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Table 2 Factors associated with a positive T-SPOT.TB in 43 patients with determinate test results. Univariate and multivariate analysis

From: Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-Infection

Variable Univariate analysis Multivariate analysis
   OR 95% CI p-value Adjusted OR 95% CI p-value
Age, per 10 years older 1.02 0.52-2.03 0.945 1.23 0.53-2.87 0.624
Female 0.78 0.21-2.89 0.707 1.36 0.17-11.1 0.775
Body mass index, per 5 kg/m2 increase 0.62 0.20-1.89 0.403 0.59 0.18-2.00 0.398
Non-white ethnicity 1.70 0.50-5.83 0.397 - - -
Risk Men who have sex with men 1* - - - - -
  Heterosexual 1.04 0.22-4.91 0.960 - - -
  Intravenous drug use 1.40 0.23-8.46 0.714 - - -
Prior AIDS-defining condition 0.65 0.16-2.70 0.553 - - -
Antiretroviral treatment 0.31 0.26-1.21 0.120 0.87 0.14-5.65 0.888
CD4 cell count, per 50 cells/μL increase 1.01 0.85-1.20 0.904 - - -
CD4 cell count ≥200 versus < 200 cells/μL 2.55 0.72-8.96 0.146 1.41 0.27-7.39 0.682
CD8 cell count, per 50 cells/μL increase 0.97 0.93-1.02 0.292 - - -
Positive TST (≥ 5 mm) 1.63 0.40-6.63 0.493 - - -
Extrapulmonary versus pulmonary TB 2.13 0.61-7.41 0.237 - - -
Time between cells freezing and IGRA performance, per month 0.99 0.98-1.01 0.453 - - -
  1. * Reference category
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