Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, Newton C, Winstanley P, Warn P, Peshu N, Pasvol G, Snow R: Indicators of life-threatening malaria in African children. N Engl J Med. 1995, 332 (21): 1399-1404. 10.1056/NEJM199505253322102.
Article
CAS
PubMed
Google Scholar
Hanson J, Lam SW, Mahanta KC, Pattnaik R, Alam S, Mohanty S, Hasan MU, Hossain A, Charunwatthana P, Chotivanich K, Maude RJ, Kingston H, Day NP, Mishra S, White NJ, Dondorp AM: Relative contributions of macrovascular and microvascular dysfunction to disease severity in falciparum malaria. J Infect Dis. 2012, 206 (4): 571-579. 10.1093/infdis/jis400.
Article
PubMed
Google Scholar
MacPherson GG, Warrell MJ, White NJ, Looareesuwan S, Warrell DA: Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Pathol. 1985, 119 (3): 385-401.
CAS
PubMed
PubMed Central
Google Scholar
Silamut K, Phu NH, Whitty C, Turner GD, Louwrier K, Mai NT, Simpson JA, Hien TT, White NJ: A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain. Am J Pathol. 1999, 155 (2): 395-410. 10.1016/S0002-9440(10)65136-X.
Article
CAS
PubMed
PubMed Central
Google Scholar
Taylor TE, Fu WJ, Carr RA, Whitten RO, Mueller JS, Fosiko NG, Lewallen S, Liomba NG, Molyneux ME: Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med. 2004, 10 (2): 143-145. 10.1038/nm986.
Article
CAS
PubMed
Google Scholar
White VA: Malaria in Malawi: inside a research autopsy study of pediatric cerebral malaria. Arch Pathol Lab Med. 2011, 135 (2): 220-226.
PubMed
Google Scholar
Kyriacou HM, Stone GN, Challis RJ, Raza A, Lyke KE, Thera MA, Kone AK, Doumbo OK, Plowe CV, Rowe JA: Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia. Mol Biochem Parasitol. 2006, 150 (2): 211-218. 10.1016/j.molbiopara.2006.08.005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Warimwe GM, Keane TM, Fegan G, Musyoki JN, Newton CR, Pain A, Berriman M, Marsh K, Bull PC: Plasmodium falciparum var gene expression is modified by host immunity. Proc Natl Acad Sci USA. 2009, 106 (51): 21801-21806. 10.1073/pnas.0907590106.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lavstsen T, Turner L, Saguti F, Magistrado P, Rask TS, Jespersen JS, Wang CW, Berger SS, Baraka V, Marquard AM, Seguin-Orlando A, Willerslev E, Gilbert MT, Lusingu J, Theander TG: Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children. Proc Natl Acad Sci USA. 2012, 109 (26): E1791-E1800. 10.1073/pnas.1120455109.
Article
CAS
PubMed
PubMed Central
Google Scholar
Warimwe GM, Fegan G, Musyoki JN, Newton CR, Opiyo M, Githinji G, Andisi C, Menza F, Kitsao B, Marsh K, Bull PC: Prognostic indicators of life-threatening malaria are associated with distinct parasite variant antigen profiles. Sci Transl Med. 2012, 4 (129): 129ra145-
Article
Google Scholar
Bull PC, Kortok M, Kai O, Ndungu F, Ross A, Lowe BS, Newbold CI, Marsh K: Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age. J Infect Dis. 2000, 182 (1): 252-259. 10.1086/315652.
Article
CAS
PubMed
Google Scholar
Nielsen MA, Staalsoe T, Kurtzhals JA, Goka BQ, Dodoo D, Alifrangis M, Theander TG, Akanmori BD, Hviid L: Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity. J Immunol. 2002, 168 (7): 3444-3450.
Article
CAS
PubMed
Google Scholar
Staalsoe T, Nielsen MA, Vestergaard LS, Jensen AT, Theander TG, Hviid L: In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African children. Parasite Immunol. 2003, 25 (8–9): 421-427.
Article
PubMed
Google Scholar
Jensen AT, Magistrado P, Sharp S, Joergensen L, Lavstsen T, Chiucchiuini A, Salanti A, Vestergaard LS, Lusingu JP, Hermsen R, Sauerwein R, Christensen J, Nielsen MA, Hviid L, Sutherland C, Staalsoe T, Theander TG: Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. J Exp Med. 2004, 199 (9): 1179-1190. 10.1084/jem.20040274.
Article
CAS
PubMed
PubMed Central
Google Scholar
Avril M, Tripathi AK, Brazier AJ, Andisi C, Janes JH, Soma VL, Sullivan DJ, Bull PC, Stins MF, Smith JD: A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells. Proc Natl Acad Sci USA. 2012, 109 (26): E1782-E1790. 10.1073/pnas.1120534109.
Article
CAS
PubMed
PubMed Central
Google Scholar
Buckee CO, Recker M: Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparum. PLoS Comput Biol. 2012, 8 (4): e1002451-10.1371/journal.pcbi.1002451.
Article
CAS
PubMed
PubMed Central
Google Scholar
Claessens A, Adams Y, Ghumra A, Lindergard G, Buchan CC, Andisi C, Bull PC, Mok S, Gupta AP, Wang CW, Turner L, Arman M, Raza A, Bozdech Z, Rowe JA: A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells. Proc Natl Acad Sci USA. 2012, 109 (26): E1772-E1781. 10.1073/pnas.1120461109.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ponsford MJ, Medana IM, Prapansilp P, Hien TT, Lee SJ, Dondorp AM, Esiri MM, Day NP, White NJ, Turner GD: Sequestration and microvascular congestion are associated with coma in human cerebral malaria. J Infect Dis. 2012, 205 (4): 663-671. 10.1093/infdis/jir812.
Article
PubMed
Google Scholar
Hollestelle MJ, Donkor C, Mantey EA, Chakravorty SJ, Craig A, Akoto AO, O’Donnell J, van Mourik JA, Bunn J: von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation. Br J Haematol. 2006, 133 (5): 562-569. 10.1111/j.1365-2141.2006.06067.x.
Article
CAS
PubMed
Google Scholar
Tchinda VH, Tadem AD, Tako EA, Tene G, Fogako J, Nyonglema P, Sama G, Zhou A, Leke RG: Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-alpha. Acta Trop. 2007, 102 (1): 20-28. 10.1016/j.actatropica.2007.02.011.
Article
CAS
PubMed
Google Scholar
Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, Piera K, Price RN, Duffull SB, Celermajer DS, Anstey NM: Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc Natl Acad Sci USA. 2008, 105 (44): 17097-17102. 10.1073/pnas.0805782105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lovegrove FE, Tangpukdee N, Opoka RO, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC, Kain KC: Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One. 2009, 4 (3): e4912-10.1371/journal.pone.0004912.
Article
PubMed
PubMed Central
Google Scholar
Amaratunga C, Lopera-Mesa TM, Brittain NJ, Cholera R, Arie T, Fujioka H, Keefer JR, Fairhurst RM: A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. PLoS One. 2011, 6 (4): e14798-10.1371/journal.pone.0014798.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fairhurst RM, Bess CD, Krause MA: Abnormal PfEMP1/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into malaria pathogenesis and protection. Microbes Infect. 2012, 14 (10): 851-862. 10.1016/j.micinf.2012.05.006.
Article
CAS
PubMed
PubMed Central
Google Scholar
Conroy AL, Glover SJ, Hawkes M, Erdman LK, Seydel KB, Taylor TE, Molyneux ME, Kain KC: Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*. Crit Care Med. 2012, 40 (3): 952-959. 10.1097/CCM.0b013e3182373157.
Article
CAS
PubMed
PubMed Central
Google Scholar
Birbeck GL, Beare N, Lewallen S, Glover SJ, Molyneux ME, Kaplan PW, Taylor TE: Identification of malaria retinopathy improves the specificity of the clinical diagnosis of cerebral malaria: findings from a prospective cohort study. Am J Trop Med Hyg. 2010, 82 (2): 231-234. 10.4269/ajtmh.2010.09-0532.
Article
PubMed
PubMed Central
Google Scholar
Moxon CA, Wassmer SC, Milner DA, Chisala NV, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Esmon CT, Downey C, Toh CH, Craig AG, Heyderman RS: Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood. 2013, 122 (5): 842-851. 10.1182/blood-2013-03-490219.
Article
CAS
PubMed
PubMed Central
Google Scholar
Turner L, Lavstsen T, Berger SS, Wang CW, Petersen JE, Avril M, Brazier AJ, Freeth J, Jespersen JS, Nielsen MA, Magistrado P, Lusingu J, Smith JD, Higgins MK, Theander TG: Severe malaria is associated with parasite binding to endothelial protein C receptor. Nature. 2013, 498 (7455): 502-505. 10.1038/nature12216.
Article
CAS
PubMed
PubMed Central
Google Scholar
Berkley JA, Mwangi I, Mellington F, Mwarumba S, Marsh K: Cerebral malaria versus bacterial meningitis in children with impaired consciousness. QJM. 1999, 92 (3): 151-157. 10.1093/qjmed/92.3.151.
Article
CAS
PubMed
Google Scholar
English M, Waruiru C, Amukoye E, Murphy S, Crawley J, Mwangi I, Peshu N, Marsh K: Deep breathing in children with severe malaria: indicator of metabolic acidosis and poor outcome. Am J Trop Med Hyg. 1996, 55 (5): 521-524.
CAS
PubMed
Google Scholar
Bull PC, Berriman M, Kyes S, Quail MA, Hall N, Kortok MM, Marsh K, Newbold CI: Plasmodium falciparum variant surface antigen expression patterns during malaria. PLoS Pathog. 2005, 1 (3): e26-10.1371/journal.ppat.0010026.
Article
PubMed
PubMed Central
Google Scholar
Kirchgatter K, Portillo Hdel A: Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residues. Mol Med. 2002, 8 (1): 16-23.
CAS
PubMed
PubMed Central
Google Scholar
Bull PC, Buckee CO, Kyes S, Kortok MM, Thathy V, Guyah B, Stoute JA, Newbold CI, Marsh K: Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks. Mol Microbiol. 2008, 68 (6): 1519-1534. 10.1111/j.1365-2958.2008.06248.x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA: Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986, 137 (1): 245-254.
CAS
PubMed
Google Scholar
Weibel ER, Palade GE: New Cytoplasmic Components in Arterial Endothelia. J Cell Biol. 1964, 23: 101-112. 10.1083/jcb.23.1.101.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cramer EM, Meyer D, le Menn R, Breton-Gorius J: Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies. Blood. 1985, 66 (3): 710-713.
CAS
PubMed
Google Scholar
Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG: The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood. 2004, 103 (11): 4150-4156. 10.1182/blood-2003-10-3685.
Article
CAS
PubMed
Google Scholar
Metcalf DJ, Nightingale TD, Zenner HL, Lui-Roberts WW, Cutler DF: Formation and function of Weibel-Palade bodies. J Cell Sci. 2008, 121 (Pt 1): 19-27.
Article
CAS
PubMed
Google Scholar
Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP: Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 2006, 3 (3): e46-10.1371/journal.pmed.0030046.
Article
PubMed
PubMed Central
Google Scholar
Dondorp AM, Desakorn V, Pongtavornpinyo W, Sahassananda D, Silamut K, Chotivanich K, Newton PN, Pitisuttithum P, Smithyman AM, White NJ, Day NP: Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med. 2005, 2 (8): e204-10.1371/journal.pmed.0020204.
Article
PubMed
PubMed Central
Google Scholar
Seydel KB, Fox LL, Glover SJ, Reeves MJ, Pensulo P, Muiruri A, Mpakiza A, Molyneux ME, Taylor TE: Plasma concentrations of parasite histidine-rich protein 2 distinguish between retinopathy-positive and retinopathy-negative cerebral malaria in Malawian children. J Infect Dis. 2012, 206 (3): 309-318. 10.1093/infdis/jis371.
Article
CAS
PubMed
PubMed Central
Google Scholar
Beare NA, Lewallen S, Taylor TE, Molyneux ME: Redefining cerebral malaria by including malaria retinopathy. Future Microbiol. 2011, 6 (3): 349-355. 10.2217/fmb.11.3.
Article
PubMed
PubMed Central
Google Scholar
Avril M, Brazier AJ, Melcher M, Sampath S, Smith JD: DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells. PLoS Pathog. 2013, 9 (6): e1003430-10.1371/journal.ppat.1003430.
Article
CAS
PubMed
PubMed Central
Google Scholar
Janes JH, Wang CP, Levin-Edens E, Vigan-Womas I, Guillotte M, Melcher M, Mercereau-Puijalon O, Smith JD: Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family. PLoS Pathog. 2011, 7 (5): e1002032-10.1371/journal.ppat.1002032.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ochola LB, Siddondo BR, Ocholla H, Nkya S, Kimani EN, Williams TN, Makale JO, Liljander A, Urban BC, Bull PC, Szestak T, Marsh K, Craig AG: Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. PLoS One. 2011, 6 (3): e14741-10.1371/journal.pone.0014741.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bengtsson A, Joergensen L, Rask TS, Olsen RW, Andersen MA, Turner L, Theander TG, Hviid L, Higgins MK, Craig A, Brown A, Jensen AT: A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies. J Immunol. 2013, 190 (1): 240-249. 10.4049/jimmunol.1202578.
Article
CAS
PubMed
Google Scholar
Berendt AR, Simmons DL, Tansey J, Newbold CI, Marsh K: Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature. 1989, 341 (6237): 57-59. 10.1038/341057a0.
Article
CAS
PubMed
Google Scholar
Tripathi AK, Sha W, Shulaev V, Stins MF, Sullivan DJ: Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium. Blood. 2009, 114 (19): 4243-4252. 10.1182/blood-2009-06-226415.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tripathi AK, Sullivan DJ, Stins MF: Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers. J Infect Dis. 2007, 195 (7): 942-950. 10.1086/512083.
Article
PubMed
Google Scholar
Zougbede S, Miller F, Ravassard P, Rebollo A, Ciceron L, Couraud PO, Mazier D, Moreno A: Metabolic acidosis induced by Plasmodium falciparum intraerythrocytic stages alters blood-brain barrier integrity. J Cereb Blood Flow Metab. 2011, 31 (2): 514-526. 10.1038/jcbfm.2010.121.
Article
CAS
PubMed
Google Scholar
Chiwakata CB, Hort G, Hemmer CJ, Dietrich M: Sera from patients with falciparum malaria induce substance P gene expression in cultured human brain microvascular endothelial cells. Infect Immun. 1996, 64 (12): 5106-5110.
CAS
PubMed
PubMed Central
Google Scholar
Hendriksen IC, Mwanga-Amumpaire J, von Seidlein L, Mtove G, White LJ, Olaosebikan R, Lee SJ, Tshefu AK, Woodrow C, Amos B, Karema C, Saiwaew S, Maitland K, Gomes E, Pan-Ngum W, Gesase S, Silamut K, Reyburn H, Joseph S, Chotivanich K, Fanello CI, Day NP, White NJ, Dondorp AM: Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement. PLoS Med. 2012, 9 (8): e1001297-10.1371/journal.pmed.1001297.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ochola LB, Marsh K, Lowe B, Gal S, Pluschke G, Smith T: Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers. Parasitology. 2005, 131 (Pt 4): 449-458.
Article
CAS
PubMed
Google Scholar
Day NP, Phu NH, Mai NT, Chau TT, Loc PP, Chuong LV, Sinh DX, Holloway P, Hien TT, White NJ: The pathophysiologic and prognostic significance of acidosis in severe adult malaria. Crit Care Med. 2000, 28 (6): 1833-1840. 10.1097/00003246-200006000-00025.
Article
CAS
PubMed
Google Scholar
Dondorp AM, Ince C, Charunwatthana P, Hanson J, van Kuijen A, Faiz MA, Rahman MR, Hasan M, Bin Yunus E, Ghose A, Ruangveerayut R, Limmathurotsakul D, Mathura K, White NJ, Day NP: Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J Infect Dis. 2008, 197 (1): 79-84. 10.1086/523762.
Article
CAS
PubMed
Google Scholar
Beare NA, Harding SP, Taylor TE, Lewallen S, Molyneux ME: Perfusion abnormalities in children with cerebral malaria and malarial retinopathy. J Infect Dis. 2009, 199 (2): 263-271. 10.1086/595735.
Article
PubMed
PubMed Central
Google Scholar