Table 1 Patient characteristics and pharmacokinetic values
Patient | 1 | 2a | 2b | |
Post-Injury Day | 18 | 15 | 21 | |
Treatment Day | 15 | 4 | 11 | |
Age (years) | 30 | 28 | 28 | |
Weight (kg) | 78.8 | 77.1 | 60.1 | |
Antifungal | L-AmB | L-AmB | Voriconazole | Voriconazole |
Dose (mg) | 400 | 400 | 320 | 320 |
Dose (mg/kg) | 5.1 (24 h) | 5.2 (24 h) | 4.2 (12 h) | 5.3 (12 h) |
Peak (μg/mL) | 25.5 | 58.4 | 10.4 | 3.5 |
Trough (μg/mL) | 6.1 | 12.8 | 3.0 | 0.7 |
AUCτ(μg · h/mL) | 262.5 | 534.7 | 67.5 | 24.1 |
T1/2 (h) | 23.3 | 16.3 | 7.6 | 3.2 |
Vd (L/kg) | 0.52 | 0.21 | 0.58 | 1.28 |
Clearance (mL/kg/min) | 0.32 | 0.16 | 1.02 | 3.69 |
Plasma % bound | 100% | 100% | 32.7 ± 8.2 | 22.1 ± 4.1% |
Effluent % bound | 55.6% (RUE) | N/A | ||
100% | 100% | 75.0% (abd.) | ||
(all sites) | (all sites) | 90.5% (calc.) | ||
eGFR (mL/min/1.73 m2) | 19.9 | 75.8 | 126.1 | |
AST/ALT (IU/L) | 193/59 | 211/318 | 61/72 | |
INR | 1.4 | 1.4 | 1.2 | |