Volume 14 Supplement 7
Resistance profile of Staphylococcus aureusstrains isolated from patients treated in a tertiary care hospital in Romania
© Săndulescu et al; licensee BioMed Central Ltd. 2014
Published: 15 October 2014
We have performed a study to assess the antimicrobial susceptibility profile of S. aureus strains isolated from clinically apparent infections treated in the National Institute for Infectious Diseases "Prof. Dr. Matei Balş". Bacterial identification and antimicrobial sensitivity testing were performed on MALDI-TOF or VITEK (bioMérieux, Paris, France).
We examined 149 strains of S. aureus, 44.9% from cutaneous wound infections, 31.2% from blood cultures, 8.4% from sputum samples and 15.3% from other infection sites. Of the total number of strains identified, 55.7% were resistant to methicillin, 35.1% were resistant to clindamycin (D-test results are presented separately), 30.9% were resistant to levofloxacin, 18.7% were resistant to rifampin and smaller percentages were identified for resistance to other drugs. Surprisingly, resistance was also identified to drugs that are not used in clinical practice in Romania, such as daptomycin (6.8%) or fusidic acid (4.8%), suggesting a possible international circulation of S. aureus strains, probably through means of nasal or axillary carriage. We excluded a mechanism of daptomycin non-susceptibility through thickened bacterial cell walls in strains of vancomycin-intermediate S. aureus, as all strains were susceptible to vancomycin.
Antimicrobial resistance remains a major issue in clinical practice, but studies describing the local antimicrobial susceptibility patterns of important pathogens can aid in guiding first-line antibiotherapy.
1) This paper is partially supported by the Sectoral Operational Programme Human Resources Development (SOP HRD), financed from the European Social Fund and by the Romanian Government under the contract numbers POSDRU/159/1.5/S/137390.
2) This paper is partially supported by the Carol Davila University of Medicine and Pharmacy, Young Researchers Projects Grant Competition, contract number 28.336/04.11.2013.
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