Table 2 Prevalence of tetracycline resistance in N. gonorrhoeae, commensal Neisseria species and S. aureus in the three included studies
Study, Year of publication | Target bacterial species | Tetracycline breakpoint (mg/L) | Baseline | Month 12 (During follow up for N. gonorrhoeae) | ||
|---|---|---|---|---|---|---|
Tetracycline arm N resistant/N tested (% resistant to tetracycline) | Placebo arm N resistant/N tested (% resistant to tetracycline) | Tetracycline arm N resistant/N tested (% resistant to tetracycline) | Placebo arm N resistant/N tested (% resistant to tetracycline) | |||
Harrison 1979 [14] | N. gonorrhoeae | ≥1 mg/L | NA | NA | 18/18 (100%) | 38/44 (86.4%) |
Harrison 1979 [14] | N. gonorrhoeae | ≥2 mg/L | NA | NA | 12/18 (66.7%) | 19/44 (43.2%) |
Molina 2018 [3] | N. gonorrhoeae | ≥1 mg/L | NA | NA | 0/2 (0%) | 4/6 (66.7%) |
Luetkemeyer 2023 [5] | N. gonorrhoeae | ≥2 mg/L | 2/7 (28.6%) | 2/8 (25%) | 5/13 (38.5%) | 2/16 (12.5%) |
Commensal Neisseria spp. | ≥2 mg/L | 189/302 (62.6%) | 92/153 (60.1%) | 85/122 (69.7%) | 25/56 (44.6%)* | |
S. aureus | ≥2 mg/L | 12/334 (3.6%) | 19/161 (11.8%) | 16/137 (11.7%) | 3/62 (4.8%) | |