Table 1 Baseline characteristics of the household contacts with latent tuberculosis infection that were randomised to either the no IPT or IPT arms

Sex

Female

16 (70)

15 (63)

Male

7 (30)

9 (37)

Age (median)

25

24

Age group

6–12

3 (13)

4 (17)

13–18

3 (13)

3 (13)

>18

17 (74)

17 (70)

Socio-economic status

Lower

11 (48)

10 (42)

higher

12 (52)

14 (58)

Relationship to index case

First degree relative

18 (78)

20 (83)

Not first degree relative

5 (22)

4 (17)

Proximity to index case

Shared meals with index case

0

2 (8)

Cared for index case

7 (30)

12 (50)

Shared room with index case

12 (52)

6 (25)

Shared bed with index case

4 (18)

4 (17)

Duration of contact with index case

>6 h/day

22 (96)

20 (83)

<6 h/day

1 (4)

4 (17)

Smoking

No

18 (78)

20 (83)

Yes

5 (22)

4 (17)

Alcohol

No

15 (65)

17 (71)

Yes

8 (35)

7 (29)

BCG scar

No

12 (52)

7 (29)

Yes

11 (48)

17 (71)

^aBaseline cytokine responses (medians (IQR)) pg/ml

IFNγ

1201.1 (336.8–2246.6)

648 (259.6–2605.4)

TNFα

1 (1–11.4)

6.8 (1–74.6)

IL-2

339.8 (138.4–415.2)

291.2 (80.6–444.4)

IL-5

2.1 (1–9.9)

1 (1–1)

IL-13

21.9 (2.3-35.3)

2.1 (1–10.6)

IL-10

1 (1–1)

1 (1–1)

IL-17a

1 (1–1)

1 (1–1.8)

IL-17f

3.8 (1–6.7)

1 (1–1.9)

IL-21

1 (1–1)

1 (1–1)

IL-22

1.1 (1–12.4)

1 (1–4.9)

M.tb specific antibody responses

PPD

5200 (2950–8800)

5550 (3250–8200)

(medians (IQR)) ng/ml

CFP-10

3100 (1500–4800)

2700 (2050–4900)

ESAT-6

5000 (2400–7900)

3700 (2550–5600)

Index case relating factors

HIV status of index case

Negative

20 (87)

18 (82)

Positive

3 (13)

4 (18)

Sputum positivity

1+

4 (17)

7 (29)

2+

10 (43)

4 (17)

3+

9 (40)

13 (54)

Duration of Index patient cough (weeks)

0–4

6 (26)

7 (29)

5–14

9 (39)

7 (29)

15–24

4 (17)

8 (33)

>25

4 (17)

2 (8)