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Table 1 General characteristics of the study population (n = 64) according to results of T-SPOT.TB assay

From: Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-Infection

Variable

Positive T-SPOT.TB

Negative

T-SPOT.TB

Indeterminate T-SPOT.TB

p-value

  

N = 25

N = 18

N = 21

 
  

n

%

n

%

n

%

 

Median age, IQR (years)

35

32-40

36

30-43

35

29-44

0.915

Males

18

72

12

67

14

67

0.904

Median body mass index, IQR (kg/m2)

22

20-25

22

21-25

23

20-26

0.906

White ethnicity

13

52

7

39

9

53

0.670

Prior AIDS-defining condition

5

20

5

25

8

38

0.396

Risk

MSM

5

20

4

22

7

28

0.978

 

Heterosexual

13

52

10

56

4

22

 
 

Intravenous drug use

7

38

10

48

5

24

 

TB disease

Pulmonary

13

52

7

39

13

62

0.357

 

Extrapulmonary

8

32

9

50

7

33

 
 

Pulmonary and extrapulmonary

4

16

2

11

1

5

 

Median CD4 cell count at TB diagnosis, IQR (cells/μL)

235

106-330

169

70-297

229

130-300

0.572

Median HIV-RNA at TB diagnosis, IQR (log10 copies/mL)

4.7

3.5-5.6

5.0

4.6-5.2

4.9

4.6-5.3

0.531

Median CD4 cell count at cells sampling, IQR (cells/μL)

235

122-320

147

70-349

256

108-379

0.498

Median CD8 cell count at cells sampling, IQR (cells/μL)

614

448-889

842

460-1191

835

510-1417

0.308

Median HIV-RNA at cells sampling, IQR (log10 copies/mL)

4.8

3.2-5.3

4.9

4.6-5.0

4.6

4.3-5.1

0.868

Antiretroviral therapy at cells sampling

13

52

14

78

12

57

0.211

Time between cells sampling and TB diagnosis, IQR (days)

63

15-126

57

12-163

72

20-284

0.786

Time between cells sampling and performance of IGRA, IQR (months)

81

48-135

107

70-141

123

84-167

0.142

TST

≥ 5 mm

10

40

7

39

5

24

0.414

 

< 5 mm

7

28

8

44

7

33

 
 

missing

8

32

3

17

9

43