From: Chronic meningitis in adults: a comparison between neurotuberculosis and neurobrucellosis
Ā | Ā | TBM (nā=ā28) | BM (nā=ā42) | Effect size (95% CI) | P-value |
---|---|---|---|---|---|
CSF analysis | CSF leukocytes/ microlitre, meana (95% CI) | 86.0 (45.1 to 139.9) | 116.2 (81.6 to 157.1) | Ī² coefficientb: -1.51 (-4.44 to 1.43) | 0.308 |
Mild pleocytosis (leukocytesā<ā50/ microlitre), n (%) | 12/27 (44.4) | 11/42 (26.2) | RR: 1.70 (0.88 to 3.28) | 0.116 | |
CSF PMN percentagea, mean (95% CI) | 34.1 (20.6 to 50.9) | 16.1 (10.9 to 22.4) | Ī² coefficientb: 1.82 (0.48 to 3.16) | 0.008 | |
CSF PMN predominance, n (%) | 12/26 (46.2) | 4/40 (10.0) | RR: 4.62 (1.67 to 12.78) | 0.001 | |
CSF protein (mg/dL), geometric mean (95% CI) | 128.0 (93.4 to 175.4) | 84.3 (61.7 to 115.3) | RoGM: 1.52 (0.96 to 2.41) | 0.076 | |
Severe hyperproteinorrhachia (proteināā„ā500 mg/dL), n (%) | 2/26 (7.7) | 2 (4.8) | RR: 1.62 (0.24 to 10.78) | 0.633 | |
CSF glucose (mg/dL), geometric mean (95% CI) | 26.8 (20.1 to 35.7) | 35.0 (28.8 to 42.6) | RoGM: 0.76 (0.55 to 1.06) | 0.107 | |
Severe hypoglycorrhachia (glucoseā<ā10 mg/dL), n (%) | 4/26 (15.4) | 2 (4.8) | RR: 3.23 (0.64 to 16.41) | 0.193 | |
Neuroimaging findings | Hydrocephalus, n (%) | 10/27 (37.0) | 2/40 (5.0) | RR: 7.41 (1.76 to 31.19) | 0.002 |
Infarct, n (%) | 7/27 (25.9) | 2/37 (5.4) | RR: 4.80 (1.08 to 21.31) | 0.029 | |
Granuloma/Abscess, n (%) | 5/26 (19.2) | 3/34 (8.8) | RR: 2.18 (0.57 to 8.30) | 0.275 | |
Meningeal enhancement, n (%) | 8/25 (32.0) | 2/35 (5.7) | RR: 5.60 (1.30 to 24.16) | 0.012 | |
Nonspecific white matter lesions on T2-weighted and FLAIR images, n (%) | 3/19 (15.8) | 10/26 (38.5) | RR: 0.41 (0.13 to 1.29) | 0.097 |