This article has Open Peer Review reports available.
Epidemiological characteristics of varicella from 2000 to 2008 and the impact of nationwide immunization in Taiwan
© Chang et al; licensee BioMed Central Ltd. 2011
Received: 9 June 2011
Accepted: 16 December 2011
Published: 16 December 2011
Varicella has an important impact on public health. Starting in 2004 in Taiwan, nationwide free varicella vaccinations were given to 1-year-old children.
Our study investigated the epidemiological characteristics of varicella from 2000 to 2008, and assessed the change of varicella epidemiology after the mass varicella immunization. ICD-9-CM codes related to varicella or chickenpox (052, 052.1, 052.2, 052.7, 052.8, 052.9) were analyzed for all young people under 20 years of age through the National Health Insurance database of Taiwan from 2000 to 2008.
Case numbers of varicella or chickenpox significantly declined after the nationwide immunization in 2004. Winter, particularly January, was the epidemic season of varicella. We found a significant post-vaccination decrease in incidence among preschool children, especially 3 to 6 year-old children-- the peak incidence was 66 per thousand for 4 and 5 year-old children before the nationwide immunization (2000 to 2003), and the peak incidence was 23 per thousand for 6 year-old children in 2008 (p < 0.001). Varicella-related hospitalization also significantly decreased in children younger than 6 years after the nationwide immunization.
The varicella annual incidence and varicella-related hospitalization markedly declined in preschool children after nationwide varicella immunization in 2004.
Varicella is the primary disease caused by the varicella-zoster virus. It is a common and highly contagious disease and has a significant health impact on children. Although the clinical course of varicella is usually mild and self-limiting, varicella does cause complications and mortality resulting in financial expense [1–3]. Chickenpox or varicella now has been considered one of the most common vaccine-preventable diseases in many countries [4–7].
In Taiwan, some areas including Taipei City, Taichung City and Taichung County gave the public free varicella vaccinations for 1-2 year-old children before 2004. Taipei City started the free varicella vaccination from 1998 and Taichung City and Taichung County from 1999. Other areas did not provide free varicella vaccination, but people could receive varicella vaccination at their own expense before 2004. Since 2004, free mass varicella immunization has been given to all one year-old children throughout Taiwan.
Since the implementation of National Health Insurance (NHI) in 1995, there has been a healthcare database in Taiwan. Taiwan has a population of 22.9 million people and the land area of 36188 Km2. Its population density is 633/Km2. Taiwan's NHI covered most of the health care costs for 98% of its population in 2006 ; the remaining 2% of it population are living in the foreign countries or in families with monthly household incomes less than 1000 US dollars. Taiwan's NHI database includes health care data collected from over 95% of the hospitals in Taiwan for more than 96% of the population receiving health care. We evaluated the disease burden and epidemiological characteristics of varicella by using the NHI database to find out the age-specific incidences, seasonal distribution and varicella-related hospitalization from 2000 to 2008-- the period covering pre- and post-public free vaccination-- so we could compare the epidemiological characteristics of varicella before and after the mass immunization.
The administration of a live attenuated varicella vaccine was licensed in Taiwan in 1997. Both Merck and GlaxoSmithKline, pharmaceutical companies, provided the varicella vaccines in Taiwan. In 2004 the varicella vaccine was incorporated into Taiwan's national immunization program, and all 1-year-old children could receive the varicella vaccine for free. The varicella coverage rate for 1-year-old children was 94% for the 2003 birth cohort, 95% for the 2004 cohort, and 97% for the 2005, 2006, and 2007 birth cohorts according to Taiwan's National Immunization Information System which was developed in the early 1990s . When a child received a vaccine, his or her vaccination would not only be recorded in a child's vaccination handbook but would also be reported to the National Immunization Information System.
Taiwan's National Health Insurance (NHI) covered most of the health care costs for 98% of its population. Taiwan's NHI database includes health care data collected from over 95% of the hospitals in Taiwan for more than 98% of the population receiving health care. From this database, hospitalization and outpatient healthcare records were collected from 2000 to 2008, and International Classifications of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes related to varicella or chickenpox were analyzed for all the population. The age-specific annual incidence and hospitalization rate were calculated. For calculating the annual population-based incidence, the annual incidence was calculated by dividing the number of varicella-related diseases by the population, which was obtained from Department of Statistics, Ministry of the Interior, Taiwan from 2000 to 2008 .
ICD-9-CM codes for chickenpox or varicella include the following: 052 chickenpox; 052.0 post-varicella encephalitis, post-chickenpox encephalitis; 052.1 varicella (hemorrhagic) pneumonitis; 052.7 with other specified complications; 052.8 with unspecified complication; 052.9 varicella without mention of complication.
For complications, we define varicella or chickenpox patients to have complications in cases where the patients had both ICD-9-CM codes for varicella or chickenpox (052 and the other related codes) and also ICD-9-CM codes for varicella-related complications which include the following: central nervous system including 320 meningitis, 322 cerebellitis, 323 encephalitis, 348 encephalopathy, 351 facial palsy, 331.81 Reye's syndrome, 780.3 febrile convulsion/seizure; skin and soft tissue including 680-686 cellulites and abscess, 035 erysipela, 728 pyomyositis and necrotizing fasciitis, 373 & 376.01 blepharitis, 034 & 041 scarlet fever and streptococcal or staphylococcal infection; skeletal system including 711 arthritis, 730-733 osteomyelitis; lower respiratory tract infection including 480-487 pneumonia, 510-519 pneumonitis, 466 & 490 bronchitis; hematological system- 287 thrombocytopenia, 283 & 285 anemia, 288 neutropenia; 038 & 790 & 995.91-995.92 for sepsis and bacteremia; 040-041 for other bacterial infection; 422 cardiomyopathy, 425 myocarditis; 070.5 & 070.9 & 573 for hepatitis.
In univariate analysis, categorical variables were compared with chi-square or Fisher's exact test; continuous variables were analyzed with Student's t test. The difference of annual incidence among various age groups, the difference of annual incidences in different years, and the difference in seasonal distribution were measured with appropriate χ2 test. A p value of < 0.05 was considered to be statistically significant. All statistical analyses were performed with SAS software, version 9.0.
Number of cases before and after the mass immunization
Age-specific annual incidence
Age-specific varicella-related hospitalization incidence
Among the 21829 hospitalized cases, 561 (2.57%) had central nervous system complications, 2721 (12.47%) had skin or soft tissue infections, 4740 (21.71%) had lower respiratory tract infections, 493 (2.26%) had hematological complications, 281 (1.29%) had septicemia or bacteremia, and 721 (3.30%) had hepatitis.
Demography and complications of 12 fatal varicella cases
Encephalitis, septic shock
Acute lymphoblastic leukemia
Acute lymphoblastic leukemia
Skin/soft tissue infections, streptococcal septicemia
Skin/soft tissue infections, pneumonia, septicemia
Severe combined immunodeficiency
Acute and subacute hepatic necrosis, gastrointestinal hemorrhage
Pulmonary vascular anomaly
Hemoptysis, acute respiratory failure
Nationwide varicella immunization has resulted in a marked reduction of varicella incidence and varicella-related hospitalization in children younger than 6 years of age in Taiwan. The impact of mass varicella immunization has so far made it possible for most preschool children to be free of varicella and varicella-related hospitalization in Taiwan. However, children beyond 7 years of age had similar annual incidence before and after the mass immunization.
As Figure 3 shows the age distribution before the mass immunization in 2000, the peak age of varicella was 3 to 6 years, which was also the age group of kindergarteners. Kindergarteners might have more exposure to varicella and also their hand hygiene and sanitation levels are generally not as high as adults' or older school children's, who may in turn lead to more varicella cases in kindergarteners without mass immunization (Figure 3). However, after the mass immunization, we observed more varicella cases in the school children than those in 3 to 4-year-old kindergarteners (Figure 4), who were supposed to have received the free varicella vaccine at 1 year of age. Therefore, mass immunization has changed the age distribution of varicella cases significantly and the peak age has subsequently moved to older children without previous immunization. Similar results were also reported by Lian et al who found that the greatest decrease in varicella incidence occurred in children aged below 6 and the incidence of varicella shifted to older age groups after implementation of the one-dose varicella vaccination policy . Lian et al also found that the incidence in early launch areas was significantly lower than that in the other areas in Taiwan . Our study additionally reported the seasonality, varicella-related hospitalization and complications from 2000 to 2008 in Taiwan. Moreover, our data in this study is nationwide rather than the selected sample size like that of Lian et al's study.
We found that the annual incidence of children beyond 7 years of age was similar before and after mass immunization. It's because most of the school children were not allowed to receive the free varicella vaccine. Thus, the varicella incidence of the school children did not change significantly after the mass immunization in this study. We suppose that the annual incidence of school children may decrease several years later if the immunized children grow up to be 6 to 12 years old. However, we have to follow up on the impact of mass immunization on school children to prove the above assumption several years later.
The infants had the highest annual incidence of varicella-related hospitalization both before and after the mass immunization (Figure 6). Infants cannot receive the varicella vaccine and they have a higher chance of severe varicella and more complications , so their varicella-related hospitalization was significantly higher than the other children.
There were 12 cases of fatality, of which 5 of them had underlying diseases. Children with underlying diseases such as acute leukemia are more susceptible to getting severe varicella with complications and have a significantly higher mortality rate . Therefore, the varicella vaccine may be administered to children with acute lymphoblastic leukemia who are in remission, or, high-titer anti-varicella-zoster virus immune globulin as post-exposure prophylaxis is recommended for immunocompromised children and newborns that are exposed maternally to varicella .
Currently, the varicella vaccine program consists of a single-dose vaccination in Taiwan, as it is in Canada, Korea and Australia . However, both varicella outbreaks and breakthrough infections have occurred after the single-dose varicella vaccine program was initiated . These might be related to a loss of immunity or to primary vaccine failure. Although the reports are limited, varicella vaccine effectiveness may be higher when two doses are administered than when a single-dose is administered. In 2006, the United States changed its immunization policy by stipulating that 2 doses be administered, once at 1 year of age and another administered between the ages of 3 and 4 years old . In Taiwan, boosters in 4-6 year-old children to reduce the breakthrough infection or amend the primary vaccine failure may be considered if further epidemiology reveals frequent outbreaks or breakthrough infections in kindergarteners.
The major limitation of this study is that we could not verify the diagnoses because we could just analyze the NHI database rather than detailed medical charts. However, at the very least the nationwide database can let us outline the comprehensive picture of varicella epidemiology in Taiwan and sketch the impact of nationwide immunization.
In conclusion, nationwide varicella immunization significantly decreased the varicella annual incidence and varicella-related hospitalization in preschool children in Taiwan. The impact of the varicella vaccine on schoolchildren may be followed up on several years later.
Acknowledgements and Funding
This study is based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by National Health Research Institutes. The interpretation and conclusions contained herein do not represent those of the Bureau of National Health Insurance, Department of Health or National Health Research Institutes. This research was supported by the grants, NSC 100-2321-B-002 -012 from National Science Council and DOH 98-CD-1010 from Centers for Disease Control, Taiwan. The funding institutes did not have any role in study design, data collection/analysis, the writing of the manuscript and the decision to submit the manuscript for publication.
- Carapetis JR, Russell DM, Curtis N: The burden and cost of hospitalised varicella and zoster in Australian children. Vaccine. 2004, 23: 755-61. 10.1016/j.vaccine.2004.07.025.View ArticlePubMedGoogle Scholar
- Poulsen A, Cabral F, Nielsen J, Roth A, Lisse I, Aaby P: Growth, morbidity and mortality after chickenpox infection in young children in Guinea-Bissau. J Infect. 2005, 51: 307-13. 10.1016/j.jinf.2004.09.004.View ArticlePubMedGoogle Scholar
- Rivest P, Bedard L, Valiquette L, Mills E, Lebel MH, Lavoie G, et al: Severe complications associated with varicella: Province of Quebec, April 1994 to March 1996. Can J Infect Dis. 2001, 12: 21-6.View ArticlePubMedPubMed CentralGoogle Scholar
- Patrick D: Prevention strategies: experience of varicella vaccination programmes. Herpes. 2007, 14 (Suppl 2): 48-51.PubMedGoogle Scholar
- Asano Y: Varicella vaccine: the Japanese experience. J Infect Dis. 1996, 174 (Suppl 3): S310-3.View ArticlePubMedGoogle Scholar
- Macartney KK, Beutels P, McIntyre P, Burgess MA: Varicella vaccination in Australia. J Paediatr Child Health. 2005, 41: 544-52. 10.1111/j.1440-1754.2005.00717.x.View ArticlePubMedGoogle Scholar
- Getsios D, Caro JJ, Caro G, De Wals P, Law BJ, Robert Y, et al: Instituting a routine varicella vaccination program in Canada: an economic evaluation. Pediatr Infect Dis J. 2002, 21: 542-7. 10.1097/00006454-200206000-00012.View ArticlePubMedGoogle Scholar
- Burea of National Health Insurance, Department of Health, Executive Yuan, Taiwan ROC: Statistical annual reports. (Accessed at http://www.doh.gov.tw/statistic/%A5%FE%A5%C1%B0%B7%ABO/95.htm)
- Taiwan Center for Disease Control, Department of Health, Executive Yuan, Taiwan: National Immunization Information System (NIIS). [http://www.cdc.gov.tw/public/Data/7121816155271.doc]
- Department of Statistics MotI, Taiwan: Population by Single Year of Age. Department of Statistics, Taiwan, [http://www.moi.gov.tw/stat/index.asp]
- Lian IB, Chien YZ, Hsu PS, Chao DY: The changing epidemiology of varicella incidence after implementation of the one-dose varicella vaccination policy. Vaccine. 2011, 29 (7): 1448-54. 10.1016/j.vaccine.2010.12.032.View ArticlePubMedGoogle Scholar
- Myers MG, Seward JF, LaRussa FS: Varicella-zoster virus. Nelson Textbook of Pediatrics. 2007, 18Google Scholar
- Heininger U, Seward JF: Varicella. Lancet. 2006, 368: 1365-76. 10.1016/S0140-6736(06)69561-5.View ArticlePubMedGoogle Scholar
- Galil K, Lee B, Strine T, et al: Outbreak of varicella at a day-care center despite vaccination. N Engl J Med. 2002, 347 (24): 1909-15. 10.1056/NEJMoa021662.View ArticlePubMedGoogle Scholar
- Marin M, Meissner HC, Seward JF: Varicella prevention in the United States: a review of successes and challenges. Pediatrics. 2008, 122: e744-51. 10.1542/peds.2008-0567.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/11/352/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.