Relationship between day 1 and day 2 Vancomycin area under the curve values and emergence of heterogeneous Vancomycin-intermediate Staphylococcus aureus (hVISA) by Etest® macromethod among patients with MRSA bloodstream infections: a pilot study

Table 1 Clinical characteristics of patients in whom hVISA population was detected

	Patient Number
	1	2	3	4	5	6	7
AUC0_0-24h/MIC_BMD ratio	420.8	226.4	358.6	519.5	251.9	302.6	759.6
AUC_24-48h/MIC_BMD ratio	506.6	600.9	505.6	806.6	534.7	442.1	545.3
Creatinine clearance (mL/min)	34.2	22.8	34.5	22.1	65.7	25.3	8.4
Days from index MRSA blood culture to emergence of hVISA	62	2	2	14	15	62	23
Days from start of vancomycin to emergence of hVISA	62	2	1	14	13	61	22
hVISA emergence on treatment	Y	Y	Y	Y	Y	N	Y

Abbreviations: hVISA heterogeneous vancomycin-intermediate Staphylococcus aureus, AUC _0-24h /MIC _BMD area under the curve from 0 to 24 h over broth microdilution minimum inhibitory concentration, AUC _24-48h /MIC _BMD, area under the curve from 24 to 48 h over broth microdilution minimum inhibitory concentration, Y yes, N, no

ISSN: 1471-2334