| |
A: impaired consciousness
|
B: cerebral malaria
|
|---|
|
Models
|
Explanatory variables
|
OR (95% CI)
|
P value
|
OR (95% CI)
|
P value
|
|---|
|
1$
|
Group A-like
|
4.5(1.7,11.4)
|
0.002
|
2.97(1.14, 7.76)
|
0.026
|
|
2
|
ang-2
|
3.0(1.9, 4.7)
|
0.000002
|
2.52(1.57, 4.03)
|
0.00012
|
|
3$
|
Parasite density (peripheral)
|
1.37(1.12, 1.67)
|
0.002
|
1.46(1.16, 1.84)
|
0.001
|
|
4
|
PfHRP2
|
1.34(1.13, 1.60)
|
0.001
|
1.43(1.17, 1.74)
|
0.0004
|
|
5$
|
IE surface antibodies
|
0.96(0.94, 0.98)
|
0.00002
|
0.96(0.94, 0.99)
|
0.001
|
|
6
|
Group A-like
|
3.5(1.32, 9.44)
|
0.012‡
|
2.3(0.84,6.33)
|
0.1
|
|
ang-2
|
2.82(1.78, 4.46)
|
0.000009‡
|
2.38(1.48, 3.82)
|
0.0003‡
|
|
7$
|
Group A-like
|
2.3(0.86, 6.3)
|
0.097
|
1.73(0.63, 4.77)
|
0.3
|
|
IE surface antibodies
|
0.96(0.94, 0.98)
|
0.0001‡
|
0.97(0.95, 0.99)
|
0.003‡
|
|
8
|
ang-2
|
2.87(1.76, 4.66)
|
0.00002‡
|
2.35(1.43, 3.85)
|
0.001‡
|
|
IE surface antibodies
|
0.96(0.94, 0.98)
|
0.00007‡
|
0.97(0.95, 0.99)
|
0.003‡
|
|
9$
|
Group A-like
|
4.15(1.6, 10.7)
|
0.003‡
|
2.65(0.99, 7.08)
|
0.05
|
|
Parasite density (peripheral)
|
1.3(1.1, 1.65)
|
0.005‡
|
1.43(1.14, 1.81)
|
0.002‡
|
|
10
|
Group A-like
|
4.24(1.6, 11.21)
|
0.004‡
|
2.68( 0.98,7.37)
|
0.05
|
| |
PfHRP2
|
1.32(1.12, 1.57)
|
0.001‡
|
1.40(1.15, 1.71)
|
0.001‡
|
|
11
|
ang-2
|
2.7(1.7, 4.3)
|
0.00005‡
|
2.17(1.33, 3.53)
|
0.002‡
|
|
Parasite density (peripheral)
|
1.21(0.97, 1.5)
|
0.09
|
1.32(1.04, 1.68)
|
0.023‡
|
|
12
|
ang-2
|
2.6(1.60, 4.24)
|
0.005‡
|
2.07(1.24, 3.44)
|
0.005‡
|
| |
PfHRP2
|
1.18(0.98, 1.41)
|
0.080
|
1.28(1.04,1.58)
|
0.019‡
|
- The analysis in this table considers the outcomes IC and CM as factors, which means non-IC/CM severe cases are included in the control group and hence the analysis is conservative. The association of group A-like with impaired consciousness is independent of ang-2 (model 6). Similarly the IE surface antibodies and ang-2 show independent association with impaired consciousness (Model 8A, compare with model 7A). In Model 6B, the association of group A-like expression with CM is not statistically significant when ang-2 was considered. However, the odd ratios of both the unadjusted and ang-2 adjusted are similar in magnitude and direction. $ indicate models that have been published in [8, 10] and repeated here for comparison. ‡ = variables that improved the fit of the model using LR χ2 improvement test. PfHRP2 data was obtained for 207 out of the 213 samples.
