Skip to main content

Table 4 Pooled test accuracy for different testing strategies (n = 52 studies)*

From: Diagnostic accuracy of tests to detect Hepatitis C antibody: a meta-analysis and review of the literature

Comparison Pooled SE 95%CI Tau-square P-value for hetero-geneity Pooled SP 95%CI Tau-square P-value for hetero-geneity
RDT versus EIA only (n = 5) 99% 98% 100% <0.001 100% 100% 100% <0.001
RDT versus NAT or Immunoblot (n = 13) 93% 91% 95% <0.001 98% 97% 99% <0.001
RDT versus EIA, NAT or Immunoblot (n = 14) 97% 96% 098% <0.001 100% 100% 100% <0.001
Oral RDT versus blood reference (n = 12) 94% 93% 96% <0.001 100% 100% 100% <0.001
Sample type
 Blood samples (n = 45) 98% 97% 98% <0.001 98% 98% 99%  
 Oral samples (n = 12) 94% 93% 96% <0.001 100% 100% 100% <0.001
Source population
 General screening (n = 17) 95% 94% 96% <0.001 99% 98% 99% <0.001
 High risk population (n = 19) 97% 96% 98% <0.001 94% 94% 95% <0.001
 Hospital patients (n = 16) 97% 96% 98% <0.001 100% 100% 100% <0.001
Antibody and Antigen Combo testing (n = 6) 86% 79% 94% <0.001 99% 98% 100% <0.001
Oral kits brand        100%  
 OraQuick (n = 8) 98% 97% 99% <0.001 100% 100% 100% <0.001
 Other brands (n = 6) 88% 84% 92% <0.001 99% 99% 100% <0.001
  1. Notes: *Studies conducted in both LMIC and high-income countries were not included here
  2. Studies conducted cross these regions were not included here
  3. SE sensitivity, SP specificity