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Table 4 Reduction of MICs of β-lactam antibiotics combined with Monolaurin (2500 µg/ml) against MSSA (n = 12)

From: Novel synergistic interactions between monolaurin, a mono-acyl glycerol and β lactam antibiotics against Staphylococcus aureus: an in vitro study

MIC (µg/mL)

FIC (A) / FIC (B)

FIC index

Interpretation

No. of isolates

P value

Alone

In combination

Ampicillin (A) /Monolaurin(B)

Ampicillin (A) /Monolaurin (B)

8/1000

1/250

0.125/0.25

0.375

Synergistic

3

 < 0.001

8/500

2/250

0.25/0.5

0.75

Partial synergy

2

16/1000

1/250

0.0625/0.25

0.3125

Synergistic

4

16/1000

4/250

0.25/0.25

0.5

Synergistic

3

Amoxicillin /Monolaurin

Amoxicillin /Monolaurin

FICA/FICB

FIC index

Interpretation

No.of isolates

P value

32/1000

0.5/250

0.015625/0.25

0.2656

Synergistic

3

 < 0.001

32/1000

2/250

0.0625/0.25

0.3125

Synergistic

4

64/500

0.5/250

0.0078/0.5

0.5078

Partial synergy

2

64/1000

2/250

0.03125/0.25

0.28125

Synergistic

3

Piperacillin /Monolaurin

Piperacillin /Monolaurin

FICA/FICB

FIC index

Interpretation

No. of isolates

P value

16/1000

2/250

0.125/0.25

0.375

Synergistic

1

 < 0.001

16/1000

4/250

0.25/0.25

0.5

Synergistic

6

16/500

8/250

0.5/0.5

1

Additive

2

128/1000

16/250

0.125/0.25

0.375

Synergistic

1

256/1000

32/250

0.125/0.25

0.375

Synergistic

2

  1. *total synergistic (FICI≤0.5), partial synergistic (0.5 < FICI < 1), additive FICI=1 or indifferent (1 < FICI < 4) and antagonistic (FICI≥4) **significant difference at P value < 0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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