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A Malaysian consensus recommendation for the prevention of influenza in older persons



Older persons are at high-risk of developing severe complications from influenza. This consensus statement was developed to provide guidance on appropriate influenza prevention strategies relevant to the Malaysian healthcare setting.


Under the initiative of the Malaysian Influenza Working Group (MIWG), a panel comprising 11 multi-speciality physicians was convened to develop a consensus statement. Using a modified Delphi process, the panellists reviewed published evidence on various influenza management interventions and synthesised 10 recommendations for the prevention of influenza among the aged population via group discussions and a blinded rating exercise.


Overall, annual influenza vaccination is recommended for individuals aged ≥ 60 years, particularly those with specific medical conditions or residing in aged care facilities (ACFs). There is no preference for a particular vaccine type in this target population. Antiviral agents can be given for post-exposure chemoprophylaxis or when vaccine contraindication exists. Infection control measures should serve as adjuncts to prevent the spread of influenza, especially during Hajj.


This consensus statement presents 10 evidence-based recommendations that can be adopted by healthcare providers to prevent influenza among the aged population in Malaysia. It could also serve as a basis for health policy planning in other lower- and middle-income countries.

Peer Review reports


Influenza (commonly known as flu) is a respiratory infectious disease caused by the influenza virus that mainly infects the nose, throat, and sometimes lungs [1]. Most people recover from uncomplicated influenza but certain populations, particularly those aged 60 years and above, are considered at higher risk of developing influenza-related complications that may result in severe disease and death [2, 3]. In 2017, the World Health Organization (WHO) indicated that 290,000 to 650,000 annual global deaths were associated with influenza [4]. A recent study estimated that the global mean annual influenza-associated excess respiratory mortality rate ranged from 0.1 to 6.4 per 100,000 individuals among people aged ≤ 64 years, 2.9–44.0 per 100,000 individuals among people aged 65–74 years, and 17.9–224.5 per 100,000 individuals among people aged ≥ 75 years [5]. These estimates suggest a greater annual burden of influenza than the figures reported by WHO in 2017, underscoring the impact that influenza has on healthcare systems worldwide.

Older persons typically suffer the most severe health effects of influenza as they have an ageing immune system (immunosenescence) and more medical comorbidities [6]. According to the US Centers for Disease Control and Prevention (CDC), approximately 90% of influenza-related deaths and up to 70% of influenza-related hospitalisations have occurred among older persons aged ≥ 65 years [7]. It has been reported that older persons in Hong Kong, specifically those aged ≥ 65 years, are about 14 times more likely to die from influenza compared with adults in the 40–65 years age group [8]. In Singapore, influenza-related deaths were 11.3 times higher among older persons than in the general population [9]. From 2010 to 2017, 16.3% of all pneumonia and influenza hospitalisations in Singapore were estimated to be attributed to influenza, with a higher excess rate estimated for individuals aged ≥ 65 years (338.0 per 100,000 person-years) [10]. In Malaysia, influenza has a disproportionately higher impact on older persons, with 28.3% of patients aged ≥ 65 years experiencing hospitalisation, intensive care unit admission, or death within a year owing to influenza-related illnesses or complications compared with 9.6% of patients in the 25–64 years age group [11]. Therefore, the prevention of influenza in this high-risk group is of great importance.

In 2020, there were 2.2 million (6.8%) people in Malaysia aged ≥ 65 years and this number is projected to reach six million by 2040 [12, 13]. To address the growing need of having a localised guideline on the prevention of influenza among the aged population in Malaysia, a consensus panel was convened to develop a consensus statement that lists a set of evidence-based recommendations, aimed at raising awareness among healthcare providers and caregivers about the importance of influenza prevention among older persons, and providing guidance on appropriate influenza prevention strategies that are relevant to the Malaysian healthcare setting.


The MIWG was formed by the Malaysian Society of Infectious Diseases and Chemotherapy (MSIDC), comprising an interdisciplinary group of experts from the fields of paediatrics, public health, infectious diseases, virology, respiratory medicine, and geriatrics, to advocate for influenza prevention in the general population in Malaysia. In 2020, a sub-committee (senior section) of MIWG was formed as an initiative between MSIDC and the Malaysian Society of Geriatric Medicine to specifically lobby for influenza vaccination in older adults. The group recognised that having appropriate guidelines for influenza prevention would strengthen the call for reducing the impact of influenza on the aged population, among policymakers, healthcare practitioners and the public. The MIWG subsequently invited 11 physicians (five consultant geriatricians, a senior consultant medical microbiologist, a senior consultant respiratory physician, a general practitioner, an infectious diseases physician, a family medicine specialist, and a public health medicine specialist) from public academic centres, public and private primary healthcare centres, as well as a private clinic to be members of the consensus panel.

A literature search of the MEDLINE database was conducted using the PubMed search engine to identify influenza-related studies—involving older persons (defined as individuals aged ≥ 60 years based on the guidelines provided by the Malaysian Ministry of Women, Family and Community Development and the Ministry of Health) [14, 15], residents and staff of ACFs, older persons with comorbidities and/or immune suppression, as well as older Hajj pilgrims—that have been published over a 15-year period (2006–2021). The following medical subject headings (MeSHs) and subheading were used as the search terms: Influenza; aged; prevention and control; and diagnosis. The inputted search syntax was: “(((“Influenza, Human“[MeSH]) AND (“Aged“[MeSH])) AND (“prevention and control“[Subheading])) AND (“Diagnosis“[MeSH]); Filters: Guideline, Meta-Analysis, Randomised Controlled Trial, 2006–2021”.

A total of 152 relevant articles were retrieved from MEDLINE. In addition, recommendations of interest were also sourced from the verified websites of medical organisations and societies. Upon reviewing the pool of information generated via the said search strategy, the consensus panel drafted 22 preliminary statements that were deemed valuable in guiding the development of the influenza prevention consensus document. These statements were subsequently subjected to a modified Delphi process where the value of various interventions in preventing influenza was scrutinised and debated to derive a list of evidence-based recommendations that would meet the objectives of this study.

Specifically, the modified Delphi technique used in this study consisted of two virtual expert meetings and one blinded rating exercise.

First expert meeting

A set of 22 preliminary statements describing various interventions for the prevention of influenza was presented for discussion. Having reviewed the statements and their corresponding supporting evidence, panellists indicated their position on the statements by openly voting for or against their inclusion in the proposed consensus document. Only statements with ≥ 70% of positive responses were shortlisted for the subsequent blinded Delphi rating exercise. During this meeting, panellists also amended the shortlisted statements for accuracy and clarity. A total of 13 statements were eventually shortlisted for the next step.

Blinded Delphi rating

The 13 shortlisted statements from the first expert meeting were subjected to a blinded Delphi rating process. Guided by scientific evidence, members of the consensus panel independently and anonymously rated each statement based on a 5-point Likert scale (‘strongly disagree’, ‘disagree’, ‘neutral’, ‘agree’, ‘strongly agree’). For each statement, the experts could also suggest minor amendments to the original phrasing, which was discussed in the second expert meeting. A consensus was defined as a combined ‘strongly agree’ and ‘agree’ acceptance rate of ≥ 70% [16, 17]. A total of 12 statements achieved consensus after the rating process. One statement did not achieve the minimum level of support required and was further discussed at the next meeting.

Second expert meeting

Results of the blinded Delphi rating exercise were compiled and shared with members of the MIWG during a second virtual expert meeting. During this meeting, the panellists reviewed the reported results and appropriate revisions were made to the accepted consensus statements. At the end of the meeting, a total of 10 consensus statements were finalised as the official recommendations of the MIWG for the prevention of influenza in the aged population.

Results and discussion

Recommendation 1: all persons aged 60 years and above who do not have contraindications should receive an influenza vaccine annually

Older persons represent 90% of influenza-related deaths and 50–70% of influenza-related hospitalisations [7]. A study that examined the effectiveness of influenza vaccine in seniors over an extended duration found that influenza vaccination was associated with a 27% reduction in the risk of hospitalisation due to influenza or pneumonia, and a 48% reduction in the risk of death [18]. Separately, a modelling study documented that influenza vaccination in Europe averted an average of 1.6–2.1 million cases of influenza, 45,300–65,600 hospitalisations, and 25,200–37,200 deaths each year [19].

A cost-benefit analysis also showed that vaccination would result in net savings of Malaysian Ringgit (MYR) 313 for each vaccinated older person and net savings of MYR 3565 per life-year gained [20]. While influenza vaccines have a good safety profile in general, their use may be limited by certain contraindications [1]. For example, people who are allergic to any components, adjuvants, or trace ingredients in influenza vaccines (e.g., neomycin, formaldehyde, or Triton X-100) and those who have prior experience of anaphylaxis after vaccination should not be vaccinated [21, 22]. For older persons with egg allergy, influenza vaccines produced using nonegg-based techniques (e.g., trivalent and quadrivalent recombinant influenza vaccines) can be considered for administration, though available published reviews have reported that severe allergic reactions to currently available egg-based influenza vaccines in individuals with egg allergy are unlikely [23]. Nonetheless, it is recommended that older persons who have a history of severe allergic reactions to eggs be vaccinated in a medical setting under the supervision of a healthcare worker who is able to identify and manage severe allergic conditions [24].

Recommendation 2: older persons with comorbidities should be prioritised for annual influenza vaccination

Older persons with comorbidities, including chronic lung diseases (e.g., chronic obstructive pulmonary disease, asthma, bronchiectasis, and lung fibrosis), heart diseases (e.g., heart failure and coronary artery disease), kidney and liver disorders, endocrine (e.g., diabetes melitus), and neurological disorders are at higher risk for influenza-related complications [25, 26]. In Malaysia, older persons are more likely to have ≥ 2 comorbidities with advanced age being an independent predictor of poor health outcomes [11]. This population should be prioritised for annual influenza vaccination, especially during periods of vaccine shortage. A randomised, double-blind, multicentre, active-controlled trial found that vaccination against influenza was 22.1% effective in preventing influenza among older persons with at least one high-risk comorbid condition and 23.6% effective among those with at least two high-risk comorbid conditions [27].

Moreover, a prospective, randomised, open with blinded endpoint study involving 439 patients who had been admitted to hospital for acute coronary syndrome (ACS) reported that patients who received influenza vaccination had a lower rate of developing major adverse cardiovascular events (including death and hospitalisation due to ACS, heart failure, or stroke) than those who did not (9.5% vs. 19.3%; unadjusted hazard ratio, 0.70 [0.57–0.86]; p = 0.004) [28].

Recommendation 3: older persons should receive any available influenza vaccine approved for use in their age group

Currently, more than one licensed influenza vaccine has been approved for use in older persons. They are available as trivalent or quadrivalent, cell-cultured or egg-based, standard-dose or high-dose, and adjuvanted or nonadjuvanted vaccines. Regardless of the vaccine type, antibodies typically develop in the body approximately two weeks after vaccination [29]. Presently, three influenza vaccines are preferentially recommended for older persons: Fluzone high-dose quadrivalent, Flublok quadrivalent recombinant, and Fluad quadrivalent adjuvanted influenza vaccines [30]. If none of the three influenza vaccines is available, older persons who have no contraindication to influenza vaccination should receive any registered and age-appropriate influenza vaccine [30]. Generally, the availability of influenza vaccines can vary from year to year and from country to country [31]; clinicians in Malaysia should administer whichever formulation that is available locally to achieve the highest possible vaccine coverage among aged individuals (Table 1).

Table 1 Influenza vaccines currently available in Malaysia (as of June 2022)

Recommendation 4: post-exposure prophylaxis with antiviral agents can be considered within 48 h for preventing the transmission of influenza in older persons

Post-exposure prophylaxis (PEP) with antiviral medications can be prescribed to older persons to prevent the transmission of influenza and should be given within 48 h of exposure to a person with influenza for 7 days after the last known exposure [2]. PEP is particularly important for those who cannot receive vaccination owing to contraindications or if they are severely immunocompromised [2]. A randomised, double-blind study assessing the effectiveness of a neuraminidase inhibitor, oseltamivir, as PEP among close contacts of individuals with influenza showed that the risk of developing influenza was reduced by 89% compared with those who received a placebo [32].

PEP with another neuraminidase inhibitor, zanamivir, protected close contacts with similarly high prophylactic efficacy, ranging from 82 to 84% [33, 34]. In 2020, a selective inhibitor of influenza cap-dependent endonuclease (i.e., baloxavir) was approved by the US Food and Drug Administration (FDA) for influenza PEP [35]. It has been demonstrated that close contacts of people with influenza who were given baloxavir were 86% less likely to contract influenza after exposure to an infected person compared with those who received a placebo (1.9% [7 of 374] vs. 13.6% [51 of 375]; adjusted risk ratio, 0.14; 95% confidence interval [CI], 0.06–0.30; p < 0.001) [36].

Recommendation 5: antiviral agents should be given as post-exposure chemoprophylaxis as soon as possible to all non-ill residents during influenza outbreaks in ACFs

An influenza outbreak at an ACF can be suspected when there is a resident with laboratory-confirmed influenza and another resident at the same facility develops influenza-like illness (ILI) within 72 h [37]. When an influenza outbreak is recognised in an ACF, chemoprophylaxis should be administered immediately to all non-ill residents, regardless of their influenza vaccination status, to prevent the spread of the virus. Oseltamivir has been shown to be 92% effective in preventing influenza in residents of ACFs exposed to influenza [38], while zanamivir was reportedly effective in controlling at least five influenza outbreaks in ACFs [39,40,41,42,43]. To effectively control influenza outbreaks, chemoprophylaxis should be taken for a minimum of two weeks and continued for seven days after the last known case of influenza was identified [2].

Recommendation 6: immunocompromised older persons should receive inactivated influenza vaccine annually

Immunocompromised patients are at high-risk of contracting influenza and have significant influenza-associated excess mortality rates [44]. Annual inactivated influenza vaccination is widely recommended for this group, including those with primary immune deficiencies related to inherited diseases that affect the immune system, as well as those with secondary immune deficiencies resulting from human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome, solid organ or stem cell transplant, cancers associated with immune deficiency, and cancer chemotherapy [45].

A randomised controlled trial indicated that the influenza vaccine was highly effective among patients with HIV, providing a protective efficacy of 100% for vaccine recipients against laboratory-confirmed symptomatic influenza (95% CI, 73–100%) [46]. Moreover, a prospective study on the immunogenicity of inactivated influenza vaccine among patients receiving cytotoxic myelosuppressive chemotherapy for solid tumours and haematologic malignancies demonstrated that the influenza vaccine could induce an immune response similar to that seen in healthy controls [47].

Recommendation 7: influenza vaccine, education on influenza prevention, and infection control measures should be recommended to all older Hajj and Umrah pilgrims

Influenza vaccination is currently not mandatory for Malaysian Hajj and Umrah pilgrims. In a cross-sectional study conducted amongst 394 Malaysian Hajj pilgrims in 2007, 96.4% of the study population had an ILI—out of which 91.5% experienced cough; 59.2%, fever; 79.3%, runny nose; and 57.1%, sore throat [48]. Alborzi and associates (2009) found that vaccinated pilgrims contracted the influenza virus less frequently than unvaccinated pilgrims (9.2% vs. 16.5%) [49]. A case-control study on the effectiveness of influenza vaccination among Malaysian pilgrims attending the Hajj in 2000 showed that the influenza vaccine was 77% effective in preventing clinic visits for ILI and 66% effective in reducing the use of antibiotics [50]. All older Hajj pilgrims who had not been immunised are recommended to receive an influenza vaccine, preferably no less than two weeks prior to their arrival in Saudi Arabia [51].

Nonetheless, vaccination alone is not an adequate infection control measure for pilgrims. In a study assessing the incidence rate of influenza among 115 pilgrims during the 2003 Hajj season, nine out of 30 vaccinated pilgrims (30%) still experienced breakthrough infection [52]. Therefore, the implementation of other supportive infection control measures, including the use of face masks, alcohol-based hand sanitisers, and health education, is important in mitigating the potential transmission of influenza during Hajj. Previous studies reported that the regular use of a face mask was a significant protective factor in reducing the incidence of infection [53, 54]. Al-Asmary and colleagues found that Hajj pilgrims who consistently used alcohol-based hand sanitisers had more than an eight-fold lower risk of acquiring infection compared with those who did not [55]. Similarly, Alqahtani et al. revealed that pilgrims who had received health education before travelling to Hajj were twice as likely to get vaccinated than those who had no exposure to proper education materials [56]. Hence, appropriate education of pilgrims by healthcare professionals and Hajj and Umrah travel agents is recommended to maximise the adherence to influenza prevention measures among pilgrims.

Recommendation 8: all residents of ACFs should be offered annual influenza vaccination

Menec and colleagues reported that hospitalisation and deaths due to influenza and pneumonia were about two to three times higher among older persons living in ACFs compared with those living in the community (31.9 vs. 9.8 per 1000 population, and 61.9% vs. 30.7%, respectively) [57]. Influenza vaccination is currently one of the most optimal ways of reducing the risk of hospitalisation and death among older persons who live in ACFs [58, 59]. Among vaccinated residents, there were significantly fewer clinical cases, hospitalisations, and deaths due to influenza (256 cases among 10,739 subjects, 32 hospitalisations, and one death) compared with unvaccinated residents (694 cases among 11,723 subjects, 150 hospitalisations, and five deaths) (p ˂ 0.001) [58], thus reducing the risks by 59.7%, 76.7%, and 78.2% respectively.

The influenza vaccine has also been shown to be effective not only in reducing the incidence of ILI and influenza-related hospitalisation but also in preventing serious complications caused by influenza, such as pneumonia (17% among vaccinated vs. 27% among unvaccinated residents; p < 0.05) and deaths (5% vs. 14%; p < 0.05) in the ACF setting [59]. Based on a nonrandomised, single-blind placebo control study on the effectiveness of influenza vaccination for the prevention of ILI among residents of ACF in Malaysia, influenza vaccination reduced the risk of contracting ILI by 14–45% and showed 55–76% vaccine effectiveness in reducing the occurrence of ILI [60].

Recommendation 9: annual influenza vaccination should be offered to all staff of ACFs

In line with WHO recommendations, annual influenza vaccination should be offered to all staff who will potentially have contact with residents of ACFs, unless contraindicated [61]. In this consensus statement, the term ‘ACFs’ encompasses long-term care facilities, nursing homes, day care centres, and residential care facilities that provide care to people who are unable to live independently owing to advanced age, physical disability, or mental disability. The term ‘staff’ includes any person employed by the ACFs, caregivers, and volunteers (e.g., doctors, nurses, cooks, laundry workers, cleaners, and security staff).

A randomised controlled trial showed that the vaccination of healthcare workers not only reduced influenza infection by 88% in vaccinated individuals but also reduced absenteeism caused by influenza illness (9.9 days per 100 vaccinated staff vs. 21.1 days per 100 unvaccinated staff) [62]. Importantly, vaccination of staff at ACFs may have beneficial effects on the aged residents. The reduction of complications afforded by vaccinating staff is equivalent to preventing five deaths, two admissions to hospital with ILI, seven general practitioner consultations for ILI, and nine cases of ILI per 100 residents [63]. Moreover, a pair-matched cluster study involving 1,059 patients in 12 geriatric medical long-term care sites also found that vaccination of staff was associated with reductions in ILI (odds ratio [OR], 0.57; 95% CI, 0.34–0.94) and total patient mortality from 17 to 10% (OR, 0.56; 95% CI, 0.40–0.80) [64].

Recommendation 10: staff and residents in ACFs with influenza-like illnesses should be isolated and tested for influenza, and outbreak control measures instituted

To prevent influenza outbreaks in ACFs, staff and residents in ACFs with ILI should be isolated from healthy individuals in a timely manner. In general, isolation should be maintained for 7 days after the onset of symptoms or until their symptoms have resolved [65]. Meanwhile, laboratory tests, including rapid influenza diagnostic tests (RIDTs), molecular assays, and virus culture should be performed to determine if their illness is due to influenza infection [21]. As compared with molecular assays such as reverse transcription polymerase chain reaction, RIDTs have a lower and inconsistent sensitivity, ranging from 10 to 80% [66, 67]. In addition, the results of RIDTs may be affected by various factors, including the prevalence of influenza activity in the population tested [66, 67]. Typically, false-negative RIDTs results are more likely to occur when the influenza prevalence is high in the community [67]. However, RIDTs have a high specificity (90–95%); thus, positive RIDTs results can rule in influenza infection but negative RIDTs results do not exclude influenza infection in individuals with symptoms suggestive of influenza [66, 67]. Confirmatory testing using molecular assay is recommended when negative RIDTs results are obtained for a symptomatic staff or resident; antiviral treatment should be initiated if clinically indicated and should not be delayed while influenza testing results are pending [2]. Standard and droplet precautions should also be implemented immediately when two cases of laboratory-confirmed influenza affecting staff or residents of the same facility are identified within 72 h (Table 2) [2, 68].

Table 2 Essential components of standard and droplet precautions


This consensus statement presents 10 evidence-based recommendations that healthcare providers and caregivers can adopt to prevent influenza among the aged population in Malaysia. It can be used as a fundamental guide to facilitate the planning and execution of influenza prevention strategies across various healthcare settings and environment. These recommendations may also help to inform policymaking decisions in other lower- to middle-income countries.

Availability of data and materials

Data sharing is not applicable to this article as all data generated and analysed during the current study are included in this article.


  1. Dhar R, Ghoshal AG, Guleria R, Sharma S, Kulkarni T, Swarnakar R, et al. Clinical practice guidelines 2019: indian consensus-based recommendations on influenza vaccination in adults. Lung India. 2020;37:4–18.

    Article  Google Scholar 

  2. Uyeki TM, Bernstein HH, Bradley JS, Englund JA, File TM, Fry AM, et al. Clinical practice guidelines by the infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza. Clin Infect Dis. 2019;68:e1–47.

    Article  Google Scholar 

  3. Feldman LY, Zhu JQ, To T. Estimating age-specific influenza-associated asthma morbidity in Ontario, Canada. Respir Med. 2019;155:104–12.

    Article  Google Scholar 

  4. World Health Organization. Up to 650,000 people die of respiratory diseases linked to seasonal flu each year. 2017. Accessed 14 Dec 2021.

  5. Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018;391:1285–300.

    Article  Google Scholar 

  6. Czaja CA, Miller L, Alden N, Wald HL, Cummings CN, Rolfes MA, et al. Age-related differences in hospitalisation rates, clinical presentation, and outcomes among older adults hospitalised with influenza - U.S. Influenza Hospitalisation Surveillance Network (FluSurv-NET). Open Forum Infect Dis. 2019;6:1–8.

    Article  Google Scholar 

  7. Centers for Disease Control and Prevention. Study shows hospitalisation rates and risk of death from seasonal flu increase with age among people 65 years and older. 2019. Accessed 28 Jun 2022.

  8. Wong CM, Chan KP, Hedley AJ, Peiris JSM. Influenza-associated mortality in Hong Kong. Clin Infect Dis. 2004;39:1611–7.

    Article  Google Scholar 

  9. Chow A, Ma S, Ai EL, Suok KC. Influenza-associated deaths in tropical Singapore. Emerg Infect Dis. 2006;12:114–21.

    Article  Google Scholar 

  10. Ng Y, Chua LAV, Ma S, Lee VJM. Estimates of influenza-associated hospitalisations in tropical Singapore, 2010–2017: higher burden estimated in more recent years. Influenza Other Respir Viruses. 2019;13:574–81.

    Article  Google Scholar 

  11. Wong PL, Sii HL, P’ng CK, Ee SS, Yong Oong X, Ng KT, et al. The effects of age on clinical characteristics, hospitalisation and mortality of patients with influenza-related illness at a tertiary care centre in Malaysia. Influenza Other Respir Viruses. 2020;14:286–93.

    Article  Google Scholar 

  12. Department of Statistics Malaysia. Launching on report on the key findings population and housing census of Malaysia 2020. 2022. Accessed 1 Jul 2022.

  13. Department of Statistics Malaysia. Ageing. 2017. Accessed 1 Jul 2022.

  14. Institute for Public Health. National Health and Morbidity Survey (NHMS) 2019: non-communicable diseases, healthcare demand, and health literacy–Key findings. 2020.

  15. Ministry of Women. Family and Community Development. Beijing declaration and platform for action: Malaysia progress report 2014–2019. 2019.

  16. Mahler DA, Selecky PA, Harrod CG. Management of dyspnea in patients with advanced lung or heart disease. Practical guidance from the American College of chest Physicians consensus statement. Pol Arch Med Wewn. 2010;120:160–6.

    Google Scholar 

  17. Sumsion T. The Delphi technique: an adaptive research tool. Br J Occup Ther. 1998;61:153–6.

    Article  Google Scholar 

  18. Nichol KL, Nordin JD, Nelson DB, Mullooly JP, Hak E. Effectiveness of influenza vaccine in the community-dwelling elderly. N Engl J Med. 2007;357:1373–81.

    Article  CAS  Google Scholar 

  19. Preaud E, Durand L, Macabeo B, Farkas N, Sloesen B, Palache A, et al. Annual public health and economic benefits of seasonal influenza vaccination: a European estimate. BMC Public Health. 2014;14:1–12.

    Article  Google Scholar 

  20. Nichol KL, Nordin J, Mullooly J, Lask R. Influenza vaccination of the elderly is associated with direct medical care cost savings. Int Congr Ser. 2004;1263:658–60.

    Article  Google Scholar 

  21. Baek JH, Seo Y, Bin, Choi WS, Kee SY, Jeong HW, Lee HY, et al. Guideline on the prevention and control of seasonal influenza in healthcare setting. Korean J Intern Med. 2014;29:265–80.

    Article  Google Scholar 

  22. Chen Q, Wang L, Xie M, Li X. Recommendations for influenza and Streptococcus pneumoniae vaccination in elderly people in China. Aging Med. 2020;3:1–11.

    Article  Google Scholar 

  23. Centers for Disease Control and Prevention. Safety of influenza vaccines. 2019. Accessed 26 Oct 2022.

  24. Centers for Disease Control and Prevention. Flu vaccine and people with egg allergies. 2022. Accessed 26 Oct 2022.

  25. World Health Organization. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. Geneva: WHO Press; 2007.

    Google Scholar 

  26. Centers for Disease Control and Prevention. People at higher risk of flu complications. 2021. Accessed 28 Jun 2022.

  27. DiazGranados CA, Dunning AJ, Robertson CA, Talbot HK, Landolfi V, Greenberg DP. Efficacy and immunogenicity of high-dose influenza vaccine in older adults by age, comorbidities, and frailty. Vaccine. 2015;33:4565–71.

    Article  CAS  Google Scholar 

  28. Phrommintikul A, Kuanprasert S, Wongcharoen W, Kanjanavanit R, Chaiwarith R, Sukonthasarn A. Influenza vaccination reduces cardiovascular events in patients with acute coronary syndrome. Eur Heart J. 2011;32:1730–5.

    Article  Google Scholar 

  29. Centers for Disease Control and Prevention. Different types of flu vaccines. 2021. Accessed 28 Jun 2022.

  30. Centers for Disease Control and Prevention. Fluzone high-dose seasonal influenza vaccine. 2021. Accessed 28 Jun 2022.

  31. Smetana J, Chlibek R, Shaw J, Splino M, Prymula R. Influenza vaccination in the elderly. Hum Vaccines Immunother. 2018;14:540–9.

    Article  Google Scholar 

  32. Welliver R, Monto AS, Hassman M, Hedrick J, Jackson HC, Huson L, et al. Effectiveness of oseltamivir in preventing influenza in household contacts. JAMA. 2001;285:748–54.

    Article  CAS  Google Scholar 

  33. Hayden FG, Gubareva LV, Monto AS, Klein TC, Elliott MJ, Hammond JM, et al. Inhaled zanamivir for the prevention of influenza in families. N Engl J Med. 2000;343:1282–9.

    Article  CAS  Google Scholar 

  34. Monto AS, Pichichero ME, Blanckenberg SJ, Ruuskanen O, Cooper C, Fleming DM, et al. Zanamivir prophylaxis: an effective strategy for the prevention of influenza types a and B within households. J Infect Dis. 2002;186:1582–8.

    Article  CAS  Google Scholar 

  35. Food and Drug Administration. FDA expands approval of influenza treatment to post-exposure prevention. 2020. Accessed 10 Jun 2022.

  36. Ikematsu H, Hayden FG, Kawaguchi K, Kinoshita M, de Jong MD, Lee N, et al. Baloxavir marboxil for prophylaxis against influenza in household contacts. N Engl J Med. 2020;383:309–20.

    Article  CAS  Google Scholar 

  37. Centers for Disease Control and Prevention. Interim guidance for influenza outbreak management in long-term care and post-acute care facilities 2020. 2020. Accessed 28 Jun 2022.

  38. Peters PH, Gravenstein S, De Bock PNV, Van Couter A, Gibbens M, Von Planta TA, et al. Long-term use of oseltamivir for the prophylaxis of influenza in a vaccinated frail older population. J Am Geriatr Soc. 2001;49:1025–31.

    Article  Google Scholar 

  39. Ambrozaitis A, Gravenstein S, Van Essen GA, Rubinstein E, Balciuniene L, Stikleryte A, et al. Inhaled zanamivir versus placebo for the prevention of influenza outbreaks in an unvaccinated long-term care population. J Am Med Dir Assoc. 2005;6:367–74.

    Article  Google Scholar 

  40. Gravenstein S, Drinka P, Osterweil D, Schilling M, Krause P, Elliott M, et al. Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population. J Am Med Dir Assoc. 2005;6:359–66.

    Article  Google Scholar 

  41. Hirji Z, O’Grady S, Bonham J, Mak M, Takata-Shewchuk J, Hawkins K, et al. Utility of zanamivir for chemoprophylaxis of concomitant influenza A and B in a complex continuing care population. Infect Control Hosp Epidemiol. 2002;23:604–8.

    Article  CAS  Google Scholar 

  42. Lee C, Loeb M, Phillips A, Nesbitt J, Smith K, Fearon M, et al. Zanamivir use during transmission of amantadine-resistant influenza A in a nursing home. Infect Control Hosp Epidemiol. 2000;21:700–4.

    Article  CAS  Google Scholar 

  43. Schilling M, Povinelli L, Krause P, Gravenstein M, Ambrozaitis A, Jones HH, et al. Efficacy of zanamivir for chemoprophylaxis of nursing home influenza outbreaks. Vaccine. 1998;16:1771–4.

    Article  CAS  Google Scholar 

  44. Lin JC, Nichol KL. Excess mortality due to pneumonia or influenza during influenza seasons among persons with acquired immunodeficiency syndrome. Arch Intern Med. 2001;161:441–6.

    Article  CAS  Google Scholar 

  45. Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:e44–100.

    Article  Google Scholar 

  46. Tasker SA, Treanor JJ, Paxton WB, Wallace MR. Efficacy of influenza vaccination in HIV-infected persons. Ann Intern Med. 1999;131:430–3.

    Article  CAS  Google Scholar 

  47. Xu Y, Methuku N, Coimbatore P, Fitzgerald T, Huang Y, Xiao Y-Y, et al. Immunogenicity of an inactivated monovalent 2009 influenza A (H1N1) vaccine in patients who have cancer. Oncologist. 2012;17:125–34.

    Article  Google Scholar 

  48. Deris ZZ, Hasan H, Sulaiman SA, Wahab MSA, Naing NN, Othman NH. The prevalence of acute respiratory symptoms and role of protective measures among malaysian Hajj pilgrims. J Travel Med. 2010;17:82–8.

    Article  Google Scholar 

  49. Alborzi A, Aelami MH, Ziyaeyan M, Jamalidoust M, Moeini M, Pourabbas B, et al. Viral etiology of acute respiratory infections among iranian Hajj pilgrims, 2006. J Travel Med. 2009;16:239–42.

    Article  Google Scholar 

  50. Mustafa AN, Gessner BD, Ismail R, Yusoff AF, Abdullah Nasuruddin, Ishak I, et al. A case-control study of influenza vaccine effectiveness among malaysian pilgrims attending the Haj in Saudi Arabia. Int J Infect Dis. 2003;7:210–4.

    Article  Google Scholar 

  51. Taghioff SM, Slavin BR, Holton T, Singh D. Examining the potential benefits of the influenza vaccine against SARS-CoV-2: a retrospective cohort analysis of 74,754 patients. PLoS One. 2021;16:e0255541.

    Article  CAS  Google Scholar 

  52. El Bashir H, Haworth E, Zambon M, Shafi S, Zuckerman J, Booy R. Influenza among U.K. pilgrims to Hajj, 2003. Emerg Infect Dis. 2004;10:1882–3.

    Article  Google Scholar 

  53. Al-Jasser FS, Kabbash IA, AlMazroa MA, Memish ZA. Patterns of diseases and preventive measures among domestic Hajjis from Central, Saudi Arabia [complete republication]. East Mediterr Health J. 2013;19(Suppl 2):34–41.

    Article  Google Scholar 

  54. Choudhry AJ, Al-Mudaimegh KS, Turkistani AM, Al-Hamdan NA. Hajj-associated acute respiratory infection among Hajjis from Riyadh. East Mediterr Heal J. 2006;12:300–9.

    CAS  Google Scholar 

  55. Al-Asmary S, Al-Shehri AS, Abou-Zeid A, Abdel-Fattah M, Hifnawy T, El-Said T. Acute respiratory tract infections among Hajj medical mission personnel, Saudi Arabia. Int J Infect Dis. 2007;11:268–72.

    Article  Google Scholar 

  56. Alqahtani AS, Alsharif SA, Garnan MA, Tashani M, BinDhim NF, Heywood AE, et al. The impact of receiving pretravel health advice on the prevention of Hajj-related illnesses among australian pilgrims: cohort study. JMIR Public Health Surveill. 2020;6:e10959.

    Article  Google Scholar 

  57. Menec VH, MacWilliam L, Aoki FY. Hospitalisations and deaths due to respiratory illnesses during influenza seasons: a comparison of community residents, senior housing residents, and nursing home residents. J Gerontol Med Sci. 2002;57A:M629-35.

    Google Scholar 

  58. Deguchi Y, Nishimura K. Efficacy of influenza vaccine in elderly persons in welfare nursing homes: reduction in risks of mortality and morbidity during an influenza A (H3N2) epidemic. J Gerontol Med Sci. 2001;56A:M391-4.

    Google Scholar 

  59. Patriarca PA. Efficacy of influenza vaccine in nursing homes. JAMA. 1985;253:1136–9.

    Article  CAS  Google Scholar 

  60. Isahak I, Mahayiddin AA, Ismail R. Effectiveness of influenza vaccination in prevention of influenza-like illness among inhabitants of old folk homes. Southeast Asian J Trop Med Public Health. 2007;38:841–8.

    Google Scholar 

  61. Lansbury L, Nguyen-Van-Tam J. Prevention and control of outbreaks of seasonal influenza in long-term care facilities: a review of the evidence and best-practice guidance. Copenhagen, Denmark: 2017.

  62. Wilde JA, McMillan JA, Serwint J, Butta J, O’Riordan MA, Steinhoff MC. Effectiveness of influenza vaccine in health care professionals: a randomised trial. J Am Med Assoc. 1999;281:908–13.

    Article  CAS  Google Scholar 

  63. Hayward AC, Harling R, Wetten S, Johnson AM, Munro S, Smedley J, et al. Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial. BMJ. 2006;333:1241.

    Article  Google Scholar 

  64. Potter J, Stott DJ, Roberts MA, Elder AG, O’Donnell B, Knight PV, et al. Influenza vaccination of health care workers in long-term-care hospitals reduces the mortality of elderly patients. J Infect Dis. 1997;175:1–6.

    Article  CAS  Google Scholar 

  65. Centers for Disease Control and Prevention. Prevention strategies for seasonal influenza in healthcare settings. Accessed 18 Oct 2022.

  66. Chartrand C, Leeflang MMG, Minion J, Brewer T, Pai M. Accuracy of rapid influenza diagnostic tests. Ann Intern Med. 2012;156:500–11.

    Article  Google Scholar 

  67. Centers for Disease and Prevention. Rapid influenza diagnostic tests. Accessed 18 Oct 2022.

  68. Centers for Disease Control and Prevention. Isolation precautions. 2019. Accessed 28 Jun 2022.

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Medical writing assistance was provided by LC Cheng and TS Jong of MIMS (Malaysia), which was funded by the MIWG and complied with Good Publication Practice 3 ethical guidelines (Battisti et al. Ann Int Med 2015;163:461–464).


This paper was supported by the Sanofi-Aventis (Malaysia) Sdn. Bhd., Abbott Laboratories (Malaysia) Sdn. Bhd., and Roche (Malaysia) Sdn. Bhd. However, there were no representatives of funders present during the expert panel discussions and they were not involved in the writing or approval of the manuscript.

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All authors reviewed the literature, provided substantial input, and reviewed the manuscript. All authors approved the final draft for submission and are accountable for all aspects of the work. All authors read and approved the final manuscript.

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Correspondence to Maw-Pin Tan.

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Tan, MP., Sekawi, Z., Abdul Manap, R. et al. A Malaysian consensus recommendation for the prevention of influenza in older persons. BMC Infect Dis 22, 943 (2022).

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  • Human influenza
  • Older person
  • Aged
  • Prevention
  • Delphi technique
  • Malaysia