Utility of paired plasma and drainage fluid mNGS in diagnosing acute intra-abdominal infections with sepsis

BMC Infectious Diseases

Table 2 Characteristics of patients for subgroup analysis

Characteristics	Matched mNGS group n = 29	Non-matched mNGS group n = 31	p
Age, yr	66.1 ± 16.5	59.8 ± 11	0.0918
Gender, n (%)
Male	19(65.5)	15(48.4)	0.1869
APACHEII	20.6 ± 7.2	19.2 ± 7.0	0.4709
SOFA	8.1 ± 2.7	6.3 ± 2.7	0.0130^*
Mortality, n(%)	5(17.2)	0(0)	0.0153^*
ICU stay time, d	19(11-30.4)	8.5(6.3–19.0)	0.0205^*
Septic shock	21(61.0)	13(47.4)	0.0169^*
Vasoactive usage duration, h	37.2(0-102.6)	0(0–23.0)	0.0134^*
MV duration, h	35.8(3.6-117.5)	5.4(0-20.7)	0.0077^**
WBC, *10⁹/L	13.5 ± 8.7	9.6 ± 5.2	0.049^*
PCT, ng/mL	1.2(0.44–5.2)	2.9(0.81–8.4)	0.2075

mNGS, metagenomic next-generation sequencing; APACHE II, Acute Physiology and Chronic Health Evaluation II score; SOFA, Sequential Organ Failure Assessment score; ICU, Intensive Care Unit; MV, mechanical ventilation; WBC, white blood cell; PCT, procalcitonin

ISSN: 1471-2334