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Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis

BMC Infectious Diseases volume 23, Article number: 305 (2023) Cite this article

Abstract

Background

Although there is increasing understanding of the changes in the laboratory parameters of Coronavirus disease 2019 (COVID-19), the correlation between circulating Mid-regional Proadrenomedullin (MR-proADM) and mortality of patients with COVID-19 is not fully understood. In this study, we conducted a systematic review and meta-analysis to evaluate the prognostic value of MR-proADM in patients with COVID-19.

Methods

The PubMed, Embase, Web of Science, Cochrane Library, Wanfang, SinoMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched from 1 January 2020 to 20 March 2022 for relevant literature. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to assess quality bias, STATA was employed to pool the effect size by a random effects model, and potential publication bias and sensitivity analyses were performed.

Results

14 studies comprising 1822 patients with COVID-19 met the inclusion criteria, there were 1145 (62.8%) males and 677 (31.2%) females, and the mean age was 63.8 ± 16.1 years. The concentration of MR-proADM was compared between the survivors and non-survivors in 9 studies and the difference was significant (P < 0.01), I2 = 46%. The combined sensitivity was 0.86 [0.73–0.92], and the combined specificity was 0.78 [0.68–0.86]. We drew the summary receiver operating characteristic (SROC) curve and calculated the area under curve (AUC) = 0.90 [0.87–0.92]. An increase of 1 nmol/L of MR-proADM was independently associated with a more than threefold increase in mortality (odds ratio (OR) 3.03, 95% confidence interval (CI) 2.26–4.06, I2 = 0.0%, P = 0.633). The predictive value of MR-proADM for mortality was better than many other biomarkers.

Conclusion

MR-proADM had a very good predictive value for the poor prognosis of COVID-19 patients. Increased levels of MR-proADM were independently associated with mortality in COVID-19 patients and may allow a better risk stratification.

Peer Review reports

Introduction

Coronavirus disease-19 (COVID-19) is a clinical syndrome caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The COVID-19 pandemic spread rapidly with more than 535 million cases and 6.3 million deaths. COVID-19 is a global problem and a significant cause of death. Therefore, accurate evaluation of patients’ prognosis is very important. Many inflammatory markers [1,2,3,4,5] and critical illness scores [6,7,8,9,10] are used to predict the prognosis and mortality of patients with COVID-19 infection.

The emergence of an increasing number of biomarkers may provide a new way to improve the accuracy of prognosis simply and quickly. Mid-regional Proadrenomedullin (MR-proADM) is a peptide produced by multiple tissues that is used to stabilize microcirculation and protect endothelial function [11,12,13,14]. Previous studies have shown that with the deterioration of microcirculation integrity and capillary leakage, the concentration of MR-proADM increases, reflecting the early development stage of organ dysfunction [14, 15]. Therefore, early evaluation of microcirculation function may provide a valuable tool to evaluate disease progression and treatment effect [15].

Some studies were devoted to investigate the relationship between MR- proADM and the outcome of patients with COVID-19 [16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33]. However, their sample sizes were small, and the conclusions were inconsistent. Using a meta-analytic method, the aim of the present study was to provide an overview of the concentration of the MR-proADM between the survivors and non-survivors and to explore the predictive value of the MR-proADM for the mortality of the hospitalized patients with COVID-19.

Methods

This meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [34]. The review protocol was registered on PROSPERO (CRD42022308638).

Search strategy

The systematic literature search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, Wanfang, SinoMed and Chinese National Knowledge Infrastructure (CNKI) for studies published from 1 January 2020 to 20 March 2022. The following search terms were used: “MR-proADM” OR “MR-pro-adrenomedullin” OR “midregional pro-adrenomedullin” OR “MR-pro-ADM” and “COVID-19” OR “SARS-CoV-2 Infection” OR “2019 Novel Coronavirus Disease” OR “2019 Novel Coronavirus Infection” OR “2019-nCoV Disease”. There was no restriction on the language of the records. See Fig. 1 for details.

Fig. 1
figure 1

Research screening flowchart

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Selection and eligibility criteria

All prospective and retrospective studies of MR-proADM and outcomes in patients with COVID-19 were included, and there were no restrictions on age, sex, setting of treatment, severity of disease, sample size, etc. Death was the primary endpoint, and studies that did not include death outcomes were excluded.

Data extraction

Two authors independently extracted data into a standardized data collection form. Discrepancies were resolved by a third party. The following data were extracted from each study: first author, publication year, country, study period, study design, setting, population, number, age, male ratio, clinical outcomes, levels of MR-proADM, mortality rate, AUC for death, cut-off value, sensitivity and specificity. See additional files for detail.

Risk of bias assessment

The quality of the included studies was assessed by two independent assessors using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) which consists of four key domains: patient selection, index test, reference standard and flow and timing (Fig. 2). Each was assessed in terms of risk of bias and the first three in terms of concerns regarding applicability. Signaling questions were included to assist in judgements about the risk of bias.

Fig. 2
figure 2

Assessment of risk of bias for the studies

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Data synthesis and statistical analysis

The main analysis was to determine the predictive ability of MR-proADM on COVID-19 mortality. The mean and standard deviation (SD) of the MR-proADM values were included in the pooled analysis. A random model was used to calculate and separately pool the concentration of MR-proADM in the survivors and non-survivors, and the weighted mean difference (WMD) and 95% confidence interval (95% CI) of survivors and non-survivors were estimated. When the mean and standard deviation could not be obtained, conversion calculations were carried out according to the sample size, median and interquartile range (IQR) as suggested by Hozo et al. [35].

The heterogeneity between the different studies was presented as I2 and P values for the I2 statistic were derived from the chi-square distribution of Cochran’s Q test. The standard for the category of heterogeneity was defined as I2 > 50%. We used STATA 16.0 to calculate the sensitivity and specificity of MR-proADM and performed the summary receiver operating characteristic (SROC) curve of MR-proADM for mortality. Public bias was examined by Egger’s test.

All statistical analyses were performed using RevMan version 5.4 (the Cochrane Collaboration) and STATA 16.0 software (StataCorp, College Station, Texas, USA). P values less than 0.05 were considered statistically significant.

Results

Literature search

We found 83 relevant studies from seven databases, Medline (21), Embase (37), Web of Science (18), Wanfang (7) and the other three databases contain zero records. Endnote software was used to delete duplications, and 37 articles remained. By checking the titles and abstracts, another 20 articles were excluded. Three of the remaining 17 articles did not meet the inclusion criteria, and finally 14 articles were ultimately included. The literature search and selection process are depicted in the PRISMA flow diagram (Fig. 1).

The included studies were published between 2021 and 2022. We looked for an association between MR-proADM and the mortality of patients with COVID-19. A total of 1822 patients met the inclusion criteria, including 1145 (62.8%) males and 677 (31.2%) females, aged 63.8 ± 16.1 years. Eight of the studies were from Italy, three were from Spain and others were from the Netherlands, Switzerland and United Kingdom. Three studies were conducted in hospital settings, three in the intensive care unit (ICU), three in the emergency department, one in a COVID center, one in an intermediate medical care unit (IMCU), one in a medium intensity-of-care COVID-19 department, one in an acute national health service (NHS) setting and the remaining study site was not determined. Nine studies used a prospective study design, and five studies were retrospective studies. Of these studies, 12 were single-center studies and two were multicenter studies. Three studies reported 28-day mortality, six reported in-hospital mortality, four reported 30-day mortality and one reported 90-day mortality. We summarized the characteristics of the included studies in Supplementary Tables 1, 2, 3.

Meta-analysis of the effects of MR-proADM on mortality

Of 14 studies, 10 studies described the specific concentration of MR-proADM in the survivors and non-survivors. Therefore, the concentration of MR-proADM was compared between the survivors and non-survivors in 10 studies and the difference was significant (P < 0.01), I2 = 79%. Due to the obvious heterogeneity, we looked for the source of heterogeneity and found that after removing the first study [24], the heterogeneity of the results decreased significantly. Finally, nine studies were included, and there was a significant difference in the concentration of MR- proADM between the survivors and the non-survivors (P < 0.01), I2 = 46% (Fig. 3). STATA was used to calculate the combined sensitivity and specificity, the combined sensitivity was 0.86 [0.73–0.92], I2 = 51.47%, and the combined specificity was 0.78 [0.68–0.86], I2 = 92.95% (Fig. 4).

Fig. 3
figure 3

Forest plots showing WMD with 95% CI for the concentration of MR-proADM Comparing survivors and non-survivors in a random-effect model. CI, confidence interval; WMD, weighted mean difference

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Fig. 4
figure 4

Forest plot of the sensitivity and specificity of MR- proADM to predict mortality in COVID-19 patients. CI, confidence interval

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To evaluate the predictive ability of MR- proADM for the mortality of patients with COVID-19, we drew the SROC curve, and calculated the AUC = 0.90 [0.87–0.92] (Fig. 5).

Fig. 5
figure 5

Summary receiver operating characteristics (SROC) curve for the included studies. SENS, sensitivity; SPEC, specificity; AUC, area under the curve

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Odds ratios (OR) and hazard ratios (HR)

We calculated an overall mortality rate of 19.0% (347/1822) for all studies, ranging from 7.2 to 54.4%. Seven studies used OR to indicate that MR-proADM was associated with mortality, and the pooled OR was 3.03 (2.26–4.06), which means that an increase of 1 nmol/L of MR-proADM was independently associated with a more than threefold increase in mortality. There was no significant heterogeneity between these studies (I2 = 0.0%, P = 0.633) (Fig. 6). Four studies used HR as an effect measure, and the pooled HR was 5.40 (1.82–16.06). Significant heterogeneity was observed (I2 = 84.0%, P = 0.000) (Fig. 6). Both of them indicated that MR-proADM can be an independent predictor for mortality among patients with COVID-19.

Fig. 6
figure 6

Effect size analysis for mortality in COVID-19 patients with MR-proADM elevation

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Comparation with other biomarkers and critical illness scores

Some studies compared the area under the curve (AUC) of MR-proADM with other biomarkers and critical illness scores. The predictive value of MR-proADM for mortality was better than the Sequential Organ Failure Assessment (SOFA) score, Acute Physiological and Chronic Health Evaluation IV (APACHE IV), Confusion blood Urea nitrogen Respiratory rate Blood pressure age 65 or older (CURB-65) score, D-dimer, cardiac troponin T (cTNT), C-reactive protein (CRP), procalcitonin (PCT), ferritin, lactate and C-terminal proendothelin-1 (CT-proET-1) [33]. Another study found that the AUC of MR-proADM was greater than those of PCT, creatinine, albumin, platelet count, interleukin-6 (IL-6) and lymphocyte count [19]. The study of Benedetti showed that its predictive power was stronger than SOFA and Simplified Acute Physiology Score II (SAPS II), but weaker than the Acute Physiology and Chronic Health Evaluation II (APACHE II) score [17]. MR-proADM was superior to CRP, PCT, neutrophils, lymphocytes [27] and many other biomarkers [18]. However, only a few studies indicated the sensitivity and specificity, and we could not calculate the combined effect of each item.

Sensitivity analysis and potential publication bias

Begg’s test was used to assess for publication bias, and the results showed no potential bias (P = 0.965) (Fig. 7). We also conducted a sensitivity analysis, and the results indicated that our study was stable (Fig. 8).

Fig. 7
figure 7

Begg’s test for publication bias

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Fig. 8
figure 8

Sensitivity analysis of the mortality in COVID-19 patients with MR-proADM elevation

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Discussion

Using a meta-analytic approach, we systematically reviewed and analyzed the contribution of MR-proADM to mortality in COVID-19 patients. In this study, we found that MR-proADM had a very good predictive value for the poor prognosis of COVID-19 patients. Increased levels of MR-proADM were independently associated with mortality in COVID-19 patients. These findings also confirm the feasibility of risk stratification by MR-proADM in COVID-19 patients.

COVID-19 patients have a high mortality rate. The mortality rate of in-hospital patients was 12.44% [36], that of ICU patients was 26% [37], and that of patients with acute respiratory distress syndrome (ARDS) was 50% [38]. The study population we included had different severities of illness, and the overall mortality rate was 19%. Many studies have used various biomarkers, such as CRP [39,40,41,42,43,44], PCT [39, 43, 45, 46], IL-6 [39, 43, 46], WBC [40, 47,48,49], D-dimer [42, 44, 46, 50, 51], lactate dehydrogenase (LDH) [39, 42,43,44, 46, 47], N-terminal pro-B-type natriuretic peptide (NT-proBNP) [39, 52, 53], and Troponin T [39, 54], and critical illness scores, such as APACHE II [55,56,57], SOFA [55, 56, 58,59,60], SAPS [61,62,63,64], and CURB65 [59, 61, 65], to evaluate the prognosis of patients with COVID-19. The APACHE II and SOFA scoring systems require the worst values of the clinical and biological parameters to be recorded within 24 h of admission [66]. In contrast, biomarkers can be measured rapidly within hours of the admission. WBC, CRP and IL-6 have a lack of specificity, and PCT is mainly used to determine if a bacterial infection is present and to guide the use of antibiotics [67].

Adrenomedullin (ADM) is a 52 amino acid peptide hormone that is associated with cardiovascular, endocrine and renal mechanisms regulating water and electrolyte balance [68]. ADM can reduce the permeability of capillaries during septic shock [11], and plays an important role in the regulation of inflammatory mediators, vascular endothelial barrier and microcirculation stability [11, 69]. Because of the rapid degradation and clearance of ADM in the cycle, the measurement of ADM in the cycle becomes complex [70]. Meanwhile, MR-proADM has a longer half-life and is relatively stable in the circulation, which can directly reflect the level of rapidly degraded active ADM peptide. It has been shown that measuring MR-proADM is more suitable for clinical practice [71].

In fact, patients with decreasing PCT concentrations but continuously high MR-proADM concentrations had a significantly increased mortality risk [72], and MR-proADM had an important role in predicting the development of organ failure over 24 h [73], suggesting that MR-proADM may have important clinical value in the early risk stratification of patients with sepsis. Recent studies have proposed that virus-induced endothelial dysfunction and damage, resulting in impaired vascular blood flow, coagulation and leakage, may partially explain the development of organ dysfunction [74, 75]. Another study showed that myocardial injury induced by SARS-CoV-2 is strongly associated with high MR-proADM values and mortality [76]. The assessment of MR-proADM may provide vital information to explain the pathophysiological mechanisms of vascular endothelial injury and subsequent organ dysfunction in patients with COVID-19.

Our study found that there was a significant difference in the concentration of MR-proADM between the survivors and the non-survivors (P < 0.01), the combined sensitivity was 0.86, and the combined specificity was 0.78. These findings are consistent with those of prior studies [72, 77, 78]. MR-proADM may be a good predictive marker for the prognosis of patients. Our data indicated that an increase of 1 nmol/L of MR-proADM was independently associated with a more than threefold increase in mortality (OR 3.03, 95% CI 2.26–4.06). In another meta-analysis, all of included studies showed that an elevated MR-proADM level was associated with higher risk of death from community-acquired pneumonia, the pooled RR was 5.83 (95% CI 4.53–7.52) [79]. In addition, PCT and MR-proADM test combination presents a high positive predictive value in pneumonia diagnosis and prognosis [80]. Furthermore, MR pro-ADM value provides additional information for better risk stratification especially for patients with high pneumonia severity score [81]. In a recent narrative review [82], directly testing for MR-proADM in the emergency department could contribute to improving the prognostic assessment of patients with sepsis. Spoto et al. [83] conducted a retrospective analysis of MR-proADM in 571 consecutive patients with sepsis and found that MR-proADM cut-off values > 3.39 nmol/L in sepsis and > 4.33 nmol/L in septic shock were associated with a significantly higher risk of 90-day mortality. These findings confirm that MR pro-ADM is a prognostic tool that can guide clinicians to develop more personalized treatment for patients.

Our study showed that MR-proADM was superior to most biomarkers and critical illness scores in predicting the prognosis of COVID-19 patients [17,18,19, 27, 33]. However, few of them indicated the sensitivity and specificity, and we could not calculate the combined effect of each item. A recent study [84] evaluated the usefulness of MR-proADM compared to CRP, PCT, and ferritin in the prognosis of influenza A (H1N1) pneumonia, and found that the initial MR-proADM, ferritin, CRP, and PCT levels effectively determined adverse outcomes and risk of ICU admission and mortality in patients with influenza virus pneumonia. MR-proADM has the highest potency for survival prediction (AUC = 0.853, P < 0.0001). The recently published TRIAGE study [85] is a multinational, prospective, observational cohort study that included consecutive medical patients presenting with a medical urgency at three tertiary-care hospitals. A total of 7,132 patients were included in the final analysis. The study found that MR-proADM was the best biomarker, especially for mortality prediction. Another study [72] indicated that the initial use of MR-proADM within the first 24 h after sepsis diagnosis resulted in the strongest association with short-term, mid-term and long-term mortality compared to all other biomarkers or clinical scores. Other studies also yielded similar results [86, 87]. Recently, a meta-analysis suggested that MR-proADM testing alone is poor at identifying invasive bacterial infections in young children [88], which may be related to the population under study, the measurement time and other factors. In addition, it may be more meaningful to determine the time trend of MR-proADM levels in septic patients with pulmonary infection [77].

There are some limitations in our study. First, selection bias and information bias are easily generated because of the observational design and different research locations. Second, there was considerable heterogeneity in some analyses, mainly due to the significant differences in the baseline patient characteristics. Third, converting the median to an average also affects our results. Due to the limited number of articles included, our analysis results may not be accurate, and more studies need to be included for verification in the future.

Conclusions

MR-proADM was associated with mortality in patients with COVID-19, and risk assessment using MR-proADM allows clinicians to identify patients with COVID-19 who are at higher risk of adverse clinical outcomes.

Data availability

The data that support the findings of this study are included in this published article and its supplementary material.

Abbreviations

COVID-19:

coronavirus disease 2019

SARS-CoV-2:

Severe Acute Respiratory Syndrome Coronavirus 2

MR-proADM:

Mid-regional Proadrenomedullin

PRISMA:

the Preferred Reporting Items for Systematic Reviews and Meta-Analyses

CNKI:

Chinese National Knowledge Infrastructure

QUADAS-2:

The Quality Assessment of Diagnostic Accuracy Studies

SD:

standard deviation

WMD:

weighted mean difference

CI:

confidence interval

IQR:

interquartile range

ICU:

intensive care unit

IMCU:

intermediate medical care unit

NHS:

national health service

AUC:

the area under the curve

SOFA:

the Sequential Organ Failure Assessment

APACHEIV:

Acute Physiological and Chronic Health Evaluation IV

CURB-65:

Confusion blood Urea nitrogen Respiratory rate Blood pressure age 65 or older

cTNT:

cardiac troponin T

CRP:

C-reactive protein

PCT:

procalcitonin

CT-proET-1:

C-terminal proendothelin-1

IL-6:

interleukin-6

SAPS II:

Simplified Acute Physiology Score II

APACHE II:

the Acute Physiology and Chronic Health Evaluation II score

ARDS:

acute respiratory distress syndrome

LDH:

lactate dehydrogenase

NT-proBNP:

N-terminal pro-B-type natriuretic peptide

ADM:

Adrenomedullin

References

  1. Regolo M, Vaccaro M, Sorce A, Stancanelli B, Colaci M, Natoli G, et al. Neutrophil-to-lymphocyte ratio (NLR) is a promising predictor of mortality and admission to Intensive Care Unit of COVID-19 patients. J Clin Med. 2022;11(8):2235.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Abrishami A, Eslami V, Arab-Ahmadi M, Alahyari S, Azhideh A, Sanei-Taheri M. Prognostic value of inflammatory biomarkers for predicting the extent of lung involvement and final clinical outcome in patients with COVID-19. J Res Med Sci. 2021;26:115.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Menez S, Moledina DG, Thiessen-Philbrook H, Wilson FP, Obeid W, Simonov M, et al. Prognostic significance of urinary biomarkers in patients hospitalized with COVID-19. Am J Kidney Dis. 2022;79(2):257–267e1.

    Article  CAS  PubMed  Google Scholar 

  4. Donoso-Navarro E, Arribas Gómez I, Bernabeu-Andreu FA. IL-6 and other biomarkers associated with poor prognosis in a cohort of hospitalized patients with COVID-19 in Madrid. Biomark Insights. 2021;16:11772719211013363.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Twe CW, Khoo DKY, Law KB, Nordin NSBA, Sathasivan S, Lim KC, et al. The role of procalcitonin in predicting risk of mechanical ventilation and mortality among moderate to severe COVID-19 patients. BMC Infect Dis. 2022;22(1):378.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Beigmohammadi MT, Amoozadeh L, Motlagh FR, Rahimi M, Maghsoudloo M, Jafarnejad B, et al. Mortality predictive value of APACHE II and SOFA Scores in COVID-19 patients in the Intensive Care Unit. Can Respir J. 2022;2022:5129314.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Giamarellos-Bourboulis EJ, Poulakou G, de Nooijer A, Milionis H, Metallidis S, Ploumidis M, et al. Development and validation of SCOPE score: a clinical score to predict COVID-19 pneumonia progression to severe respiratory failure. Cell Rep Med. 2022;3(3):100560.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Peruzzo MB, Requião-Moura L, Nakamura MR, Viana L, Cristelli M, Silva HT et al. Predictive ability of severity scores and outcomes for mortality in kidney transplant recipients with coronavirus disease 2019 admitted to the intensive care unit: results from a Brazilian single-center cohort study. J Bras Nefrol. 2022; S0101–28002022005008401.

  9. Surme S, Tuncer G, Bayramlar OF, Copur B, Zerdali E, Nakir IY, et al. Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients. Biomark Med. 2022;16(8):577–88.

    Article  CAS  PubMed  Google Scholar 

  10. Citu C, Gorun F, Motoc A, Ratiu A, Gorun OM, Burlea B, et al. Evaluation and comparison of the predictive value of 4 C mortality score, NEWS, and CURB-65 in poor outcomes in COVID-19 patients: a retrospective study from a single Center in Romania. Diagnostics (Basel). 2022;12(3):703.

    Article  CAS  PubMed  Google Scholar 

  11. Temmesfeld-Wollbruck B, Brell B, David I, Dorenberg M, Adolphs J, Schmeck B, et al. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Intensive Care Med. 2007;33(4):703–10.

    Article  PubMed  Google Scholar 

  12. Muller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, et al. Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin. Crit Care. 2014;18(2):R73.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Carrizo GJ, Wu R, Cui X, Dwivedi AJ, Simms HH, Wang P. Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Surgery. 2007;141(2):245–53.

    Article  PubMed  Google Scholar 

  14. Vigue B, Leblanc PE, Moati F, Pussard E, Foufa H, Rodrigues A, et al. Mid-regional pro-adrenomedullin (MR- proADM), a marker of positive fluid balance in critically ill patients: results of the ENVOL study. Crit Care. 2016;20(1):363.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Xie Z, Chen WS, Yin Y, Chan EC, Terai K, Long LM, et al. Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease). J Leukoc Biol. 2018;103(4):749–59.

    Article  CAS  PubMed  Google Scholar 

  16. Zaninotto M, Mion MM, Marchioro L, Padoan A, Plebani. Endothelial dysfunction and mid-regional proAdrenomedullin: what role in SARS-CoV-2 infected patients? Clin Chim Acta. 2021;523:185–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Benedetti I, Spinelli D, Callegari T, Bonometti R, Molinaro E, Novara E, et al. High levels of mid-regional proadrenomedullin in ARDS COVID-19 patients: the experience of a single, italian Center. Eur Rev Med Pharmacol Sci. 2021;25(3):1743–51.

    CAS  PubMed  Google Scholar 

  18. García de Guadiana-Romualdo L, Calvo Nieves MD, Rodríguez Mulero MD, Calcerrada Alises I, Hernández Olivo M, Trapiello Fernández W, et al. MR-proADM as marker of endotheliitis predicts COVID-19 severity. Eur J Clin Invest. 2021;51(5):e13511.

    Article  PubMed  PubMed Central  Google Scholar 

  19. García de Guadiana-Romualdo L, Martínez Martínez M, Rodríguez Mulero MD, Esteban-Torrella P, Hernández Olivo M, Alcaraz García MJ, et al. Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients. Int J Infect Dis. 2021;111:211–8.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Gregoriano C, Koch D, Kutz A, Haubitz S, Conen A, Bernasconi L, et al. The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study. Clin Chem Lab Med. 2021;59(5):995–1004.

    Article  CAS  PubMed  Google Scholar 

  21. Honore PM, Redant S, Moorthamers S, Preseau T, Kaefer K, Barreto Gutierrez L, et al. MR-proADM has a good ability to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia: beware of some potential confounders! J Crit Care. 2022;67:212–3.

    Article  CAS  PubMed  Google Scholar 

  22. Indirli R, Bandera A, Valenti L, Ceriotti F, Di Modugno A, Tettamanti M, et al. Prognostic value of copeptin and mid-regional proadrenomedullin in COVID-19-hospitalized patients. Eur J Clin Invest. 2022;52(5):e13753.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Lippi G, Henry BM. Pooled analysis of mid-regional pro-adrenomedullin values in COVID-19 patients with critical illness. Intern Emerg Med. 2021;16(6):1723–5.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lo Sasso B, Gambino CM, Scichilone N, Giglio RV, Bivona G, Scazzone C, et al. Clinical utility of Midregional Proadrenomedullin in patients with COVID-19. Lab Med. 2021;52(5):493–8.

    Article  PubMed  Google Scholar 

  25. Minieri M, Di Lecce VN, Lia MS, Maurici M, Bernardini S, Legramante JM. Role of MR-proADM in the risk stratification of COVID-19 patients assessed at the triage of the Emergency Department. Crit Care. 2021;25(1):407.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Montrucchio G, Sales G, Rumbolo F, Palmesino F, Fanelli V, Urbino R, et al. Effectiveness of mid-regional proadrenomedullin (MR-proADM) as prognostic marker in COVID-19 critically ill patients: an observational prospective study. PLoS ONE. 2021;16(2):e0246771.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Moore N, Williams R, Mori M, Bertolusso B, Vernet G, Lynch J et al. Mid-regional proadrenomedullin (MR-proADM), C-reactive protein (CRP) and other biomarkers in the early identification of disease progression in patients with COVID-19 in the acute NHS setting.“J Clin Pathol. 2022; jclinpath-2021-207750.

  28. Oblitas CM, Galeano-Valle F, Ramírez-Navarro J, López-Cano J, Monterrubio-Manrique Á, García-Gámiz M, et al. Mid-regional Pro-Adrenomedullin, Methemoglobin and Carboxyhemoglobin as prognosis biomarkers in critically ill patients with COVID-19: an observational prospective study. Intensive Care Medicine Experimental. 2021;13(12):2445.

    CAS  Google Scholar 

  29. Roedl K, Jarczak D, Fischer M, Haddad M, Boenisch O, de Heer G, et al. MR-proAdrenomedullin as a predictor of renal replacement therapy in a cohort of critically ill patients with COVID-19. Biomarkers. 2021;26(5):417–24.

    Article  CAS  PubMed  Google Scholar 

  30. Saeed K, Legramante JM, Angeletti S, Curcio F, Miguens I, Poole S, et al. Mid-regional pro-adrenomedullin as a supplementary tool to clinical parameters in cases of suspicion of infection in the emergency department. Expert Rev Mol Diagn. 2021;21(4):397–404.

    Article  CAS  PubMed  Google Scholar 

  31. Sozio E, Tascini C, Fabris M, D’Aurizio F, De Carlo C, Graziano E, et al. MR-proADM as prognostic factor of outcome in COVID-19 patients. Sci Rep. 2021;11(1):5121.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Spoto S, Agrò FE, Sambuco F, Travaglino F, Valeriani E, Fogolari M, et al. High value of mid-regional proadrenomedullin in COVID-19: a marker of widespread endothelial damage, disease severity, and mortality. J Med Viro. 2021;93(5):2820–7.

    Article  CAS  Google Scholar 

  33. van Oers JAH, Kluiters Y, Bons JAP, de Jongh M, Pouwels S, Ramnarain D, et al. Endothelium-associated biomarkers mid-regional proadrenomedullin and C-terminal proendothelin-1 have good ability to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia: a prospective cohort study. J Crit Care. 2021;66:173–80.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Asaduzzaman MD, Romel Bhuia M, Nazmul Alam Z, Zabed Jillul Bari M, Ferdousi T. Significance of hemogram-derived ratios for predicting in-hospital mortality in COVID-19: a multicenter study. Health Sci Rep. 2022;5(4):e663.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA. 2020;323(16):1574–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Hartmann B, Verket M, Balfanz P, Hartmann NU, Jacobsen M, Brandts J, et al. Glycaemic variability is associated with all-cause mortality in COVID-19 patients with ARDS, a retrospective subcohort study. Sci Rep. 2022;12(1):9862.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Aziz F, Stöcher H, Bräuer A, Ciardi C, Clodi M, Fasching P, et al. Biomarkers predictive for In-Hospital mortality in patients with diabetes Mellitus and Prediabetes hospitalized for COVID-19 in Austria: an analysis of COVID-19 in Diabetes Registry. Viruses. 2022;14(6):1285.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Giorgino R, Soroush E, Soroush S, Malakouti S, Salari H, Vismara V, et al. COVID-19 Elderly Patients treated for proximal femoral fractures during the Second Wave of Pandemic in Italy and Iran: a comparison between two countries. Med (Kaunas). 2022;58(6):781.

    Google Scholar 

  41. Giner-Galvañ V, Pomares-Gómez FJ, Quesada JA, Rubio-Rivas M, Tejada-Montes J, Baltasar-Corral J, et al. C-Reactive protein and serum albumin ratio: a feasible prognostic marker in hospitalized patients with COVID-19. Biomedicines. 2022;10(6):1393.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Jawad Zaidi SM, Awan MH, Bhatti HW, Sabir S, Ahmed S, Arshad I, et al. Investigating the role of inflammatory markers at admission in defining the severity of moderate-to-critical COVID-19: a cross-sectional analysis. J Community Hosp Intern Med Perspect. 2022;12(2):1–5.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Cao B, Jing X, Liu Y, Wen R, Wang C. Comparison of laboratory parameters in mild vs. severe cases and died vs. survived patients with COVID-19: systematic review and meta-analysis. J Thorac Dis. 2022;14(5):1478–87.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Romero-Gameros CA, Vargas-Ortega G, Rendón-Macias ME, Cuevas-García CF, Colín-Martínez T, Sánchez-Hurtado LA, et al. Risk factors Associated with Mortality among patients with COVID-19: analysis of a cohort of 1213 patients in a Tertiary Healthcare Center. J Clin Med. 2022;11(10):2780.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Patel N, Adams C, Brunetti L, Bargoud C, Teichman AL, Choron RL. Evaluation of Procalcitonin’s utility to predict concomitant bacterial pneumonia in critically ill COVID-19 patients. J Intensive Care Med. 2022;16:8850666221108636.

    Google Scholar 

  46. Lee TA, Wang SH, Kuo CT, Li CW, McCullough LD, Bello D, et al. Prognostic serum biomarkers in cancer patients with COVID-19: a systematic review. Transl Oncol. 2022;21:101443.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Armin S, Mirkarimi M, Pourmoghaddas Z, Tariverdi M, Shamsizadeh A, Alisamir M, et al. Evidence-based prediction of COVID-19 severity in hospitalized children. Int J Clin Pract. 2022;2022:1918177.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Feigin E, Levinson T, Wasserman A, Shenhar-Tsarfaty S, Berliner S, Ziv-Baran T. Age-dependent biomarkers for prediction of In-Hospital mortality in COVID-19 patients. J Clin Med. 2022;11(10):2682.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Bao PL, Deng KL, Yuan AL, Yan YM, Feng AQ, Li T, et al. Early renal impairment is associated with in-hospital death of patients with COVID-19. Clin Respir J. 2022;16(6):441–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Folkman R, Kamal H, Ahl M, Szum A, Magnusson M, Aleman S. Postacute elevation of D-dimer levels in severe acute respiratory syndrome coronavirus 2-positive nonhospitalized patients with mild symptoms. Blood Coagul Fibrinolysis. 2022;33(5):285–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Stavileci B, Ereren E, Özdemir E, Özdemir B, Cengiz M, Enar R. The impact of daily troponin I and D-dimer serum levels on mortality in COVID-19 pneumonia patients. Cardiovasc J Afr. 2022;33:1–7.

    PubMed  Google Scholar 

  52. Qiang Z, Wang B, Garrett BC, Rainey RP, Superko HR. Coronavirus disease 2019: a comprehensive review and meta-analysis on cardiovascular biomarkers. Curr Opin Cardiol. 2021;36(3):367–73.

    Article  PubMed  Google Scholar 

  53. Calvo-Fernández A, Izquierdo A, Subirana I, Farré N, Vila J, Durán X, et al. Markers of myocardial injury in the prediction of short-term COVID-19 prognosis. Rev Esp Cardiol. 2021;74(7):576–83.

    Article  PubMed  Google Scholar 

  54. Almeida Junior GLG, Braga F, Jorge JK, Nobre GF, Kalichsztein M, Faria PMP, et al. Prognostic value of Troponin-T and B-Type natriuretic peptide in patients hospitalized for COVID-19. Arq Bras Cardiol. 2020;115(4):660–6.

    Article  PubMed  Google Scholar 

  55. Wilfong EM, Lovly CM, Gillaspie EA, Huang LC, Shyr Y, Casey JD, et al. Severity of illness scores at presentation predict ICU admission and mortality in COVID-19. J Emerg Crit Care Med. 2021;5:7.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Asmarawati TP, Suryantoro SD, Rosyid AN, Marfiani E, Windradi C, Mahdi BA, et al. Predictive value of sequential organ failure Assessment, Quick Sequential Organ failure Assessment, Acute Physiology and Chronic Health evaluation II, and new early warning Signs Scores Estimate Mortality of COVID-19 patients requiring Intensive Care Unit. Indian J Crit Care Med. 2022;26(4):464–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Burrell AJ, Pellegrini B, Salimi F, Begum H, Broadley T, Campbell LT, et al. Outcomes for patients with COVID-19 admitted to australian intensive care units during the first four months of the pandemic. Med J Aust. 2021;214(1):23–30.

    Article  PubMed  Google Scholar 

  58. Citu C, Citu IM, Motoc A, Forga M, Gorun OM, Gorun F. Predictive value of SOFA and qSOFA for In-Hospital mortality in COVID-19 patients: a single-center study in Romania. J Pers Med. 2022;12(6):878.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Innocenti F, De Paris A, Lagomarsini A, Pelagatti L, Casalini L, Gianno A, et al. Stratification of patients admitted for SARS-CoV2 infection: prognostic scores in the first and second wave of the pandemic. Intern Emerg Med. 2022;22:1–9.

    Google Scholar 

  60. Torres A, Motos A, Cillóniz C, Ceccato A, Fernández-Barat L, Gabarrús A, et al. Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study. Intensive Care Med. 2022;48(7):850–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Kim S, Choi H, Sim JK, Jung WJ, Lee YS, Kim JH. Comparison of clinical characteristics and hospital mortality in critically ill patients without COVID-19 before and during the COVID-19 pandemic: a multicenter, retrospective, propensity score-matched study. Ann Intensive Care. 2022;12(1):57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Kokoszka-Bargieł I, Cyprys P, Madeja P, Rutkowska K, Wajda-Pokrontka M, Madowicz J, et al. Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study. Anaesthesiol Intensive Ther. 2022;54(2):132–40.

    Article  PubMed  Google Scholar 

  63. Lázaro APP, Albuquerque PLMM, Meneses GC, Zaranza MS, Batista AB, Aragão NLP, et al. Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3. Trans R Soc Trop Med Hyg. 2022;22:trac046.

    Google Scholar 

  64. Aziz F, Reisinger AC, Aberer F, Sourij C, Tripolt N, Siller-Matula JM, et al. Simplified Acute Physiology score 3 performance in austrian COVID-19 patients admitted to Intensive Care units with and without diabetes. Viruses. 2022;14(4):777.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Olry de Labry-Lima A, Saez-de la Fuente J, Abdel-Kader Martin L, Alegre-Del Rey EJ, García-Cabrera E, Sierra-Sánchez JF. Factors associated with mortality in patients hospitalized for COVID-19 in Spain. Data from the RERFAR registry. Farm Hosp. 2022;46(2):57–71.

    PubMed  Google Scholar 

  66. Minne L, Abu-Hanna A, De Jonge E. Evaluation of SOFA-based models for predicting mortality in the ICU: a systematic review. Crit Care. 2008;12(6):R161.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Méndez R, Aldás I, Menéndez R. Biomarkers in Community-Acquired Pneumonia (Cardiac and Non-Cardiac). J Clin Med. 2020;9(2):549.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Samson WK, Resch ZT, Murphy TC, Vargas TT, Schell DA. Adrenomedullin: is there physiological relevance in the Pathology and Pharmacology? News Physiol Sci. 1999;14:255–9.

    CAS  PubMed  Google Scholar 

  69. Gonzalez-Rey E, Chorny A, Varela N, Robledo G, Delgado M. Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response. Am J Pathol. 2006;168(6):1921–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Lewis LK, Smith MW, Yandle TG, Richards AM, Nicholls MG. Adrenomedullin (1–52) measured in human plasma by radioimmunoassay: plasma concentration, adsorption, and storage. Clin Chem. 1998;44:571–7.

    Article  CAS  PubMed  Google Scholar 

  71. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem. 2005;51(10):1823–9.

    Article  CAS  PubMed  Google Scholar 

  72. Elke G, Bloos F, Wilson DC, Brunkhorst FM, Briegel J, Reinhart K, et al. The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial. Crit Care. 2018;22(1):79.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Spoto S, Nobile E, Carnà EPR, Fogolari M, Caputo D, De Florio L, et al. Best diagnostic accuracy of sepsis combining SIRS criteria or qSOFA score with procalcitonin and mid-regional pro-adrenomedullin outside ICU. Sci Rep. 2020;10(1):16605.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Mosleh W, Chen K, Pfau SE, Vashist A. Endotheliitis and endothelial dysfunction in patients with COVID-19: its role in thrombosis and adverse outcomes. J Clin Med. 2020;9(6):1862.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Spoto S, Mangiacapra F, D’Avanzo G, Lemme D, Bustos Guillén C, Abbate A, et al. Synergistic effect of myocardial injury and mid-regional proAdrenomedullin elevation in determining clinical outcomes of SARS-CoV-2 patients. Front Med (Lausanne). 2022;9:929408.

    Article  PubMed  Google Scholar 

  77. Bima P, Montrucchio G, Caramello V, Rumbolo F, Dutto S, Boasso S, et al. Prognostic Value of Mid-Regional Proadrenomedullin sampled at Presentation and after 72 hours in septic patients presenting to the Emergency Department: an observational Two-Center Study. Biomedicines. 2022;10(3):719.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Li P, Wang C, Pang S. The diagnostic accuracy of mid-regional pro-adrenomedullin for sepsis: a systematic review and meta-analysis. Minerva Anestesiol. 2021;87(10):1117–27.

    Article  PubMed  Google Scholar 

  79. Liu D, Xie L, Zhao H, Liu X, Cao J. Prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with community-acquired pneumonia: a systematic review and meta-analysis. BMC Infect Dis. 2016;26:16:232.

    Article  Google Scholar 

  80. Spoto S, Legramante JM, Minieri M, Fogolari M, Terrinoni A, Valeriani E, et al. How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin. Biomark Med. 2020;14(7):549–62.

    Article  CAS  PubMed  Google Scholar 

  81. Legramante JM, Mastropasqua M, Susi B, Porzio O, Mazza M, Miranda Agrippino G, et al. Prognostic performance of MR-pro-adrenomedullin in patients with community acquired pneumonia in the Emergency Department compared to clinical severity scores PSI and CURB. PLoS ONE. 2017;12(11):e0187702.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Piccioni A, Saviano A, Cicchinelli S, Valletta F, Santoro MC, de Cunzo T, et al. Proadrenomedullin in Sepsis and septic shock: a role in the Emergency Department. Med (Kaunas). 2021;57(9):920.

    Google Scholar 

  83. Spoto S, Fogolari M, De Florio L, Minieri M, Vicino G, Legramante J, et al. Procalcitonin and MR-proAdrenomedullin combination in the etiological diagnosis and prognosis of sepsis and septic shock. Microb Pathog. 2019;137:103763.

    Article  CAS  PubMed  Google Scholar 

  84. Valenzuela-Méndez B, Valenzuela-Sánchez F, Rodríguez-Gutiérrez JF, Bohollo-de-Austria R, Estella Á, Martínez-García P, et al. Plasma levels of Mid-Regional Proadrenomedullin accurately identify H1N1pdm09 influenza virus patients with risk of Intensive Care Admission and Mortality in the Emergency Department. J Pers Med. 2022;12(1):84.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Schuetz P, Hausfater P, Amin D, Amin A, Haubitz S, Faessler L, et al. Biomarkers from distinct biological pathways improve early risk stratification in medical emergency patients: the multinational, prospective, observational TRIAGE study. Crit Care. 2015;19:377.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Enguix-Armada A, Escobar-Conesa R, La Torre AG, De La Torre-Prados MV. Usefulness of several biomarkers in the management of septic patients: C-reactive protein, procalcitonin, presepsin and mid-regional pro-adrenomedullin. Clin Chem Lab Med. 2016;54(1):163–8.

    Article  CAS  PubMed  Google Scholar 

  87. Andaluz-Ojeda D, Cicuéndez R, Calvo D, Largo E, Nogales L, Muñoz MF, et al. Sustained value of proadrenomedullin as mortality predictor in severe sepsis. J Inf Secur. 2015;71(1):136–9.

    CAS  Google Scholar 

  88. Corr MP, Fairley D, McKenna JP, Shields MD, Waterfield T. Diagnostic value of mid-regional pro-adrenomedullin as a biomarker of invasive bacterial infection in children: a systematic review. BMC Pediatr. 2022;22(1):176.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors thank all staff of the emergency department of China rehabilitation research center, Capital Medical University.

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  1. Na Wang and Lushan Liu contributed equally to this work.

Authors and Affiliations

  1. Emergency department of China Rehabilitation Research Center, Capital Medical University, no.10 Jiaomen north Street, Fengtai District, Beijing, 100068, China

    Na Wang, Lushan Liu, Wei He, Na Shang, Junyu Li & Zhou Qin

  2. Department of neurorehabilitation of China Rehabilitation Research Center, Capital Medical University, no.10 Jiaomen north Street, Fengtai District, Beijing, 100068, China

    Xiaoxia Du

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Contributions

NW and LSL performed the data analysis, and drafted the manuscript. WH and NS were responsible for literature research. JYL and ZQ conducted data acquisition and extracted all of the raw date. XXD designed the study and helped to revise manuscript. All authors read and approved the final manuscript.

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Wang, N., Liu, L., He, W. et al. Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis. BMC Infect Dis 23, 305 (2023). https://doi.org/10.1186/s12879-023-08275-z

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BMC Infectious Diseases

ISSN: 1471-2334

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