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Table 1 General characteristics of the study population (n = 64) according to results of T-SPOT.TB assay

From: Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-Infection

Variable Positive T-SPOT.TB Negative
T-SPOT.TB
Indeterminate T-SPOT.TB p-value
   N = 25 N = 18 N = 21  
   n % n % n %  
Median age, IQR (years) 35 32-40 36 30-43 35 29-44 0.915
Males 18 72 12 67 14 67 0.904
Median body mass index, IQR (kg/m2) 22 20-25 22 21-25 23 20-26 0.906
White ethnicity 13 52 7 39 9 53 0.670
Prior AIDS-defining condition 5 20 5 25 8 38 0.396
Risk MSM 5 20 4 22 7 28 0.978
  Heterosexual 13 52 10 56 4 22  
  Intravenous drug use 7 38 10 48 5 24  
TB disease Pulmonary 13 52 7 39 13 62 0.357
  Extrapulmonary 8 32 9 50 7 33  
  Pulmonary and extrapulmonary 4 16 2 11 1 5  
Median CD4 cell count at TB diagnosis, IQR (cells/μL) 235 106-330 169 70-297 229 130-300 0.572
Median HIV-RNA at TB diagnosis, IQR (log10 copies/mL) 4.7 3.5-5.6 5.0 4.6-5.2 4.9 4.6-5.3 0.531
Median CD4 cell count at cells sampling, IQR (cells/μL) 235 122-320 147 70-349 256 108-379 0.498
Median CD8 cell count at cells sampling, IQR (cells/μL) 614 448-889 842 460-1191 835 510-1417 0.308
Median HIV-RNA at cells sampling, IQR (log10 copies/mL) 4.8 3.2-5.3 4.9 4.6-5.0 4.6 4.3-5.1 0.868
Antiretroviral therapy at cells sampling 13 52 14 78 12 57 0.211
Time between cells sampling and TB diagnosis, IQR (days) 63 15-126 57 12-163 72 20-284 0.786
Time between cells sampling and performance of IGRA, IQR (months) 81 48-135 107 70-141 123 84-167 0.142
TST ≥ 5 mm 10 40 7 39 5 24 0.414
  < 5 mm 7 28 8 44 7 33  
  missing 8 32 3 17 9 43  
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