Molecular epidemiology and characteristic of virulence gene of community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus isolates in Sun Yat-sen Memorial hospital, Guangzhou, Southern China

Table 4 The relationship of molecular characterization, antimicrobial resistance, and the main virulence factor profiles of 62 MRSA isolates

PFGE profile	SCCmec(n)	ST (n)	CA-MRSA (n)	HA-MRSA (n)	The main virulence factor profiles	Resistance profile
A(33)	I(2)	ST8(1)	0	1	sea, PVL, hla,hlb,hlg	CIP/CN/E/TET
	I(2)	ST239(1)	0	1
	III(30)	ST239(29)	7	22
	III(30)	ST1 (1)	0	1
	V(1)	ST5(1)	0	1
B(12)	III (11)	ST239(9)	2	7	sea,seg, hla,hlb,hlg	CIP/CN/E/TET/RD
		ST537(1)	0	1
		ST1(1)	1	0
	IVa(1)	7(1)	1	0
C (8)	I(1)	ST59(1)	1	0	sea,seb,seg,PVL, hla,hlb,hlg	E/TET
	III(1)	ST59(1)	1	0
	IVa(3)	ST59(3)	2	1
	IVd(3)	ST59(1)	3	0
		ST239(1)
		ST338(1)
D (2)	III(1)	ST950(1)	1	0	seg,sei,sem ~ o,PVL, hla,hlb,hlg	E
D (2)	II(1)	ST239(1)	0	1	seg,sei,sem ~ o,PVL, hla,hlb,hlg	E
E (2)	III(2)	ST10(1)	1	0	sea(seb),sec,seg(sei),sem ~ o,PVL,hla,hlb,hlg	E
E (2)	III(2)	ST3073(1)	0	1	sea(seb),sec,seg(sei),sem ~ o,PVL,hla,hlb,hlg	E
F (1)	I(1)	ST45(1)	1	0	sec,seg,sei,PVL,hla,hlb,hlg	E/TET
G (1)	III(1)	NT(1)	0	1	hla,hlb,hlg	E/TET/RD
H (1)	IVa(1)	ST59(1)	1	0	seb,PVL, hla,hlb,hlg	E/TET

PFGE pulsed-field gel electrophoresis, SCCmec staphylococcal cassette chromosome mec, ST sequence type, Sea ~ see, seg ~ sej, sem ~ seo, gene encoding staphylococcal enterotoxins; eta and etb, gene encoding exfoliative toxin A and B; hla ~ hlg, gene encodingα-hemolysin ~ γ-hemolysin; tsst-1, gene encoding toxic shock syndrome toxin 1; PVL Panton-Valentine leukocidin, CIP ciprofloxacin, CN gentamicin, E erythromycin, TET tetracycline, RD rifampicin, NT non-typable

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