Table 4 Data collection and measurements for the observational cohort

Written information and informed consent

X

Baseline characteristics

X

Physical examination

X

Recording LB manifestation, treatment and concomitant medication

X

X

X

X

X

Recording adverse events

X

X

X

X

 B. burgdorferi s.l. serology

X

X

 Spirofind Revised

X

X

 QuantiFERON-LB

X

X

 iSpot Lyme

X

X

 LTT-MELISA

X

X

 CIS1 (subscale fatigue), SF-36 (subscale pain), CFQ

X

X^a

X

X^a

X

 Clinical parameters: PHQ-15, SF-36 (subscale physical functioning and subscale social functioning), TiC-P (health care use and absenteeism of work)

X

X

X

X

X

 Cognitive-behavioral parameters: brief IPQ, CBRSQ, HADS, SES-F, PCS, IPAQ

X

X

X

 Comorbidities: TiC-P (co-morbidity list)

X

X

 Comorbidities: PREDIS

X