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Table 3 Multivariate multilevel regression model predicting peripheral blood T lymphocyte subpopulations from relevant parameters (n = 55)*

From: Impact of viral replication inhibition by entecavir on peripheral T lymphocyte subpopulations in chronic hepatitis B patients

  CD3+T Lymphocyte CD4+T Lymphocyte CD8+T Lymphocyte
Variables β SE P value β SE P value β SE P value
Fixed effects          
Intercept 44.50 1.31 -- 28.09 0.88 -- 39.85 1.09 --
Weeks ** 0.21 0.01 <0.0001 0.18 0.01 <0.0001 -0.23 0.01 <0.0001
Period (4–48 week vs < 4 week) 0.99 0.75 0.19 1.92 0.72 <0.01 -2.07 0.86 0.02
HBV DNA (Log, copies/mL) ** 0.07 0.09 0.47 -0.01 0.09 0.92 0.09 0.11 0.41
HBV DNA (Log, copies/mL) × period -0.29 0.14 0.03 -0.48 0.13 <0.001 0.42 0.16 <0.01
Random effects: Intercept = 8.49 Intercept = 4.71 Intercept = 6.02
  SD = 1.73 SD = 1.66 SD = 1.97
  1. *β = Coefficients from the model, SE = Standard Error, SD = Standard Deviation. **Continuous variable.
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