Schematic representation of a single model cell. Mosquito population dynamics, human movement, infection dynamics and mosquito flight characteristics are calculated for each cell. Mosquito population dynamics are governed by the weather, vector control and mosquito flight characterisitcs. Human movement patterns are subject to the time and type of day (morning, daytime, evening, night, weekday, weekend). In the human disease progression, the dark ‘I’ indicates symptomatic infections and the grey ‘I’ indicates asymptomatic infections (a detailed explanation of symptomatic and asymptomatic infections is presented in the Additional file 1: Figure S24).