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Table 4 Pooled test accuracy for different testing strategies (n = 52 studies)*

From: Diagnostic accuracy of tests to detect Hepatitis C antibody: a meta-analysis and review of the literature

Comparison

Pooled SE

95%CI

Tau-square P-value for hetero-geneity

Pooled SP

95%CI

Tau-square P-value for hetero-geneity

RDT versus EIA only (n = 5)

99%

98%

100%

<0.001

100%

100%

100%

<0.001

RDT versus NAT or Immunoblot (n = 13)

93%

91%

95%

<0.001

98%

97%

99%

<0.001

RDT versus EIA, NAT or Immunoblot (n = 14)

97%

96%

098%

<0.001

100%

100%

100%

<0.001

Oral RDT versus blood reference (n = 12)

94%

93%

96%

<0.001

100%

100%

100%

<0.001

Sample type

 Blood samples (n = 45)

98%

97%

98%

<0.001

98%

98%

99%

 

 Oral samples (n = 12)

94%

93%

96%

<0.001

100%

100%

100%

<0.001

Source population

 General screening (n = 17)

95%

94%

96%

<0.001

99%

98%

99%

<0.001

 High risk population (n = 19)

97%

96%

98%

<0.001

94%

94%

95%

<0.001

 Hospital patients (n = 16)

97%

96%

98%

<0.001

100%

100%

100%

<0.001

Antibody and Antigen Combo testing (n = 6)

86%

79%

94%

<0.001

99%

98%

100%

<0.001

Oral kits brand

      

100%

 

 OraQuick (n = 8)

98%

97%

99%

<0.001

100%

100%

100%

<0.001

 Other brands (n = 6)

88%

84%

92%

<0.001

99%

99%

100%

<0.001

  1. Notes: *Studies conducted in both LMIC and high-income countries were not included here
  2. Studies conducted cross these regions were not included here
  3. SE sensitivity, SP specificity
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BMC Infectious Diseases

ISSN: 1471-2334

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