A case of septicaemic anthrax in an intravenous drug user
© Powell et al; licensee BioMed Central Ltd. 2011
Received: 5 August 2010
Accepted: 20 January 2011
Published: 20 January 2011
In 2000, Ringertz et al described the first case of systemic anthrax caused by injecting heroin contaminated with anthrax. In 2008, there were 574 drug related deaths in Scotland, of which 336 were associated with heroin and or morphine. We report a rare case of septicaemic anthrax caused by injecting heroin contaminated with anthrax in Scotland.
A 32 year old intravenous drug user (IVDU), presented with a 12 hour history of increasing purulent discharge from a chronic sinus in his left groin. He had a tachycardia, pyrexia, leukocytosis and an elevated C-reactive protein (CRP). He was treated with Vancomycin, Clindamycin, Ciprofloxacin, Gentamicin and Metronidazole. Blood cultures grew Bacillus anthracis within 24 hours of presentation. He had a computed tomography (CT) scan and magnetic resonance imagining (MRI) of his abdomen, pelvis and thighs performed. These showed inflammatory change relating to the iliopsoas and an area of necrosis in the adductor magnus.
He underwent an exploration of his left thigh. This revealed chronically indurated subcutaneous tissues with no evidence of a collection or necrotic muscle. Treatment with Vancomycin, Ciprofloxacin and Clindamycin continued for 14 days. Negative Pressure Wound Therapy (NPWT) device was applied utilising the Venturi™ wound sealing kit. Following 4 weeks of treatment, the wound dimensions had reduced by 77%.
Although systemic anthrax infection is rare, it should be considered when faced with severe cutaneous infection in IVDU patients. This case shows that patients with significant bacteraemia may present with no signs of haemodynamic compromise. Prompt recognition and treatment with high dose IV antimicrobial therapy increases the likelihood of survival. The use of simple wound therapy adjuncts such as NPWT can give excellent wound healing results.
Anthrax is believed to be the cause of the 5th plague described in the book of Exodus (chap 9:3). It is a zoonosis affecting most herbivores, however, transmission from human to human has never been documented [1–3]. It is caused by Bacillus anthracis, a gram positive spore forming bacillus. It occurs when Bacillus anthracis' endospores enter the body either through breaks in the skin, ingestion or inhalation. Anthrax characterisation is based upon its original mode of transmission; cutaneous, gastrointestinal and inhalational. Anthrax is derived from the Greek word meaning coal after the black skin lesions seen in its cutaneous form .
Anthrax remains relatively rare with between 20,000 and 100,000 cases occurring in the world annually . It is predominantly related to occupational exposure as seen in farmers, veterinarians and people handling wool . Only a handful of anthrax cases have been seen in Britain over the last decade. In 2006, a fatal case of inhalation anthrax was reported in the Scottish borders . This was the first case of anthrax seen in nearly 30 years. In 2000, Ringertz et al described the first case of systemic anthrax caused by injecting heroin contaminated with anthrax .
In 2008, there were 574 drug related deaths in Scotland, of which 336 were associated with heroin and or morphine . Of the 574 deaths, 197 (34%) occurred in Greater Glasgow & Clyde. NHS Greater Glasgow and Clyde covers the city of Glasgow and a population of approximately (1.2 million) . In 2000, it was estimated that 6809 people in Glasgow were intravenous drug users (IVDU) . Due to the risky behaviour associated with illicit drug use, mortality rates in IVDU patients have been estimated to be 12-22% higher than an age-adjusted population [11–13].
In December 2009, the first case of fatal anthrax relating to intravenous drug abuse was documented in the British media . In total there were 47 confirmed cases and 13 anthrax related deaths during this outbreak [15, 16]. Systemic anthrax infection is associated with high mortality rates with 45% of patients with inhalation anthrax ultimately dying from the infection [17, 18]. Cutaneous anthrax infection, however, is not associated with high mortality rates .
We present an interesting case of septicaemic anthrax, in a patient with no evidence of septic shock, caused by injecting heroin contaminated with anthrax in the UK. In our case report, we discuss the clinical and pathological aspects of the case, the use of wound therapy adjuncts in promoting wound healing and review the current literature.
A 32 year old male who was a known IVDU, presented with a 12 hour history of increasing swelling in his left leg. He had a purulent discharge from a chronic sinus in his left groin.
He underwent an exploration of his left thigh. This revealed chronically indurated subcutaneous tissues in keeping with his long history of injecting into the area. There was some oedematous fluid but no evidence of a collection or necrotic muscle. Post-operatively he made a steady recovery.
Treatment with Vancomycin, Ciprofloxacin and Clindamycin continued for 14 days. Negative Pressure Wound Therapy (NPWT) device was applied utilising the Venturi™ wound sealing kit. This followed the therapy application technique first described by Chariker et al using saline-moistened gauze, a silicone drain and clear, semi-permeable adhesive film, together with lower pressures, usually between 60-80 mmHg.15
We present an interesting case of septicaemic anthrax in an intravenous drug user, who despite having B. anthracis bacteraemia and severe cutaneous infection, displayed no evidence of septic shock and made an uneventful recovery following IV antibiotic therapy and surgical debridement. This case was part of a large outbreak of septicaemic anthrax infection in an IVDU population of 47 patients with a mortality rate of 27% .
Mortality associated with systemic anthrax infection is well known to be high with 40% of the patients in the 2001 bioterrorist attacks dying from the infection . Of the 10 patients in their series, 7 patients presented with severe sepsis and grew B. anthracis on blood culture. Of the 7 patients with bacteraemia 4 died of acute circulatory collapse. This suggests the presence of positive blood cultures foretells a high risk of mortality. Doganay and colleagues described a series of 22 patients presenting with cutaneous anthrax infection over a 7 year period . Of these, 10 patients had severe infection and 2 patients suffered from septic shock. In contrast to our case, all patients with positive blood culture had evidence of severe infection and septic shock. Of interest, none of the patients in their series died from anthrax.
It is believed this outbreak resulted from exposure to a batch of contaminated heroin. This is suggested by the geographical distribution and the occurrence of contemporaneous outbreaks within the city. McGuigan et al reported a similar outbreak in 2000; however, the aetiological agent is thought to have been Clostridium novyi . Street heroin in Britain is thought to originate from Afghanistan [13, 20]. Non-sterile methods for its production, 'cutting' and transportation increase the risk of contamination.
The lethal outbreak of Clostridium novyi in 2000 prompted the production of consensus guidelines for treating severe cutaneous infection in IVDU patients. In the case series reported by McGuigan et al, the commonest organisms seen, were Clostridium novyi, Staphylococcus aureus, group A beta-haemolytic streptococci and anaerobes. Based on this finding they suggested using an antimicrobial regimen of Flucloxacillin, Benzylpenicillin, Gentamicin, Clindamycin and Metronidazole .
In 2001, Swartz published guidelines for the recognition and management of anthrax. He suggested using ciprofloxacin 400 mg IV combined with a penicillin for inhalation and severe cutaneous anthrax infection . His recommendations were based on consensus guidelines published by Iglesby et al. The efficacy of ciprofloxacin in anthrax had been poorly studied in humans, however, in animal models excellent recovery has been demonstrated despite the lack of an immune response . This finding led to the recommendation that all patients surviving anthrax should continue antibiotic therapy for 60 days.
The evidence published by McGuigan et al suggested that of all the patients who were classified as a 'definite' diagnosis of Clostridium novyi, approximately 20% grew an alternative organism. This suggests, even during a recognised outbreak, the diagnosis of a particular infection based on clinical parameters alone is unreliable.
All IVDU patients presenting with severe cutaneous infection were treated with Benzylpenicillin, Flucloxacillin, Gentamicin, Clindamycin, Ciprofloxacin and Metronidazole. In the case of penicillin allergy Vancomycin was used in place of Benzylpenicillin and Flucloxacillin. Once a causative agent was found, the antimicrobial therapy was rationalised. The diagnosis of anthrax was confirmed by isolation of Bacillus anthracis in early blood cultures in some patients. This was supported by PCR testing of blood or excised tissues at the Health Protection Agency (HPA) Special Pathogens Reference Unit (SPRU) at Porton Down.
NPWT is a non-invasive technology comprising a negative pressure pump connected by a tube to a dressing that occupies the wound cavity. The dressing is sealed to the peri-wound skin using an adhesive film. This provides a closed system, so that negative (sub-atmospheric) pressure is generated at the wound/dressing interface. NPWT is suitable for acute, chronic and traumatic wounds as an adjunct to surgery . Despite NPWT appearing in the literature for over 50 years, the physiological and molecular biological mechanisms by which NPWT accelerates wound healing remain largely unknown .
Although systemic anthrax infection is rare, it should be considered when faced with severe cutaneous infection in IVDU patients. The presence of Bacillus anthracis on blood culture is normally associated with septic shock and high rates of mortality; however, our case suggests that these patients may not exhibit haemodynamic compromise despite having significant bacteraemia. Prompt recognition and treatment with high dose IV antimicrobial therapy increases the likelihood of survival. Adherence to antimicrobial prescribing guidelines reduces the possibility of missing other potentially lethal organisms. The use of simple wound therapy adjuncts such NPWT can give excellent wound healing results over a relatively short period.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Dixon TC, Meselson M, Guillemin J, Hanna PC: Anthrax. N Engl J Med. 1999, 341: 815-26. 10.1056/NEJM199909093411107.View ArticlePubMedGoogle Scholar
- Doganay M: Anthrax. Infectious Diseases. Edited by: Powderly CJ. 2004, St Louis, MO: Mosby, 1685-9. 2Google Scholar
- Doganay L, Welsby PD: Anthrax: a disease in waiting?. Postgrad Med J. 2006, 82: 754-756. 10.1136/pgmj.2005.044487.View ArticlePubMedPubMed CentralGoogle Scholar
- Friedlander AM: Anthrax: clinical features, pathogenesis, and potential biological warfare threat. Current clinical topics in infectious diseases. Edited by: Remington JS, Swartz MN. 2000, Malden, Blackwell Science, 20: 335-49.Google Scholar
- Bush LM, Abrams BH, Beall A, Johnson CC: Index Case of Fatal Inhalation Anthrax Due to Bioterrorism in the United States. N Engl J Med. 2001, 345: 1607-1610. 10.1056/NEJMoa012948.View ArticlePubMedGoogle Scholar
- Cramb A: First British anthrax death in 30 years due to 'freak circumstances'. [http://www.telegraph.co.uk/health/healthnews/4527107/First-British-anthrax-death-in-30-years-due-to-freak-circumstances.html]
- Ringertz SH, Hoiby EA, Jensenius M, Maehlen J, Caugant DA, Myklebust A, Fossum K: Injectional anthrax in a heroin skin popper. The Lancet. 2000, 356 (241): 1574-1575. 10.1016/S0140-6736(00)03133-0.View ArticleGoogle Scholar
- General Register office for Scotland: Drug related deaths in Scotland in 2008. Edinburgh. 2009Google Scholar
- General Register office of Scotland: Mid-2008 Population Estimates Scotland. Population estimates by sex, age and administrative area. Edinburgh. 2009Google Scholar
- Hutchinson SJ, Bird SM, Taylor A, Goldberg DJ: Estimating the prevalence, incidence and cessation of injecting drug use in Glasgow 1960-2000: Combining expert opinion with capture-recapture prevalence data. International Journal of Drug Policy. 2006, 17: 29-34. 10.1016/j.drugpo.2005.06.011.View ArticleGoogle Scholar
- Oppenheimer E, Tobutt C, Taylor C, Andrew T: Death and survival in a cohort of heroin addicts from London clinics: a 22-year follow-up study. Addiction. 1994, 89: 1299-1308. 10.1111/j.1360-0443.1994.tb03309.x.View ArticlePubMedGoogle Scholar
- Frischer M, Goldberg D, Rahman M, Berney L: Mortality and survival among a cohort of drug injectors in Glasgow, 1982-1994. Addiction. 1997, 92: 419-427.View ArticlePubMedGoogle Scholar
- McGuigan CC, Penrice GM, Gruer L, Ahmed S, Goldberg D, Black M, Salmon JE, Hood J: Lethal outbreak of infection with Clostridium novyi type A and other spore-forming organisms in Scottish injecting drug users. J Med Microbiol. 2002, 51: 971-977.View ArticlePubMedGoogle Scholar
- McLaughlin M: Anthrax in heroin kills addict. [http://news.scotsman.com/health/Anthrax-in-heroin-kills-addict.5922626.jp]
- Health Protection Scotland: Anthrax Outbreak Information. [http://www.hps.scot.nhs.uk/anthrax/index.aspx]
- Ramsay CN, Stirling A, Smith J, Kawkins G, Brooks T, Hood J, Penrice G, Browning LM, Ahmed S: An outbreak of infection with bacillus anthracis in injecting drug users in Scotland. Eurosurveillance. 2010, 15 (2):Google Scholar
- Jernigan JA, Stephens DS, Ashford DA, Omenaca C, Topiel MS, Galbraith M, Tapper M, Fisk TL, Zaki S, Popovic T, Meyer RF, Quin CP, Harper SA, Fridkin SK, Sejvar JJ, Shepard CW, McConnell M, Guarner J, Shieh WJ, Malecki JM, Gerberding JL, Hughes JM, Perkins BA: Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States. Emerg Infect Dis. 2001, 7 (6): 933-44. 10.3201/eid0706.010604.View ArticlePubMedPubMed CentralGoogle Scholar
- Holty JE, Bravata DM, Liu H, Olshen RA, McDoanld KM, Owens DK: Systematic review: a century of inhalational anthrax cases from 1900 to 2005. Ann Intern Med. 2006, 144 (4): 270-80.View ArticlePubMedGoogle Scholar
- Doganay M, Metan G, Alp E: A review of cutaneous anthrax and its outcome. J Infect Publich Health. 2010, 3 (3): 98-105. 10.1016/j.jiph.2010.07.004.View ArticleGoogle Scholar
- Tuazon CU, Hill R, Sheagren JN: Microbiologic study of street heroin and injection paraphernalia. J Infect Dis. 1974, 129: 327-329.View ArticlePubMedGoogle Scholar
- Swartz MN: Recognition and management of anthrax: an update. N Eng J Med. 2001, 345: 1621-6. 10.1056/NEJMra012892.View ArticleGoogle Scholar
- Inglesby TV, Henderson DA, Bartlett JA, Ascher MS, Eitzen E, Friedlander AM, Hauer J, McDade J, Osterholm MT, O'Toole T, Parker G, Perl TM, Russell PK, Tonat K: Anthrax as a Biological Weapon: Medical and Public Health Management. JAMA. 1999, 281 (18): 1735-1745. 10.1001/jama.281.18.1735.View ArticlePubMedGoogle Scholar
- MA Healthcare: Wound Care Handbook 2009 - 2010. 2009, MA Healthcare LondonGoogle Scholar
- Borgquist O, Gustafsson L, Ingemansson R, Malmsjo : Tissue Ingrowth In to Foam but Not Into Gauze During Negative Pressure Wound Therapy. Wounds. 2009, 21 (11): 302-9.PubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/11/21/prepub
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