Nowadays, there is an increasing trend in the isolation of Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia and plenty of questions regarding the best therapy to treat this kind of condition [1, 2]. According to this, we have carefully read the very recent article written by Shi et al.  which tries to respond the previous question, however we have found different flaws that prevent the generalization of these results.
The following are a few issues to be considered: 1. The search strategy is not presented in reproducible way, as it is described in Cochrane manual and other methodological strategies . Besides, three elements are the most important to construct it: Population, Intervention and type of study . On the contrary, the items shown were: Population, intervention, control and outcome, which might explain the limited number of articles found; 2. There are different strategies to saturate information in systematic reviews, however these were not shown here (P.e. Grey literature databases, clinical trial registries, thesis databases, google scholar, among others); 3.Regarding the Sensitivity analysis, authors explain that they excluded each publication, nonetheless they do not report the new results excluding the most weighted study (McDanel 2017; 81.5%) in the general analysis.
As we previously said, these important flaws, might lead to selection, publication and information bias that prevent the generalization and application of these results. Therefore, we might take them very carefully in our clinical practice.