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The Lisbon patient: exceptional longevity with HIV suggests healthy aging as an ultimate goal for HIV care


In the context of global aging, HIV infection has become a new chronic disease and requires innovative models of care. Treating isolated comorbidities represents a useless and potentially harmful practice at advanced age. Therefore, a patient-centered approach, in which the interventions are focused on the biology and function of the individual, with understanding of the importance of securing social and home environment that provides psychosocial support, better suits unmet health needs. We present a paradigmatic case of healthy aging: the first reported HIV-infected patient who achieved 100th of life – the Lisbon patient. The construct of healthy aging, recently introduced by the World Health Organization, is the best example of this comprehensive model and could represent the fourth target of UNAIDS agenda of the end of AIDS.

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Epidemiological models suggest that life expectancy of people living with HIV achieving immunological success is similar to that of the general population [1], nevertheless the clinical experience of extreme longevity is still limited.

This review gets inspiration from the first reported, and presumably not unique, 100-year-old HIV-infected person, to discuss new principles of geriatric medicine that could be applied in HIV setting. We will use this case as a paradigm to identify opportunities in joining HIV and geriatric medicine to improve the care of older people living with HIV (OPLWH). We obtained consent to present this case from patient’s daughter.

The hereby called “Lisbon patient” was diagnosed with HIV infection at the age of 84, and peacefully died in his sleep 4 months after turning 100 years.

The date of HIV acquisition was not known; at the time of diagnosis, he presented with non-Hodgkin lymphoma and CMV colitis. Nadir CD4 T cell count was < 100 c/μL.

He started antiretroviral therapy (ART) immediately after being diagnosed and was exposed to chemotherapy and toxic ART drugs, including zidovudine, stavudine and first-generation protease inhibitors. He has achieved an undetectable level of HIV-RNA since the beginning of HIV treatment up to death. His last available CD4+ T-lymphocyte count were 560 cells/μL (34%) with CD4/CD8 = 0.97.

From a geriatric perspective, the Lisbon patient had multi-morbidity with hypertension, liver steatosis, osteoarthrosis, and benign prostate hypertrophy. With regards to geriatric syndromes he had sarcopenia and was phenotypically frail [2], due to muscle weakness, slow gait speed, and sedentariness. He had no polypharmacy: the only drug he was taking (apart from ART) was antihypertensive medication. His cognitive function was normal (as estimated by MOCA score).

He had a fortunate genetic inheritance given that his father and siblings reached more than 90 years of age. He had been living in a good environment with no socio-economic difficulties with support and love of his daughter who took care of him (even though she is 75 years old).

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The number of OPLWH is increasing thanks to the synergistic result of two phenomena: people living with HIV live longer and more people acquire HIV at an older age [3]. The former is represented by OPLWH that have been longer exposed to antiretroviral regimens with harmful metabolic effects leading to accentuated risk for co-morbidities, while the latter comprises OPLWH with lower perception of sexual risk that might have developed co-morbidities that are not HIV-associated [4, 5].

To better characterize the diversity of OPLWH, aging cohorts are rising across Europe to address similarities and differences with the complexity of aging trajectories in the general population [5].

In the context of global aging, HIV infection represents a new chronic disease in which the principles of geriatric medicine should be applied. Relevant clinical outcomes go far beyond immune-virologic parameters or even age-related non-infectious co-morbidities alone [6] and include geriatric syndromes. They are multifactorial health conditions that occur when the accumulated deficits in multiple systems, at a clinical level most commonly represented by frailty. It describes a lack of homeostatic reserves exposing the individual to a higher risk of negative outcomes [7].

Frailty assessment allows to identify the causes of individual’s increased vulnerability and implement a person-tailored intervention plan, called comprehensive geriatric assessment.

The new EACS guidelines recommend screening of OPLWH for frailty in the context of a Comprehensive Geriatric Assessment (CGA) [8], defined as a multidisciplinary diagnostic and treatment process that identifies medical, psychosocial, and functional limitations of a frail older person to develop a coordinated plan to maximize overall health with aging [6, 9].

Healthy aging was described in the World report on Aging and Health, developed by World Health Organization, as the process of developing and maintaining the functional ability that enables well-being in older age [10].. This construct relies on the interplay between intrinsic capacity (IC), that includes all physical and cognitive functions of an individual, and the environment. Healthy aging is influenced by our genetic inheritance and personal characteristics such as sex, ethnicity, education and occupation [10]. Assessing IC is both a multidisciplinary and multidimensional process, designed to evaluate the individual’s characteristics on the basis of five functional domains: locomotion, cognitive, psychologic, vitality-related and sensory [11].

Moreover, the IC might be considered as an evolution of the frailty concept, as it takes into special consideration functional reserves expressed by vitality domain, the need for a worldwide implementation of prevention, the continuum of the aging process [11]. This novel approach provides a few advantages over frailty as it gives a positive connotation to the aging phenomenon, provides a possibility to better describe aging trajectories instead of using cross-sectional cut-points and promotes self-empowerment of the individual for his/her health [12].

Both frailty and IC are based on the assumption that the aging individual need to be assessed and managed in a patient centered model through integration of multidisciplinary health services and data obtained by the health environment of the subject [12].

This geriatric approach changes the medical perspective from disease management to preservation of health status maintaining the individual’s functional ability, thus having the capabilities that enable all people to be and do what they have reason to value. This includes a person’s ability to meet their basic needs, to learn, grow and make decisions, to be mobile, to build and maintain relationships, and to contribute to society [10].

IC domains, except for sensory function, were all preserved in the Lisbon patient. Considering the environmental part of healthy aging, we can say that the Lisbon patient had been living in a favorable environment that allowed him to achieve longevity. He taught us that it is possible experience healthy aging regardless of being affected by HIV as a chronic condition. We might indeed consider our ‘Lisbon patient’ as an icon inspiring scientific and community commitment.

However, there is still a lot to be done, as we are seeking for the reliable healthy aging and IC tool. The WHO has launched the Integrated Care for Older People (ICOPE) guidelines with the aim to assist health care professionals to identify declines in physical and mental capacity and to deliver effective interventions to prevent and delay progression of disease and disability [13, 14]. Health care services should meet the needs of those with declining IC, but also of those with preserved IC.

In HIV scenario, OPLWH may present a similar viro-immunological status, but completely different health needs that require different intensity of care [14]. This approach leads to tailored interventions taking into an account management of ART and co-morbidities, social care and preservation of IC [15].

The Joint United Nations Program on HIV/AIDS (UNAIDS) launched the agenda for the end of AIDS introducing the “90–90–90 targets” [16]. This program introduces an equity principle for HIV care. Lazarus et al. suggested to add a fourth 90% in the 90–90-90 cascade paradigm: 90% of all virally suppressed patients should reach good quality of life [17]. The idea of introducing quality of life as the major outcome in people living with HIV originates from the era of first ART regimens, when it was proposed as a part of the evaluation of new and existing treatment strategies [18].


In a patient related outcome context, quality of life may represent a valuable contribution focusing on the subjective perception of the individual’s status and implicitly based on his socio-cultural and economic environment. The limit of this patient-related outcome is that it may fail to represent a robust and standardized parameter for driving public health decisions. Furthermore, quality of life is not necessarily related to the functional competence of the aging individual, as depicted by the Lisbon Patient’s suboptimal quality of life, assessed by the EQ-5D-5 L questionnaire [19].

On the other hand, healthy aging, although designed for the general population, can perfectly fit to OPLWH, as it reinforces a patient-centered approach and asks for a reshaped healthcare model. An integrated model that includes community, the patient, and healthcare providers could identify both medical and social needs, and increase the possibilities for effective intervention [14].

The Lisbon patient commits us to be ambitious to add healthy aging as the fourth target to the UNAIDS 90–90-90 program.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.



Acquired immune deficiency syndrome


Antiretroviral therapy




Human immunodeficiency virus


Integrated Care for Older People


The Montreal Cognitive Assessment


Older people living with HIV


United Nations Program on HIV/AIDS


World Health Organization


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Authors and Affiliations



IP, HS and NM are the physicians who have the patient presented in this report in clinical care. GG suggested to describe this case report putting it in the perspective of UNAIDS treatment goals. MC, CM, IF contributed to the discussion of the case. IP, JM and GG were responsible for writing the manuscript.

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Correspondence to Giovanni Guaraldi.

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The patient’s daughter provided the informed written consent to publish the information contained within the manuscript.

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Pintassilgo, I., Cesari, M., Santos, H.N. et al. The Lisbon patient: exceptional longevity with HIV suggests healthy aging as an ultimate goal for HIV care. BMC Infect Dis 20, 290 (2020).

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