Patient characteristics | Pneumonia-related bacteremia (n = 45) | Nonpneumonia-related bacteremia(n = 72) | P value |
---|---|---|---|
Demographic | Â | Â | Â |
Age (year), median (IQR) | 60.664 ± 18.42 | 60.143 ± 16.57 | 0.875 |
Sex, n (%) | 34 (75.6%) | 50 (69.4%) | 0.475 |
Underlying diseases | Â | Â | Â |
History of allergy to antibiotic, n (%) | 6 (13.3%) | 6 (8.3%) | 0.580 |
History of smoking, n (%) | 27 (60%) | 13 (18.1%) | < 0.001 |
History of alcohol, n (%) | 20 (44.4%) | 9 (12.5%) | < 0.001 |
Diabetes, n (%) | 13 (28.9%) | 14 (19.4%) | 0.238 |
Chronic respiratory disease, n (%) | 6 (13.3%) | 3 (4.2%) | 0.146 |
Hypertension, n (%) | 16 (35.6%) | 29 (40.3%) | 0.610 |
Chronic cardiac dysfunction, n (%) | 3 (6.7%) | 5 (6.9%) | 1.000 |
Chronic kidney dysfunction, n (%) | 4 (8.9%) | 7 (9.7%) | 1.000 |
Cerebrovascular disease, n (%) | 19 (42.2%) | 16 (22.2%) | 0.022 |
Malignant tumor, n (%) | 7 (15.6%) | 22 (30.6%) | 0.068 |
Recent invasive procedures | Â | Â | Â |
Endotracheal tube, n (%) | 34 (75.6%) | 26 (36.1%) | < 0.001 |
Mechanical ventilation, n (%) | 42 (93.3%) | 28 (38.9%) | < 0.001 |
Tracheostomy, n (%) | 22 (48.9%) | 9 (12.5%) | < 0.001 |
Percutaneous drainage, n (%) | 23 (51.1%) | 46 (63.9%) | 0.172 |
Central venous catheter, n (%) | 39 (86.7%) | 31 (43%) | < 0.001 |
Fiberoptic bronchoscopy, n (%) | 24 (53.3%) | 8 (11.1%) | < 0.001 |
Indwelling urinary catheter, n (%) | 43 (95.6%) | 41 (56.9%) | < 0.001 |
Nasogastric tube, n (%) | 43 (95.6%) | 32 (44.4%) | < 0.001 |
Enteral nutrition | 24 (53.3%) | 37 (51.4%) | 0.838 |
Special therapy (contain CRRT/ECOMO), n (%) | 11 (24.4%) | 10 (13.9%) | 0.148 |
Invasive interventions used prior to culture (n > = 3 types) | 43(95.6%) | 35(48.6%) | < 0.001 |
Conditions on bacteremia day | Â | Â | Â |
Immunocompromised status, n (%) | 24 (53.3%) | 20 (27.8%) | 0.005 |
Length of hospital stay prior to culture, median (IQR) | 12 (8, 23) | 7 (5, 11.5) | 0.010 |
Length of ICU stay prior to culture, median (IQR) | 10 (2, 18) | 0 (0, 6) | < 0.001 |
Inpatient department of ICU prior to culture, n (%) | 40 (88.9%) | 31 (43%) | < 0.001 |
CRAB, n (%) | 36 (80%) | 33 (45.8%) | < 0.001 |
MDRAB, n (%) | 38 (84.4%) | 34 (47.2%) | < 0.001 |
Antibiotic used (> 3 types) prior to culture, n (%) | 31 (68.9%) | 18 (25%) | < 0.001 |
Appropriate antimicrobial therapy, n (%) | 17 (37.8%) | 38 (52.8%) | 0.114 |
Recent surgery (within 1 mo), n (%) | 22 (48.9%) | 47 (65.3%) | 0.080 |
Laboratory indicators prior to culture | Â | Â | Â |
Creatinine, median (IQR) | 69 (47, 125) | 66 (51.5, 103.6) | 0.760 |
Blood urea nitrogen (BUN), median (IQR) | 12.85 (7.1, 19.1) | 6.74 (5.29, 10.57) | 0.001 |
Albumin (ALB), median (IQR) | 15.8 (9.8, 30.6) | 20.7 (10.35, 48.5) | 0.356 |
Bilirubin, mean ± sd | 31.631 ± 4.5215 | 33.786 ± 5.4495 | 0.029 |
C-reactive protein(CRP), median (IQR) | 89.5 (54.57, 153.21) | 67.985 (23.055, 127.27) | 0.047 |
Procalcitonin (PCT), median (IQR) | 0.741 (0.3, 2.161) | 2.833 (0.482, 8.2775) | 0.016 |
Lactate (Lac), median (IQR) | 1.3 (1.2, 1.8) | 1.6 (1.1, 2.2) | 0.137 |
Disease severity | Â | Â | Â |
SOFA score, median (IQR) | 8 (7, 11) | 4 (1, 7) | < 0.001 |
APACHE score, mean ± sd | 19.033 ± 5.6598 | 19.958 ± 6.8872 | 0.590 |
PITT score, median (IQR) | 6 (4, 9) | 2.5 (1, 5) | < 0.001 |
Outcomes | Â | Â | Â |
28-d mortality, n (%) | 35 (77.8%) | 31 (43.1%) | < 0.001 |
Length of hospital stay (d) after onset of bacteremia, n (%) | 9 (4.75, 15) | 11 (4, 26) | 0.510 |
Survival > 14 d after onset of bacteremia, n (%) | 22 (48.9%) | 58 (80.6%) | < 0.001 |