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Table 5 Reduction of MICs of β-lactam antibiotics combined with Monolaurin (500 µg/ml) against MSSA (n = 12)

From: Novel synergistic interactions between monolaurin, a mono-acyl glycerol and β lactam antibiotics against Staphylococcus aureus: an in vitro study

MIC (µg/mL)

FIC (A) / FIC (B)

FIC index

Interpretation

No. of isolates

P value

Alone

In combination

Ampicillin (A) /Monolaurin(B)

Ampicillin (A) /Monolaurin (B)

8/500

0.5/500

0.0625/1

1.0625

Indifference

2

 < 0.001

8/1000

0.5/500

0.0625/0.5

0.5625

Partial synergy

3

16/1000

0.5/500

0.031/0.5

0.531

Partial synergy

4

16/1000

1/500

0.0625/0.5

0.5625

Partial synergy

3

Amoxicillin /Monolaurin

Amoxicillin /Monolaurin

FICA/FICB

FIC index

Interpretation

No. of isolates

P value

32/500

0.5/500

0.015625/1

1.0156

Indifference

2

 < 0.001

32/1000

0.5/500

0.015625/0.5

0.515625

Partial synergy

5

64/1000

0.5/500

0.0078/0.5

0.5078

Partial synergy

5

Piperacillin /Monolaurin

Piperacillin /Monolaurin

FICA/FICB

FIC index

Interpretation

No. of isolates

P value

16/500

0.5/500

0.031/1

1.031

Indifference

2

 < 0.001

16/1000

0.5/0.5

0.031/0.5

0.531

Partial synergy

7

128/1000

1/500

0.0078/0.5

0.5078

Partial synergy

1

256/1000

1/500

0.0039/0.5

0.5039

Partial synergy

1

256/1000

8/500

0.031/0.5

0.531

Partial synergy

1

  1. *total synergistic (FICI≤0.5), partial synergistic (0.5 < FICI < 1), additive FICI=1 or indifferent (1 < FICI < 4) and antagonistic (FICI≥4) **significant difference atPvaluse < 0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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