Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries

BMC Infectious Diseases

Table 2 In silico Staphylococcus aureus virulence factors analysed for both onset and outcome of sepsis

		Onset				Outcome
Function	VF	EOS	LOS	ND	Total	Alive	Deceased	ND	Total
Targeting leukocytes	PVL	10	19	1	30	17	6	7	30
	lukD	25	29	12	66	36	14	16	66
	hlgABC	40	46	14	100	62	18	20	100
Inhibiting host complement systems	chp	16	15	5	36	19	8	9	36
Inhibiting host complement systems	scn	39	39	13	91	60	14	17	91
Death of B cells	spa	18	22	8	48	27	10	11	48
Formation of aggregates in blood	coa	3	3	2	8	8	0	0	8
	clfB	1	2	1	4	4	0	0	4
	clfA	10	5	1	16	12	3	1	16
	vWbp	10	5	2	17	12	3	2	17
S. aureus tether to endothelial cells	fnbB	3	3	1	7	6	0	1	7
S. aureus tether to endothelial cells	fnbA	5	8	0	13	12	0	1	13
Toxin expression causing injury to endothelium disrupting barrier	hly/hla	30	36	13	79	47	14	18	79

Virulence factors (VF) grouped into reported biological functions [43] and further delineated to show the frequency of S. aureus isolates containing VFs for both onset of sepsis (early onset [EOS] and late onset sepsis [LOS]) and neonatal outcome (not reported deceased from the latest available follow up date, and deceased). ND indicates an unknown onset and/or outcome of sepsis

ISSN: 1471-2334