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  1. We describe drug-induced liver injury (DILI) secondary to antituberculous treatment (ATT) in a large tuberculosis (TB) centre in London; we identify the proportion who had risk factors for DILI and the timing ...

    Authors: Aula Abbara, Sarah Chitty, Jennifer K. Roe, Rohma Ghani, Simon M. Collin, Andrew Ritchie, Onn Min Kon, John Dzvova, Harriet Davidson, Thomas E. Edwards, Charlotte Hateley, Matthew Routledge, Jim Buckley, Robert N. Davidson and Laurence John
    Citation: BMC Infectious Diseases 2017 17:231
    Content type: Research article Published on:

  2. Levels of non-neutralising antibodies (AB) to the C5 domain of HIV Env gp120 are inversely related to progression of HIV infection. In this phase I/II clinical study we investigated safety of Vacc-C5, a peptid...

    Authors: Kristin Brekke, Maja Sommerfelt, Mats Ökvist, Anne Margarita Dyrhol-Riise and Dag Kvale
    Citation: BMC Infectious Diseases 2017 17:228
    Content type: Research article Published on:

  3. Periprosthetic joint infections are mainly caused by Gram-positive cocci. Leuconostoc mesenteroides is a rare microorganism mainly causing bloodstream infections. At times, it might be confused with another type ...

    Authors: Rafael Franco-Cendejas, Claudia A. Colín-Castro, Melissa Hernández-Durán, Luis E. López-Jácome, Silvestre Ortega-Peña, Guillermo Cerón-González, Samuel Vanegas-Rodríguez, Jaime A. Mondragón-Eguiluz and Eduardo Acosta-Rodríguez
    Citation: BMC Infectious Diseases 2017 17:227
    Content type: Case report Published on:

  4. There is limited data on the genotype distribution of human papillomavirus (HPV) in the Taihu River Basin, home to 1.29 million people on the coast of eastern China. This study evaluated the prevalence and gen...

    Authors: Jing-fen Lu, Guo-rong Shen, Qiong Li, Xu Chen, Chun-fang Ma and Tong-hua Zhu
    Citation: BMC Infectious Diseases 2017 17:226
    Content type: Research article Published on:

  5. Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determi...

    Authors: Anu Ramachandran, Yukari Manabe, Radha Rajasingham and Maunank Shah
    Citation: BMC Infectious Diseases 2017 17:225
    Content type: Research article Published on:

  6. The outcome of CMV/HIV co-infection in infants treated early with combined antiretroviral therapy (cART) in resource-limited settings has not been described.

    Authors: Anfumbom K. W. Kfutwah, Paul Alain T. Ngoupo, Casimir Ledoux Sofeu, Francis Ateba Ndongo, Georgette Guemkam, Suzie Tetang Ndiang, Félicité Owona, Ida Calixte Penda, Patrice Tchendjou, Christine Rouzioux, Josiane Warszawski, Albert Faye and Mathurin Cyrille Tejiokem
    Citation: BMC Infectious Diseases 2017 17:224
    Content type: Research article Published on:

  7. Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel. A robust, rapid and cost effective diagnostic test ...

    Authors: Sandeep Verma, Ruchi Singh, Vanila Sharma, Ram Avtar Bumb, Narendra Singh Negi, V Ramesh and Poonam Salotra
    Citation: BMC Infectious Diseases 2017 17:223
    Content type: Research article Published on:

  8. This multi-country prospective study of infants aged <1 year aims to assess the frequency of influenza virus and respiratory syncytial virus (RSV) infections associated with hospitalizations, to describe clini...

    Authors: Mark G. Thompson, Danielle R. Hunt, Ali K. Arbaji, Artan Simaku, Veronica L. Tallo, Holly M. Biggs, Carolyn Kulb, Aubree Gordon, Ilham Abu Khader, Silvia Bino, Marilla G. Lucero, Eduardo Azziz-Baumgartner, Pat Shifflett, Felix Sanchez, Basima I. Marar, Ilirjana Bakalli…
    Citation: BMC Infectious Diseases 2017 17:222
    Content type: Study protocol Published on:

  9. Chagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by heart failure and sudden death. Identifying which factors are involved in evolution and treatment response is actually challengi...

    Authors: Héctor Rodríguez-Angulo, Juan Marques, Ivan Mendoza, Marco Villegas, Alfredo Mijares, Núria Gironès and Manuel Fresno
    Citation: BMC Infectious Diseases 2017 17:221
    Content type: Research article Published on:

  10. Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact...

    Authors: Lucy Pembrey, Dagmar Waiblinger, Paul Griffiths, Mauli Patel, Rafaq Azad and John Wright
    Citation: BMC Infectious Diseases 2017 17:220
    Content type: Research article Published on:

  11. Efforts to control the global burden of tuberculosis (TB) have been jeopardized by the rapid evolution of multi-drug resistant Mycobacterium tuberculosis (MTB), which is resistant to at least isoniazid and rifamp...

    Authors: Setegn Eshetie, Mucheye Gizachew, Mulat Dagnew, Gemechu Kumera, Haile Woldie, Fekadu Ambaw, Belay Tessema and Feleke Moges
    Citation: BMC Infectious Diseases 2017 17:219
    Content type: Research article Published on:

  12. In Vietnam, dengue fever (DF) is still a leading cause of hospitalization. The main objective of this study was to evaluate the seasonality and association with climate factors (temperature and precipitation) ...

    Authors: Hu Suk Lee, Hung Nguyen-Viet, Vu Sinh Nam, Mihye Lee, Sungho Won, Phuc Pham Duc and Delia Grace
    Citation: BMC Infectious Diseases 2017 17:218
    Content type: Research article Published on:

  13. Herpes simplex virus (HSV) is a common human pathogen that causes a variety of diseases, including oral-labial, genital lesions and life-threatening encephalitis. The antiviral nucleoside analogues such as acy...

    Authors: Jue Hou, Zili Zhang, Qiang Huang, Jun Yan, Xiaohu Zhang, Xiaoliang Yu, Guihua Tan, Chunfu Zheng, Feng Xu and Sudan He
    Citation: BMC Infectious Diseases 2017 17:217
    Content type: Research article Published on:

  14. Imported cases of infections due to Dengue (DENV) and Chikungunya (CHIKV) viruses and, more recently, Zika virus (ZIKV) are commonly reported among travelers returning from endemic regions. In areas where pote...

    Authors: Claudia Fortuna, Maria Elena Remoli, Caterina Rizzo, Eleonora Benedetti, Cristiano Fiorentini, Antonino Bella, Claudio Argentini, Francesca Farchi, Concetta Castilletti, Maria Rosaria Capobianchi, Lorenzo Zammarchi, Alessandro Bartoloni, Nadia Zanchetta, Maria Rita Gismondo, Luca Ceccherini Nelli, Giustina Vitale…
    Citation: BMC Infectious Diseases 2017 17:216
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:335

  15. Little is known about the applicability of dual treatments based on integrase inhibitors. We explored the combination of lamivudine + dolutegravir as an option when switching from standard cART in virologicall...

    Authors: Franco Maggiolo, Roberto Gulminetti, Layla Pagnucco, Margherita Digaetano, Simone Benatti, Daniela Valenti, Annapaola Callegaro, Diego Ripamonti and Cristina Mussini
    Citation: BMC Infectious Diseases 2017 17:215
    Content type: Research article Published on:

  16. The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of...

    Authors: ShalloDaba Hamusse, Meaza Demissie, Dejene Teshome, Mohammed Suaudi Hassen and Bernt Lindtjørn
    Citation: BMC Infectious Diseases 2017 17:214
    Content type: Research article Published on:

  17. Herpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vu...

    Authors: Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M. F. Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S. Poblete…
    Citation: BMC Infectious Diseases 2017 17:213
    Content type: Review Published on:

  18. Atazanavir (ATV) not boosted by ritonavir (uATV) has been frequently used in the past for switching combination antiretroviral therapy (cART). However, the clinical outcomes and predictors of such strategy are...

    Authors: Maria Concetta Postorino, Mattia Prosperi, Emanuele Focà, Eugenia Quiros-Roldan, Elisa Di Filippo, Franco Maggiolo, Alberto Borghetti, Nicoletta Ladisa, Massimo Di Pietro, Andrea Gori, Laura Sighinolfi, Angelo Pan, Nicola Mazzini and Carlo Torti
    Citation: BMC Infectious Diseases 2017 17:212
    Content type: Research article Published on:

  19. Although sickle cell disease (SCD) children are highly susceptible to bacterial infections (BIs), there is a dreadful lack of data related to the burden and spectrum of BIs in sub-Saharan Africa (SSA), the hig...

    Authors: Anastasie Nicole Alima Yanda, Jobert Richie N. Nansseu, Hubert Désiré Mbassi Awa, Sandra A. Tatah, Judith Seungue, Charlotte Eposse and Paul Olivier N. Koki
    Citation: BMC Infectious Diseases 2017 17:211
    Content type: Research article Published on:

  20. Mannose-binding lectin (MBL) is an important protein in the lectin pathway of the immune system. This study explores the association between MBL polymorphism and the susceptibility to tuberculosis (TB). The as...

    Authors: Yan-Ling Guo, Yang Liu, Wu-Juan Ban, Qi Sun and Guang-Li Shi
    Citation: BMC Infectious Diseases 2017 17:210
    Content type: Research article Published on:

  21. Three diagnostic criteria have been proposed used for invasive pulmonary aspergillosis (IPA) diagnosis, namely EORTC/ MSG criteria, Bulpa criteria and intensive care unit (ICU) criteria. The Bulpa criteria wer...

    Authors: Linna Huang, Hangyong He, Jingjing Jin and Qingyuan Zhan
    Citation: BMC Infectious Diseases 2017 17:209
    Content type: Research article Published on:

  22. The sustained health-related quality-of-life of patients surviving community-acquired pneumonia has not been accurately quantified. The aim of the current study was to quantify differences in health-related qu...

    Authors: Marie-Josée J. Mangen, Susanne M. Huijts, Marc J. M. Bonten and G. Ardine de Wit
    Citation: BMC Infectious Diseases 2017 17:208
    Content type: Research article Published on:

  23. External and intraocular infections can lead to visual impairments, which is a major public health problem. Bacteria are the most frequent pathogens affecting ocular structures; the increasing rate of antimicr...

    Authors: Mebrahtu Teweldemedhin, Muthupandian Saravanan, Araya Gebreyesus and Dawit Gebreegziabiher
    Citation: BMC Infectious Diseases 2017 17:207
    Content type: Research article Published on:

  24. Routes of transmission of multidrug-resistant gram-negative organisms (MDRGN) are not completely understood. Since sexual transmission of MDRGN might represent a potential mode that has not been noticed so far...

    Authors: Claudia Reinheimer, Oliver T. Keppler, Christoph Stephan, Thomas A. Wichelhaus, Imke Friedrichs and Volkhard A. J. Kempf
    Citation: BMC Infectious Diseases 2017 17:206
    Content type: Research article Published on:

  25. Studies from several countries indicate that the incidence and mortality of bloodstream infection (BSI) have been increasing over time.

    Authors: Arne Mehl, Bjørn Olav Åsvold, Stian Lydersen, Julie Paulsen, Erik Solligård, Jan Kristian Damås, Stig Harthug and Tom-Harald Edna
    Citation: BMC Infectious Diseases 2017 17:205
    Content type: Research article Published on:

  26. Dengue is an acute febrile illness considered the major arboviral disease in terms of morbidity, mortality, economic impact and dissemination worldwide. Brazil accounts for the highest notification rate, with ...

    Authors: Sibelle Nogueira Buonora, Flavia Barreto dos Santos, Regina Paiva Daumas, Sonia Regina Lambert Passos, Manoela Heringer da Silva, Monique Rocha de Lima and Rita Maria Ribeiro Nogueira
    Citation: BMC Infectious Diseases 2017 17:204
    Content type: Research article Published on:

  27. Carbapenem-resistant Klebsiella pneumoniae (CRKP) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas. Treatment failures and delay in appropriate ...

    Authors: Alessandra Micozzi, Giuseppe Gentile, Clara Minotti, Claudio Cartoni, Saveria Capria, Daniele Ballarò, Stefania Santilli, Emanuele Pacetti, Sara Grammatico, Giampaolo Bucaneve and Robin Foà
    Citation: BMC Infectious Diseases 2017 17:203
    Content type: Research article Published on:

  28. The number of Acute Dental Infections (ADI) presenting for emergency department (ED) care are steadily increasing. Outpatient Parenteral Antibiotic Therapy (OPAT) programs are increasingly utilized as an alter...

    Authors: William J. Connors, Heidi H. Rabie, Rafael L. Figueiredo, Donna L. Holton and Michael D. Parkins
    Citation: BMC Infectious Diseases 2017 17:202
    Content type: Research article Published on:

  29. Clusters of infectious diseases are frequently detected late. Real-time, detailed information about an evolving cluster and possible associated conditions is essential for local policy makers, travelers planni...

    Authors: Geert H. Groeneveld, Anton Dalhuijsen, Chakib Kara-Zaïtri, Bob Hamilton, Margot W. de Waal, Jaap T. van Dissel and Jim E. van Steenbergen
    Citation: BMC Infectious Diseases 2017 17:201
    Content type: Technical advance Published on:

  30. Timely and accurate identification of people with latent tuberculosis infection (LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold standard for diagnosis of LTBI. Screening test...

    Authors: Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Noel McCarthy, Paul Sutcliffe and Aileen Clarke
    Citation: BMC Infectious Diseases 2017 17:200
    Content type: Research article Published on:

  31. To support the evaluation of the 2010-15 National Plan for Measles and Congenital Rubella Elimination, the authors designed and performed a serosurveillance survey to verify the immunity/susceptibility rate ag...

    Authors: Gallone Maria Serena, Gallone Maria Filomena, Larocca Angela Maria Vittoria, Germinario Cinzia and Tafuri Silvio
    Citation: BMC Infectious Diseases 2017 17:199
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Infectious Diseases 2017 17:630

  32. The incidence of herpes zoster (HZ) is increasing and poses a significant health concern to aging populations. Several studies suggest an increased risk of stroke following zoster infection, but the results ar...

    Authors: Fawziah Marra, Jeremy Ruckenstein and Kathryn Richardson
    Citation: BMC Infectious Diseases 2017 17:198
    Content type: Research article Published on:

  33. Difficult-to-treat infections caused by rapidly growing mycobacteria (RGM) are increasingly observed in clinical settings. However, studies on antimicrobial susceptibilities and effective treatments against RG...

    Authors: Shuji Hatakeyama, Yuki Ohama, Mitsuhiro Okazaki, Yoko Nukui and Kyoji Moriya
    Citation: BMC Infectious Diseases 2017 17:197
    Content type: Research article Published on:

  34. Human adenovirus 7 (HAdV-7) was responsible for a significant number of fatalities during the 2011 community outbreak in Taiwan. The mechanisms underlying the pathogenesis of severe adenovirus infections in no...

    Authors: Ching-Fen Shen, Shih-Min Wang, Tzong-Shiann Ho and Ching-Chuan Liu
    Citation: BMC Infectious Diseases 2017 17:196
    Content type: Research article Published on:

  35. Preparedness is considered essential for healthcare organizations to respond effectively to outbreaks. In the current study we aim to capture the views of first responders on what they consider key recommendat...

    Authors: Evelien Belfroid, Aura Timen, Jim E. van Steenbergen, Anita Huis and Marlies E. J. L. Hulscher
    Citation: BMC Infectious Diseases 2017 17:195
    Content type: Research article Published on:

  36. Understanding why some recently with HIV diagnosed men who have sex with men (MSM) choose for safer sex and regular STI testing, whereas others do not, is important for the development of interventions that ai...

    Authors: Titia Heijman, Freke Zuure, Ineke Stolte and Udi Davidovich
    Citation: BMC Infectious Diseases 2017 17:194
    Content type: Research article Published on:

  37. Two biomarkers, the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), have been shown to be indicative of systemic inflammation and predictive of mortality in general population. We ...

    Authors: Elena Raffetti, Francesco Donato, Salvatore Casari, Filippo Castelnuovo, Laura Sighinolfi, Alessandra Bandera, Franco Maggiolo, Nicoletta Ladisa, Massimo di Pietro, Chiara Fornabaio, Simona Digiambenedetto and Eugenia Quiros-Roldan
    Citation: BMC Infectious Diseases 2017 17:193
    Content type: Research article Published on:

  38. The objective of this study was to investigate the distribution and susceptibility of aerobic and facultative Gram-negative bacilli isolated from Chinese patients with UTIs collected within 48 h (community acq...

    Authors: Qiwen Yang, Hui Zhang, Yao Wang, Zhipeng Xu, Ge Zhang, Xinxin Chen, Yingchun Xu, Bin Cao, Haishen Kong, Yuxing Ni, Yunsong Yu, Ziyong Sun, Bijie Hu, Wenxiang Huang, Yong Wang, Anhua Wu…
    Citation: BMC Infectious Diseases 2017 17:192
    Content type: Research article Published on:

  39. Diagnosis of tuberculosis is difficult among pregnant women because the signs and symptoms of the disease, such as fatigue, shortness of breath, sweating, cough, and mild fever are similar to some manifestatio...

    Authors: Edward Broughton, Samson Haumba, Marianne Calnan, Sandile Ginindsa, Rosanna Jeffries, Gugu Maphalala, Sikhathele Mazibuko, Munamato Mirara, Surbhi Modi, Pasipamire Munyaradzi, Peter Preko and Batsabile Simelane
    Citation: BMC Infectious Diseases 2017 17:191
    Content type: Study protocol Published on:

  40. Very little is known about the link of T. gondii infection and depression. Through an age-, gender-, and month of pregnancy-matched case-control study, we determined the association of T. gondii infection and dep...

    Authors: Cosme Alvarado-Esquivel, Ana Liliana Martínez-Martínez, Luis Francisco Sánchez-Anguiano, Jesús Hernández-Tinoco, Juan Manuel Castillo-Orona, Carlos Salas-Martínez, Antonio Sifuentes-Álvarez, Ada Agustina Sandoval-Carrillo, José M. Salas-Pacheco, Oliver Liesenfeld and Elizabeth Irasema Antuna-Salcido
    Citation: BMC Infectious Diseases 2017 17:190
    Content type: Research article Published on:

  41. In rural India, mobile medical clinics are useful models for delivering health promotion, education, and care. Mobile medical clinics use fewer providers for larger catchment areas compared to traditional clin...

    Authors: Noah Kojima, Karl Krupp, Kavitha Ravi, Savitha Gowda, Poornima Jaykrishna, Caitlyn Leonardson-Placek, Anand Siddhaiah, Claire C. Bristow, Anjali Arun, Jeffrey D. Klausner and Purnima Madhivanan
    Citation: BMC Infectious Diseases 2017 17:189
    Content type: Research article Published on:

  42. Streptococcus Suis (S.suis) is increasingly being recognised as a potentially preventable emerging zoonotic infection in humans with a global distribution. It is a major cause of menin...

    Authors: Giri Shan Rajahram, Ahneez Abdul Hameed, Jayaram Menon, Timothy William, Paul Anantharajah Tambyah and Tsin Wen Yeo
    Citation: BMC Infectious Diseases 2017 17:188
    Content type: Case report Published on:

  44. The focus of nursing home infection control procedures has been on decreasing transmission between healthcare workers and residents. Less evidence is available regarding whether decontamination of high-touch e...

    Authors: Christine R. Kovach, Yavuz Taneli, Tammy Neiman, Elaine M. Dyer, Alvin Jason A. Arzaga and Sheryl T Kelber
    Citation: BMC Infectious Diseases 2017 17:186
    Content type: Research article Published on:

  45. Sexual transmission of Hepatitis C virus (HCV) in men who have sex with men (MSM) and its interaction with HIV status, sexually transmitted infections and sexual behaviour is poorly understood. We assessed the...

    Authors: Nicholas A. Medland, Eric P. F. Chow, Catriona S. Bradshaw, Timothy H. R. Read, Joseph J. Sasadeusz and Christopher K. Fairley
    Citation: BMC Infectious Diseases 2017 17:185
    Content type: Research article Published on:

  46. Identification of the types of strains of Mycobacterium tuberculosis (M. tuberculosis) complex causing tuberculosis (TB) could contribute to TB control program of specific geographic region as well as it could ad...

    Authors: Zufan Bedewi, Adane Worku, Yalemtsehay Mekonnen, Getnet Yimer, Girmay Medhin, Gezahegne Mamo, Rembert Pieper and Gobena Ameni
    Citation: BMC Infectious Diseases 2017 17:184
    Content type: Research article Published on:

  47. Carbapenem antibiotics are considered the treatment of choice for serious extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria (GNB) infections. The study objectives were to evaluate effica...

    Authors: Pinyo Rattanaumpawan, Peerawong Werarak, Anupop Jitmuang, Pattarachai Kiratisin and Visanu Thamlikitkul
    Citation: BMC Infectious Diseases 2017 17:183
    Content type: Research article Published on:

  48. Reactivation of occult or inactive Hepatitis B virus (HBV) infection during immunosuppressant treatments is well known and widely described in literature. The same observation has been made in Hepatitis C (HCV...

    Authors: Gabriele Fabbri, Ilaria Mastrorosa, Alessandra Vergori, Valentina Mazzotta, Carmela Pinnetti, Susanna Grisetti, Mauro Zaccarelli, Adriana Ammassari and Andrea Antinori
    Citation: BMC Infectious Diseases 2017 17:182
    Content type: Case report Published on:

  50. Multidrug-resistant Gram-negative bacterial infections are recognized as one of the major threats to global health. In this study, we describe for the first time bla NDM-1 gene carrying...

    Authors: Michael Pritsch, Ahmed Zeynudin, Maxim Messerer, Simon Baumer, Gabriele Liegl, Soeren Schubert, Thomas Löscher, Michael Hoelscher, Tefara Belachew, Andrea Rachow and Andreas Wieser
    Citation: BMC Infectious Diseases 2017 17:180
    Content type: Research article Published on:

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