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Table 4 Multivariate analysis of cocaine/crack use and liver fibrosis progression using cut-off of 2 for APRI

From: Cocaine/crack use is not associated with fibrosis progression measured by AST-to-Platelet Ratio Index in HIV-HCV co-infected patients: a cohort study

  Recent cocaine/crack use
  HR 95% CI
Time independent variables (at baseline)
 Cocaine/crack use ever at baseline 0.83 0.50, 1.40
 Baseline age (per 10 years) 1.04 0.83, 1.29
 Female sex 1.48 1.03, 2.13
 Baseline HCV infection duration (per 5 years) 1.05 0.95, 1.16
 Baseline ln (APRI) 2.54 1.69, 3.81
Time updated variables
 Recent cocaine/crack use 0.69 0.45, 1.04
 Recent other drug usea 1.19 0.82, 1.72
 Current alcohol abuseb 1.76 1.14, 2.72
 CD4 count (per 100 cells/μL) 0.91 0.85, 0.98
  1. aHeroin and opiates, steroids, methylphenidate, hallucinogens (PCP, LSD), benzodiazepine, barbiturates, methamphetamine, amphetamine, other
  2. bDefined as >6 drinks at least once a month and >2 drinks on a typical day when drinking