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Table 1 The patterns of gyrA mutations and OFX MICs profile of OFX-resistant MTB strains

From: Association of mutation patterns in gyrA/B genes and ofloxacin resistance levels in Mycobacterium tuberculosisisolates from East China in 2009

Codon mutation

Nucleotide change

No. of strains

  

MIC (mg/L)

  

2

4

8

16

32

D94A

GAC-GCC

4

 

2

 

1

D94G

GAC-GGC

5

10

10

3

3

D94N

GAC-AAC

2

2

2

1

 

D94Y

GAC-TAC

1

3

4

  

D94F

GAC-TTC

1

    

A90V

GCG-GTC/GTG

6

10

7

1

 

S91P

TCG-CCG

2

2

 

2

 

A90V&D94Y

GCG-GTC & GAC-TAC

   

1

Â