MIC (µg/mL) | FIC (A) / FIC (B) | FIC index | Interpretation | No. of isolates | P value | |
Alone | In combination | |||||
Ampicillin (A) /Monolaurin(B) | Ampicillin (A) /Monolaurin (B) | |||||
8/1000 | 0.5/500 | 0.0625/0.5 | 0.56 | Partial synergy | 24 | < 0.001 |
8/250 | 0.5/500 | 0.062/2 | 2.062 | Indifference | 3 | |
8/500 | 2/500 | 0.25/1 | 1.25 | Indifference | 9 | |
8/1000 | 2/500 | 0.25/0.5 | 0.75 | Partial synergy | 2 | |
16/1000 | 0.5/500 | 0.03125/0.5 | 0.53 | Partial synergy | 28 | |
16/1000 | 2/500 | 0.125/0.5 | 0.625 | Partial synergy | 4 | |
32/1000 | 0.5/500 | 0.015625/0.5 | 0.515 | Partial synergy | 22 | |
32/1000 | 2/500 | 0.0625/0.5 | 0.5625 | Partial synergy | 3 | |
32/2000 | 2/500 | 0.0625/0.125 | 0.1875 | Synergistic | 8 | |
Amoxicillin /Monolaurin | Amoxicillin /Monolaurin | FICA/FICB | FIC index | Interpretation | No.of isolates | P value |
32/250 | 0.5/500 | 0.015625/2 | 2.015 | Indifference | 3 | < 0.001 |
32/1000 | 0.5/500 | 0.015625/0.5 | 0.515 | Partial synergy | 20 | |
32/1000 | 4/500 | 0.125/0.5 | 0.625 | Partial synergy | 6 | |
64/500 | 0.5/500 | 0.0078/1 | 1.0078 | Indifference | 9 | |
64/1000 | 0.5/500 | 0.0078/0.5 | 0.5078 | Partial synergy | 44 | |
64/1000 | 1/500 | 0.015625/0.5 | 0.515 | Partial synergy | 5 | |
64/1000 | 4/500 | 0.0625/0.5 | 0.5625 | Partial synergy | 6 | |
128/1000 | 0.5/500 | 0.0039/0.5 | 0.5039 | Partial synergy | 2 | |
128/2000 | 0.5/500 | 0.0039/0.25 | 0.2539 | Synergistic | 8 | |
Piperacillin /Monolaurin | Piperacillin /Monolaurin | FICA/FICB | FIC index | Interpretation | No. of isolates | P value |
16/250 | 1/500 | 0.0625/2 | 2.0625 | Indifference | 2 | < 0.001 |
16/250 | 0.5/500 | 0.03125/2 | 2.03125 | Indifference | 1 | |
16/1000 | 0.5/500 | 0.03125/0.5 | 0.53125 | Partial synergy | 25 | |
64/500 | 0.5/500 | 0.0078/1 | 1.0078 | Indifference | 5 | |
64/500 | 1/500 | 0.0156/1 | 1.0156 | Indifference | 4 | |
128/1000 | 1/500 | 0.0078/0.5 | 0.5078 | Partial synergy | 16 | |
128/1000 | 8/500 | 0.0625/0.5 | 0.5625 | Partial synergy | 12 | |
128/1000 | 0.5/500 | 0.0039/0.5 | 0.5039 | Partial synergy | 12 | |
128/1000 | 1/500 | 0.0078/0.5 | 0.5078 | Partial synergy | 6 | |
128/1000 | 16/500 | 0.125/0.5 | 0.625 | Partial synergy | 12 | |
256/2000 | 8/500 | 0.03125/0.25 | 0.28 | Synergistic | 8 |