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Survival of community-acquired Bacillus cereus sepsis with venous sinus thrombosis in an immunocompetent adult man – a case report and literature review



Bacillus cereus infections in immunocompetent patients are uncommon and mainly observed in fragile patients. It can cause lethal infections with multiple organ dysfunction syndrome (MODS). However, a patient presenting as venous sinus thrombosis and survival without sequela has not been reported.

Case presentation

A 20-year-old previously healthy male developed gastroenteritis after a meal, followed by fever, convulsions, and severe disturbance of consciousness. The patient had significant leukocytosis with a mildly elevated D-dimer, creatinine level, and respiratory failure. The CT(computed tomography) revealed fatal brain edema and subarachnoid hemorrhage. Previous blood culture in a local hospital revealed B. cereus, which was confirmed by mNGS(metagenomic next-generation sequencing) using blood and urine in our hospital. Accordingly, B. cereus sepsis with MODS were considered. Later, cerebral venous sinus thrombosis was proved. After anti-infection (linezolid 0.6 g, Q12h; and meropenem 1.0 g, Q8h), anti-coagulant (enoxaparin 6000U, Q12h), and other symptomatic treatments, the patient recovered completely without sequela at the 6-month follow-up.


This case suggests that in immunocompetent adults, there is still a risk of infection with B. cereus, causing severe MODS. Special attention should be paid to venous sinus thrombosis and subarachnoid hemorrhage in such cases, while, anti-coagulant is essential therapy.

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Bacillus cereus (B. cereus) is a common gram-positive, aerobic and facultative anaerobic bacillus widely distributed in soil, water, air and intestine [1]. B. cereus is usually non-pathogenic and considered as a contaminating bacteria in clinical practices, but it can also cause food poisoning with self-limiting symptoms, such as vomiting and diarrhea. In immunosuppressed people, severe infectious symptoms by B. cereus might occur [2]. Several studies have reported that the bacterium can cause severe bacteremia, leading to multiple organ failure, especially in patients with hematological malignancies. The delay in treatment may result in an even poor prognosis [3, 4]. Here, we report a previously healthy young patient with B. cereus sepsis, complicated by central nervous system involvement, multiple organ dysfunction, and venous sinus thrombosis, in addition, a patient presenting as venous sinus thrombosis and survival without sequela has not been reported. A relevant literature review on B. cereus infection in previously healthy individuals has also been provided.

Case presentation

A 20-year-old male college student visited the local hospital due to fever, disturbance of consciousness, and convulsion. He had abdominal distension, vomiting, and gradual abdominal pain without diarrhea after meal three days before. The patient had no meningeal irritation and no history of neurological disorder in his family. Physical examination on admission showed body temperature of 40.2 °C, blood pressure of 90/50 mmHg, and heart rate of 160 bpm. The patient developed a coma and abdominal distension of no reason. He became hypotensive and was commenced on norepinephrine treatment (Maximum dose reached 0.72ug/kg/min). Hematological examination revealed raised white blood cell (WBC) of 30.89 × 109/L and D-dimer level of 13,484 ng/ml (normal value 0–243 ng/ml), slightly decreased blood platelet (PLT) of 75 × 109/L. Coagulation tests suggested abnormal coagulation profile with prothrombin time (PT) of 14.5S (normal value 11.5–14.8S), activated partial thromboplastin time (APTT) of 35.8S (normal value 25.1–36.5S), thrombin time (TT) of 36.5 S (normal value 14-21S), fibrinogen (FIB) of 1.64 g/L (normal value 2.38–4.98 g/L), and fibrin degradation products (FDP) of 71.2ug/ml (normal value 0–2.01ug/ml). There were apparent liver and kidney dysfunction with alanine aminotransferase (ALT) of 131.6 U/L, aspartate aminotransferase (AST) of 111.3 U/L, total bilirubin (TBIL) of 33.8 μmol/L, creatinine of 125 μmol/L, and urea of 8.2 mmol/L. Laboratory investigations showed elevated level of C-reactive protein (CRP 221.85 mg/L) and procalcitonin (PCT 1.76 μg/L). But normal range of serum amylase and lipase, and the results of immunoglobulin lymphocyte subsets and connective tissue diseases are normal. CSF (cerebrospinal fluid) examination showed pale bloody CSF, red blood cells of 12,000 × 106/L, white blood cell of 100 × 106/L, with a pressure of 230cmH2O. Head CT performed at local hospital showed cerebral edema and subarachnoid hemorrhage (Fig. 1A and B). No abnormality was found in digital subtraction angiography (DSA) of skull. Purulent urine was drained from the indwelling urinary catheter. The patient was initially diagnosed with subarachnoid hemorrhage, sepsis, and septic shock. Therefore, meropenem (1.0 g, Q8h) and datomycin (0.5 g per day) were given for anti-infection, and anticoagulant therapy (enoxaparin 6000U, Q12h) was given, blood culture was also performed before antibiotics are used.

Fig. 1
figure 1

Radiographic findings of the patient. A-B showed cerebral edema and subarachnoid hemorrhage by cranial CT in local hospital; C-D showed local edema and thickening of the ascending colon wall with peritoneal thickening by abdominal CT plain scans in our hospital; E–F showed aggravated cerebral edema and subarachnoid hemorrhage by CT One day later; G-H showed significantly aggravated cerebral edema and multiple subarachnoid hemorrhages by CT After 12 days; I showed fine contrast in the left transverse sinus, sigmoid sinus and the opposite side of the internal jugular vein, and less uniform local density of transverse sinusAfter 12 days; J ~ K showed alleviated cerebral edema and subarachnoid hemorrhage after 2 weeks

One day later, the patient was transferred to our hospital due to shock and multiple organ dysfunction. Abdominal CTA (computed tomography arteriography) and CTV (computed tomography venography) revealed no abnormalities, but local edema and thickening of the ascending colon wall with peritoneal thickening were found by abdominal CT plain scans (Fig. 1C and D). Head CT plain scans showed aggravated cerebral edema and subarachnoid hemorrhage (Fig. 1E and F). Lumbar puncture was not performed due to severe cerebral edema and high intracranial pressure. Four days later, both blood and urine were used for PACE seq mNGS (pathogen capture engine mutagenic next-generation sequencing), which detected 23 and 3 unique reads of B. cereus, respectively (Fig. 2A and B). Six days later, the blood culture results at the local hospital were reported as Bacillus cereus, and the results of drug sensitivity report that Cefazolin, cefoperazone sulbactam, levofloxacin, vancomycin and linezolid are effective.

Fig. 2
figure 2

mNGS results of the patient. A. The DNA reads positions of B. cereus and the content of detected microbes by blood mNGS. The coverage of B. cereus detected by blood mNGS was 0.0361%. B. The DNA reads positions of B. cereus and the content of detected microbes by urine mNGS. The coverage of B. cereus detected by urine mNGS were 0.0081%

Accordingly, the patient was diagnosed with B. cereus sepsis and sepsis-associated encephalopathy, complicated with multiple organ dysfunction, including gastroenteritis, acute kidney injury, urinary tract infection, and acute respiratory distress syndrome. Anticoagulation was promptly discontinued in view of the patient's increased subarachnoid hemorrhage. Sufficient meropenem (1.0 g, Q8h) combined with linezolid (0.6 g, Q12h) was administered for anti-infection. Adjuvant treatments, such as sedative and analgesic anti-sympathetic therapy, body temperature management, cerebral protection, assisted ventilation, hemoperfusion to remove inflammatory mediators, and volume management were also given. The patient's vital signs were gradually stabilized, and the laboratory test indicators showed improvement after a week. The patient had gastrointestinal bleeding during the treatment of patients, and was given symptomatic hemostatic treatment.

After 12 days, the patient developed increased heart rate (> 100 beats/min) and fever (39.2 °C). Reexamination of head CT showed significantly aggravated cerebral edema and multiple subarachnoid hemorrhages (Fig. 1G and H). Head CTA showed bilateral anterior, middle and posterior cerebral arteries with uneven thickness, multiple luminal narrowing, and dilatation changes, suggesting local cerebrovascular inflammation. CTV showed fine contrast in the left transverse sinus, sigmoid sinus and the opposite side of the internal jugular vein, and less uniform local density of transverse sinus (Fig. 1I). Venous sinus thrombosis was considered. Active adequate anticoagulation therapy was given, and because meropenem and linezolid had been anti-infective treatment for 2 weeks, considering the side effects of the drugs, the anti-infective treatment regimen was adjusted to cefoperazone/sulbactam (3.0 g, Q8h) combined with vancomycin (1.0 g, Q12h). Repeated head CT showed alleviated cerebral edema and subarachnoid hemorrhage after 2 weeks. (Fig. 1J and K).

After forty days, the patient's organ function and consciousness recovered, but he was in a minimally conscious state, and his limbs could move spontaneously and still could not communicate. He was transferred to a rehabilitation hospital for continued treatment. During this period, lumbar puncture examination was performed intermittently, and no abnormality was found. After 2 months, the patient was able to communicate and take care of himself, but his cognitive function remained poor. After 4 months, his cognitive function gradually recovered. Six months later, he was able to return to school and continued his education. Clinical course timeline is described in Fig. 3.

Fig. 3
figure 3

Timeline for the reported case


B. cereus is widely distributed in various environments, such as contaminated meat, rice, and pasta of the living environment. Intravascular catheters, open wounds and contaminated sheets are the major medical environmental sources of B. cereus [5]. B. cereus is often responsible for self-limiting food poisoning, mainly characterized by diarrhea and vomiting, usually causing transient gastroenteritis in immunocompetent patients [6]. For immunosuppressed patients, B. cereus can cause not only gastrointestinal diseases, but also other infectious diseases such as fulminant bacteremia, central nervous system infections [7], endophthalmitis [8], osteomyelitis [9], urinary tract infections [10], skin infections [11], endocarditis [12], and pneumonia [13]. The rapid and fulminant progress of B. cereus caused illnesses seriously threatens the patients' life [14]. Currently, patients with hematological disorders, who received intravascular catheters, have become the high risk population for fulminant bloodstream and even blood-borne disseminated central nervous system infections caused by B. cereus [2, 15]. Severe illnesses with or without gastroenteritis caused by B. cereus in previously healthy individuals are uncommon. We reviewed the reported cases with B. cereus infections, who were previously healthy (Table 1), and found there were only five patients with bloodstream infections. In this case, the patient was previously healthy, who presented with discomfort after eating rice, severe B. cereus sepsis, accompanied by impaired consciousness and multiple organ dysfunction was considered.

Table 1 Summary of cases of B. Cereus reported in previously healthy individuals

The pathogenicity and virulence of B. cereus are associated with toxins and enzymes production by this pathogen, including hemolytic, non-hemolytic enterotoxins, emetic toxins, and some enzymes that cause tissue necrosis [22]. The emetic toxin with a lipophilic ring structure belongs to mitochondrial toxins [23] and can resist heating and proteolysis, which can destroy mitochondrial function leading to impaired mitochondrial β oxidation process and then cause cell death and promote multiple organ dysfunction. A case of a chef with B. cereus infection caused by eating rice was recently reported, in which large amounts of B. cereus were detected in his leftover, and the non-ribosomal peptide synthase gene (ces) and the non-hemolytic enterotoxin gene (nhe) of the emetic toxin were detected. The patient's clinical presentation from initial vomiting and diarrhea to acute liver failure and renal tubular necrosis [21]. In addition, enzymes that promote tissue necrosis can also cause liver abscesses [15]. It is reported that the liver may become another target organ for B. cereus infection [18]. Fat droplet deposition is seen in liver biopsies of B. cereus-associated liver dysfunction, causing liver failure in severe cases [17, 21, 24]. In 1997, a 17-year-old boy was reported to have vomiting, diarrhea, and rapid development of liver failure and rhabdomyolysis after eating overnight spaghetti leftovers. Autopsy showed diffuse microbubble steatosis and intermediate zone necrosis in the liver [23]. Our patient presented with elevated liver enzymes and bilirubin after onset, and abdominal ultrasound and CT revealed diffuse abnormalities in the liver.

Emetic toxin of B. cereus can cross the blood–brain barrier to attack the central nervous system in immunocompetent people [20, 25], causing subarachnoid hemorrhage, parenchymal hemorrhage, brain abscess, cerebral edema, and disturbance of consciousness [15, 17]. Patients with hematological diseases combined with central nervous system involvement have a very poor prognosis for B. cereus infection [26]. For example, B. cereus has been reported to cause bacteremia in a patient with a history of neutropenic acute myeloid leukemia following chemotherapy, resulting in poor prognosis, including multiple parenchymal hemorrhages and subarachnoid hemorrhages in the brain, as well as diffuse intraparenchymal and subcortical liquefaction necrosis [27]. In 1995, a 26-year-old man with leukemia died after infection with B. cereus. Cellulose in the meningeal vessels and B. cereus in the meningeal vessels and intracranial necrotic indicated that B. cereus might trigger thrombosis [15]. This patient we reported was previously healthy and had no underlying diseases, such as hematological diseases. Early head CT showed cerebral edema and subarachnoid hemorrhage, but cranial DSA showed no vascular abnormalities. Anticoagulant therapy had been administered for suspected thrombotic disease due to the high level of D-dimer, which was later discontinued due to an expanding extent of subarachnoid hemorrhage. Later, head CTA and CTV examination revealed that there was indeed thrombus in the venous sinus. To our knowledge, this is the first case report of venous sinus thrombosis caused by community-acquired B. cereus infection in healthy adults with good outcomes.

Urinary tract infections caused by B. cereus have rarely been reported (only one case with invasive bladder cancer who underwent radical cystectomy with percutaneous left ureterostomy followed by irrigation of the ureter with saline) [10]. Our patient presented with pyuria drained from the urinary catheter after admission. Urine mNGS revealed B. cereus, consistent with blood mNGS detection, suggesting hematogenous systemic dissemination of bacteria from gastrointestinal infections. However, the patient's coagulation function did not deteriorate significantly, and the platelet count remained at 75 × 109/L. The drained ascites was pale bloody, considering that B. cereus might cause systemic vascular injury, with multiple serous luminal hemorrhage, further observation was required.

B. cereus was highly susceptible to meropenem, linezolid and vancomycin [26, 27]. There are also reports of susceptibility of B. cereus to cefazolin [16], imipenem, levofloxacin [19], and ciprofloxacin [9]. The patient of this report was very young and had no underlying disease, with regular lifestyle. Systemic diseases rather than infection were considered due to the rapid progress and multiple organ dysfunction development. Fortunately, mNGS of blood and urine and blood culture detected the pathogen as B. cereus. Meropenem in combination with linezolid were subsequently given against B. cereus, which was later adjusted to cefoperazone/sulbactam in combination with vancomycin, resulting in good clinical outcome and normal final organ function as well as good recovery of consciousness. In addition, anticoagulation regimen against the definite venous sinus thrombosis of the patient also obtained good clinical effect. No similar treatment (anticoagulation regimen) has been reported at present, and this treatment may provide some reference for other cases.

This patient has severe sepsis with multiple organ dysfunction, it carries a risk for mortality, considerably exceeding that of a mere infection. Therefore, we actively give broad-spectrum antibiotics to fight infection and conduct bedside hemoperfusion treatment. There have been many literature reports on the clearance of inflammatory factors by hemoperfusion, and good results have been achieved[28, 29].


In conclusion, we report a previously healthy, immunocompetent young male patient with community-acquired sepsis and sepsis-associated encephalopathy caused by B. cereus. Rapid and accurate pathogenic diagnosis by mNGS provides a significantly important role for the rapid diagnosis and timely adjustment of antibiotic treatment, saving the patient’s life. Appropriate anticoagulant therapy may help improve the conditions of patients with venous embolism caused by B. cereus. In addition, clinicians should raise vigilance for foodborne infections, fully recognize fulminant diseases caused by B. cereus.

Availability of data and materials

The authors are ready to provide the data in response to the need.



Bacillus cereus


Multiple organ dysfunction syndrome


Metagenomic next-generation sequencing


Computed tomography


Cerebrospinal fluid


Computed tomography arteriography


Computed tomography venography


Deoxyribo nucleic acid


Pathogen capture engine metagenomic next-generation sequencing


Digital subtraction angiography


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This study was supported by Shanxi Provincial Natural Science Foundation (NO.201801D121332), Shanxi Provincial Scholarship Council Foundation (NO.20220039).JC wrote this paper and contributed to diagnosis and clinical decision for treatment.

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Zr W and JC wrote this paper. Zr W, JC, HL, JZ and Ff F contributed to diagnosis and clinical decision for treatment. HX contributed in giving advice from mNGS. All authors reviewed the manuscript. All Authors read and approved the final version of this manuscript.

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Correspondence to Jing Cao.

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Wang, Z., Xia, H., Fan, F. et al. Survival of community-acquired Bacillus cereus sepsis with venous sinus thrombosis in an immunocompetent adult man – a case report and literature review. BMC Infect Dis 23, 213 (2023).

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