Figure 5

Pearson correlation between RNA expression level and apoptosis score. RNA expression data of individual rats are based on chip analysis, the apoptosis score is the mean value of apoptotic cells of corresponding rat brains. Expression levels of up-regulated genes such as BDNF (A) (Pearson correlation p = 0.002), Npas4 (C) (p = 0.005) and Nr4a1 (D) (p = 0.003) negatively correlate with apoptosis score, e.g. the less transcript, the more apoptotic cells. In contrast, expression levels of down-regulated genes such as Lyz 2 (B) (p < 0.001) and Pafah2 (E) (p = 0.005) postitively correlate with apoptosis score. Samples from vitamin B6-treated rats (bare circles) are arranged separately from samples of animals treated with saline (solid circles).