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Table 2 Clinical characteristics of children with invasive S. aureus infections

From: Clinical and molecular characteristics of invasive community-acquired Staphylococcus aureusinfections in Chinese children

Characteristics Total n =163 N (%) MRSA n =71 N (%) MSSA n = 92 N (%) P
Infection sites a     
Bacteremia 107 (65.6) 34 (47.9) 73 (79.3) 0.000
Pneumonia 86 (52.8) 43 (60.6) 43 (46.7) 0.08
Severe pneumonia 72 (83.7) 38 (88.4) 34 (79.1) 0.243
 Necrotizing pneumonia 16 (18.6) 8 (18.6) 8 (18.6) 1.0
Moderate pneumonia 14 (16.3) 5 (11.6) 9 (20.9) 0.243
Musculoskeletal infection 32 (19.6) 8 (11.3) 24 (26.1) 0.018
 Osteomyelitis 27 (84.3) 8 (100) 19 (79.2) 0.29
 Arthritis 15 (46.9) 3 (37.5) 17 (70.8) 0.116
 Pyomyositis 10 (31.2) 4 (50) 6 (25) 1.0
 Necrotizing fasciitis 8 (25) 2 (25) 6 (25) 1.0
Meningitis 7 (3.7) 3 (4.2) 4 (4.3) 1.0
Endocarditis 3 (1.8) 2 (2.8) 1 (1.1) 0.82
Orbital abscess 4 (2.5) 4 (5.6) 0 0.073
Deep-seated abscess 4 (2.5) 1 (1.4) 3 (3.3) 0.805
Othersb 6 (3.6) 4 (5.6) 2 (2.2) 0.457
Clinical diagnosis     
Single-site infections 51 (31.3) 29 (40.8) 22 (23.9) 0.021
Pneumonia 23 (45.1) 18 (62.1) 5 (22.7) 0.005
Bacteremia 15 (29.4) 6 (20.7) 9 (40.9) 0.117
Musculoskeletal infection 7 (13.7) 2 (6.9) 5 (22.7) 0.224
Othersc 6 (11.8) 3 (10.3) 3 (13.6) 1.0
Multi-site infections 112 (68.7) 42 (59.2) 70 (76.1) 0.021
Two infection sites 87 (77.7) 35 (49.3) 52 (74.3) 0.266
Bacteremia + SSTI 22 (19.6) 10 (23.8) 12 (17.1) 0.39
Bacteremia + Pneumonia 29 (25.9) 7 (16.7) 22 (31.4) 0.084
 Bacteremia-related Pneumonia 16 (14.3) 3 (7.1) 13 (18.6) 0.094
 Pneumonia-related Bacteremia 13 (11.6) 4 (9.5) 9 (12.9) 0.594
Bacteremia + Musculoskeletal infection 12 (10.7) 2 (4.8) 10 (14.3) 0.207
Pneumonia + SSTI 10 (8.9) 9 (21.4) 1 (1.4) 0.001
Othersd 14 (12.5) 7 (16.7) 7 (10) 0.302
The infection sites ≥3 25 (22.3) 7 (16.7) 18 (25.7) 0.266
Bacteremia + Pneumonia + SSTI 12 (10.7) 2 (4.8) 10 (14.3) 0.207
Otherse 13 (11.6) 5 (11.9) 8 (11.4) 1.00
  1. MRSA: methicillin-resistant S. aureus; MSSA: methicillin-susceptible S. aureus; SSTI: skin and soft tissue infections.
  2. aNot mutually exclusive.
  3. bOne MRSA case each of lymphadenitis, peritonitis, hepatapostema, and appendiceal abscess and one MSSA case each of peritonitis and hydrocele complicated with infection.
  4. cOne MRSA case each of appendiceal abscess, deep-seated abscess, and orbital abscess and three MSSA cases of deep-seated abscess.
  5. dTwo MRSA cases of bacteremia + orbital abscess, one MRSA case each of pneumonia + musculoskeletal infection, pneumonia + meningitis, pneumonia + peritonitis, pneumonia + hepatapostema, and musculoskeletal infection + SSTI; three MSSA cases of musculoskeletal infection + SSTI; one MSSA case each of pneumonia + meningitis, bacteremia + peritonitis, endocarditis + meningitis, and bacteremia + hydrocele complicated with infection.
  6. eOne MRSA case each of bacteremia + meningitis + endocarditis, bacteremia + pneumonia + lymphadenitis, pneumonia + musculoskeletal infection + endocarditis, bacteremia + pneumonia + orbital abscess + meningitis, and bacteremia + pneumonia + musculoskeletal infection + SSTI; four MSSA cases of bacteremia + musculoskeletal infection + SSTI; two cases of bacteremia + pneumonia + meningitis + SSTI; one MSSA case each of bacteremia + pneumonia + musculoskeletal infection and bacteremia + pneumonia + musculoskeletal infection + SSTI.