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Table 1 Baseline characteristics of the household contacts with latent tuberculosis infection that were randomised to either the no IPT or IPT arms

From: Effect of isoniazid preventive therapy on immune responses to mycobacterium tuberculosis: an open label randomised, controlled, exploratory study

Variable Level No IPT (n = 23) n (%) IPT (n = 24) n (%)
Household contact relating factors    
Sex Female 16 (70) 15 (63)
  Male 7 (30) 9 (37)
Age (median)   25 24
Age group 6–12 3 (13) 4 (17)
  13–18 3 (13) 3 (13)
  >18 17 (74) 17 (70)
Socio-economic status Lower 11 (48) 10 (42)
  higher 12 (52) 14 (58)
Relationship to index case First degree relative 18 (78) 20 (83)
  Not first degree relative 5 (22) 4 (17)
Proximity to index case Shared meals with index case 0 2 (8)
  Cared for index case 7 (30) 12 (50)
  Shared room with index case 12 (52) 6 (25)
  Shared bed with index case 4 (18) 4 (17)
Duration of contact with index case >6 h/day 22 (96) 20 (83)
  <6 h/day 1 (4) 4 (17)
Smoking No 18 (78) 20 (83)
  Yes 5 (22) 4 (17)
Alcohol No 15 (65) 17 (71)
  Yes 8 (35) 7 (29)
BCG scar No 12 (52) 7 (29)
  Yes 11 (48) 17 (71)
aBaseline cytokine responses (medians (IQR)) pg/ml IFNγ 1201.1 (336.8–2246.6) 648 (259.6–2605.4)
  TNFα 1 (1–11.4) 6.8 (1–74.6)
  IL-2 339.8 (138.4–415.2) 291.2 (80.6–444.4)
  IL-5 2.1 (1–9.9) 1 (1–1)
  IL-13 21.9 (2.3-35.3) 2.1 (1–10.6)
  IL-10 1 (1–1) 1 (1–1)
  IL-17a 1 (1–1) 1 (1–1.8)
  IL-17f 3.8 (1–6.7) 1 (1–1.9)
  IL-21 1 (1–1) 1 (1–1)
  IL-22 1.1 (1–12.4) 1 (1–4.9)
M.tb specific antibody responses PPD 5200 (2950–8800) 5550 (3250–8200)
(medians (IQR)) ng/ml CFP-10 3100 (1500–4800) 2700 (2050–4900)
  ESAT-6 5000 (2400–7900) 3700 (2550–5600)
Index case relating factors    
HIV status of index case Negative 20 (87) 18 (82)
  Positive 3 (13) 4 (18)
Sputum positivity 1+ 4 (17) 7 (29)
  2+ 10 (43) 4 (17)
  3+ 9 (40) 13 (54)
Duration of Index patient cough (weeks) 0–4 6 (26) 7 (29)
  5–14 9 (39) 7 (29)
  15–24 4 (17) 8 (33)
  >25 4 (17) 2 (8)
  1. aBaseline cytokine responses were obtained from QFN culture supernatants and are represented as net (antigen stimulated minus unstimulated) values
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