Hofhuis A, Harms M, Bennema S, van den Wijngaard CC, van Pelt W. Physician reported incidence of early and late Lyme borreliosis. Parasit Vectors. 2015;8:161.
Article
PubMed
PubMed Central
Google Scholar
Hofhuis A, Harms M, van den Wijngaard C, Sprong H, van Pelt W. Continuing increase of tick bites and Lyme disease between 1994 and 2009. Ticks Tick Borne Dis. 2015;6(1):69–74.
Article
PubMed
Google Scholar
Stanek G, Fingerle V, Hungeld KP, Jaulhac B, Kaiser R, Krause A, Kristoferitsch W, O'Connell S, Ornstein K, Strle F, et al. Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clin Microbiol Infect. 2011;17:69–79.
Article
CAS
PubMed
Google Scholar
Berglund J, Eitrem R, Ornstein K, Lindberg A, Ringér A, Elmrud H, Carlsson M, Runehagen A, Svanborg C, Norrby R. An epidemiologic study of Lyme disease in southern Sweden. N Engl J Med. 1995;333(20):1319–27.
Article
CAS
PubMed
Google Scholar
Huppertz HI, Bohme M, Standaert SM, Karch H, Plotkin SA. Incidence of Lyme borreliosis in the Wurzburg region of Germany. Eur J Clin Microbiol Infect Dis. 1999;18(10):697–703.
Article
CAS
PubMed
Google Scholar
Hansen K, Asbrink E. Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. J Clin Microbiol. 1989;27(3):545–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hammers-Berggen SH, Lebech AM, Karlsson M, Svenungsson B, Hansen K, Stiernstedt G. Serological follow-up after treatment of patients with erythema Migrans and Neuroborreliosis. J Clin Microbiol. 1994;32(6):1519–25.
Article
Google Scholar
Leeflang MM, Ang CW, Berkhout J, Bijlmer HA, Van Bortel W, Brandenburg AH, Van Burgel ND, Van Dam AP, Dessau RB, Fingerle V, et al. The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis. BMC Infect Dis. 2016;16:140.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kalish RA, McHugh G, Granquist J, Shea B, Ruthazer R, Steere AC. Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10–20 years after active Lyme disease. Clin Infect Dis. 2001;33:780–5.
Article
CAS
PubMed
Google Scholar
Aguero-Rosenfeld ME, Nowakowski J, Bittker S, Cooper D, Nadelman RB, Wormser GP. Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema Migrans. J Clin Microbiol. 1996;34(1):1–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cerar D, Cerar T, Ruzic-Sabljic E, Wormser GP, Strle F. Subjective symptoms after treatment of early Lyme disease. Am J Med. 2010;123(1):79–86.
Article
PubMed
Google Scholar
Weitzner E, McKenna D, Nowakowski J, Scavarda C, Dornbush R, Bittker S, Cooper D, Nadelman RB, Visintainer P, Schwartz I, et al. Long-term assessment of post-treatment symptoms in patients with culture-confirmed early Lyme disease. Clin Infect Dis. 2015;61(12):1800–6.
Article
PubMed
PubMed Central
Google Scholar
Eikeland R, Mygland A, Herlofson K, Ljostad U. European neuroborreliosis: quality of life 30 months after treatment. Acta Neurol Scand. 2011;124(5):349–54.
Article
CAS
PubMed
Google Scholar
Wormser GP, Weitzner E, McKenna D, Nadelman RB, Scavarda C, Nowakowski J. Long-term assessment of fatigue in patients with culture-confirmed Lyme disease. Am J Med. 2015;128(2):181–4.
Article
PubMed
Google Scholar
van den Wijngaard CC, Hofhuis A, Harms MG, Haagsma JA, Wong A, de Wit GA, Havelaar AH, Lugner AK, Suijkerbuijk AW, van Pelt W. The burden of Lyme borreliosis expressed in disability-adjusted life years. Eur J Pub Health. 2015;25(6):1071–8.
Article
Google Scholar
Cairns V, Godwin J. Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms. Int J Epidemiol. 2005;34(6):1340–5.
Article
PubMed
Google Scholar
Shadick NA, Phillips CB, Sangha O, Logigian EL, Kaplan RF, Wright EA, Fossel AH, Fossel K, Berardi V, Lew RA, et al. Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease. Ann Intern Med. 1999;131(12):919–26.
Article
CAS
PubMed
Google Scholar
Stupica D, Lusa L, Cerar T, Ruzic-Sabljic E, Strle F. Comparison of post-Lyme Borreliosis symptoms in erythema migrans patients with positive and negative Borrelia burgdorferi sensu lato skin culture. Vector Borne Zoonotic Dis (Larchmont, NY). 2011;11(7):883–9.
Article
Google Scholar
Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, et al. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention clinical practice guidelines: diagnosis of tuberculosis in adults and children. Clin Infect Dis. 2017;64(2):e1–e33.
Article
PubMed
Google Scholar
Valentine-Thon E, Ilsemann K, Sandkamp M. A novel lymphocyte transformation test (LTT-MELISA) for Lyme borreliosis. Diagn Microbiol Infect Dis. 2007;57(1):27–34.
Article
CAS
PubMed
Google Scholar
Von Baehr V, Doebis C, Volk H, von Baehr R. The lymphocyte transformation test for Borrelia detects active Lyme Borreliosis and verifies effective antibiotic treatment. Open Neurol J. 2012;6:104–12.
Article
Google Scholar
Nordberg M, Forsberg P, Nyman D, Skogman BH, Nyberg C, Ernerudh J, Eliasson I, Ekerfelt C. Can ELISPOT be applied to a clinical setting as a diagnostic utility for Neuroborreliosis? Cells. 2012;1(2):153–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krause A, Brade V, Schoerner C, Solbach W, Kalden JR, Burmester GR: T-cell proliferation induced by Borrelia burgdorferi in patients with Lyme borreliosis. Arthritis Rheum 1991;34(4):393–402.
Jin C, Roen DR, Lehmann PV, Kellermann GH. An enhanced ELISPOT assay for sensitive detection of antigen-specific T cell responses to Borrelia burgdorferi. Cells. 2013;2(3):607–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Puri BK, Segal DRM, Monro JA. Diagnostic use of the lymphocyte transformation test-memory lymphocyte immunostimulation assay in confirming active Lyme borreliosis in clinically and serologically ambiguous cases. Int J Clin Exp Med. 2014;7(12):5890–2.
PubMed
PubMed Central
Google Scholar
Widhe M, Ekerfelt C, Jarefors S, Skogman BH, Peterson EM, Bergstrom S, Forsberg P, Ernerudh J. T-cell epitope mapping of the Borrelia garinii outer surface protein a in Lyme neuroborreliosis. Scand J Immunol. 2009;70(2):141–8.
Article
CAS
PubMed
Google Scholar
Huppertz HI, Mösbauer S, Busch DH, Karch H. Lymphoproliferative responses to Borrelia burgdorferi in the diagnosis of Lyme arthritis in children and adolescents. Eur J Pediatr. 1996;155(4):297–302.
Article
CAS
PubMed
Google Scholar
Forsberg P, Ernerudh J, Ekerfelt C, Roberg M, Vrethem M, Bergström S. The outer surface proteins of Lyme disease borrelia spirochetes stimulate T cells to secrete interferon-gamma (IFN-gamma): diagnostic and pathogenic implications. Clin Exp Immunol. 1995;101(3):453–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dressler F, Yoshinari NH, Steere AC. The T-cell proliferative assay in the diagnosis of Lyme disease. Ann Intern Med. 1991;115(7):533–9.
Article
CAS
PubMed
Google Scholar
Horowitz HW, Pavia CS, Bittker S, Forseter G, Cooper D, Nadelman RB, Byrne D, Johnson RC, Wormser GP. Sustained cellular immune responses to Borrelia burgdorferi: lack of correlation with clinical presentation and serology. Clin Diagn Lab Immunol. 1994;1(4):373–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rutkowski S, Busch DH, Huppertz HI. Lymphocyte proliferation assay in response to Borrelia burgdorferi in patients with Lyme arthritis: analysis of lymphocyte subsets. Rheumatol Int. 1997;17:151–8.
Article
CAS
PubMed
Google Scholar
Yoshinari NH, Reinhardt BN, Steere AC. T cell responses to polypeptide fractions of Borrelia burgdorferi in patients with Lyme arthritis. Arthritis Rheumatol. 1991;34(6):707–13.
Article
CAS
Google Scholar
Callister SM, Jobe DA, Stuparic-Stancic A, Miyamasu M, Boyle J, Dattwyler RJ, Arnaboldi PM. Detection of IFN-gamma secretion by T cells collected before and after successful treatment of early Lyme disease. Clin Infect Dis. 2016;62(10):1235–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vrijmoeth HD, Ursinus J, Harms MG, Zomer TP, Gauw SA, Tulen AD, Kremer K, Sprong H, Knoop H, Vermeeren YM, et al. Prevalence and determinants of persistent symptoms after treatment for Lyme borreliosis: study protocol for an observational, prospective cohort study (LymeProspect). BMC Infect Dis. 2019;19:324.
Healthcare CIfQo: Dutch guideline for Lyme disease. Available on https://www.rivm.nl/sites/default/files/2018-11/CBO%20richtlijn%20Lymeziekte%20definitief%20juli%202013.pdf. Accessed 24 July 2019.
Strle F, Nelson JA, Ruzic-Sabljic E, Cimperman J, Maraspin V, Lotric-Furlan S, Cheng Y, PM M, Trenholme GM, PR N. European Lyme borreliosis: 231 culture-confirmed cases involving patients with erythema migrans. Clin Infect Dis. 1996;23(1):61–5.
Article
CAS
PubMed
Google Scholar
Strle F, Videcnik J, Zorman P, Cimperman J, Lotric-Furlan S, Maraspin V. Clinical and epidemiological findings for patients with erythema migrans. Comparison of cohorts from the years 1993 and 2000. Wien Klin Wochenschr. 2002;114(13–14):493–7.
PubMed
Google Scholar
Nadelman R, Nowakowski J, Forseter G, et al. The clinical spectrum of early Lyme borreliosis in patients with culture-confirmed erythema migrans. Am J Med. 1996;100(5):502–8.
Article
CAS
PubMed
Google Scholar
Strle F, Nadelman RB, Cimperman J, Nowakowski J, Picken RN, Schwartz I, Maraspin V, Aguero-Rosenfeld ME, Varde S, Lotric-Furlan S, et al. Comparison of culture-confirmed erythema migrans caused by Borrelia burgdorferi sensu stricto in New York state and by Borrelia afzelii in Slovenia. Ann Intern Med. 1999;130(1):32–6.
Article
CAS
PubMed
Google Scholar
Dessau RB, Fingerle V, Gray J, Hunfeld KP, Jaulhac B, Kahl O, Kristoferitsch W, Stanek G, Strle F. The lymphocyte transformation test for the diagnosis of Lyme borreliosis has currently not been shown to be clinically useful. Clin Microbiol Infect. 2014;20(10):O786–7.
Article
CAS
PubMed
Google Scholar
von Baehr V. The lymphocyte transformation test for the diagnosis of Lyme borreliosis could fill a gap in the difficult diagnostics of borreliosis. Clin Microbiol Infect. 2014;20(12):O1155–6.
Article
Google Scholar
von Baehr V. The lymphocyte transformation test for the diagnosis of Lyme borreliosis. Clin Microbiol Infect. 2015;21(3):e22.
Article
Google Scholar
Dessau RB, Fingerle V, Gray J, Hunfeld KP, Jaulhac B, Kristoferitsch W, Stanek G, Strle F. The authors reply to comments on "the lymphocyte transformation test for the diagnosis of Lyme borreliosis has currently not been shown to be clinically useful." Clin Microbiol infect 2014;20:O786-O787. Clin Microbiol Infect. 2015;21(3):e21.
Article
CAS
PubMed
Google Scholar
Rutjes AW, Reitsma JB, Vandenbroucke JP, Glas AS, Bossuyt PM. Case-control and two-gate designs in diagnostic accuracy studies. Clin Chem. 2005;51(8):1335–41.
Article
CAS
PubMed
Google Scholar