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Visceral disseminated varicella zoster infection: a rare cause of acute abdomen in a patient with well-controlled diabetes mellitus—a case report



Visceral disseminated varicella zoster virus (VZV) infections frequently affect immunocompromised patients. Diabetes mellitus has been associated with VZV infection, and most cases of disseminated infection involve patients with poorly controlled blood glucose levels. It initially presents as severe abdominal pain, which is evaluated as an acute abdomen, however, the cause is typically unidentified due to unremarkable computed tomography (CT) findings. We report a case of visceral disseminated VZV infection in a patient with well-controlled diabetes mellitus with fat stranding around the celiac and superior mesenteric artery on CT.

Case presentation

A 61-year-old Japanese woman with well-controlled diabetes mellitus presented to the emergency department with severe abdominal pain that gradually worsened. She had stable vital signs and skin rashes, suggestive of varicella. Abdominal CT showed fat stranding around the celiac and superior mesenteric arteries. The patient tested positive for the VZV antigen and was diagnosed with a visceral disseminated VZV infection. Acyclovir was administered, and the patient was discharged on the 14th day.


Visceral disseminated VZV infection may affect patients with well-controlled diabetes mellitus and causes acute abdomen. Periarterial fat stranding on CT is associated with abdominal pain due to visceral disseminated VZV infection.

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Varicella zoster virus (VZV) infections have a severe clinical course in immunocompromised patients. Specifically, patients who underwent bone marrow transplantation have the highest risk of developing disseminated infection [1]. Abdominal pain is often the initial symptom of visceral disseminated VZV infection, and the skin rash, characteristic of VZV infection, appears after than abdominal pain [2, 3]. Therefore, this disease is difficult to diagnosis early. However, delayed treatment can lead to multiorgan failure [4], and misdiagnosis in the emergency department negatively affects patient prognosis. In immunocompromised patients, visceral disseminated VZV infection should be considered a differential diagnosis for acute abdomen due to the high risk of developing the disease. Diabetes mellitus (DM) is also associated with VZV infection, and most cases of disseminated VZV infection involve patients with poorly controlled blood glucose levels [5, 6]. Visceral disseminated VZV infection rarely affects patients with well-controlled DM.

The cause of severe abdominal pain, associated with visceral disseminated VZV infection, remains unclear with negative imaging findings [7, 8]. Recently, periarterial fat stranding around the celiac artery (CA) and superior mesenteric artery (SMA) was reportedly confirmed by computed tomography (CT) [8,9,10].

We report a case of visceral disseminated VZV infection in a patient with well-controlled DM with severe abdominal pain and periarterial fat stranding on CT.

Case presentation

A 61-year-old Japanese woman with postoperative ovarian cancer and DM, controlled with oral antidiabetic medications or drugs, presented to the emergency department (ED) with a complaint of abdominal pain that worsened over four days. She underwent surgery for ovarian cancer 11 years ago and received no chemotherapy as the disease was still at an early stage. She had been followed up as an outpatient for approximately six years and was confirmed to have no recurrence. She had other medical histories of hypertension and hyperlipidemia, with no recent history of taking any steroids or immunosuppressive medications.

On the day of her visit to the ED, skin rashes were noted on her face, abdomen, and thighs. Within the four days between the onset of abdominal pain and the patient’s visit to the ED, she had experienced few episodes of vomiting. Abdominal examination revealed tenderness in the epigastric area without muscular guarding or rebound tenderness. The skin rashes were accompanied by blisters. The patient had a Glasgow Coma Scale of 15 (E4V5M6), blood pressure of 139/81 mmHg, heart rate of 76/min, respiratory rate of 16/min, body temperature of 35.9 ℃, and oxygen saturation level of 100% (room air). Blood tests in the ED showed a slight increase in the C-reactive protein level, as shown in Table 1. Abdominal contrast-enhanced CT, which was performed to evaluate the abdominal pain, showed periarterial fat stranding around the CA and SMA (Fig. 1a, b). No other abnormal findings were observed, and the patient tested positive for the VZV antigen and was diagnosed with visceral disseminated VZV infection. Moreover, she had severe abdominal pain, requiring fentanyl administration. Similarly, she also received acyclovir (10 mg/kg/day).

Table 1 Laboratory data at the emergency department
Fig. 1
figure 1

Abdominal computed tomography (CT) scan at the time of emergency department visit; a Increased CT value (fat stranding) around the celiac artery and its branches. b Fat stranding around the superior mesenteric artery

Blood tests after admission showed that both VZV-immunoglobulin (Ig)M and VZV-IgG were positive;similarly, blood VZV DNA was elevated. There was an increase in antinuclear antibodies; however, other specific antibody tests were negative (Table 2). Her abdominal pain gradually improved, and on day 5, she no longer required fentanyl. Her vital signs or blood tests did not deteriorate, and her abdominal pain was alleviated by oral acetaminophen. The patient was discharged on day 14.

Table 2 VZV and immunological test

Discussion and conclusions

This case highlighted two important clinical learning points. First, visceral disseminated VZV infection affected patients with well-controlled DM. Second, CT findings of periarterial fat stranding around the CA and SMA were associated with abdominal pain in visceral disseminated VZV infection.

Visceral disseminated VZV infection has commonly been reported among immunocompromised patients, such as bone marrow or renal transplant recipients, and patients under immunosuppressive therapy [1, 8,9,10]. In this case, the patient had a medical history of ovarian cancer, however, the surgery was performed more than 10 years ago, and no chemotherapy was administered. Therefore, the association with ovarian cancer was considered unlikely.

Additionally, disseminated VZV infection has been reported among patients with poorly controlled DM (glycated hemoglobin > 10%) [6, 11]. Previous studies have identified both type 1 and type 2 DM as risk factors for herpes zoster infection, and patients with DM had a significantly lower cell-mediated immunity to VZV [5, 12, 13]. In this case, the patient had a glycated hemoglobin of 6.2%, which indicated good control of blood glucose levels in the last one to two months. Thus, patients with DM can develop disseminated VZV infection even during periods when the blood glucose level is well-controlled. However, visceral disseminated VZV infections have not previously been reported among patients with well-controlled DM without other immunocompromising conditions, such as in this case.

Visceral disseminated VZV infection causes severe abdominal pain in 80–100% of cases [7]. VZV infection involves afferent sympathetic fibers to abdominal organs that originate from the posterior nerve roots, including cutaneous sensory fibers [14]. Disseminated VZV infection may cause inflammation of abdominal organs, such as the liver, pancreas, and intestines, due to latency and activation of the celiac ganglia, which may lead to frequent abdominal pain. Although, various etiologies of abdominal pain have been described, these remain unclear [7, 8]. Despite the appearance of severe abdominal pain, abdominal CT usually shows no specific findings in most cases. Nevertheless, there have been reports of increased fat density around the CA and SMA, as in our case [8,9,10, 15]. Although several conditions present with findings of periarterial fat stranding, it is unusual for fat stranding around the CA and SMA to be the isolated finding [15]. Since VZV infections have been associated with vascular disorders, especially in the cerebrovascular system [16], VZV infections may also affect visceral arteries and cause fat stranding around the CA and SMA. Furthermore, the association with visceral arteries may be a factor causing abdominal pain. Based on previous reports [8,9,10, 15], the isolated finding of fat stranding around the CA and SMA should be considered a probable cause of disseminated VZV infection.

In 20–60% of visceral disseminated VZV infections, abdominal pain appeared before the skin rash [3, 9]. It is difficult to diagnose this disease based on a general abdominal examination. As in this case, visceral disseminated VZV infection should be considered a cause of acute abdomen in patients with a history of DM or fat stranding around the CA or SMA on abdominal CT.

In conclusion, visceral disseminated VZV infections may affect patients with well-controlled DM. CT findings of fat stranding around the CA and SMA suggest visceral disseminated VZV infection as the cause of abdominal pain. Nonetheless, further cases are needed to confirm these findings.



Computed tomography


Celiac artery


Diabetes mellitus


Emergency Department




Superior mesenteric artery


Varicella zoster virus


  1. Balkis MM, Ghosn S, Sharara AI, Atweh SF, Kanj SS. Disseminated varicella presenting as acute abdominal pain nine days before the appearance of the rash. Int J Infect Dis. 2009;13:e93–5.

    Article  Google Scholar 

  2. Yagi T, Karasuno T, Hasegawa T, Yasumi M, Kawamoto S, Murakami M, et al. Acute abdomen without cutaneous signs of varicella zoster virus infection as a late complication of allogeneic bone marrow transplantation: importance of empiric therapy with acyclovir. Bone Marrow Transplant. 2000;25:1003–5.

    Article  CAS  Google Scholar 

  3. Hyland JM, Butterworth J. Severe acute visceral pain from varicella zoster virus. Anesth Analg. 2003;97:1117–8 (table of contents).

    Article  Google Scholar 

  4. de Jong MD, Weel JF, van Oers MH, Boom R, Wertheim-van Dillen PM. Molecular diagnosis of visceral herpes zoster. Lancet. 2001;357:2101–2.

    Article  Google Scholar 

  5. Heymann AD, Chodick G, Karpati T, Kamer L, Kremer E, Green MS, et al. Diabetes as a risk factor for herpes zoster infection: results of a population-based study in Israel. Infection. 2008;36:226–30.

    Article  CAS  Google Scholar 

  6. Malkud S, Patil SM. Disseminated cutaneous herpes zoster in a patient with uncontrolled diabetes mellitus. J Clin Diagn Res. 2015;9:WD01–2.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. David DS, Tegtmeier BR, O’Donnell MR, Paz IB, McCarty TM. Visceral varicella-zoster after bone marrow transplantation: report of a case series and review of the literature. Am J Gastroenterol. 1998;93:810–3.

    Article  CAS  Google Scholar 

  8. Furuto Y, Kawamura M, Namikawa A, Takahashi H, Shibuya Y. Successful management of visceral disseminated varicella zoster virus infection during treatment of membranous nephropathy: a case report. BMC Infect Dis. 2019;19:625.

    Article  Google Scholar 

  9. Yamada S, Iwasaki T, Satoh A, Tsuboi Y, Yanagi M, Takahashi T, et al. Case of visceral varicella zoster virus infection after autologous peripheral blood stem cell transplantation in which severe abdominal pain preceded the skin rash. Nihon Shokakibyo Gakkai Zasshi. 2010;107:1947–55.

    PubMed  Google Scholar 

  10. Takada H, Kohara S, Ito T, Yoshioka H, Okada I, Kiriu N, et al. Disseminated Varicella zoster infection with abdominal pain and periarterial fat stranding in a patient taking pomalidomide. Acute Med Surg. 2020;7: e494.

    Article  Google Scholar 

  11. Graue N, Grabbe S, Dissemond J. Disseminated herpes zoster in diabetes mellitus. Dtsch Med Wochenschr. 2006;131:384–6.

    Article  CAS  Google Scholar 

  12. Okamoto S, Hata A, Sadaoka K, Yamanishi K, Mori Y. Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals. J Infect Dis. 2009;200:1606–10.

    Article  CAS  Google Scholar 

  13. Papagianni M, Metallidis S, Tziomalos K. Herpes zoster and diabetes mellitus: a review. Diabetes Therapy. 2018;9:545–50.

    Article  Google Scholar 

  14. Rau R, Fitzhugh CD, Baird K, Cortez KJ, Li L, Fisher SH, et al. Triad of severe abdominal pain, inappropriate antidiuretic hormone section, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therapy. Pediatr Infect Dis J. 2008;27:265–8.

    Article  Google Scholar 

  15. Spernovasilis N, Raissaki M, Papakitsou I, Pitsigavdaki S, Louka K, Tavlas E, et al. Viscral varicella-zoster virus infection presenting with severe abdomimal pain without a rash in a patient with psoriatic arthritis treated with infliximab biosimilar and steroids: a case report. Mediterr J Rheumatol. 2021;32:280–4.

    Article  Google Scholar 

  16. Nagel MA, Bubak AN. Varicella zoster virus vasculopathy. J Infect Dis. 2018;218:S107–12.

    Article  Google Scholar 

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DM and HN managed the patient and comprehensively analyzed and interpreted the patient data. DM drafted the manuscript. HN, YM and KA supervised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Daisuke Mizu.

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Mizu, D., Nishida, H., Matsuoka, Y. et al. Visceral disseminated varicella zoster infection: a rare cause of acute abdomen in a patient with well-controlled diabetes mellitus—a case report. BMC Infect Dis 22, 215 (2022).

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