anne Lindberg, Annika Forssén, Magnus Evander, Marie Eriksson and Clas Ahlm
    Citation: BMC Infectious Diseases 2016 16:566
  15. HCV treatment among people who inject drugs (PWID) is low. Education programs may be suitable strategies to improve patients’ knowledge about their condition and to overcome barriers to access treatment.

    Authors: Rui Tato Marinho, António Costa, Teodomiro Pires, Helena Raposo, Carlos Vasconcelos, Cristina Polónia, Joaquim Borges, Mariana Soares, Graça Vilar and Ana Maria Nogueira
    Citation: BMC Infectious Diseases 2016 16:565
  16. Tuberculosis (TB) disproportionately affects immigrants, HIV-infected individuals, and those living in crowded settings such as homeless shelters and correctional facilities. Although the majority of jails and...

    Authors: Ank E. Nijhawan, Princess A. Iroh, Larry S. Brown, Daniel Winetsky and Esmaeil Porsa
    Citation: BMC Infectious Diseases 2016 16:564
  17. The spread of resistance to carbapenems among Enterobacteriaceae has become a major public health problem in recent years. In this study, we describe an outbreak of Klebsiella pneumoniae in the neonatal ward. Fir...

    Authors: Jing Yu, Kun Tan, Zhihui Rong, Yue Wang, Zhongju Chen, Xuhui Zhu, Li Wu, Li Tan, Wei Xiong, Ziyong Sun and Ling Chen
    Citation: BMC Infectious Diseases 2016 16:563
  18. A substantial proportion of HIV-infected adults starting antiretroviral therapy (ART) in sub-Saharan Africa are malnourished. We aimed to increase understanding of the factors affecting their high mortality, p...

    Authors: Susannah L Woodd, Paul Kelly, John R. Koethe, George Praygod, Andrea M. Rehman, Molly Chisenga, Joshua Siame, Douglas C. Heimburger, Henrik Friis and Suzanne Filteau
    Citation: BMC Infectious Diseases 2016 16:562
  19. Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are responsible for a significant disease burden amongst Māori and Pacific populations in New Zealand (NZ). However, contemporary data are lacking ...

    Authors: Deborah A Williamson, Pierre R Smeesters, Andrew C Steer, Julie Morgan, Mark Davies, Philip Carter, Arlo Upton, Stephen Y.C. Tong, John Fraser and Nicole J Moreland
    Citation: BMC Infectious Diseases 2016 16:561
  20. Differences between the characteristics of culture positive pyogenic spondylitis (CPPS) and tuberculous spondylitis (TS) are well known. However, differences between the characteristics of culture negative pyo...

    Authors: Chung-Jong Kim, Eun Jung Kim, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong-Bin Kim, Myoung-don Oh and Nam Joong Kim
    Citation: BMC Infectious Diseases 2016 16:560
  21. Among septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. Since clinical judgment is sometimes uncertain biomarkers ...

    Authors: P. E. Charles, R. Noel, F. Massin, J. Guy, P. E. Bollaert, J. P. Quenot and S. Gibot
    Citation: BMC Infectious Diseases 2016 16:559
  22. Worldwide, human brucellosis remains an important and widespread infection. In the past, there were limited data on the occurrence of human brucellosis in the United Arab Emirates and the reported incidence ap...

    Authors: Nawal Al Shehhi, Faisal Aziz, Farida Al Hosani, Bashir Aden and Iain Blair
    Citation: BMC Infectious Diseases 2016 16:558
  23. Mycoplasma hominis, a well known cause of neonatal infection, has been reported as a pathogen in urogenital infections in adults; however, central nervous system (CNS) infections are rare. We report here the firs...

    Authors: Menglan Zhou, Peng Wang, Sharon Chen, Bin Du, Jinlong Du, Fengdan Wang, Meng Xiao, Fanrong Kong and Yingchun Xu
    Citation: BMC Infectious Diseases 2016 16:557
  24. Fosfomycin is increasingly called upon for the treatment of multi drug-resistant (MDR) organisms causing urinary tract infection (UTI). We reviewed oral fosfomycin use for UTI treatment in a large UK hospital....

    Authors: Philippa C. Matthews, Lucinda K. Barrett, Stephanie Warren, Nicole Stoesser, Mel Snelling, Matthew Scarborough and Nicola Jones
    Citation: BMC Infectious Diseases 2016 16:556
  25. Little is known about survival outcomes of HIV patients on first-line antiretroviral therapy (ART) on a large-scale in India, or facility level factors that influence patient survival to guide further improvem...

    Authors: Rakhi Dandona, Bharat B. Rewari, G. Anil Kumar, Sukarma Tanwar, S. G. Prem Kumar, Venkata S. Vishnumolakala, Herbert C. Duber, Emmanuela Gakidou and Lalit Dandona
    Citation: BMC Infectious Diseases 2016 16:555
  26. Performing a test of cure (TOC) could demonstrate success or failure of antimicrobial treatment of Chlamydia trachomatis infection, but recommendations for the timing of a TOC using nucleic acid amplification tes...

    Authors: Carolien M. Wind, Maarten F. Schim van der Loeff, Magnus Unemo, Rob Schuurman, Alje P. van Dam and Henry J. C. de Vries
    Citation: BMC Infectious Diseases 2016 16:554
  27. The best surgical modality for treating chronic periprosthetic hip infections remains controversial, with a lack of randomised controlled studies. The aim of this systematic review is to compare the infection ...

    Authors: D. A. George, N. Logoluso, G. Castellini, S. Gianola, S. Scarponi, F. S. Haddad, L. Drago and C. L. Romano
    Citation: BMC Infectious Diseases 2016 16:553
  28. Many nations maintain stockpiles of neuraminidase inhibitor (NAI) antiviral agents for use in influenza pandemics to reduce transmission and mitigate the course of clinical infection. Pandemic preparedness pla...

    Authors: Robert Moss, James M. McCaw, Allen C. Cheng, Aeron C. Hurt and Jodie McVernon
    Citation: BMC Infectious Diseases 2016 16:552
  29. Septic shock is a common and often devastating syndrome marked by severe cardiovascular dysfunction commonly managed with vasopressors. Whether markers of heart rate complexity before vasopressor up-titration ...

    Authors: Samuel M. Brown, Jeffrey Sorensen, Michael J. Lanspa, Matthew T. Rondina, Colin K. Grissom, Sajid Shahul and V. J. Mathews
    Citation: BMC Infectious Diseases 2016 16:551
  30. Coccidioidomycosis, a potentially fatal fungal infection, is considered an emergent mycotic disease because of the increased incidence of fungal infections registered over recent years. Infection occurs throug...

    Authors: María del Rocío Reyes-Montes, María Ameyali Pérez-Huitrón, Jorge Luis Ocaña-Monroy, María Guadalupe Frías-De-León, Erick Martínez-Herrera, Roberto Arenas and Esperanza Duarte-Escalante
    Citation: BMC Infectious Diseases 2016 16:550
  31. Rotavirus is acknowledged as an important cause of paediatric gastroenteritis worldwide. In Spain, comprehensive data on the burden of rotavirus disease was lacking.

    Authors: J. Arístegui, J. Ferrer, I. Salamanca, E. Garrote, A. Partidas, M. San-Martin and B. San-Jose
    Citation: BMC Infectious Diseases 2016 16:549
  32. Visceral leishmaniasis (VL) is a protozoan disease that is invariably fatal if left untreated. The disease is found in 70 countries with incidence of 0.2 – 0.4 million cases. The mainstay of treatment in resou...

    Authors: Aschalew Tamiru, Bethlehem Tigabu, Sisay Yifru, Ermias Diro and Asrat Hailu
    Citation: BMC Infectious Diseases 2016 16:548
  33. This study aims to identify dengue neutralizing antibody response in patients with dengue from a well-characterized cohort during an outbreak in central Brazil, 2012–2013.

    Authors: Angela Ferreira Lopes de Teive e Argolo, Valéria Christina de Rezende Féres, Marli Tenório Cordeiro, Lucimeire Antonelli da Silveira, Adriana Oliveira Guilarde, Ernesto Torres de Azevedo Marques Jr., Wayner Vieira de Souza and Celina Maria Turchi Martelli
    Citation: BMC Infectious Diseases 2016 16:546
  34. HIV-1 infection impairs tuberculosis (TB) specific immune responses affecting the diagnosis of latent TB. We aimed to (1) determine the proportion of HIV-1-infected adults with a negative QuantiFERON®-TB Gold ...

    Authors: Hanif Esmail, Friedrich Thienemann, Tolu Oni, Rene Goliath, Katalin A. Wilkinson and Robert J. Wilkinson
    Citation: BMC Infectious Diseases 2016 16:545
  35. E protein of tick-borne encephalitis virus (TBEV) and other flaviviruses is located on the surface of the viral particle. Domain III of this protein seems to be a promising component of subunit vaccines for pr...

    Authors: Anna S. Ershova, Olga A. Gra, Alexander M. Lyaschuk, Tatyana M. Grunina, Artem P. Tkachuk, Mikhail S. Bartov, Darya M. Savina, Olga V. Sergienko, Zoya M. Galushkina, Vladimir P. Gudov, Liubov I. Kozlovskaya, Ivan S. Kholodilov, Larissa V. Gmyl, Galina G. Karganova, Vladimir G. Lunin, Anna S. Karyagina…
    Citation: BMC Infectious Diseases 2016 16:544
  36. Yemen has witnessed several dengue fever outbreaks coincident with the social unrest and war in the country. The aim of the present study was to describe the knowledge, attitudes and practices (KAPs) of at-ris...

    Authors: Thaker A. A. Alyousefi, Rashad Abdul-Ghani, Mohammed A. K. Mahdy, Samira M. A. Al-Eryani, Abdulsalam M. Al-Mekhlafi, Yahia A. Raja, Shamusul Azhar Shah and John C. Beier
    Citation: BMC Infectious Diseases 2016 16:543
  37. In 2010, a universal nomenclature for varicella-zoster virus (VZV) clades was established, which is very useful in the monitoring of viral evolution, recombination, spread and genetic diversity. Currently, inf...

    Authors: Songtao Xu, Mukai Chen, Huanying Zheng, Haiyan Wang, Meng Chen, Jianhui Zhou, Wang Shuang, Pengbo Yu, Chaofeng Ma, Jilan He, Daxing Feng, Zhu Zhen, Zhang Yan, Mao Naiying, Aili Cui, Qiuhua Wu…
    Citation: BMC Infectious Diseases 2016 16:542
  38. Coxiella burnetii is an important zoonotic pathogen of global distribution. Still, in most parts of South America including Chile, systematic epidemiological data are lacking. The presented study aims to determin...

    Authors: Thomas Weitzel, Javier López, Gerardo Acosta-Jamett, Sophie Edouard, Philippe Parola and Katia Abarca
    Citation: BMC Infectious Diseases 2016 16:541
  39. Immigrants from countries with high incidence of tuberculosis (TB) are usually offered screening when they arrive to low incidence countries. The tuberculin skin test (TST) is often used. The interferon gamma ...

    Authors: Margret Johansson Gudjónsdóttir, Karsten Kötz, Ruth Stangebye Nielsen, Philip Wilmar, Sofia Olausson, Daniel Wallmyr and Birger Trollfors
    Citation: BMC Infectious Diseases 2016 16:540
  40. New methods for controlling sand fly are highly desired by the Visceral Leishmaniasis (VL) elimination program of Bangladesh, India and Nepal for its consolidation and maintenance phases. To support the progra...

    Authors: M. Mamun Huda, Vijay Kumar, Murari Lal Das, Debashis Ghosh, Jyoti Priyanka, Pradeep Das, Abdul Alim, Greg Matlashewski, Axel Kroeger, Eduardo Alfonso-Sierra and Dinesh Mondal
    Citation: BMC Infectious Diseases 2016 16:539
  41. Infections remain a leading cause of morbidity and mortality among liver transplant (LT) recipients. The aim of our study was to define the factors associated with outcome of early bacterial and fungal infecti...

    Authors: Francesco Barchiesi, Roberto Montalti, Pamela Castelli, Daniele Nicolini, Silvia Staffolani, Federico Mocchegiani, Alessandro Fiorentini, Esther Manso and Marco Vivarelli
    Citation: BMC Infectious Diseases 2016 16:538
  42. Tuberculosis (TB) now ranks alongside HIV as the leading infectious disease cause of death worldwide and incurs a global economic burden of over $12 billion annually. Directly observed therapy (DOT) recommends...

    Authors: Zoë M. McLaren, Amanda A. Milliken, Amanda J. Meyer and Alana R. Sharp
    Citation: BMC Infectious Diseases 2016 16:537
  43. Carbapenem-resistant Enterobacteriaceae (CRE) is a concern in South Africa and worldwide. It is therefore important that these organisms be accurately identified for infection prevention control purposes.

    Authors: Ashika Singh-Moodley and Olga Perovic
    Citation: BMC Infectious Diseases 2016 16:536
  44. Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wish...

    Authors: Oddvar Oppegaard, Steinar Skrede, Haima Mylvaganam and Bård Reiakvam Kittang
    Citation: BMC Infectious Diseases 2016 16:535
  45. Guangzhou reported its first laboratory-confirmed case of influenza A (H7N9) on January 10, 2014. A total of 25 cases were reported from the first wave of the epidemic until April 8, 2014. The fatality rate wa...

    Authors: Hui Wang, XinCai Xiao, Jianyun Lu, Zongqiu Chen, Kuibiao Li, Hui Liu, Lei Luo, Ming Wang and ZhiCong Yang
    Citation: BMC Infectious Diseases 2016 16:534
  46. Globally, prison inmates are a high-risk population for tuberculosis (TB), but the specific drivers of disease and impact of mass screening interventions are poorly understood.

    Authors: Dayse Sanchez Guimarães Paião, Everton Ferreira Lemos, Andrea da Silva Santos Carbone, Renata Viebrantz Enne Sgarbi, Alexandre Laranjeira Junior, Fellipe Matos da Silva, Letícia Marques Brandão, Luciana Squarizi dos Santos, Vaneli Silva Martins, Simone Simionatto, Ana Rita Coimbra Motta-Castro, Maurício Antônio Pompílio, Juliana Urrego, Albert Icksang Ko, Jason Randolph Andrews and Julio Croda
    Citation: BMC Infectious Diseases 2016 16:533
  47. Generic drug policies are often associated with concerns about the quality and effectiveness of these products. Phase IV clinical trials may be a suitable design to assess the effectiveness and safety of gener...

    Authors: Jaime Galindo, Pedro Amariles, Héctor F. Mueses-Marín, Jaime A. Hincapié, Sebastián González-Avendaño and Ximena Galindo-Orrego
    Citation: BMC Infectious Diseases 2016 16:532

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